Prevalence of self-reported hypertension and its relation to dietary habits, in adults; a nutrition & health survey in Greece
© Pitsavos et al; licensee BioMed Central Ltd. 2006
Received: 11 April 2006
Accepted: 13 August 2006
Published: 13 August 2006
Hypertension leads to many degenerative diseases, the most common being cardiovascular in origin. This study has been designed to estimate the prevalence of self-reported hypertension in a random nationwide sample of adult Greek population, while focus was set to the assessment of participants' nutritional habits in relation to their hypertension status.
A random-digit dialed telephone survey. Based on a multistage, stratified sampling, 5003 adults (18 – 74 yr) participated (men: 48.8%, women: 51.2%). All participants were interviewed via telephone by trained personnel who used a standard questionnaire. The questionnaire included demographic and socioeconomic characteristics, medical history, lifestyle habits and nutritional assessment.
The prevalence of self-reported hypertension was 13.3% in men and 17.7% in women (P < 0.001). Furthermore, women reported higher values of systolic blood pressure (180 ± 27 mmHg) than men (169 ± 24 mmHg). Positive relationships were found between hypertension status and the prevalence of the rest investigated health conditions (i.e. hypercholesterolaemia, diabetes mellitus, renal failure and obesity). Nutritional assessment showed that consumption of fish, fruits and juices, cereals, and low fat milk and yogurt was significantly higher among hypertensive subjects while the opposite was observed for food items as red meat, pork, egg, pasta and rice, full fat dairy products and desserts.
Hypertension seems to be a serious public health problem in Greece. It is encouraging that hypertensives may have started adopting some more healthy nutritional behaviour compared to normotensive ones. However, they can gain significant benefits regarding to blood pressure control, if they increase the level of compliance with dietary recommendations.
High blood pressure  has been identified as a major risk factor for stroke, congestive heart failure, renal disease and myocardial infarction [2, 3]. According to World Health Organization the number of people with high blood pressure levels, worldwide, is estimated to be about 600 million and the annual mortality attributable to hypertension is estimated to be about 7.14 million deaths. As far as the European developed countries is concerned, it is estimated that hypertension is responsible for about 17% of total annual mortality or in other words, for approximately 680 thousands deaths annually . However, the prevalence of hypertension shows a significant variability among different countries. For instance, according to the work of Wolf-Maier and colleagues  prevalence of hypertension was found to be 37.7% in Italy, 38.4% in Sweden, 41.7% in England, 48.7% in Finland, 46.8% in Spain, and 55.3% in Germany. In the same review paper, it is stated that the mean prevalence of hypertension is higher in Europe (approximately 44%) compared to the US (approximately 28%). Despite the motivational finding, that treating hypertension is associated with about a 40% reduction in the risk of stroke and about a 15% reduction in the risk of myocardial infarction , only approximately 12.5% of hypertensive subjects show adequate control of their blood pressure [7–9]. The risk of cardiovascular complications and organ damage in persons with high blood pressure is increased when other risk factors such as smoking, obesity, inappropriate dietary habits and physical inactivity are also present. In the opposite, the benefits from healthy dietary patterns on blood pressure control have been reported in several studies [10–15]. Therefore, appropriate nutrition related life-style modifications should be employed at all stages of high blood pressure managing. This is in accordance with the National High Blood Pressure Education Program  in US which emphasizes 6 approaches with proven efficacy for prevention of hypertension: engage in moderate physical activity; maintain normal body weight; limit alcohol consumption; reduce sodium intake; maintain adequate intake of potassium; and consume a diet rich in fruits, vegetables, and low-fat dairy products and reduced in saturated and total fat.
Current data regarding the epidemiology of hypertension in the Greek population are lacking. Therefore the primary aim of this study was to evaluate the prevalence of hypertension in a representative nationwide sample of Greek adults and to investigate the nutritional habits of the participants in relation to their hypertension status.
During autumn of 2004, 62,538 men and women from all Greek regions were randomly selected through telephone catalogues in order to participate in a random-digit dialed (RDD) telephone survey. From the design of the study it has been decided that the sample should be stratified by age group, sex and Greek region in order to be more representative. The randomized procedure was based on the following rule: we selected 1 every 10 names of each particular area using a sequence of random numbers. Furthermore, only one person per household was decided to be interviewed, by trained personnel who used a standard questionnaire. Of the contacted people, 48% did not answer the telephone-call because of various reasons (i.e. 39.1% absences, 4.5% occupied phones, 3.9% wrong numbers recorded in the catalogues); 14.3% of the contacted persons were not suitable for interviewing (i.e. children or house girls etc); 11% were not suitable based on the quotas (i.e. they did not correspond to the sampling targets we had pre-designed for each area, in order the stratified sample to be as much representative as we can) and 0.4% were calls were interrupted due to unknown reasons. Thus, 16,760 of the contacted adult people were eligible for the study. Of them, 5003 (18 – 74 years, men: 48.8%) agreed to participate (participation rate: 30%); the participation rate is considered acceptable since according to the Council of American Survey Research Organizations (CASRO) the response rate estimation of a RDD telephone surveys , based on our data, should be 29.59%. All participants were informed by the interviewer about the aims and procedures of the study. However, since this was a telephone interview no written informed consent was obtained from the participants. The ethical committee of our Institution approved the design of the study.
The questionnaire addressed individuals' demographic and socioeconomic characteristics (age, sex, years of education, type of occupation and residence), information relevant to health status with focus on arterial hypertension (defined as: systolic/diastolic blood pressures > 140/90 mmHg  or use of anti-hypertensive treatment), hypercholesterolemia (defined as: total serum cholesterol levels > 200 mg/dl  or use of lipid lowering agents) and diabetes mellitus (defined as: fasting blood glucose > 125 mg/dl  or use of hypoglycemic treatment), food consumption pattern, other lifestyle habits, such as smoking habits, level of physical activity as well as characteristics related to body composition (recalled weight and height). Family history of all the aforementioned health problems was also recorded (type of answer: yes/no/don't know for father, mother, brother and sister).
Specifically for the assessment of hypertension status, the subjects were considered as hypertensive if they were reporting that they had been previously diagnosed by a registered physician (type of answer: yes/no). In case of positive answer, they were asked to report an average value of their systolic blood pressure during hypertensive episodes and to provide data relevant to the selected way of treatment (antihypertensive medication or/and diet or no treatment, years of treatment).
Relatively to the nutritional component of the questionnaire, the participants were asked to report their average weekly consumption (in servings) of a list of food items of all different food groups. The educational level of the participants was measured by the years of schooling (Group I: < 9 years, Group II: up to high school or technical colleges (10 – 14 years) and Group III: university). Current smokers were defined as those who smoked at least one cigarette per day; never smokers those who have never tried a cigarette in their life and former smokers were defined as those who had stopped smoking in the past. Physically active were considered all the participants who reported either that they participated in an exercise program (such as gym, sports, jogging etc.) during their leisure time at least once a week, or that their occupation presupposes certain level of physical fatigue. The rest of the subjects were defined as physically inactive. Finally, we used data of self reported weight and height to calculate body mass index (BMI). Participants were classified as obese if BMI was ≥ 30 kg/m2.
Continuous variables are presented as mean values ± standard deviation, while qualitative variables are presented as absolute and relative frequencies. Relationships between categorical variables were tested by the use of contingency tables and the calculation of Pearson's chi-squared test. All comparisons among paired groups of sample (males – females, normotensives – hypertensives) in relation to normally distributed continuous variables were performed using the student t-test. Every reported P-value is based on two-sided tests and compared to a significance level of 1%. SPSS version 13 (Statistical Package for Social Sciences, SPSS Inc, Chicago, Illinois, U.S.A.) software was used for all the statistical calculations.
Proportional distribution (in percentages) of the Greek population, aged ≥ 18 years and of the present study's participants (N = 5003), by sex and age
Total Greek Population *
Characteristics of the study's participants (% by sex)
Men (n = 2439)
Women (n = 2564)
43.7 ± 16.1
44.7 ± 16.0
Education status a
710 (29.1 %)
997 (38.9 %)
763 (31.3 %)
787 (30.7 %)
966 (39.6 %)
779 (30.4 %)
1664 (67.8 %)
2110 (82.3 %)
784 (32.2 %)
454 (17.7 %)
700 (28.7 %)
1381 (53.9 %)
1176 (48.2 %)
901 (35.1 %)
563 (23.1 %)
282 (11.0 %)
BMI (Kg/m2) b
26.3 ± 5.7
25.0 ± 5.3
Obesity (BMI ≥ 30 Kg/m2)
322 (13.2 %)
345 (13.5 %)
325 (13.3 %)
455 (17.7 %)
400 (16.4 %)
560 (21.8 %)
152 (6.2 %)
146 (5.7 %)
23 (0.5 %)
39 (0.8 %)
Prevalence of health conditions and anthropometric indices in relation to hypertension status.
Body mass index (Kg/m2)
25.15 ± 5.66
27.99 ± 4.28
73.12 ± 14.29
77.96 ± 13.30
Distribution of hypertensive study's participants by age group
5 (1.5 %)
2 (0.6 %)
7 (1.1 %)
9 (1.7 %)
12 (2.4 %)
21 (2.0 %)
25 (5.3 %)
31 (6.3 %)
56 (5.8 %)
51 (12.4 %)
75 (17.3 %)
126 (14.9 %)
99 (27.7 %)
135 (33.3 %)
234 (30.7 %)
136 (39.5 %)
200 (49.6 %)
336 (45.0 %)
325 (13.3 %)
780 (15.6 %)
Statistically significant difference (P < 0.001) was observed among women and men participants in relation to the reported values of blood pressure, when they faced episodes of hypertension. In particular, women had higher values of systolic blood pressure (180 ± 27 mmHg) than men (169 ± 24 mmHg). However, no difference was found relatively to parameters as "number of years that they have the problem" (men: 8.6 ± 7.8 yr, women: 9.4 ± 8.2 yr, P = 0.155) and "number of years that they use antihypertensive medication" (men: 7.5 ± 6.7 yr, women: 8.4 ± 7.6 yr, P = 0.126). Furthermore, analysis of participants' family history of hypertension showed a positive association (P < 0.001) only between brothers (independently of sex) and not between parents and descendants. Specifically, only 1.32% of normotensive participants have a hypertensive brother or a sister, while 6.56% of hypertensive participants have a brother or a sister who faces the same problem.
Food items consumed (in servings/week), in relation to hypertension status
Red meat and products
1.63 ± 1.28
1.40 ± 1.13
1.26 ± 1.15
0.94 ± 0.92
1.43 ± 1.10
1.39 ± 0.93
1.32 ± 1.09
1.56 ± 1.26
1.23 ± 1.63
0.87 ± 1.14
Bread and cereals
11.93 ± 8.83
12.79 ± 7.71
Pasta and rice
2.08 ± 1.47
1.61 ± 1.32
2.23 ± 1.71
1.81 ± 1.55
7.15 ± 3.81
7.31 ± 3.80
Fruits and juices
7.52 ± 6.26
8.34 ± 6.57
Milk and yogurt (Full Fat)
3.61 ± 4.98
2.53 ± 3.98
Milk and yogurt (Low Fat)
2.38 ± 4.22
3.28 ± 4.70
2.22 ± 2.50
1.80 ± 2.36
4.99 ± 3.30
4.74 ± 3.18
1.23 ± 0.93
1.16 ± 0.96
Dessert, ice cream
2.13 ± 2.69
1.41 ± 2.28
This study provided data on the prevalence of self – reported hypertension among a nationwide sample of about 5000 Greek adults. Furthermore the nutritional habits of the participants were evaluated in relation to their blood pressure status. The prevalence of self-reported hypertension was about 13% in men and 18% in women, denoting a serious public health problem in Greece. However, it is encouraging that hypertensive subjects may have started adopting some more healthy nutritional behaviour compared to normotensive ones.
Only a few epidemiological studies [20–23] have provided data regarding the prevalence of hypertension in Greek population. Two of them, the ATTICA study  and the Greek EPIC study , are well organized and large – scale health surveys and provided information about the prevalence and awareness of high blood pressure levels in representative Greek samples. In particular, the ATTICA study is a health and nutrition survey that enrolled 3042 adult men and women, without clinical evidence of cardiovascular disease, from the province of Attica in which Athens, the capital of the country, is located. The sampling was random and multistage, and was based on the age-sex distribution of the province of Attica, provided by the National Statistical Service according to the census of 2001. Additionally, the EPIC study is a multi-country, prospective cohort study that was conducted in 22 research centres in 10 European countries, examining the role of dietary, lifestyle, and environmental factors in the aetiology of cancer and other chronic diseases. In Greece, the EPIC study started in 1994 and is being conducted by the Department of Hygiene and Epidemiology of the University of Athens. The subjects of the EPIC study were volunteers (n = 26,913), aged 20–86 years and recruited from several regions of Greece. Arterial blood pressure measurements were taken in both of the aforementioned studies in order to diagnose hypertension among participants.
According to the ATTICA study, the prevalence of hypertension was 37.5% for men and 25% for women, while according to the Greek EPIC study, the respective figures were 40.2% and 38.9%. Another local, small – scale, observational study (Didima study) , showed similar to the ATTICA study results when evaluated the prevalence of hypertension (30% in men and 27% in women). The present study estimated that the prevalence of self-reported hypertension was much lower comparing to data provided from the studies mentioned above (13.3% for men and 17.7% for women). This large difference among these specific studies can be possibly ascribed to the selected way of identifying hypertensive participants in the present study. Due to the fact that the participants self – reported whether they are hypertensives (without clinical examination), it is actually likely that the prevalence's figures were underestimated as it is generally accepted that there is a large group of hypertensive subjects unaware of their condition (according to the ATTICA study: 68% in men and 54% in women ). However, studying population-based surveys the calculated prevalence may be an overestimate, as blood pressure measurement was performed once during the study and numerous reasons for elevated blood pressure readings may have been present, including the white coat phenomenon .
It is also noteworthy the finding that hypertension is more prevalent in women than in men, something that is in contrast with the results from the other similar surveys (ATTICA, EPIC and Didima). However, in the EPIC study it is stated that although the prevalence of hypertension before the age of 55 years is higher among men than among women, it is slightly higher among women thereafter. A different explanation of the above finding could possibly be the different level of high blood pressure awareness between the two sexes, as it has been suggested that hypertensive women show higher level of awareness than men . Another finding of this study, which is in accordance with the results from the aforementioned studies, is that the prevalence of the discussed condition increases with age (Table 4). Particularly, distribution of hypertensive study's participants by age showed that prevalence's figures among consecutive age groups (decades) differ approximately per 15 percentage units, with highest values observed in the older age group (65 – 74 yr) examined (men: 39.5%, women: 49.6%).
The significant strong relationship observed between prevalence of hypertension and hypercholesterolaemia, diabetes mellitus and obesity (Table 3) confirm the frequent conclusion from other studies [27–29], that hypertensives usually, apart from high blood pressure, have additional cardiovascular risk factors. Although elevated levels of blood pressure and cholesterol are known as two of the most important risk factors of coronary heart disease , the strong relationships detected between hypertension and diabetes mellitus should not be underestimated, because evidence of diabetes substantially increases cardiovascular disease risk in hypertensive  while the risk of vascular complications in diabetes is related to the level of blood pressure . Furthermore, obesity which was found to be more prevalent in the present survey's subgroup of hypertensive participants, also enhances total cardiovascular risk possibly by increasing low density lipoproteins-cholesterol (LDL-C) levels, reducing high density lipoproteins – cholesterol (HDL-C) levels, diminishing glucose tolerance and predisposing to the development of left ventricular hypertrophy, according to previous studies [32, 33]. Above findings in combination to one of the conclusions from ATTICA study, that only about one out of six Greek hypertensives is adequately controlled, emphasize in the need for policies in Greece for the detection and control of hypertension similar to those that US as well as some other countries have adopted for years [7, 34, 35].
Diet and nutrition have been extensively investigated as risk factors for major cardiovascular diseases like coronary heart disease and stroke and are also linked to other cardiovascular risk factors like diabetes, high blood pressure and obesity [7, 8, 10, 11]. Furthermore, arterial pressure regulation has been linked to a variety of nutrients and nutritional issues. Current guidelines for the management of hypertension emphasize the importance of achieving several nutritional goals simultaneously. In particular, according to the recent "2004 Canadian recommendations for the management of hypertension", apart from suggestions relevant to improvement of physical fitness and stress management, nutritional guidelines are highlighted. Specifically, key recommendations include the following: an ideal body weight (BMI: 18.5 kg/m2 to 24.9 kg/m2) should be maintained and weight loss strategies should use a multidisciplinary approach; alcohol consumption should be limited to two drinks or fewer per day, and weekly intake should not exceed 14 standard drinks for men and 9 standard drinks for women; a reduced fat, low cholesterol diet that emphasizes fruits, vegetables and low fat dairy products, and maintains an adequate intake of potassium, magnesium and calcium, should be followed; salt intake should be restricted to 65 mmol/day to 100 mmol/day in hypertensive individuals and less than 100 mmol/day in normotensive individuals at high risk for developing hypertension. It is also stated that the above lifestyle modifications should be extended to non-hypertensive individuals who are at risk for developing high blood pressure.
In the present study, the expected higher prevalence of obesity in the subgroup of hypertensive participants was confirmed, as well as the greater values of BMI in the same subgroup (Table 3). This finding shows that although hypertensive participants are aware of their hypertensive status, they have not managed yet to approach an ideal body weight. However, data came out after the analysis of food frequency questionnaires reveal that they may have started adopting some more healthy nutritional behaviour compared to normotensive ones. As it was mentioned in the results section, consumption of fish, fruits and juices, cereals, and low fat milk and yogurt was found to be higher among hypertensive subjects while the opposite was observed for food items as red meat, pork, egg, pasta and rice, full fat dairy products and desserts (Table 5), something that is encouraging relatively to their attempts of controlling their blood pressure in a better way. However, the reported quantities consumed are quite different than recommended ones, according to the beneficial dietary pattern of Mediterranean Diet [14, 15, 37] which among others highlights the importance of adequate consumption of vegetables and legumes.
It is noteworthy that eggs and full fat dairy products are included in the list of food items preferred more by present study's subgroup of normotensives. A first possible explanation could be that hypertensive participants try to follow more strictly the recommendations of nutritional experts. However, composition of these specific food items may reveal a better explanation of the observed relationships. In particular, peptides formed during the digestion of milk [38–41] and egg proteins  and oligopeptides from chicken egg yolk [43, 44], have been demonstrated to have a blood pressure lowering effect in human, possibly via their strong angiotensin I – converting enzyme (ACE) inhibitory activity. So, it is possible this dietary habit observed among normotensive subjects to be able of providing a prophylactic effect against hypertension. Taking under consideration recent studies which demonstrated that there are no convincing evidence of an increased risk of vascular disease from milk [45, 46] and egg  consumption, future focused research is needed before a possible update of global recommendations in relation to optimum consumption of egg and dairy products takes place.
This study as a cross-sectional one cannot establish causal relations, but only generate hypothesis that could be evaluated by future prospective randomized trials. Additionally, the applied method of self – reporting hypertension status neither is able to provide data in relation to level of hypertension's awareness (thus the evaluated prevalence of hypertension may be underestimated), nor can be as accurate as clinical examination. However, validity studies suggest that self – reported hypertension may be used for surveillance of hypertension trends in the absence of measured blood pressure . For example, according to a recent survey , the results of which were based on blood pressure measurements, it was estimated that approximately 27 % of the US adults had hypertension and that among them about 69 % were aware of their status (corresponding to about 19 % of the study sample). In another study (with no blood pressure measurements) Ayala and colleagues  reported a prevalence of 20 % for self-reported hypertension among US adults, which is close with the expected value of 19%. Meanwhile, caution has to be given when interpreting results derived from self-reporting quantifiable variables, due to low reliability and validity of the self-reporting method. For instance, self-reported BMI tends to be underestimated in those with higher values. Thus, the rate of obesity is most probably underestimated [51, 52]. Another methodological limitation of the present study is that semi-quantitative food frequency questionnaires in general cannot be used for subsequent analysis of specific nutrients, so conclusions can be expressed only in relation to food groups or items tested. Finally, the participation rate, although small (i.e. 30%) is considered acceptable in RDD telephone surveys. Unfortunately, no sensitivity analysis could be performed since no information was recorded by the people that they did not want to participate. Moreover, the statistical analysis showed that the selected sample shares the same distribution of age-group and sex as the total population.
According to presented data, hypertension can be considered as a major public health problem in Greece, albeit the estimated prevalence is relatively low when compared with the rest European developed countries. Possibly the adoption of "western" dietary patterns by Greeks during last decades, had a strong causative role for this phenomenon. However, this problem can be prevented or controlled by complementary to clinical management application of strategies that target the general population. Among non – pharmacological approaches, nutritional interventions, that will incorporate the newest relevant scientific knowledge, are extremely challenging in the primary and secondary prevention of hypertension. Moreover a finding of this work, which implies certain actions towards health policy and quality improvement, is that although hypertensive participants seem to be aware of their condition, they have not managed as yet to approach an ideal body weight. All these carry an important message for primary care physicians and other health care scientists and reveals the value of the spread and understanding of European guidelines on cardiovascular disease prevention . This study opens also room for further research with the same methodology that will explore whether patients with hypertension were seeking proper care by their personal physician and discuss to what extent they complied with their physicians' recommendations.
The study is supported by research grants from the Unilever Institute. The authors would also like to thank Dr K. Mitsopoulos and his team for his contribution in the enrollment of the participants.
- Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JLJ, Jones DW, Materson BJ, Oparil S, Wright JTJ, Roccella EJ: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Jama. 2003, 289 (19): 2560-2572. 10.1001/jama.289.19.2560.View ArticlePubMedGoogle Scholar
- Kannel WB: Blood pressure as a cardiovascular risk factor: prevention and treatment. Jama. 1996, 275 (20): 1571-1576. 10.1001/jama.275.20.1571.View ArticlePubMedGoogle Scholar
- Stamler J, Stamler R, Neaton JD: Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Arch Intern Med. 1993, 153 (5): 598-615. 10.1001/archinte.153.5.598.View ArticlePubMedGoogle Scholar
- Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJ: Selected major risk factors and global and regional burden of disease. Lancet. 2002, 360 (9343): 1347-1360. 10.1016/S0140-6736(02)11403-6.View ArticlePubMedGoogle Scholar
- Wolf-Maier K, Cooper RS, Banegas JR, Giampaoli S, Hense HW, Joffres M, Kastarinen M, Poulter N, Primatesta P, Rodriguez-Artalejo F, Stegmayr B, Thamm M, Tuomilehto J, Vanuzzo D, Vescio F: Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. Jama. 2003, 289 (18): 2363-2369. 10.1001/jama.289.18.2363.View ArticlePubMedGoogle Scholar
- Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA, Godwin J, Qizilbash N, Taylor JO, Hennekens CH: Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990, 335 (8693): 827-838. 10.1016/0140-6736(90)90944-Z.View ArticlePubMedGoogle Scholar
- Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D: Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension. 1995, 25 (3): 305-313.View ArticlePubMedGoogle Scholar
- Palmer A, Bulpitt C, Beevers G, Coles E, Fletcher A, Ledingham J, Petrie J, Webster J, Dollery C: Risk factors for ischaemic heart disease and stroke mortality in young and old hypertensive patients. J Hum Hypertens. 1995, 9 (8): 695-697.PubMedGoogle Scholar
- EUROASPIRE. A European Society of Cardiology survey of secondary prevention of coronary heart disease: principal results. EUROASPIRE Study Group. European Action on Secondary Prevention through Intervention to Reduce Events. Eur Heart J. 1997, 18 (10): 1569-1582.Google Scholar
- Ascherio A, Rimm EB, Giovannucci EL, Colditz GA, Rosner B, Willett WC, Sacks F, Stampfer MJ: A prospective study of nutritional factors and hypertension among US men. Circulation. 1992, 86 (5): 1475-1484.View ArticlePubMedGoogle Scholar
- Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N: A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997, 336 (16): 1117-1124. 10.1056/NEJM199704173361601.View ArticlePubMedGoogle Scholar
- Lip GY, Beevers DG: Alcohol, hypertension, coronary disease and stroke. Clin Exp Pharmacol Physiol. 1995, 22 (3): 189-194.View ArticlePubMedGoogle Scholar
- Kafatos A, Diacatou A, Voukiklaris G, Nikolakakis N, Vlachonikolis J, Kounali D, Mamalakis G, Dontas AS: Heart disease risk-factor status and dietary changes in the Cretan population over the past 30 y: the Seven Countries Study. Am J Clin Nutr. 1997, 65 (6): 1882-1886.PubMedGoogle Scholar
- de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N: Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999, 99 (6): 779-785.View ArticlePubMedGoogle Scholar
- Kris-Etherton P, Eckel RH, Howard BV, St Jeor S, Bazzarre TL: AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. Circulation. 2001, 103 (13): 1823-1825.View ArticlePubMedGoogle Scholar
- Whelton PK, He J, Appel LJ, Cutler JA, Havas S, Kotchen TA, Roccella EJ, Stout R, Vallbona C, Winston MC, Karimbakas J: Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program. Jama. 2002, 288 (15): 1882-1888. 10.1001/jama.288.15.1882.View ArticlePubMedGoogle Scholar
- Frankel LR: On the definition of response rates. A special report of the CASRO Task Force on Completion Rates. 1982, New York , The Council of American Survey Research OrganizationsGoogle Scholar
- Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Jama. 2001, 285 (19): 2486-2497. 10.1001/jama.285.19.2486.Google Scholar
- Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997, 20 (7): 1183-1197.Google Scholar
- Pitsavos C, Panagiotakos DB, Chrysohoou C, Stefanadis C: Epidemiology of cardiovascular risk factors in Greece: aims, design and baseline characteristics of the ATTICA study. BMC Public Health. 2003, 3 (1): 32-10.1186/1471-2458-3-32.View ArticlePubMedPubMed CentralGoogle Scholar
- Psaltopoulou T, Orfanos P, Naska A, Lenas D, Trichopoulos D, Trichopoulou A: Prevalence, awareness, treatment and control of hypertension in a general population sample of 26,913 adults in the Greek EPIC study. Int J Epidemiol. 2004, 33 (6): 1345-1352. 10.1093/ije/dyh249.View ArticlePubMedGoogle Scholar
- Stergiou GS, Thomopoulou GC, Skeva II, Mountokalakis TD: Prevalence, awareness, treatment, and control of hypertension in Greece: the Didima study. Am J Hypertens. 1999, 12 (1O Pt 1): 959-965. 10.1016/S0895-7061(99)00136-3.View ArticlePubMedGoogle Scholar
- Lindholm LH, Koutis AD, Lionis CD, Vlachonikolis IG, Isacsson A, Fioretos M: Risk factors for ischaemic heart disease in a Greek population. A cross-sectional study of men and women living in the village of Spili in Crete. Eur Heart J. 1992, 13 (3): 291-298.PubMedGoogle Scholar
- Panagiotakos DB, Pitsavos CH, Chrysohoou C, Skoumas J, Papadimitriou L, Stefanadis C, Toutouzas PK: Status and management of hypertension in Greece: role of the adoption of a Mediterranean diet: the Attica study. J Hypertens. 2003, 21 (8): 1483-1489. 10.1097/00004872-200308000-00011.View ArticlePubMedGoogle Scholar
- Klungel OH, de Boer A, Paes AH, Nagelkerke NJ, Seidell JC, Bakker A: Estimating the prevalence of hypertension corrected for the effect of within-person variability in blood pressure. J Clin Epidemiol. 2000, 53 (11): 1158-1163. 10.1016/S0895-4356(00)00228-6.View ArticlePubMedGoogle Scholar
- Okura Y, Urban LH, Mahoney DW, Jacobsen SJ, Rodeheffer RJ: Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure. J Clin Epidemiol. 2004, 57 (10): 1096-1103. 10.1016/j.jclinepi.2004.04.005.View ArticlePubMedGoogle Scholar
- Foucan L, Bangou-Bredent J, Ekouevi DK, Deloumeaux J, Roset JE, Kangambega P: Hypertension and combinations of cardiovascular risk factors. An epidemiologic case-control study in an adult population in Guadeloupe (FWI). Eur J Epidemiol. 2001, 17 (12): 1089-1095. 10.1023/A:1021213729434.View ArticlePubMedGoogle Scholar
- Rudnichi A, Safar M, Asmar R, Guize L, Benetos A: Prevalence of cardiovascular risk factors in a French population. J Hypertens Suppl. 1998, 16 (1): S85-90. 10.1097/00004872-199816010-00013.View ArticlePubMedGoogle Scholar
- Castelli WP, Anderson K: A population at risk. Prevalence of high cholesterol levels in hypertensive patients in the Framingham Study. Am J Med. 1986, 80 (2A): 23-32. 10.1016/0002-9343(86)90157-9.View ArticlePubMedGoogle Scholar
- Alderman MH, Cohen H, Madhavan S: Diabetes and cardiovascular events in hypertensive patients. Hypertension. 1999, 33 (5): 1130-1134.View ArticlePubMedGoogle Scholar
- Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group. Bmj. 1998, 317 (7160): 703-713.Google Scholar
- Ostlund REJ, Staten M, Kohrt WM, Schultz J, Malley M: The ratio of waist-to-hip circumference, plasma insulin level, and glucose intolerance as independent predictors of the HDL2 cholesterol level in older adults. N Engl J Med. 1990, 322 (4): 229-234.View ArticlePubMedGoogle Scholar
- Lauer MS, Anderson KM, Kannel WB, Levy D: The impact of obesity on left ventricular mass and geometry. The Framingham Heart Study. Jama. 1991, 266 (2): 231-236. 10.1001/jama.266.2.231.View ArticlePubMedGoogle Scholar
- Joffres MR, Ghadirian P, Fodor JG, Petrasovits A, Chockalingam A, Hamet P: Awareness, treatment, and control of hypertension in Canada. Am J Hypertens. 1997, 10 (10 Pt 1): 1097-1102. 10.1016/S0895-7061(97)00224-0.View ArticlePubMedGoogle Scholar
- De Backer G, Myny K, De Henauw S, Doyen Z, Van Oyen H, Tafforeau J, Kornitzer M: Prevalence, awareness, treatment and control of arterial hypertension in an elderly population in Belgium. J Hum Hypertens. 1998, 12 (10): 701-706. 10.1038/sj.jhh.1000695.View ArticlePubMedGoogle Scholar
- Touyz RM, Campbell N, Logan A, Gledhill N, Petrella R, Padwal R: The 2004 Canadian recommendations for the management of hypertension: Part III--Lifestyle modifications to prevent and control hypertension. Can J Cardiol. 2004, 20 (1): 55-59.PubMedGoogle Scholar
- Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D: Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr. 1995, 61 (6 Suppl): 1402S-1406S.PubMedGoogle Scholar
- Groziak SM, Miller GD: Natural bioactive substances in milk and colostrum: effects on the arterial blood pressure system. Br J Nutr. 2000, 84 Suppl 1: S119-25.PubMedGoogle Scholar
- Tuomilehto J, Lindstrom J, Hyyrynen J, Korpela R, Karhunen ML, Mikkola L, Jauhiainen T, Seppo L, Nissinen A: Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension. J Hum Hypertens. 2004, 18 (11): 795-802. 10.1038/sj.jhh.1001745.View ArticlePubMedGoogle Scholar
- FitzGerald RJ, Murray BA, Walsh DJ: Hypotensive peptides from milk proteins. J Nutr. 2004, 134 (4): 980S-8S.PubMedGoogle Scholar
- Clare DA, Swaisgood HE: Bioactive milk peptides: a prospectus. J Dairy Sci. 2000, 83 (6): 1187-1195.View ArticlePubMedGoogle Scholar
- Davalos A, Miguel M, Bartolome B, Lopez-Fandino R: Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis. J Food Prot. 2004, 67 (9): 1939-1944.PubMedGoogle Scholar
- Fujita H, Sasaki R, Yoshikawa M: Potentiation of the antihypertensive activity of orally administered ovokinin, a vasorelaxing peptide derived from ovalbumin, by emulsification in egg phosphatidylcholine. Biosci Biotechnol Biochem. 1995, 59 (12): 2344-2345.View ArticlePubMedGoogle Scholar
- Yoshii H, Tachi N, Ohba R, Sakamura O, Takeyama H, Itani T: Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks. Comp Biochem Physiol C Toxicol Pharmacol. 2001, 128 (1): 27-33. 10.1016/S1532-0456(00)00172-1.View ArticlePubMedGoogle Scholar
- Elwood PC, Strain JJ, Robson PJ, Fehily AM, Hughes J, Pickering J, Ness A: Milk consumption, stroke, and heart attack risk: evidence from the Caerphilly cohort of older men. J Epidemiol Community Health. 2005, 59 (6): 502-505. 10.1136/jech.2004.027904.View ArticlePubMedPubMed CentralGoogle Scholar
- Massey LK: Dairy food consumption, blood pressure and stroke. J Nutr. 2001, 131 (7): 1875-1878.PubMedGoogle Scholar
- Hu FB, Stampfer MJ, Rimm EB, Manson JE, Ascherio A, Colditz GA, Rosner BA, Spiegelman D, Speizer FE, Sacks FM, Hennekens CH, Willett WC: A prospective study of egg consumption and risk of cardiovascular disease in men and women. Jama. 1999, 281 (15): 1387-1394. 10.1001/jama.281.15.1387.View ArticlePubMedGoogle Scholar
- Vargas CM, Burt VL, Gillum RF, Pamuk ER: Validity of self-reported hypertension in the National Health and Nutrition Examination Survey III, 1988-1991. Prev Med. 1997, 26 (5 Pt 1): 678-685. 10.1006/pmed.1997.0190.View ArticlePubMedGoogle Scholar
- Wang Y, Wang QJ: The prevalence of prehypertension and hypertension among US adults according to the new joint national committee guidelines: new challenges of the old problem. Arch Intern Med. 2004, 164 (19): 2126-2134. 10.1001/archinte.164.19.2126.View ArticlePubMedGoogle Scholar
- Ayala C, Neff LJ, Croft JB, Keenan NL, Malarcher AM, Hyduk A, Bansil P, Mensah GA: Prevalence of self-reported high blood pressure awareness, advice received from health professionals, and actions taken to reduce high blood pressure among US adults--Healthstyles 2002. J Clin Hypertens (Greenwich). 2005, 7 (9): 513-519.View ArticleGoogle Scholar
- Kuskowska-Wolk A, Rossner S: The "true" prevalence of obesity. A comparison of objective weight and height measures versus self-reported and calibrated data. Scand J Prim Health Care. 1989, 7 (2): 79-82.View ArticlePubMedGoogle Scholar
- Gunnell D, Berney L, Holland P, Maynard M, Blane D, Frankel S, Smith GD: How accurately are height, weight and leg length reported by the elderly, and how closely are they related to measurements recorded in childhood?. Int J Epidemiol. 2000, 29 (3): 456-464. 10.1093/ije/29.3.456.View ArticlePubMedGoogle Scholar
- De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J, Ebrahim S, Faergeman O, Graham I, Mancia G, Manger Cats V, Orth-Gomer K, Perk J, Pyorala K, Rodicio JL, Sans S, Sansoy V, Sechtem U, Silber S, Thomsen T, Wood D: European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J. 2003, 24 (17): 1601-1610. 10.1016/S0195-668X(03)00347-6.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/6/206/prepub
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