Effects of integrated chronic care models on hypertension outcomes and spending: a multi-town clustered randomized trial in China
© The Author(s). 2017
Received: 22 October 2016
Accepted: 23 February 2017
Published: 11 March 2017
Hypertension affects one billion people globally and is one of the leading risk factors for cardiovascular and renal diseases. However, hypertension management remains poor, especially in rural China.
A clustered randomized controlled trial was conducted in six towns in China’s Qianjiang county between 7/2012 and 6/2014, including 5462 hypertension patients above 35 years old. Six towns were randomly assigned to three groups: Group 1 had the integrated care model including a multidisciplinary team and continuous care coordination, Group 2 had both the integrated care model and provider-level financial incentives, and the control group had the usual care. Primary outcomes were systolic blood pressure and health-related quality of life measured by SF36; secondary outcomes included hypertension-related hospitalization rate and inpatient spending. Blood pressure was measured sixteen times bimonthly between 12/1/2011 and 6/30/2014, and quality of life was measured on 7/1/2012 and 6/30/2014. Inpatient data between 7/1/2010 and 8/31/2014 were used. This trial is registered at the World Health Organization’s International Clinical Trials Registry, number ChiCTR-OOR-14005563.
We found that the integrated care model effectively lowered blood pressure by 1.93 mmHg (95% CI 0.063–3.8), improved self-assessed health-related quality of life, and reduced the rate of hypertension-related hospitalization by 0.17 percentage points (95% CI 0.094–0.24). We also found that the provider-level financial contract further lowered blood pressure by 1.76 mmHg (95% CI 0.73–2.79) and reduced rates of hospitalization and inpatient spending, but it also reduced patients’ self-assessed health-related quality of life.
Integrated care and financial incentives are effective in lowering blood pressure and reducing hospitalization rate, but financial contracts may hurt patient quality of life.
This trial was registered at the Chinese Clinical Trial Registry (ChiCTR-OOR-14005563) on November 23, 2014. It was a retrospective registration.
KeywordsIntegrated chronic care model Clustered randomized trial Hypertension China
As the burden of disease has shifted from acute illness to chronic diseases worldwide, patients’ needs require more continuous care coordination and integration across multiple professional providers. However, in the current healthcare delivery system, patients often experience fragmented medical care, and the fragmentation of care has become one of the major challenges many countries face [1, 2]. To reform the fragmented system, new integrated care models, with or without new funding models, are being tried out around the world, including American Accountable Care Organizations, Australian Primary Health Networks, British Integrated Care Pioneers, and the Germany’s Gesundes Kinzigtal model [1, 3, 4].
Healthcare is particularly fragmented in rural China, where the healthcare system includes three tiers: village, town, and county . Patients go to village clinics for simple outpatient care and preventive care, and go to town hospitals or county hospitals for inpatient care or outpatient conditions village clinics cannot handle. Communications among multiple professional providers are limited and there are virtually no document sharing and interactions among providers across the three tiers. Thus, an integrated care model shows particular promise for improving care in China. However, no large-scale interventions have been conducted to test alternative chronic-care models that integrate care across providers and across tiers in rural China.
Some new integrated care models being tested out in western countries include a new funding component in which providers can share savings if spending falls below a pre-specified financial benchmark. There is some early evidence showing that these types of financial incentives are associated with potential savings in total healthcare costs [3, 4, 6]. However, in general, fewer studies have evaluated effects of provider-level financial incentives on chronic care management, especially through randomized control trials [7, 8].
In this study, we conducted a multi-town clustered randomized trial on hypertension management in rural China. Six towns were randomly assigned to three groups: Group 1, with the integrated care model including a multidisciplinary team and continuous care coordination; Group 2, with both the integrated care model and provider-level financial incentives; and a control group, with usual care.
Patients in our study sample had been diagnosed with hypertension for at least 6 months and had three or more measures of blood pressure greater than 140/90 mmHg in the Chinese national official medical record before our interventions began. Hypertension is prevalent, affecting nearly one billion people worldwide and over 442 million people in China [9, 10]. It is one of the leading risk factors for cardiovascular and renal diseases and is estimated to cause 12.8% of total deaths worldwide and 20% of deaths in China [9, 10]. In China, the proportion of patients with hypertension unaware of their conditions was over 30% and the proportion of known hypertensive patients who received treatment was only 56.1% in 2012 [11, 12]. The rate of uncontrolled blood pressure (defined as blood pressure greater than 140/90 mmHg) among Chinese with hypertension is much higher than in the West, estimated to be 78.3% in 2008 and 63.4% in 2012 [11, 13]. In addition, inequality in hypertension management is prevalent in China: poor or rural residents were much less likely to receive treatment, compared to those living in urban or affluent areas . For all these reasons, there are potentially large health gains from validating better hypertension treatment models in rural China.
Previous studies have found that inadequate control of hypertension is often related to gaps in continuity of health care , poor adherence to medications , and unhealthy lifestyle , and integrated care can improve hypertension management . For example, Glynn and colleagues reviewed 72 clinical trials designed to improve hypertension management in primary care settings and concluded that patients benefited from an organized system of regular patient follow-up and a multidisciplinary team to improve coordination of care . An integrated healthcare delivery system in northern California has demonstrated an effective program to manage hypertension, often considered as best practice . This program includes a comprehensive hypertension registry, standardization of blood pressure measurements, an evidence-based treatment algorithm, and a multidisciplinary team including medical assistants, nurses, and pharmacists . Several recent review articles note that multidisciplinary team-based care for hypertension management consistently results in improved blood pressure [17–20], and may be cost-effective .
Our work therefore builds upon evidence from previous studies, but two contributions of our study are especially distinctive: First, to our knowledge, this is the first large-scale randomization to study integrated care and provider financial incentives in China. We therefore provided some first-hand evidence of how the integrated care model and the financial contract can be incorporated in less developed areas where inadequate medical resources, fragmented care, and poor quality of care are prevalent. Second, previous interventions were often randomized at clinic or provider level, while as we relied on a distinctive randomization at the town level. This design choice is important because it enables us to evaluate the integration across village-town-county tiers in rural China, for the first time.
Study setting and usual care
Rural residents obtain their health insurance through the New Rural Cooperative Medical Scheme, which provides health insurance for 627 million Chinese rural residents, accounting for 46% of the total Chinese population as of 2014 . Rural residents seek care from a village-town-county three-tier healthcare delivery system. A typical village has one clinician with limited medical care training, who provides patient education, simple outpatient care and preventive care to all villagers. The village clinic, sometimes in the clinician’s home, has a small supply of medications but often lacks rudimental medications that are included in the national essential medicine list. There are no hospitals in the villages. Each town has one hospital and rural residents go to town hospitals for inpatient care and outpatient care that the village clinic is not equipped to handle.
If town hospitals cannot treat the patient’s illness, the patient goes to county or city hospitals. Under the current system, in most areas, patients can also go to county or city hospitals directly without going through town hospitals, but the inpatient reimbursement rate is much lower for services provided in county or city hospitals compared to town hospitals. For example, in 2012 in Qianjiang, the inpatient policy reimbursement rate was 70% for services provided in town hospitals and 55% in county hospitals. The actual effective reimbursement rate in county hospitals was even lower, about 44% in 2012, because many services provided in county hospitals were not eligible for reimbursement. Regardless of where rural residents in Qianjiang seek their inpatient care (town, county or city), the reimbursable portion of the medical care is paid with social health insurance pooled at Qianjiang county level. The gross costs of an inpatient stay in a county hospital can easily double the cost in town hospitals for the same procedure, and the difference in costs between city and county hospitals is even larger. Residents are incentivized to seek care in lower level hospitals because of their lower gross costs and higher reimbursement rate.
We tested two new care components: the integrated care model started on Aug 1, 2012, and the financial incentive contract started on Jun 1, 2013, (because it took some time to negotiate contracts), in comparison with usual care. Both interventions ended on Jun 30, 2014. We conducted a clustered randomized controlled trial with two intervention groups (Group 1 and Group 2) and a control group (usual care). Group 1 only received the integrated care model, while Group 2 received both the integrated care model and the financial incentives. Thus, we use Group 1 to test the improvements in integrated care that could be made within the current funding model, and Group 2 to test the additional effects of the financial incentives.
Integrated care model
Our integrated care model for chronic conditions has two important features: one is to combine treatment and prevention care with a multidisciplinary team; the other is to provide continuous care coordination across the village-town-county three-tier delivery system.
Each patient in our sample potentially has a team of 27 providers, consisting of 23 clinicians and four non-clinical staff. The team includes the patient’s village clinician (each village only has one clinician), two physicians (one outpatient and one inpatient) and four non-clinicians (three chronic disease coordinators/educators, and one case manager) at the town hospital (each town hospital has three to four physicians and four non-clinician staff to treat patients with hypertension), and 20 clinicians at the county hospitals. Qianjiang has two public county-level hospitals; from each hospital, we enrolled ten doctors: two outpatient physicians and three inpatient physicians from each of the two departments: neurology and cardiology. Each country hospital has about 16 to 20 doctors to treat hypertension patients.
Continuous care coordination
We designed three mechanisms through which continuous care could be effectively provided to patients. First, patient medical records, lab results, and other health related documents were shared among all participating providers. Second, each month, county doctors gave lectures to township clinicians on how to diagnose and treat patients with hypertension and conducted case reviews on selected patients. Town doctors then provided monthly lectures and discussed cases with village doctors. The group learning was recorded by the case manager and assessed later by the grant project manager. Third, we categorized four different types of clinical pathways depending on the severity of hypertension (Appendix). In each pathway, we specified clear guidelines on definitions of severity, on measurements town physicians should provide before referring to county clinicians, and on what county clinicians could and could not do based on the reports from village and town providers.
A contract was signed with each of two towns in Group 2 on Jun 1, 2013. The contract clearly stated that if at the end of the performance year, the total actual inpatient spending for all patients with hypertension in Group 2 towns was above the benchmark amount, the providers who participated in the trial would be paid according to the regular reimbursement schemes; however, if the total actual inpatient spending was below the predicted benchmark amount, they would obtain a bonus at 60% of total savings.1 The provider team is responsible for the total actual inpatient spending for all patients in the Group 2 towns, regardless whether the patients seek care at town, county or city hospitals. Thus, healthcare providers cannot reduce cost through patient selection. Because inpatient spending is much higher in upper-level hospitals than lower-level hospitals, providers have incentives to encourage patients to use lower-level hospitals.
Randomization at the town level
Comparison of Characteristics Used to Randomly Assign Six Towns To Three Groups, July 2012
Intervention Group 1
Intervention Group 2
Number of residents
Annual average income per capita (CNY)
Distance to county (minutes)
Medical facility revenue (CNY10K)
Randomization at the patient level
We obtained the entire list of patients residing in the six towns who had been officially registered as a chronic patient with hypertension in the national chronic disease database between Jan 1, 2008, and Jan 1, 2012. Not everyone with hypertension was registered during this period. Having a national official medical record means that these patients were aged 35 and over, had a history of hypertension for at least 6 months, had blood pressure recorded at least four times a year, and had at least three measures of blood pressure greater than 140/90 mmHg. Our list includes 5,789 patients. We obtained all of their inpatient claim data between Jan 1, 2010, and Dec 31, 2014.
To collect more person-level blood pressure, health related quality of life, and life style information through in-person in-house survey, we randomly selected 300 patients from each town, because we did not have resources to interview all 5789 patients. We stratified a random sample on the basis of three variables: gender (female and male), age (35–60, 61+), and risk level of hypertension (high, medium, and low). Using these three variables, we stratified 12 mutually exclusive subgroups per town and selected patients by subgroup. Before random sampling, we excluded patients who: 1) had a stable blood pressure history (consistently under 120/80 mmHg) for longer than 1 year because they did not need to take medications; 2) were estimated for a life expectancy less than 2 years due to old age, vegetative state or severe complications such as cerebral infarction or pancreatic cancer; 3) were considered to be difficult to follow up because they were away for over 6 months a year due to migration for work, education or caring for family; and 4) were unable to complete surveys due to intellectual incompetence, mental damage or inability to communicate.
Among 1800 randomly-sampled patients, 1641 patients agreed to participate and conducted the baseline interview (91.2%), but only 1408 had valid complete baseline survey data (85.8%), 1,245 (75.9%) of which also completed the end-point interview and had valid data. The response rate was relatively high because village clinicians who know patients well accompanied the interviewers to patient homes and subjects were provided some household staples (toothpastes, soap, etc.) as gifts if they agreed to participate in the study.
Data sources and outcomes
We used three main data sources: inpatient claims data for all 5,789 patients, patient-level survey data and blood pressure measures from the national chronic condition management registry database for 1,245 randomly selected patients. Inpatient data did not include death information, so we obtained death information from the Qianjiang Health Bureau but we could not get death records before 2012.
For patient-level survey data, we had two points: one measured at the baseline on Jul 1, 2012, and the other measured at the end-point on Jun 30, 2014. Systolic blood pressure was measured bimonthly between Dec 1, 2011, and Jun 30, 2014, for four times in the baseline period and 12 times post interventions.
In order to test each intervention and because inpatient data is highly volatile, we consolidated inpatient data into ten 5-month periods between Jul 1, 2010, and Aug 31, 2014: five periods in the baseline before intervention 1, two periods between interventions 1 and 2, and three periods after intervention 2. For those who died during our intervention period, we followed them up until they died. The unit of observations is person-period. For each person-period, we calculated three outcomes to measure hypertension related hospitalization: rates of hospitalization (1 = any hypertension related inpatient stay; 0 = otherwise), likelihood of using a county/city hospital, and total gross inpatient spending. We define hypertension related hospitalization as hospitalization related to hypertension as well as other conditions for which hypertension is a risk factor, including cardiovascular diseases and stroke.
Health related quality of life was measured with in-house surveys using the Medical Outcome Study Short-Form 36-Item Health Survey (SF36 Scale) that was developed by the RAND Corporation Health Insurance Experiment . In reporting results, we primarily focused on three summary scores: SF36 physical health, psychological health, and total scores. Some subjects had missing values on these variables, so we only had 1,082 subjects with both baseline and end-point measurements.
Covariates included age, gender, family structure (living alone, with spouse, with children only, with spouse and children, or with others), education (no education, elementary and middle school, high school and above), average annual income, average annual medical expenditure, salt and fat control, and self-assessed competence in treatment adherence. These were collected through in-person surveys at both baseline and the end-point.
We used difference-in-differences models to test the effects of both interventions simultaneously. Specifically, we included the post intervention 1 indicator (≥Aug 1, 2012), the indicator for being exposed to intervention 1 (individuals in group 1 and group 2), their interaction term, the post intervention 2 indicator (≥Jun 1, 2013), the indicator for being exposed to intervention 2 (individuals in group 2), and their interaction term. Our variables of interest are the two interaction terms, which represent the marginal effects of the two interventions.
Because the baseline trends in blood pressure before our interventions were different between intervention groups and the control group, to avoid overestimating the intervention effects on blood pressure, we included linear bi-month time trends in the model. In addition, we also conducted sensitive analyses to only use data points between Jun 2012 and Jun 2014, and report this as our primary results as lower bound. The model also included individual fixed effects to control for unobserved characteristics within individuals and time fixed effects.
For health-related quality of life, we estimated a similar difference-in-differences model that included the post intervention indicator, the indicator for being exposed to intervention 1, the indicator for being exposed to intervention 2, and the two interaction terms between post intervention indicator and intervention exposure indicators. The model also controlled for individual fixed effects and time-variant covariates mentioned above.
For three outcomes on hypertension related hospitalizations, we conducted three separate models; in each model, we controlled for time and town fixed effects, and used individual random effects instead of individual fixed effects, because many individuals had zero inpatient visits. First, we used logistic regression models to estimate the intervention effects on rates of hospitalization. Second, to estimate the utilization rate for town or county/city hospitals, we adopted a two-part model which consisted of two logistic regressions: we first estimated the rate of having any hospital stays and then estimated the rate of using county/city hospitals conditioning on having any hospital stays. Third, we evaluated the effect on inpatient spending using a two-part model: first, we estimated the use of hospitalization with a logistic regression, and second, we estimated effects on inpatient spending conditional on having an inpatient stay using a generalized linear model with gamma distribution and logarithm link. We then estimated the marginal effects and the standard errors of the interaction terms using bootstrap .
The project protocol was approved by the Tongji Medical College Academic Ethics Committee of Huazhong University of Science and Technology in China (IORG No: IORG0003571). This trial is registered at the Chinese Clinical Trials Registry (ChiCTR-OOR-14005563).
Comparison of Characteristics by Group at the Baseline, July 2012
Group 1-Group 2
Family structures, %
Living with spouse only
Living with kids only
Living with both spouse and kids
Other family structure
Attend elementary school
Attend high school or above
Average annual income, ¥
Personal annual medical expenditure, ¥
Self-assessed competence to treatment adherence
SF36 Physical health
SF36 Psychological health
SF36 Total Score
Effects of Interventions on Systolic Blood Pressure from the Difference-in-differences Model
Integrated Care Model
Financial Contract Model
No. of observations
Data starting time
Relative to the control group, the integrated care model was associated with a 1.93 mmHg (95% CI 0.063–3.8; p < 0.001) reduction in systolic blood pressure, or 1.3% of the pre-intervention level at 149.3 mmHg. Relative to the integrated care model, financial incentives were associated with an additional 1.76 mmHg (95% CI 0.73–2.79; p < 0.001) reduction in systolic blood pressure, or 1.2% of the pre-intervention level.
Marginal Effects of Interventions on Overall Hospitalization Rate, Rate of Using Upper Level Hospitals, and Inpatient Spending for Hypertension Related Hospitalization, Bootstrapping Results from Two-step Difference-in-differences Models
Integrated Care Model
Likelihood of using an upper level hospital
Total inpatient spending
No. of observations
We observed a consistent pattern that both interventions resulted in lower rates of hypertension-related hospitalization. Specifically, the integrated care model reduced the rate of hospitalization by 0.17 percentage points (95% CI 0.094–0.24), or 8.9% from the baseline 1.9 percentage points per person every 5 months in Group 1 and 2 (Table 4 Column 1). The financial incentives further reduced the rate of hospitalization by 0.096 percentage points (95% CI 0.029–0.16), or 5.1% from the Group 2 baseline level (Table 4 Column 2).
The likelihood of using a county level hospital increased slightly due to integrated care but did not change with additional financial incentives. Integrated care was associated with a slight increase in total inpatient spending, by $9.40 (95% CI 6.16–12.64) per person every 5 months, or 13.3% from the baseline 70.89. This can be partially explained by more use of county level hospital instead of town hospitals because gross costs in the former more than doubled gross costs in the latter. Financial incentives were associated with lower total inpatient spending, by $5.21 (95% CI 2.55–7.86), or 7.9% from the baseline 65.68 in Group 2.
We found that the integrated care model effectively lowered blood pressure, improved self-assessed health-related quality of life, and reduced the rates of hypertension-related hospitalization, but we did not find that the integrated care model reduced total inpatient spending, partially because integrated care increased the use of county-level hospitals instead of town hospitals. We also found that the provider-level financial contract further lowered blood pressure and reduced rates of hospitalization and inpatient spending, but it also reduced patients’ self-assessed health-related quality of life.
These results are encouraging, given over half of hypertensive patients currently have uncontrolled blood pressure globally [11, 26, 27]. Our interventions lowered systolic blood pressure, to an extent on the lower spectrum of findings in previous studies [15, 17, 18, 20, 28, 29]. Our observed effects are small for two main reasons: first, our interventions target on healthcare system delivery changes, which may take a long time to realize effects. Second, subjects in our study had much higher baseline blood pressure than those in previous studies and therefore are more difficult to treat, However, for subjects in our study, even a small reduction in blood pressure could result in meaningful effects on lowering hospitalizations and cardiovascular risk. Indeed, we observed that interventions reduced the rate of cardiovascular related hospitalization. A recent meta-analysis reviewed nineteen clinical trials and confirmed the effects of lowering blood pressure on reducing major cardiovascular events, myocardial infarction, stroke, albuminuria, and retinopathy progression . More importantly, our subjects are mainly farmers, and physical health has large and direct effects on their income, and therefore the improved hypertension control has more economic impact which is not measured here.
It is interesting to observe that provider-level financial incentives are associated with reductions in patient self-assessed quality of life. When provider payments are aligned with total inpatient spending, providers may discourage patients from using hospital services, especially more expensive services in higher-level hospitals. If patients do not trust their doctors, which is very common in China, patients may think they were not provided the best medical treatment and thus feel worse about their own health or simply report worse health than they perceive.
Our study is not without limitations. First, the financial contract in Group 2 was not fully executed. By design, the potential bonus to providers was tied with outcome-based performance measures and savings in total inpatient spending in the town. However, in reality, the assessment on performance was weak and not fully monitored. Second, our interventions were conducted in one county in China, and therefore results may not be generalizable to other areas. However, Qianjiang county is highly representative of China’s rural areas, in terms of its population size, mobility, economic development state, and prevalence rates of chronic diseases. In addition, we obtained our patient list from the national chronic disease registry for hypertension, and patients officially registered in the registry were sicker than general patients ever diagnosed with hypertension.
Because our study groups were randomly assigned, our findings are guarded against some selection biases that are common in other recent evaluations of integrated care models that were conducted through observational data [3, 4]. Taken together, our findings have important clinical and policy implications on how to better manage chronic conditions. First, the integrated care model substantially lowered blood pressure and improved patients’ health. Our findings support changing from the current fragmented care model to the more integrated, multidisciplinary-team-based care model, even in the current funding model. This result is consistent with other integrated care models that are being tried out in other countries. Second, continuous care coordination across provider disciplines and village-town-county tiers was important; so was sharing medical records among providers and developing continuous quality improvement processes. Third, combining integrated care with a new funding model further reduced blood pressure and inpatient spending, but also reduced patients’ quality of life. This suggests that financial incentives should not be too quickly introduced in rural China without further evaluations.
Because the relatively low costs (USD25K) and potential savings to conduct the interventions, it is feasible to roll out the integrated care model to other rural areas in China more broadly. Most rural areas in China have the financial ability to support such a new delivery model. The key to the success is the central government’s willingness to try and the local administration team’s leadership to implement it.
In sum, the integrated care model and the financial contract are effective in lowering blood pressure and reducing rates of hypertension-related hospitalization. Integrated care is also associated with better health-related quality of life. However, the long-term savings in healthcare costs from these models remain to be seen.
During the intervention period, the operations of the social health insurance in Qianjiang were reorganized from county level to city level and the Qianjiang county health bureau no longer had authority to change the reimbursement policy. As a result, although the contract stated a bonus to be 60% of the savings, the actual bonus at the end of the project was set by the head of the Qianjiang administrative office as CNY70K (USD10,654) per town in Group 2, and it was actually paid through the research grant to be shared among 23 clinicians and four non-clinical staff. However, during the intervention period, providers were not aware of this change, so they were still subject to the incentives in the contracts.
We gratefully acknowledge all the staff in Qianjiang who participated in this project: including administrators from the Qianjiang Health Bereau, Qianjiang Medical Insurance Department of Human Resource and Social Security Bureau, and from local community-based health facilities.
China Medical Board (grant # 11–069). The funding body plays no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Availability of data and materials
The datasets generated and analysed during the current study are not publicly available due to subject privacy protection without permissions from the Qianjiang government, but are available from the corresponding author on reasonable request.
YZ (Yuting Zhang) interpreted the analyses results and wrote the first draft of the manuscript. WT and YZ (Yan Zhang) designed the field study and collected data. LL analyzed the data and revised the manuscript. LZ obtained funding and supervised the field study. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Ethics approval and consent to participate
This trial has received the ethics approval from the Tongji Medical College Academic Ethics Committee of Huazhong University of Science and Technology (IORG No: IORG0003571). Patient informed consents were achieved before the baseline investigation. Written informed consents were obtained before patient enrollment.
Name of institutions at which the research was conducted
Data were collected at Huazhong University of Science and Technology
Data analyses and manuscript writing were conducted at the University of Pittsburgh.
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