Skip to main content
Download PDF

Determinants and levels of cervical Cancer screening uptake among women of reproductive age in South Africa: evidence from South Africa Demographic and health survey data, 2016

BMC Public Health volume 21, Article number: 2013 (2021) Cite this article

Abstract

Background

Cervical cancer (CC) is the cancer with the most incidents and the leading cause of cancer mortality among women in South Africa. CC screening is one of the most cost-effective control approaches for the disease burden. This study assessed the determinants and individual-level indicators of cervical cancer screening uptake among women of reproductive age in South Africa.

Methods

We analyzed data from the 2016 South Africa Demographic Health Survey. Our analysis focused on 5903 women (15–49 years). We conducted Chi-square test for bivariate analysis, and multivariate binary logistics regression was used to analyze independent association between individual-level factors and women who have had Pap smear testing. Statistical significance was set at p < 0.05.

Results

The mean age at cervical cancer screening uptake among women in South Africa was 40.8 years (SD 18.6, range 15–95 years). A majority of the women (39.3%) were aged 45 years and above and 54.6% of them resides in urban settlements. About 35.4% of women (n = 2098) have had a Pap smear test, with 66.5% of them who had a Pap smear test resides in Western Cape province. The proportion of women who had a Pap smear test was significantly higher among those with higher educational attainment (68.7%, p = 0.000), in the rich wealth index (50.1%, p = 0.000), and those with health insurance cover (60.3%, p = 0.000). Pap smear testing was found to be more prevalent among women aged 45+ years, were in the white population group, had higher education, were divorced, and had health insurance cover. The predominance of Pap smear test was 14% higher among women who are working in the professional/formal sector (AOR; 1.38, 95% CI; 1.14–1.69). The uptake of Pap smear test was also higher among women aged 35–44 years.

Conclusions

The prevalence of cervical cancer uptake is substantially low among women aged 15–24 years in South Africa and shows a degree of between-provinces differences. Therefore, heath educational interventions aimed at increasing the uptake of cervical cancer screening services in South Africa are critically needed.

Peer Review reports

Background

Cervical cancer is a serious public health problem and is one of the second leading causes of cancer-related mortality among women worldwide. Its epidemiology and health impacts are not only affecting women, but also their families, communities and social institutions [1]. Although it is also one of the most preventable disease through proper screening, treatment and follow-up, more than half a million women worldwide develop intrusive cervical cancer each year [2]. Middle- and low-income countries bear an unequal share (83%) of the global cervical cancer burden, but only achieve an average successful screening coverage of 19%, compared to 63% in high-income countries [3]. Studies [4,5,6] have accounted for over 275,000 female deaths and approximately 529,000 new diagnoses each year; besides, cervical cancer disease burden is more prevalent in older women who are post-childbearing [7,8,9,10,11,12]. In the developing countries, lack of resources limits coverage of cervical screening for women [13,14,15], and notably, for those from rural communities compared with urban areas, as the rural population is extensively poor and their access to health services is more difficult [16,17,18,19,20,21,22]. Overall, developed countries such as the United States of America (USA) and United Kingdom, 40 and 42% of the women diagnosed with cervical cancer respectively, die from it [7, 10, 11, 22, 23], while in Africa and South Asia, the equivalent death rates are nearly twice (78%) as high as the rates experienced in high-income countries [23, 24].

In sub-Saharan Africa, cervical cancer encompasses 20–25% of all cancers among women. The estimate is double that of women globally, as its incidence ranges from 30 to 40 per 100,000 women [24]. In South Africa, cervical cancer is the cancer with the most incidents and the leading cause of cancer mortality among women [25]. Contemporary estimates have shown that every year in South Africa, 5743 women are diagnosed with cervical cancer and 3027 die from the disease. Also, it is the second most frequent cancer among women of reproductive age between 15 and 44 years of age, after breast cancer. Studies [26,27,28] have shown that young women are at higher risk as they tend to be sexually active and have higher numbers of sexual partners. Several studies [8, 26, 27] have reported that young women are poorly informed about cervical cancer with its associated risk factors, and are unclear about the intent of cervical cancer screening, as well as holding on to negative or inaccurate beliefs or attitudes to Pap testing. Furthermore, one of the known main causative agents in cervical cancer is HPV and there are over 200 recognized serotypes of the HPV virus. Existing studies [29, 30] have documented that about 21.0% of women in the general population of South Africa are estimated to harbor cervical HPV infection in South Africa. These reports have shown that 62.8% of invasive cervical cancers among women in South Africa are attributed to HPVs 16 or 18 [29], which fall in the high-risk HPV serotypes classification, and which are responsible for almost 70% of cervical cancer cases.

Other factors for increasing young women’s susceptibility to cervical dysplasia (dysplasia is defined as medically unusual growth or unusual development or growth of a part of the body such as an organ, bone or cell, including the total absence of such a part) include smoking, oral contraceptive use, and vulnerability of the adolescent cervix to sexually transmitted infections [31,32,33]. As a consequence of the sexually transmitted nature of HPV, early exposure to sexual intercourse and multiple sex partners are significant risk factors for cervical cancer [5, 34]. Studies have reported that 80–90% of women will have this sexually transmitted infection at some point in their life, although only 3–4% of them will develop cervical cancer [35, 36]. Earlier studies [29, 37] have indicated that the South African Cancer Association (SACA) report in the year 2006 revealed that the age-standardized incidence rate for cervical cancer was 24.71 per 100,000 population. As a result of SACA reports, the South African Department of Health developed the Cervical Cancer Screening Programme, which allows three Pap smears per lifetime, at 10-year intervals, starting at the age of 30. This screening policy programme was designed for target coverage of at least 70% of women nationally [37].

Even with the implementation of the Cervical Cancer Screening Policy Programme in South Africa, the screening coverage is 20%, nationally low for women over the age of 30 years [38]. A population-based study conducted among rural South African women reported that only 18% of the women had ever had a Pap smear test [39]. Another study conducted among female university students found that 42.9% of the participants had heard of cervical cancer, but only 9.8% of the participants had ever had a Pap smear test [40]. Another study conducted in Vhembe District of South Africa, reported that campaigns and motivational talks on cervical cancer as well as cervical cancer screening services are provided for women in all the clinics in the district [41], yet very few women voluntarily present themselves for cervical cancer screening services.

Moreover, women who utilized the cervical cancer screening services do so because they have been referred by other health facilities, or the women are presenting with symptoms. Factors that are associated with poor uptake of cervical cancer screening services are pain, stigmatization, and fear of embarrassment [42,43,44], time constraint [25, 45], the related costs [25, 42, 45], insolence of health workers [46], lack of awareness about where to get screening [25, 47] and delays in hospital cancer screening [25]. Therefore, cervical cancer becomes a public health burden in countries where there are no cervical cancer screening services, or poor utilization of screening services. Cervical cancer screening services could be utilized better if awareness campaigns are sustained and the services are accessible, affordable and available [48]. Early screening is proven to be cost-effective and a form of control strategy of the disease burden [6, 33]. Thus, early screening of cervical cancer is an important preventative strategy for the disease burden. Improving screening services will not be sufficient to result in increased screening uptake among women, unless we understand and address the multidimensional causes that are likely to impel women’s disposition towards cervical cancer screening. Very little is known about determinants and levels of cervical cancer uptake among women of reproductive age in South Africa. No previous study conducted in South Africa has investigated the determinants and levels of cervical cancer uptake among women of reproductive age (15–49 years) in South Africa. The objectives of this study were to examine the association between determinants and cervical cancer uptake at the individual- and community-factor levels using a logistic statistical model, and to assess the extent of the variation in the uptake levels of cervical cancer screening services in South Africa. The findings of this study will provide insight into the provision of appropriate educational interventions for disease risk reduction and effective cervical cancer screening uptake among women of reproductive age in South Africa.

Methods

Study setting

South Africa, officially the Republic of South Africa (RSA), covering 471,445 km2, has a population of approximately 59.62 million people, comprising diverse cultures, religions, origins and languages [49]. South African culture is not homogeneous but rather a collection of cultures, with different cultures being predominant in different regions. The country has an upper middle-income economy identified as newly industrialized country [50]. However, poverty and inequality remain widespread, with about a quarter of the population unemployed and living on less than US$1.25 a day. The country has been identified as a middle power in international affairs, and maintains a significant regional influence [50]. However, wide differences exist in the political and administrative economy of the country, with nine provinces: Western Cape, Eastern Cape, Northern Cape, North West, Free State, KwaZulu-Natal, Gauteng, Limpopo and Mpumalanga [51]. Most provinces, except Limpopo, have high levels of socioeconomic development and tourist attractions in terms of infrastructure, industries and services. Limpopo province is a known typical developing area, with export and import of primary products and manufactured goods and services, as well as a large platinum deposit. Yet it is one of the poorest regions of South Africa, with a big gap between poor and rich residents, especially in rural areas [51].

The country operates a three-tier system of government (Legislative, Executive and Judicial) with an independent judiciary operating in a parliamentary system. The provincial governments of the nine provinces of South Africa have their own executive and legislative branches, but not separate judicial systems [49], while the local government consists of municipalities of various types. The largest metropolitan areas are governed by metropolitan municipalities, while the rest of the country is divided into district municipalities, each of which consists of several local municipalities [49]. This synopsis of political economy underlines vital aspects of culture and contextual influences on people’s lifestyles and behaviours.

Data and sample

This study used data from the most recent 2016 South African Demographic and Health Survey (SADHS) [51], conducted in South Africa, which is the third DHS, and follows the surveys carried out in 1998 and 2003. The SADHS is a nationally representative survey dataset conducted and collected as a collaboration between Statistics South Africa (Stats SA), the South African Medical Research Council (SAMRC) and the National Department of Health (NDoH), with technical support from ICF through the DHS Program of the United States Agency for International Development (USAID). The survey was designed to provide representative estimates for main demographic and health indicators for the country as a whole, for urban and non-urban areas separately, and for each of the nine provinces in South Africa.

A two-stage stratified sampling design was applied that involved randomly selecting the sampling clusters that were created in the first stage, followed by randomly selecting households in the second stage. Implicit stratification and proportional allocation were achieved at each of the lower administrative levels within a given sampling stratum by sorting the sampling frame according to administrative units at different levels in each stratum and using probability proportional to size selection at the first stage of sampling. Questionnaires were pre-tested to ensure that the questions were clear and could be understood by respondents. Our analysis focused on women of reproductive age (15–49 years) in 5903 clusters who were interviewed face-to-face about cervical cancer.

Measures

Outcome variables

The outcome variable for this study is a Pap smear (Pap smear test is one of the types of test used in cervical cancer screening that is carried out on a sample of cells from the cervix to check for abnormalities that may be indicative of cervical cancer) uptake, which is a binary variable whereby the respondents were asked if they have had a Pap smear test. Specifically, respondents were asked “Have you ever been tested or examined for cervical cancer?” (No/Yes). Respondents who answered “Yes” were then asked “Whether they ever had a Pap smear?”

Individual-level variables

Individual-level variables at the micro level included were twenty: women’s age (15–24, 25–34, 34–44 and 45+ years), population group (Black African, White, Coloured, and Indian/Asian), province (Western Cape, Eastern Cape, Northern Cape, Free State, KwaZulu-Natal, North West, Gauteng, Mpumalanga, and Limpopo), place of residence (urban and rural), educational level (no education, primary, secondary, and higher), occupation (not working, professional/formal, and non-professional/informal), marital status (never married, married, divorced, and widowed), health insurance cover (yes, and no) and own health perception (poor, average, good, and excellent). The household wealth index was a composite score measured by ownership of household items and facilities based on a DHS-generated quintile index and was categorized as poorest, poorer, middle, richer and richest. The quintile index for poorest and poorer was merged as poor wealth index; and richest and richer was also merged as rich wealth index. In this study, the principal investigators re-categorized the merged DHS-generated quintile index as poor, middle and rich wealth index.

Community-level variables

Geographical type and provinces were non-aggregate community-level variables. Geographical type was recorded as urban and rural. Provinces were defined as the region where a woman comes from. Basically, South Africa is demarcated into nine provinces: Western Cape, Eastern Cape, Northern Cape, Free State, KwaZulu-Natal, North West, Gauteng, Mpumalanga, and Limpopo, and the living status of their population, and settings may have a relationship with cervical cancer screening uptake. Another group of community-level variables were constructed through an aggregation from individual-level using an average approaches to conceptualize the neighborhood effect on cervical cancer screening uptake by women of reproductive age. The other group of community-level variables were: women’s age, population group, province, place of residence (urban and rural), educational level, occupation, marital status, health insurance cover, own health perception, and wealth index.

Statistical analyses

Data were weighted to give an explanation for multistage sample design, and analysed using Stata 14 (StataCorp, 2017). Univariate analysis illustrated frequencies and percentages for socio-demographic variables. Cross-tabulations of each independent variable and ever had a Pap smear were applied for inferential analysis. A chi-squared test ascertained whether there was any association between population characteristics and ever had a Pap smear. Multivariate binary logistics regression using variables whose univariate analysis was significant was used to estimate the independent association between respondents who have had Pap smear testing and population characteristics. Unadjusted and adjusted models were constructed in the logistics binary regression, and only individual variables were included to bring out interested findings for this study. Hence, the odds ratios (ORs) for the binary logistic regression with 95% confidence intervals (95% CIs) were reported.

Ethical considerations

All data were obtained from the 2016 SADHS. Informed consent was obtained from each respondent before the interviews (2016 SADHS). We obtained approval to use the data from the DHS repository (http://dhsprogram.com/data/available-datasets.cfm).

Results

Table 1 shows the socio-demographic characteristics of women of reproductive age with a total of 5903 who participated in the study. From the table below, 35.5% of women indicated that they have had a Pap smear test, and 64.5% of them reported that they have not had a Pap smear test. The mean age at cervical cancer screening among women in South Africa was 40.8 years (SD 18.6, range 15–95 years). Most women were 45+ years (39.0%) followed by 15–24 years (23.6%) who participated in the survey. A majority of the women were from the African/Black population group (84.9%), with the Indian/Asian population group having the least (1.3%). Out of all the women interviewed, 15.9% of the respondents were from KwaZulu-Natal province, followed by 14.1% from Limpopo province. More women were from the urban areas (54.6%) than rural areas (45.5%) (Table 1).

Table 1 Distribution of Population by Socio-Demographic Characteristics, South Africa
Full size table

The majority of the respondents had secondary education (64.0%) and 17.3% of them have primary education. Among the women interviewed, 69.9% of the women are not working while 17.3% work in the professional/formal sector and 12.8% work in the non-professional/informal sector. Three thousand six hundred and sixty-seven (62.1%) of them have never been married; most (41.2 and 36.5%) were in the poor and rich wealth index categories respectively (Table 1). The majority (86.5%) of the women do not have health insurance cover and 40.4% perceived themselves to have good health status.

Table 2 presents the results of the bivariate analysis of the individual-level characteristics and Pap smear testing. In the bivariate analysis, all individual-level variables (age group, population group, province, geographical type, educational attainment, occupation, marital status, wealth index, health insurance cover and perceived health status) were significantly associated with women’s responses to cervical cancer screening (Pap smear test). Regarding the age group showing the most significant association with Pap smear testing (χ2 = 724.93, p = 0.000), a majority of women (52.5%) in age cohorts of 35–44 years have undertaken a Pap smear test compared to those in other age groups.

Table 2 Population Characteristics by Pap Smear Testing among Females Aged 15–49 Years in South Africa
Full size table

A large proportion of white women (76.5%) have undertaken a Pap smear test compared to women in the other population groups, and this shows a significant association between population group and Pap smear uptake (χ2 = 306.76, p = 0.000), while educational attainment was found to be significantly associated with Pap smear testing (χ2 = 306.7635; p = 0.000), and 43.2% of urban women have had a Pap smear test compared to their rural counterparts, at only 26.31%.

It can be deduced from the findings that urban women have higher chances of undertaking Pap smear testing, as geographical type was significantly associated with Pap smear testing (χ2 = 183.80; p = 0.000) (Table 2). Figure 1 depicts the proportion of women of reproductive age who have had Pap smear by province. Western Cape Province had the highest proportion (66.52%) of women who have had a Pap smear, while Limpopo province had the lowest proportion of women who have had a Pap smear (Fig. 1).

Fig. 1
figure 1

Graph showing proportion of women of reproductive age who have ever had a Pap smear, by province

Full size image

However, a majority of women (39.95%) who perceived their health status to be poor had taken a Pap smear test compared to those with perceived excellent health status (27.94%) (Fig. 2).

Fig. 2
figure 2

Graph depicting perceived health status of women aged 15–49 years who have ever had a Pap smear

Full size image

Table 3 presented the multivariate analysis illustrating both the unadjusted (U) and adjusted (A) Odds Ratios (OR) of population characteristics which were found to be significant predictors of Pap smear uptake among women of reproductive age. Women aged 35–44 years were found to have 14 and 12% (UOR: 12.14: 95% CI = 9.36–15.72; AOR = 13.62: 95% CI = 10.56–17.55) higher odds of having a Pap smear compared to those aged 15–24 years, and this was found to be statistically significant. Population group has a significant association with Pap smear uptake as the odds of having a Pap smear among white respondents were 2.2 and 2.5 times (UOR; 2.21, 95% CI; 1.54–3.15; AOR; 2.47, 95% CI; 1.75–3.50) higher as compared to African/Black women. Province was significantly associated with lesser odds of having Pap smear uptake: Gauteng (UOR: 0.24, 95% CI: 0.17–0.34; AOR: 0.24, 95% CI = 0.17–0.33); Limpopo (UOR; 0.30, 95% CI; 0.21–0.43; AOR; 0.30, 95% CI; 0.21–0.42); KwaZulu-Natal (UOR; 0.30, 95% CI; 0.22–0.42; AOR; 0.30, 95% CI; 0.21–0.41).

Table 3 Logistic Regression Showing Odds Estimates of Pap Smear Testing amongst Women aged 15–49 years by Population Characteristics in South Africa
Full size table

Also, educational attainment has a significant association with Pap smear uptake, as the odds of being screened for cervical cancer among women having secondary and higher education were 2.7 and 4.4 times higher as compared to women who have no education (Table 3). Women who had health insurance cover had 13% higher odds of having Pap smear uptake compared to those who had no health insurance cover, and this was found to be statistically significant (UOR; 1.36, 95% CI; 1.11–1.68). For occupational status, women who are in the professional/formal sector had 14% higher odds of taking Pap smear test compared to those who are not working (AOR; 1.38, 95% CI; 1.14–1.69).

Discussion

This study examined in an all-inclusive manner the background determinants of the use of cervical cancer screening among women of reproductive age in South Africa, with particular emphasis on individual proportion of geographical type demerit (urban and rural), occupation disadvantage (not working, professional and non-professional), wealth index drawback (poor, middle and rich), health insurance cover (yes and no), and educational attainment disadvantage (no education, secondary and higher). The study found that unmeasured irregularity in cervical cancer screening routine across age and population groups was significant through peripheral factors, as population characteristics are explained by significant differences. Such significant differences have been observed in several studies, where population characteristics have accounted for specific background unpredictability factors that determine cervical cancer screening utilization among women of reproductive age [6, 52, 53].

Generally, all the background factors for the study were found to be significantly associated with cervical cancer screening uptake at the individual level, a lattice of other factors (Model II). This observation is not unusual when all individual-level variables are considered simultaneously [8, 54, 55]. This is a key finding showing the significance of the multilevel models in examining classified structured datasets of the 2016 SADHS. Further, access to health facilities have been established to be an important determinant of cervical cancer screening among women [28, 32, 56], as population characteristics seem to be more significant in health matters. The identified significant individual-level factors were age group, population group, province, geographical type, educational attainment, marital status, health insurance, wealth index, occupation, and perceived health status. The consequences of these factors in cervical cancer screening uptake are well established in studies conducted in African countries [5, 57].

Our study contributes to the understanding of determinants and levels associated with cervical cancer screening uptake in South Africa, where the cervical cancer screening prevalence remains low [58, 59]. To the best of the authors’ knowledge, this is the first study that assesses population factors associated with cervical cancer screening uptake in South Africa using the 2016 SADHS. Our findings reveal that a significant number of women (64.46%) did not have an uptake of cancer screening; while the small fraction of the female population who had had a Pap smear were majorly found in Limpopo (25.96%) and KwaZulu-Natal (28.27%) provinces. Thus, lack of knowledge, younger age, lack of income, apprehension of Pap smear testing, and poor accessibility of health facilities’ screening services were significantly associated with low cervical cancer screening outcomes [4, 33, 60]. Consequently, in most industrialized countries, cervical cancer screening programmes have shifted from clinician-sampling to self-sampling for HPV testing, which has been proven to be equally accurate in combination with a follow-up Pap smear test. This implies that various health stakeholders can incorporate self-sampling HPV DNA testing into cervical cancer screening health educational programmes, especially at grassroots’ levels. Present studies have recommended self-sampling HPV DNA testing to be feasible, and may significantly improve cervical cancer screening uptake in South Africa [61,62,63].

Our study revealed that the prevalence of women who had Pap smear testing was higher among women with poor perceived health status, and also among those residing in Western Cape and North West provinces, respectively. A possible explanation for the provincial variation observed is that the urban settlements characteristically have higher socioeconomic status, less cultural conservatism, and easier access to health care services [64,65,66]. Corroborating the results of similar studies, our results demonstrate that women’s occupation and wealth index were positively associated with cervical cancer screening [5, 31, 57]. The lower outcome of cervical cancer screening among women of reproductive age may indicate a financial burden, which is a barrier to accessing cervical cancer screening services. Women with higher occupational status were more likely to undergo screening because these groups of women are most likely to own health insurance cover [1, 67]. Our study determined that individual-level factors such as women’s wealth index had a positive influence on cervical cancer screening behaviour and attitude, indicating that gender disparity, as assessed through wealth index, can affect screening services uptake.

Studies have indicated that women do not accumulate properties converted as wealth as much as men, resulting in a gender wealth gap [68, 69], as women are often perceived as passive and powerless; in addition, societies have apportioned wealth and assets ownership as mostly in the male domain. Besides, several myths and misinformation related to women that have undergone cervical cancer screening have been accepted generally [34], and consequently have various health implications among such women who will tend towards denial of life-threatening health problems [20, 21]. Empowering women with the right knowledge of the benefits of Pap smear testing is necessary and key to having prior information about health matters, especially with terminal diseases. Women who resided in urban settlements, comprising a higher proportion of women with secondary and higher educational attainment, were more likely to undergo screening. This finding is consistent with the findings of previous studies, suggesting that communities with a high concentration of educated women can increase the utilization of health care facilities, including cervical cancer screening services [70, 71]. Education is frequently associated with increased access to health care services and improved knowledge regarding health matters and behaviours. Increasing the proportion of educated women may facilitate the dissemination of knowledge and awareness to those with lower education, aiding them in accessing health services through informal social networks and contacts within their community space [18, 69].

Supporting our study objectives and previous findings of other studies [33, 59, 72], we found a positive association between the white female population group and cervical cancer screening. The possible explanation for this unexpected result is that the white population group may have higher expectations for health services and accessibility to health facilities. Other structural reasons may be gaining full access to transportation and finance to access cervical cancer screening services, which can influence screening behaviour among the white population group [33, 60]. Urban women were seen to have undertaken more Pap smear testing than rural women, as geographical type was significantly associated with Pap smear testing. It could be inferred that women in urban settlements may have access to sensitization programmes on Pap smear testing, health facilities and health insurance cover. Women in Western Cape Province were found to have undergone more Pap smear tests than women from Limpopo province. The outlying areas in South Africa play a role in sensitization of women on the benefits of cervical cancer, as these provinces are stratified as urban and rural settlements due to infrastructural facilities put in place in these areas.

Further research should include these potential factors associated with cervical cancer screening in the study design and analysis. As anticipated, health insurance coverage was strongly associated with cervical cancer screening outcomes, as our findings regarding the association between health insurance cover and Pap smear testing are consistent with the outcomes of previous studies [58, 59]. Our study findings prove that the adoption of a universal health insurance scheme ensuring equity in access to health care can largely enhance the possibility of cervical cancer screening use [6]. The cost of a Pap smear test may be a major impediment in cervical cancer screening uptake among women with meagre earnings, as this may further explain the low turn-out for cervical cancer screening among rural women [52, 59]. In a geographical area where poverty is high, alternative health services are given greater priority to out-of-pocket payments than preventive services [53, 59], and consequently, health insurance cover may potentially reduce the financial burden for rural women to have access to preventive health care services, including Pap smear testing.

In line with other studies, this study has shown a positive relationship between perceived health status and uptake of Pap smear testing. Women of reproductive age with consistent upkeep and maintenance may have regular dealings with health facilities and health care workers, including going for a Pap smear test when necessary [1, 59]. Specifically, in constrained settings, interaction with community health personnel after visitation to health facilities may increase women’s exposure to undertake preventive measures and encourage adoption of accurate health information on the benefits of cervical cancer screening [4]. Preceding studies have also validated that having a prescription from a doctor and treatment medic’s prescription and medicament was constantly found to be a strong predictor of adherence to cervical cancer screening [6, 53]. Our study has some prospective limitations. First, the cross-sectional study design restricted our capacity to draw underlying deductions for the relationship of individual-level factors with uptake of a Pap smear test, which require a longitudinal designs, but could not be determined. In addition, due to limited number of variables collected by the 2016 SADHS, we could not examine a full array of factors related to cervical cancer screening, particularly cultural factors including the quality of the health service and other factors related to user-friendliness of cancer screening facilities. The study also suggests the use of ethnographic methods that may unravel community factors that may influence the outcomes of cervical cancer screening.

Conclusion and recommendation

Most women in South Africa demonstrated a low uptake of cervical cancer screening, as utilization of Pap smear testing among women of reproductive age in the study area was 35.5%. Despite that, when compared to previous studies conducted in countries within East Africa (Uganda – 20.6%; Kenya – 12.3%), West Africa (Nigeria – 13.5%; Benin – 0.6%) and Southern Africa (Namibia – 23.6%; Zimbabwe – 17.0%), there is still a high coverage of Pap smear testing among women of reproductive age in South Africa [73,74,75,76,77]. As implied in the literature, cervical cancer screening is associated with an increase in demographic factors that will influence the utilization of the services [33, 60]. Although in this study, demographic factors (such as age, educational attainment, health insurance cover, occupation, geographical type, and perceived health status) were significantly associated with utilization of cervical cancer screening services, yet in reality cervical cancer screening uptake is relatively low. Thus, these factors that result in cervical cancer screening services usage vary between individuals and from community to community [8, 54, 55]. The most basic conclusion is that there is a significant variation that exists in the population group and provinces in the use of cervical cancer screening services among women in South Africa.

The selected broad range of individual-level factors was not able to explain contextual variation as there is much more variation in cervical cancer screening among factors related to women’s utilization of cervical cancer screening services. Policies that look at women’s individual characteristics, such as promoting women employment, especially in professional occupations, higher educational level attainment and wealth accumulation, should continue to be implemented in order to increase Pap smear test uptake and achieve the universal health coverage goal. To mitigate those problems, there should be consistent monitoring of the cervical cancer detection and preventive actions among women through sensitization of health education, to modify women’s behaviours and attitude towards adopting cervical cancer screening. Health professionals and community health workers should promote educational and health recreational programmes provided by local councilors for individuals in their respective communities to have a prior knowledge of the dangers of not undergoing Pap smear testing.

Since early case detection through screening is the most cost effective activity for reducing the disease burden, reproductive health workers and policy stakeholders are needed to demonstrate more commitment in creating awareness about cervical cancer. Stakeholders in the Ministry of Health are needed to design and make Pap smear tests free for women through the establishment of more screening centres in different geographical areas of the provinces in South Africa. The existing Pap smear testing programmes mostly provided by non-governmental as well as faith-based organizations, which are majorly located in urban settlements, need to be decentralized and harmonized for greater efficiency in South Africa. Also, there is need to integrate the cervical cancer screening exercise into the mainstream health care services in the medical institutions. Women who are at least 15 years of age, particularly those with a family history of cervical cancer, must be encouraged to opt for cervical cancer screening at every available opportunity. Lastly, there is need to increase the number of medical professionals and community health workers with the requisite skills to conduct cervical cancer screening in South Africa.

Implications for practice and/or policy

Our findings suggest that the implementation of health educational policies promoting cervical cancer screening through awareness and sensitization programmes can enhance the uptake of the testing by women. Thus, employment programmes should be targeted to provide occupation and job opportunities among women, as instituting income-generating programmes may intensify women’s intent in uptake of screening services. In addition, the impact of expanding improved health insurance coverage could be considerable. Health insurance coverage can possibly aid in the reduction of out-of-pocket health expenses for women of reproductive age, and empower them financially to claim and be able to access cervical cancer screening services. Also, health policymakers should address the problem of geographical disparities in the uptake of Pap smear testing; this can be achieved through effective approaches such as building up better cancer screening health facilities and health workers in rural settlements to minimize geographical inequity. Public health programmes must be intensified to target women of childbearing age about the advantages of early detection of cervical cancer and to encourage them to adopt preventive behavioural modifications. Furthermore, to increase the improvement of the overall coverage of Pap smear testing in order to attain optimum safeguarding of themselves against cervical cancer burden, self-testing and collecting samples of human papilloma virus can be a possible proposition for cervical cancer screening in future policy development.

Availability of data and materials

Data are from the Demographic and Health Survey and the dataset is open to qualified researchers free of charge. In order to access the data from DHS Measure, a written request was submitted to the DHS MACRO and permission was granted to use the data for this survey. To request access to the dataset, please apply at https://dhsprogram.com/data/dataset_admin/login_main.cfm?

Abbreviations

CC:

Cervical cancer

AOR:

Adjusted odds ratio

CI:

Confidence interval

HPV:

Human papilloma virus

ORs:

Odds ratio

SADHS:

South Africa demographic health survey

Adjusted:

A

Unadjusted:

U

DNA:

Deoxyribonucleic acid

STATA:

Statistical analysis software

SSA:

Sub-Saharan Africa

RC:

Reference Category

References

  1. Ginsburg O, Bray F, Coleman MP, Vanderpuye V, Eniu A, Kotha SR, et al. The global burden of women’s cancers: a grand challenge in global health. Lancet. 2017;389(10071):847–60. https://doi.org/10.1016/S0140-6736(16)31392-7.

    Article  PubMed  Google Scholar 

  2. Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet. 2019 Jan 12; 393(10167):169–182, DOI: https://doi.org/10.1016/S0140-6736(18)32470-X.

  3. Matenge TG, Mash B. Barriers to accessing cervical cancer screening among HIV positive women in Kgatleng district, Botswana: a qualitative study. PLoS One. 2018;13(10):e0205425. https://doi.org/10.1371/journal.pone.0205425.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Rahimzadeh M, Pourhoseingholi MA, Kavehie B. Survival rates for breast cancer in Iranian patients: a meta-analysis. Asian Pacific J Cancer Prevention: APJCP. 17(4):2223–7.

  5. Bisi-Onyemaechi AI, Chikani UN, Nduagubam O. Reducing incidence of cervical cancer: knowledge and attitudes of caregivers in Nigerian city to human papilloma virus vaccination. Infect Agent Cancer. 2018;13(1):29. https://doi.org/10.1186/s13027-018-0202-9.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Dolatkhah R, Somi HM, Jafarabadi MA, Hosseinalifam M, Sepahi S, Belalzadeh M, Nezamdoust M, Dastgiri S. Breast Cancer Survival and Incidence: 10 years Cancer Registry Data in the Northwest, Iran. Int. Journal of Breast Cancer 2020; Article ID 1963814, 6 pages.

  7. Torre LA, Islami F, Siegel RL, Ward EM, Jemal A. Global Cancer in women: burden and trends. Cancer Epidemiol Biomark Prev. 2017;26(4):444–57. https://doi.org/10.1158/1055-9965.EPI-16-0858.

    Article  Google Scholar 

  8. Jedy-Agba E, Joko WY, Liu B, Buziba NG, Borok M, Korir A, et al. Trends in cervical cancer incidence in sub-Saharan Africa. Br J Cancer. 2020;123(1):148–54. https://doi.org/10.1038/s41416-020-0831-9.

    Article  PubMed  PubMed Central  Google Scholar 

  9. World Health Organization (WHO) (2016). The United Nations Global Cervical Cancer Programme End cervical cancer: prevent, treat, care. The Joint Programmes is about catalysing country and global action. The United Nations Inter-Agency Task Force on the Prevention and Control of Non-communicable Diseases (UNIATF). November 2016. WHO/NMH/NMA/16.96 © World Health Organization 2016.

  10. LaVigne AW, Triedman SA, Randall TC, Trimble EL, Viswanathan AN. Cervical cancer in low and middle income countries: addressing barriers to radiotherapy delivery. Gynecologic oncology reports. 2017;22:16–20. https://doi.org/10.1016/j.gore.2017.08.004.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ifediora CO. Re-thinking breast and cervical cancer preventive campaigns in developing countries: the case for interventions at high schools. BMC Public Health. 2019;19(1):503. https://doi.org/10.1186/s12889-019-6890-2.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Jacques-Ferlay Ir, Bray F. Estimates of incidence and mortality of cervical cancer in 2018: A worldwide analysis. The Lancet Global Health;, 2020 8 (2): e191-e203, DOI: https://doi.org/10.1016/S2214-109X(19)30482-6.

  13. Catarino R, Petignat P, Dongui G, Vassilakos P. Cervical cancer screening in developing countries at a crossroad: emerging technologies and policy choices. World journal of clinical oncology. 2015;6(6):281–90. https://doi.org/10.5306/wjco.v6.i6.281.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Ahmed HG, Bensumaidea SH, Alshammari FD, Alenazi F, ALmutlaq BA, Alturkstani MZ, et al. Prevalence of human papillomavirus subtypes 16 and 18 among Yemeni patients with cervical Cancer. Asian Pacific journal of cancer prevention: APJCP. 2017;18(6):1543–8.

    PubMed  PubMed Central  Google Scholar 

  15. Chan CK, Aimagambetova G, Ukybassova T, Kongrtay K, Azizan A. Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening, and Vaccination—Review of Current Perspectives. Hindawi Journal of Oncology 2019; Article ID 3257939, 11 pages, 1, 11, DOI: https://doi.org/10.1155/2019/3257939.

  16. Thapa N, Maharjan M, Shrestha I, Maharjan N, Petrini MA, Na Z, et al. Prevalence and type-specific distribution of human papillomavirus infection among women in mid-western rural, Nepal- A population-based study. BMC Infect Dis. 2018;18(1):338. https://doi.org/10.1186/s12879-018-3175-9.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Ndejjo R, Mukama T, Musabyimana A, Musoke D. Uptake of cervical Cancer screening and associated factors among women in rural Uganda: a cross sectional study. PLoS One. 2016;11(2):e0149696. https://doi.org/10.1371/journal.pone.0149696.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Akokuwebe ME, Adekanbi DM. Corruption in the health sector and implications for service delivery in Oyo state public hospitals. Ilorin Journal of Sociology. 2017;9(1):200–17.

    Google Scholar 

  19. Olubodun T, Odukoya OO, Balogun MR. Knowledge, attitude and practice of cervical cancer prevention, among women residing in an urban slum in Lagos, south west. Nigeria The Pan African medical journal. 2019;32:130. https://doi.org/10.11604/pamj.2019.32.130.14432.

    Article  PubMed  Google Scholar 

  20. Akokuwebe ME, Clifford OC. Socioeconomic determinants of knowledge of kidney disease among residents in Nigerian communities in Lagos state. Nigeria Oman Medical Journal. 2019;34(5):444–55. https://doi.org/10.5001/omj.2019.81.

    Article  PubMed  Google Scholar 

  21. Akokuwebe ME, Clifford Odimegwu C, Omololu F. Prevalence, risk-inducing lifestyle, and perceived susceptibility to kidney diseases by gender among Nigerians residents in South Western Nigeria. Afr Health Sci. 2020;20(2):860–70. https://doi.org/10.4314/ahs.v20i2.40.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Vhuromu EN, Goon DT, Maputle MS, Lebese RT, Okafor BU. Utilization of cervical Cancer screening services among women in Vhembe District, South Africa: a cross-sectional study. The Open Public Health Journal. 2018;11(1):451–63. https://doi.org/10.2174/1874944501811010451.

    Article  Google Scholar 

  23. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. https://doi.org/10.3322/caac.21262.

    Article  PubMed  Google Scholar 

  24. Lyimo FS, Beran TN. Demographic, knowledge, attitudinal, and accessibility factors associated with uptake of cervical cancer screening among women in a rural district of Tanzania: three public policy implications. BMC Public Health. 2012;12(1):22. https://doi.org/10.1186/1471-2458-12-22.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Abotchie PN, Shokar NK. Cervical cancer screening among college students in Ghana: knowledge and health beliefs. Int J Gynecol Cancer. 2009;19(3):412–6. https://doi.org/10.1111/IGC.0b013e3181a1d6de.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Romero-Estudillo E, González-Jiménez E, Mesa-Franco MC, García-García I. Gender-based differences in the high-risk sexual behaviours of young people aged 15-29 in Melilla (Spain): a cross-sectional study. BMC Public Health. 2014;14(1):745. https://doi.org/10.1186/1471-2458-14-745.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Chidyaonga-Maseko F, Chirwa ML, Muula AS. Underutilization of cervical cancer prevention services in low and middle income countries: a review of contributing factors. The Pan African Medical Journal. 2015;21:231. https://doi.org/10.11604/pamj.2015.21.231.6350.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Simms KT, Steinberg J, Caruana M, Smith MA, Lew JB, Soerjomataram I, et al. Impact of scaled up human papillomavirus vaccination and cervical screening and the potential for global elimination of cervical cancer in 181 countries, 2020-99: a modelling study. Lancet Oncol. 2019;20(3):394–407. https://doi.org/10.1016/S1470-2045(18)30836-2.

    Article  PubMed  Google Scholar 

  29. HPV Center WHO/ICO. HPV Centre WHO/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human Papillomavirus and Related Cancers in South Africa. Summary Report 2010. Accessed on October 14th, 2020 from https//www.who.in t/hpvcentre.

  30. Hoque ME, Ghuman S, Coopoosmay R, Van Hal G. Cervical Cancer screening among university students in South Africa: a theory based. Study PLoS ONE. 2014;9(11):e111557. https://doi.org/10.1371/journal.pone.0111557.

    Article  CAS  PubMed  Google Scholar 

  31. Johnson LG, Armstrong A, Joyce CM, Teitelman AM, Buttenheim AM. Implementation strategies to improve cervical cancer prevention in sub-Saharan Africa: a systematic review. Implement Sci. 2018;13(1):28. https://doi.org/10.1186/s13012-018-0718-9.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Boyle P, Ngoma T, Sullivan R, Brawley O. Cancer in Africa: the way forward. Special Issue ecancer medical science. 13:953.

  33. Arbyn M, Weiderpass E, Bruni L, de Sanjose S, Saraiya M, Ferlay Ir J, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2019;8(2):E191–203. https://doi.org/10.1016/S2214-109X(19)30482-6.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Morounke SG, Ayorinde JB, Benedict AO, Adedayo FF, Adewale FO, et al. Epidemiology and incidence of common cancers in Nigeria. J Cancer Biol Res. 2017;5(3):1105.

    Google Scholar 

  35. Collins SI, Mazloomzadeh S, Winter H, Rollason TP, Blomfield P, Young LS, et al. Proximity of first intercourse to menarche and the risk of human papillomavirus infection: a longitudinal study. Int J Cancer 2005. 2005;114(3):498–500. https://doi.org/10.1002/ijc.20732.

    Article  CAS  Google Scholar 

  36. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet. 2007;370(9590):890–907. https://doi.org/10.1016/S0140-6736(07)61416-0.

    Article  CAS  PubMed  Google Scholar 

  37. National Department of Health (NDOH). National guidelines for cervical cancer screening programme, NDOH, Pretoria, South Africa. National Department of Health. 2000:2000.

  38. Foon S, Bloch B, Mabina M, Carpenter S, Cronje H, et al. Prevalence of pre-cancerous lesions and cervical cancer in South Africa- a multicentre study. S Afr Med J. 2002;92(2):148–56.

    Google Scholar 

  39. Hoque M, Hoque E, Kader SB. Evaluation of cervical Cancer screening program at a rural community of South Africa. East Afr J Public Health. 2008;5(2):111–6.

    PubMed  Google Scholar 

  40. Hoque E, Hoque M. Knowledge of and attitude towards cervical cancer among female university students in South Africa. South Afr J Epidemiol Infect. 2009;24(1):21–4. https://doi.org/10.1080/10158782.2009.11441335.

    Article  Google Scholar 

  41. Limpopo Department of Health (LDOH). Vote 7 2013/2014 Annual Report 2013/2014 financial year Department of Health 2013/2014. Limpopo Department of Health (LDOH), (2013/2014).

  42. Arulogun OS, Maxwell OO. Perception and utilization of cervical cancer screening services among female nurses in university college hospital, Ibadan. Nigeria Pan Afr Med J. 2012;11(1):69.

    PubMed  Google Scholar 

  43. Lim JN, Ojo AA. Barriers to utilisation of cervical cancer screening in sub-Saharan Africa: a systematic review. Eur J Cancer Care (Engl). 2017;26(1):1–9.

    Article  Google Scholar 

  44. Chigbu CO, Aniebue UU. Experiences of women undergoing colposcopy in south eastern Nigeria. Int J Gynaecol Obstet. 2012;119(2):182–4. https://doi.org/10.1016/j.ijgo.2012.06.005.

    Article  PubMed  Google Scholar 

  45. Ezechi OC, Gab-Okafor CV, Ostergren PO, Odberg PK. Willingness and acceptability of cervical cancer screening among HIV positive Nigerian women. BMC Public Health. 2013;13(1):46. https://doi.org/10.1186/1471-2458-13-46.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Ndikom CM, Ofi BA. Awareness, perception and factors affecting utilization of cervical cancer screening services among women in Ibadan, Nigeria: a qualitative study. Reprod Health. 2012;9(1):11. https://doi.org/10.1186/1742-4755-9-11.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Rachet B, Ellis L, Maringe C, Chu T, Nur U, Quaresma M, et al. Socioeconomic inequalities in cancer survival in England after the NHS cancer plan. Br J Cancer. 2010;103(4):446–53. https://doi.org/10.1038/sj.bjc.6605752.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Bammeke OA, Ndikom CM. Awareness and attitudes of women towards cervical cancer screening in Oyo state. Nigeria Afr J Midwifery Women’s Health. 2014;8(2):91–7. https://doi.org/10.12968/ajmw.2014.8.2.91.

    Article  Google Scholar 

  49. Statistics South Africa General Household Survey 2017. Statistics South Africa 2018.

  50. World Bank. Overcoming poverty and inequality in South Africa: an assessment of drivers, constraints, and opportunities. 2018:148.

  51. South Africa Demographic and Health Survey (SADHS), 2016. National Department of Health (NDoH), Statistics South Africa (Stats SA), South African Medical Research Council (SAMRC), and ICF. 2017. South Africa Demographic and health survey 2016: key indicators. Pretoria, South Africa, and Rockville, Maryland, USA: NDoH, Stats SA, SAMRC, and ICF.

  52. Iqbal J, Ginsburg O, Rochon PA, Sun P, Narod SA. Differences in breast cancer stage at diagnosis and cancer-specific survival by race and ethnicity in the United States. JAMA. 313(2):165–73.

  53. Azubuike SO, Muirhead C, Hayes L, McNally R. Rising global burden of breast cancer: the case of sub-Saharan Africa (with emphasis on Nigeria) and implications for regional development: a review. World J Surg Onc. 2018;16(63):1–13. https://doi.org/10.1186/s12957-018-1345-2.

    Article  Google Scholar 

  54. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. https://doi.org/10.3322/caac.21492.

    Article  PubMed  Google Scholar 

  55. Stewart TS, Moodley J, Walter FM. Population risk factors for late-stage presentation of cervical cancer in sub-Saharan Africa. Cancer Epidemiol. 2018;53:81–92. https://doi.org/10.1016/j.canep.2018.01.014.

    Article  PubMed  Google Scholar 

  56. Lott BE, Trejo MJ, Baum C, McClelland DJ, Adsul P, Madhivanan P, et al. Interventions to increase uptake of cervical screening in sub-Saharan Africa: a scoping review using the integrated behavioral model. BMC Public Health. 2020;20(1):654. https://doi.org/10.1186/s12889-020-08777-4.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Olorunfemi G, Ndlovu N, Masukume G, Chikandiwa A, Pisa PT, Singh E. Temporal trends in the epidemiology of cervical cancer in South Africa (1994–2012). Int J Cancer. 2018;143(9):2238–49. https://doi.org/10.1002/ijc.31610.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Somdyala NIM, Parkin DM, Sithole N, Bradshaw D. Trends in cancer incidence in rural eastern Cape Province; South Africa, 1998-2012. Int J Cancer. 2015;136(5):E470–4. https://doi.org/10.1002/ijc.29224.

    Article  CAS  PubMed  Google Scholar 

  59. Somdyala NIM, Bradshaw D, Dhansay MA, Stefan DC. Increasing cervical cancer incidence in rural Eastern Cape Province of South Africa from 1998 to 2012: A population-based cancer registry study. JCO Glob Oncol. 2020; 6: JGO. 19.00198.

  60. Agarwal S, Ying J, Boucher KM, Agarwal JP. The association between socioeconomic factors and breast cancer-specific survival varies by race. PLoS One. 2017;12(12):Article e0187018.

    Article  Google Scholar 

  61. Mwaka AD, Garimoi CO, Were EM, Roland M, Wabinga H, Lyratzopoulos G. Social, demographics and healthcare factors associated with stage at diagnosis of cervical cancer: cross-sectional study in a tertiary hospital in northern Uganda. BMJ Open. 2016;6(1):e007690. https://doi.org/10.1136/bmjopen-2015-007690.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Gizaw M, Addissie A, Getachew S, Ayele W, Mitiku I, Moelle U, et al. Cervical cancer patients’ presentation and survival in the only oncology referral hospital. Ethiopia: a retrospective cohort study Infect Agent Cancer. 2017;12(1):61. https://doi.org/10.1186/s13027-017-0171-4.

    Article  PubMed  Google Scholar 

  63. Rudd P, Gorman D, Meja S, Mtonga P, Jere Y, Chidothe I, et al. Cervical cancer in southern Malawi: a prospective analysis of presentation, management, and outcomes. Malawi Med. 2017;29(2):124–9. https://doi.org/10.4314/mmj.v29i2.9.

    Article  Google Scholar 

  64. Makuza JD, Nsanzimana S, Muhimpundu MA, Pace LE, Ntaganira J, Riedel DJ. Prevalence and risk factors for cervical cancer and pre-cancerous lesions in Rwanda. Pan African Medical Journal. 2015;22:26. https://doi.org/10.11604/pamj.2015.22.26.7116.

    Article  Google Scholar 

  65. Bouassa R-SM, Prazuck T, Lethu T, Jenabian M-A, Meye J-F, Belec L. Cervical cancer in sub-Saharan Africa: a preventable non-communicable disease. Expert Rev Anti-Infect Ther. 2017;15(6):613–27. https://doi.org/10.1080/14787210.2017.1322902.

    Article  CAS  Google Scholar 

  66. de Sanjose S, Diaz M, Castellsague X, Clifford G, Bruni L, Munoz N, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect. Dis. 2017;7:453–453–9.

    Google Scholar 

  67. Isa Modibbo F, Dareng E, Bamisaye P, Jedy-Agba E, Adewole A, Oyeneyin L, et al. Qualitative study of barriers to cervical cancer screening among Nigerian women. BMJ Open. 2016;6(1):e008533. https://doi.org/10.1136/bmjopen-2015-008533.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Huh WK, Ault KA, Chelmow D, Davey DD, Goulart RA, Garcia FA, et al. Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance. Gynecol Oncol. 2015;136(2):178–82. https://doi.org/10.1016/j.ygyno.2014.12.022.

    Article  PubMed  Google Scholar 

  69. Akokuwebe ME, Okafor EE. Maternal health and the implications for sustainable transformation in Nigeria. Res Humanit Soc Sci. 2015;5(6):1–3.

    Google Scholar 

  70. Stefan DC. Cancer care in Africa: an overview of resources. J Glob Oncol. 2015;1(1):30–6. https://doi.org/10.1200/JGO.2015.000406.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Idowu A, Olowookere SA, Fagbemi AT, Ogunlaja OA. Determinants of cervical cancer screening uptake among women in Ilorin, North Central Nigeria: A community-based study. J Cancer Epidemiology 2016; Article ID 6469240, 8 pages.

  72. Kantelhardt EJ, Muluken G, Sefonias G, Wondimu A, Gebert HC, Unverzagt S, et al. A review on breast cancer care in Africa. Breast Care. 2015;10(6):364–70. https://doi.org/10.1159/000443156.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Tiruneh FN, Chuang K-Y, PAM N, Chuang Y-C. Individual-level and community-level determinants of cervical cancer screening among Kenyan women: a multilevel analysis of a nationwide survey. BMC Women’s Health. 2012;17:109.

    Article  Google Scholar 

  74. Abdikarim IK, Atieno WMC, Habtu M. Prevlence and associated factors of cervical cancer screening among Somali women in an urban settlement in Kenya. J Comm Pub Health Nursing. 2017;3(01):159. https://doi.org/10.4172/2471-9846.1000159.

    Article  Google Scholar 

  75. Ilevbare OE, Adegoke AA, Adelowo CM. Drivers of cervical cancer screening yptake in Ibadan Nigeria. Heliyon. 2020;6(3):e03505. https://doi.org/10.1016/j.heliyon.2020.e03505.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Barrow A, Onikan A, Nzoputan CI, Ekholuenetale M. Prevalence and determinants of cervical cancer awareness among women of reproductive age: evidence from Benin and Zimbabwe population-based data. Appl Cancer Res. 2020;40(1):8. https://doi.org/10.1186/s41241-020-00092-z.

    Article  Google Scholar 

  77. Bruni L, Albero G, Serrano B, Mena M., Gomez D, Munoz J, Bosch FX, de Sanjose S. ICO/IARC Information Centre on HPV and cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in Namibia. Summary Report 17 June 2019. [Accessed on July 27th, 2021].

Download references

Acknowledgements

We give thanks to the MEASURE DHS for providing us with the population-based dataset through their archives which can be downloaded from http://dhsprogram.com/data/available-datasets.cfm. The authors acknowledge Mrs. Helen Thomas for her editing role. The authors also gratefully acknowledge the support of the North-West University Faculty of Humanities, Mafikeng, South Africa.

Funding

Monica Ewomazino Akokuwebe received funding for this research from the North-West University Postdoctoral Research Fellowship (PDRF), Mafikeng, South Africa (Postdoc Grant no. NWU PDRF Fund NW. 1G01487). The funders played no role in the design of the study, data collection and analysis, interpretation of data or writing of the manuscript.

Author information

Authors and Affiliations

  1. North-West University Faculty of Humanities, North-West University, Mafikeng, South Africa

    Monica Ewomazino Akokuwebe, Erhabor Sunday Idemudia, Abiel M. Lekulo & Ogone Warona Motlogeloa

Authors
  1. Monica Ewomazino Akokuwebe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Erhabor Sunday Idemudia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Abiel M. Lekulo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ogone Warona Motlogeloa
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MEA conceived and designed the study, undertook the literature searches, wrote and revised the manuscript by providing critical comments to build the manuscript content. MEA and ESI was involved in revising and editing the manuscript critically for important intellectual content. MEA and ESI facilitated the publication fees payment in BMC Public Health Journal. AML and OWM were involved in data collection and analyses of the data. All authors read and approved the final manuscript.

Authors’ information

MEA has a PhD degree in Sociology from the University of Ibadan (Nigeria) and is currently awarded a Postdoctoral Fellowship with North-West University Faculty of Humanities, Mafikeng, South Africa. Her research interests are in the fields of Sociology, Public Health, Health Demography and Population Studies. iDhttps://orcid.org/0000-0001-8945-345X

ESI is currently a tenured Full Professor of the Research-Social Science Cluster in the Faculty of Humanities, Mafikeng Campus. His research contributions are anchored in four domains: (1) applied research in psychopathology and interventions with vulnerable populations such as migrants/refugees, IDPs (2) application of clinical issues in prisons (3) gender studies (4) cultural aspects of African-oriented psychology and illness attributions. iDhttps://orcid.org/0000-0002-5522-7435.

AML has a BA Honours and Masters’ degree in Demography and Population Studies from the University of Witwatersrand, Johannesburg, South Africa. He is presently an Associate Researcher in North-West University Faculty of Humanities, Mafikeng, South Africa. His areas of expertise are Fertility and Reproductive Behaviour, Population Morbidity and Health Risks. iD https://orcid.org/0000-0003-3826-4477.

OWM has a Masters’ degree in Health Demography from the University of Witwatersrand, Johannesburg, South Africa. Presently, she is a Researcher in North-West University Faculty of Humanities, Mafikeng, South Africa. Her expertise is in the areas of Demography, Public Health and Biometeorology.. iD https://orcid.org/0000-0003-2939-4296.

Corresponding author

Correspondence to Monica Ewomazino Akokuwebe.

Ethics declarations

Ethics approval and consent to participate

All data were obtained from the 2016 SADHS. Informed consent was obtained from each respondent before the interviews. Procedures and questionnaires for standard DHS surveys have been reviewed and approved by the ICF International Institutional Review Board (IRB). We obtained approval to use the data from the DHS repository (https://dhsprogram.com/data/available-datasets.cfm). All methods used in this study were performed in accordance with the Declaration of Helsinki as well as with the relevant guidelines and regulations.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Akokuwebe, M.E., Idemudia, E.S., Lekulo, A.M. et al. Determinants and levels of cervical Cancer screening uptake among women of reproductive age in South Africa: evidence from South Africa Demographic and health survey data, 2016. BMC Public Health 21, 2013 (2021). https://doi.org/10.1186/s12889-021-12020-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12889-021-12020-z

Keywords

BMC Public Health

ISSN: 1471-2458

Contact us