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A dose-response relationship between exposure to a large-scale HIV preventive intervention and consistent condom use with different sexual partners of female sex workers in southern India
BMC Public Health volume 11, Article number: S8 (2011)
The Avahan Initiative, a large-scale HIV preventive intervention targeted to high-risk populations including female sex workers (FSWs), was initiated in 2003 in six high-prevalence states in India, including Karnataka. This study assessed if intervention exposure was associated with condom use with FSWs’ sexual partners, including a dose-response relationship.
Data were from a cross-sectional study (2006-07) of 775 FSWs in three districts in Karnataka. Survey methods accounted for the complex cluster sampling design. Bivariate and multivariable logistic regression was used to separately model the relationships between each of five intervention exposure variables and five outcomes for consistent condom use (CCU= always versus frequently/sometimes/never) with different sex partners, including with: all clients; occasional clients; most recent repeat client; most recent non-paying partner; and the husband or cohabiting partner. Linear tests for trends were conducted for three continuous intervention exposure variables.
FSWs reported highest CCU with all clients (81.7%); CCU was lowest with FSWs’ husband or cohabiting partner (9.6%). In multivariable analysis, the odds of CCU with all clients and with occasional clients were 6.3-fold [95% confidence intervals, CIs: 2.8-14.5] and 2.3-fold [95% CIs: 1.4-4.1] higher among FSWs contacted by intervention staff and 4.9-fold [95% CIs: 2.6-9.3] and 2.3-fold [95% CIs: 1.3-4.1] higher among those who ever observed a condom demonstration by staff, respectively, compared to those who had not. A significant dose-response relationship existed between each of these CCU outcomes and increased duration since first contacted by staff (P=0.001; P=0.006) and numbers of condom demonstrations witnessed (P=0.004; P=0.026); a dose-response relationship was also observed between condom use with all clients and number of times contacted by staff (P=0.047). Intervention exposure was not associated with higher odds of CCU with the most recent repeat client, most recent non-paying partner or with the husband or cohabiting partner.
Study findings suggest that exposure to a large-scale HIV intervention for FSWs was associated with increased CCU with commercial clients. Moreover, there were dose-response relationships between CCU with clients and increased duration since first contacted by staff, times contacted by staff and number of condom demonstrations. Additional program effort is required to increase condom use with non-commercial partners.
Sex work-related harms are linked inextricably to the social, economic, policy, and physical environments of sex workers. Individual behaviour (high- or low-risk) both shapes and is shaped by individual and environmental factors [1, 2]. There has thus been increasing recognition of the importance of using structural and community-level strategies that modify sex work environments to reduce risk and promote health among sex workers and their clients, and in particular, improve condom use with sex partners [3–6]. Notably, in response to high rates of HIV and sexually transmitted infections (STIs) among female sex workers (FSWs) in the early 1990s, several countries in east Asia instituted a 100% condom use campaign intended to increase social acceptance of condoms, influence men to agree to use condoms and empower FSWs to demand condom use with clients, as well as increase access to STI testing and treatment. This programme is thought to have contributed to dramatic declines in STIs and HIV in Thailand and Cambodia, as well as influence similar campaigns across Asia [7–9]. The Sonagachi Project in Kolkata, India, implemented a community empowerment model for FSWs that framed health risks to sex workers as occupational hazards, focusing on addressing community- and individual-level factors influencing risk for HIV. Subsequently, large increases in condom use have been observed and HIV prevalence remains low in FSWs associated with the Sonagachi Project [10, 11].
Another large-scale intervention designed to reduce HIV infection rates among groups with high HIV risk (FSWs; men-who-have-sex-with-men; injection drug users) and groups that bridge high- and low-risk groups (clients of FSWs) is Avahan, the India AIDS Initiative [12, 13], which began in 2003 in the six states with the highest HIV prevalence in India. Using community involvement and mobilization strategies, combined with condom promotion and increased STI clinical services among these populations, the ongoing Avahan AIDS Initiative addresses proximal and distal determinants of risk. The Avahan AIDS Initiative aims to increase condom use among groups at high risk for HIV by modifying their environments to enable individuals to use condoms . For FSWs, this is achieved through a combination of approaches. Avahan includes peer-led outreach to increase awareness of condoms and ability to negotiate condom use with clients  and efforts to increase the availability of and access to condoms and STI testing and treatment centres . The program also includes actions to improve community mobilization and involvement. FSWs have played important roles in mapping local hotspots, informing outreach plans, developing peer networks in communities and participating in training and implementation of Avahan surveys [16, 17]. The program has also supported the development and operation of safer sex work spaces, including sex work drop-in centres and collectives, where women can rest safely, take classes (e.g., literacy training) and interact with staff and other FSWs [18–20]. Legal empowerment training has also been offered to 25,000 FSWs across Karnataka state, to improve legal literacy and inform FSWs about their legal rights . The evaluation of this large-scale intervention remains challenging, as is the case for many similar evaluation efforts where conventional methods (e.g., randomized control trials of communities) are unethical and/or impractical to implement [13, 21]. A multi-pronged evaluation framework is necessary to gain an overall understanding of an intervention’s impact . This includes an examination of programmatic (e.g., numbers of peer educators, clinics or services to meet the population’s needs) and health indicators (e.g., increases in condom use, decreases in HIV or STI incidence). The consistency of study results from a combination of study designs, including transmission dynamics modelling (e.g., testing hypotheses while taking into account uncertainty in parameter estimates), cost-effectiveness analysis, surveillance and epidemiological approaches, can together provide a stronger understanding of the effectiveness of the intervention .
As part of this comprehensive evaluation framework, the objective of the current analysis was to determine if the Avahan AIDS Initiative had an impact on condom use amongst FSWs in urban areas of three districts in Karnataka State, India. HIV prevalence among FSWs was 12.7% in Bangalore district, 15.7% in Bellary and 33.9% in Belgaum in the mid-2000s . Specifically, we assessed whether five variables measuring intervention exposure were associated with consistent condom use (CCU) (i.e. 100%) among FSWs with: (1) all clients on the most recent day worked; (2) their current occasional clients (i.e., clients who FSWs are not familiar with and who visit FSWs once); (3) their most recent repeat client (i.e., regular clients who FSWs are familiar with and who visit FSWs more than once); (4) their most recent non-paying partner and (5) their husband or cohabiting partner.
Study design and sampling
During 2006-07, in-depth face-to-face interviews (Special Behavioural Surveys, SBS) were conducted with 775 FSWs in three districts in Karnataka state, located in southern India. A probability sampling method was employed, using time-location cluster sampling with normalized weights calculated to account for the complex sampling design. Sampling methods were similar to those reported by Ramesh et al  for other studies carried out among FSWs in Karnataka state.
Survey organization and methods
The surveys were implemented by the CHARME-India project in collaboration with the Institute of Population Health and Clinical Research (IPHCR), St John’s Medical College, and the Karnataka Health Promotion Trust (KHPT), Bangalore, India, the Centre hospitalier affilié universitaire de Québec (CHA), Québec, Canada, and the University of Manitoba, Winnipeg, Canada. The surveys were administered face-to-face by trained interviewers in the local language (Kannada) and were conducted anonymously, with no names or personal identifiers recorded. Ethics approval was attained from the CHA and the University of Manitoba as well as St. John’s Medical College.
The first outcome, CCU with all clients (including both occasional and repeat) during all instances of sexual intercourse in the most recent day worked was derived by dividing the reported number of instances of sexual intercourse in which condoms were used by the reported total number of instances of sexual intercourse in the most recent day worked. This was used to create a dichotomized variable of 100% versus <100% of instances of sexual intercourse in which condoms were used. The remaining four outcomes described CCU with FSWs’ different sexual partners, including: commercial sex clients (their current occasional clients; their most recent repeat client); and non-commercial partners (their most recent non-paying partner who was neither a husband nor the main cohabiting partner; and their husband or main cohabiting partner (if they had one)). These outcomes were derived from survey items about general condom frequency with each type of partner (e.g. “How often do you use condoms with <this partner>?”). Condom use was considered to be CCU with their partners, if they answered ‘always’, as opposed to ‘often’, ‘sometimes’ or ‘never’.
We examined five variables measuring exposure to the intervention, including: if FSWs had been contacted by intervention staff; if FSWs had been given condoms by intervention staff; the duration of time since contacted by intervention staff (years), which was specific to each district and limited to the total number of years women could have been exposed to the intervention (the year/month of the start of the intervention subtracted from the year/month of the survey – 1.5-2.5 years); the number of times in the past month FSWs had been contacted by intervention staff; and the number of condom demonstrations by intervention staff that FSWs had seen in the past month.
For each model, we adjusted for social and environmental factors that may influence condom use. Social factors included age, marital status (married versus unmarried, including those of the Devadasi tradition, a form of temple-based sex work whereby women are dedicated through marriage to gods or goddesses) [24–26], age at first sex, age at first sex work and duration of sex work. Environmental factors included district of residence, education (literacy) and having sex work as sole income (no other paid work versus any, including non-agricultural labour, petty business, maid servant, agricultural labour, handicrafts and other). It also included FSWs’ working environment, which was represented by the type of solicitation (independent or through a middleman/pimp) and the place of solicitation of clients of FSWs, which was grouped into three categories: home-based (home; rented room), brothel-based (lodge; dabha [road-side lodge-type establishment]; brothel); and public-places-based (vehicle; bar/night club; public places, such as bus stops, train stations and the street).
Statistical analysis was conducted using survey methods in SAS Version 9.1 , taking into account the sampling clusters and weights. FSWs sampled from the same clusters are assumed to be more similar to each other than they are to FSWs from different clusters; survey methods account for this by estimating the overall variance from the variation among the clusters . Descriptive statistics were calculated for sample characteristics. The prevalence of outcomes was calculated for each variable describing exposure to the intervention. Bivariate and multivariable logistic regression was used to model the relationship between the condom use outcomes and the five variables describing exposure to the intervention. Five separate logistic models were created for each of the five dichotomous outcomes, for a total of 25 separate models. Inclusion into multivariable models was based on significance at the P<0.10-level from Wald chi-squared tests in bivariate regression analyses, or if they were perceived to be important confounders a priori (district, typology of sex work). Each single intervention variable was forced into the five different multivariable models to examine the independent relationship between intervention exposure and CCU. Two intervention exposure variables were dichotomous (ever been contacted by intervention staff, ever seen a condom demonstration by intervention staff), while three were originally continuous (duration since first contacted by intervention staff, number of times contacted by intervention staff, number of condom demonstrations given by staff). The continuous variables were categorized prior to analysis. To examine a dose-response relationship, a linear test for trends across categories for each of the three continuous intervention exposure variables and each CCU outcome was conducted. The median of each category was taken, and the exposure variable was treated as a continuous variable. Odds ratios (ORs) and adjusted odds ratios (AORs) and their 95% confidence interval [95% CIs] were reported for logistic regression and P-values were reported for the tests for trends. All P-values reported are two-sided.
Table 1 presents characteristics of the overall sample of FSWs in three districts in Karnataka state. The sample sizes for Belgaum, Bellary and Bangalore districts were 208, 198 and 369 (N=775) respectively, and the median age of FSWs across the three districts was 30 years (interquartile range [IQR]=25-35; mean=30.3 years). Of the total sample, the majority of women, 348 (55.6%), primarily solicited clients in public places, while 245 (26.2%) solicited clients from their homes and 182 (18.2%) women solicited clients in brothels. Overall, 371 (52.5%) women in the sample were divorced, separated or widowed, 229 (26.0%) were currently married, 119 (15.5%) were Devadasi and 56 (5.9%) were other women who were never married (Table 1).
Relationship between the intervention and condom use
Commercial sex clients
The sample of 775 FSWs all reported having occasional clients. Of these women, 433 had repeat clients. Overall, 585 (81.7%) of FSWs reported CCU with all clients in the most recent day worked, 530 (69.5%) women reported CCU with current occasional clients and 269 (57.5%) women reported CCU with their most recent repeat client. CCU with all clients was higher among FSWs who had ever been contacted by intervention staff compared to those who had not (84.6% versus 65.6%), as was CCU with occasional clients (71.9% versus 53.5%) (Figure 1a). The same patterns were observed for FSWs who had ever been given condoms by intervention staff compared to those who had not (CCU with all clients: 86.6% versus 65.8%; CCU with occasional clients: 73.9% versus 53.6%) (Figure 1b). CCU was approximately the same with the most recent repeat client for women who had ever been contacted by intervention staff compared to those who had not (57.7% versus 56.2%) and for those who had ever seen a condom demonstration (57.9% versus 58.0%) compared to those who had not.
CCU with all clients in the most recent day worked, with occasional clients and with the most recent repeat client, increased overall as the duration of time since first contact by intervention staff increased, but only steadily increased with increased duration for CCU with occasional clients (Figure 1c). CCU with all clients increased steadily as the number of times contacted by staff in the past month increased (Figure 1d). CCU was highest with occasional clients and with the most recent repeat client among women who had been contacted <5 times (relative to women who had never been contacted or who had been contacted 5+ times). Finally, and consistent with the previous outcome, CCU with all clients in the last day worked, with occasional clients and the most recent repeat client increased with the number of condom demonstrations observed in the last month, but levelled off and decreased (substantially for the two latter outcomes) at two condom demonstrations in the last month (Figure 1e).
In bivariate analysis, all five intervention variables were significantly associated (on a P<0.10 significance level) with CCU with all clients in the most recent day worked and CCU with occasional clients (Table 1). Other explanatory variables that were significant on a P<0.10-level, or included in multivariable models a priori, are also listed in Table 1. In multivariable analysis (Table 2), after adjusting for social and environmental factors, the odds of CCU with all clients in the most recent day worked and CCU with occasional clients were 6.3-fold [95% CIs 2.8-14.5] and 2.3-fold [95% CIs: 1.3-4.1] higher among FSWs who had ever been contacted by intervention staff and 4.9-fold [95% CIs 2.6-9.3] and 2.3-fold [95% CIs: 1.3-4.1] higher among FSWs who had ever been given condoms by intervention staff, compared to those who never had been. None of the intervention exposure variables were significantly associated with CCU with the most recent repeat client in bivariate or multivariable analysis (Tables 1 and 2).
In bivariate analysis testing for trends, CCU with all clients in the most recent day worked was significantly associated with an increased duration since first contacted by intervention staff, the number of times contacted by intervention staff, and the number of condom demonstrations seen by staff in the last month. CCU with occasional clients was significantly associated with an increased duration since first being contacted by intervention staff, and the number of condom demonstrations seen by staff in the last month. In multivariable analysis, significant tests for trends indicated a dose-response relationship between CCU with all clients in the most recent day worked and CCU with occasional clients, and increased duration since first being contacted by staff (P=0.001, P=0.006 respectively). For both of these outcomes, significant tests for trends also indicated a dose-response relationship between CCU with all clients in the most recent day worked and CCU with occasional clients and increased numbers of condom demonstrations witnessed (P=0.004 and P=0.026 respectively). Finally, a dose-response relationship was also observed between CCU with all clients and number of times contacted by staff (P=0.047).
Of the total sample, 226 FSWs reported having a non-paying sexual partner in the last year (who was neither the husband nor main cohabiting partner) and 354 had a husband or cohabiting partner. Overall, 68 (31.1%) and 40 (9.6%) reported CCU with their most recent non-paying partner and their husband or cohabiting partner respectively (Table 1). In contrast to CCU with all clients and with occasional clients, CCU with their most recent non-paying partner was higher among FSWs who had never been contacted by intervention staff compared to those who had been contacted (35.8% versus 31.4%); the same was true for CCU with their husband or cohabiting partner (15.5% versus 8.8%). CCU with their most recent non-paying partner was higher for those who had seen a condom demonstration compared with those who had not (34.0% versus 26.6%), while CCU with their husband or cohabiting partner was higher for those who had never seen a condom demonstration compared to those who had (12.9% versus 9.3%) (Figures 2a-2b). Figure 2c demonstrates how CCU with both types of partners decreased and then increased as the duration of time since first contacted by intervention staff increased. CCU with both their most recent non-paying partner and CCU with their husband or cohabiting partner decreased as the number of times contacted by staff in the past month increased (Figure 2d). CCU with the most recent non-paying partner initially increased as the number of condom demonstrations witnessed increased, and then dropped by almost half for women who had seen three or more demonstrations in the past month. CCU with the husband or cohabiting partner increase slightly for one compared to zero demonstrations, then decreased steadily with increasing number of condom demonstrations (Figure 2e).
In bivariate logistic regression, only the variable number of times contacted by intervention staff was significantly associated with CCU with FSWs’ most recent non-paying partner (on a P<0.10 significance level). In multivariable analysis, after adjusting for social and environmental factors, none of the intervention exposure variables were significantly associated with CCU with their non-paying partner or husband or cohabiting partner (Table 3). In bivariate analysis testing for trends, CCU with FSWs’ most recent non-paying partner was inversely associated with the number of times contacted by intervention staff and CCU with their husband or cohabiting partner was inversely associated with the number of condom demonstrations by intervention staff. In multivariable analysis testing for trends, CCU with FSWs’ husband or cohabiting partner remained inversely significantly associated with the number of condom demonstrations by intervention staff (P=0.05).
The results from our analysis suggest that exposure to a large-scale HIV prevention initiative in Karnataka, India, was associated with higher reported consistent condom use (CCU) among women engaged in sex work with their commercial sex clients. After adjusting for social and environmental factors, a strong independent association was observed between CCU with all clients in the most recent day worked and CCU with occasional clients, and five measures of intervention exposure. Moreover, a significant dose-response relationship was observed between these two outcomes and increased duration since first contacted by intervention staff, as well as number of condom demonstrations seen by staff in the last month. There was also a significant dose-response relationship observed between CCU with all clients and the number of times contacted by staff in the past month. In multivariable analysis, intervention exposure was not significantly associated with increased CCU with FSWs’ most recent repeat commercial client, their most recent non-paying partner or their husband or cohabiting partner.
The association between increased intervention exposure and increased CCU with all clients likely reflects higher condom use with occasional clients, which constitute the majority of commercial clients in Karnataka. On a micro-level, condom use with occasional clients likely improved due to regular contact between FSWs and peer outreach workers (i.e., members of local sex worker communities), who were responsible for providing condoms to FSWs, giving demonstrations of correct condom use and facilitating conversations about risk and vulnerability . Of note, our exposure variables measuring contacts by peers were not independent of our variables measuring condom demonstrations by peers. Although intervention exposure variables could not directly capture the influence of community involvement or mobilization strategies, peers also encouraged membership in community groups and were proponents of community mobilization, which is intended to facilitate condom negotiation by FSWs and use with clients through both individual-level and collective empowerment and agency [14, 18]. Interestingly, CCU with clients in this analysis was highest for FSWs who had seen two condom demonstrations by staff in the previous month and lower for FSWs who had seen three or more. CCU with occasional clients and repeat clients was also higher among FSWs who had been contacted <5 times compared to those who had been contacted 5+ times. These results could suggest that there may be a point where increased contact by staff or education about correct condom use by intervention staff will not improve condom use . Resources may be better directed to other features of the intervention if additional increases in condom use are to be observed. CCU was found to steadily increase with increased duration since first contacted by the intervention. This effect may not have levelled off (as with the previous two intervention exposure variables) over time due to the limited amount of time since the intervention began in some districts (varied from 1.5-2.5 years). Condom use may also have naturally increased over time in southern India (reflected in the duration since first contacted by staff) albeit likely at slower rates than in if the intervention was not present. Condom use may not have reached 100% in all commercial sex acts due to the timing of survey data collection (e.g., condom use may still increase with increased exposure to the intervention). There may also be groups of highly vulnerable FSWs who may be unable to negotiate condom use with all clients who refuse to wear condoms, even if exposed to the intervention. Condom use with commercial clients was relatively high for those FSWs who reported that they were not exposed to the intervention. This may be due to the presence of other HIV prevention programmes in place prior to Avahan. SBS surveys were also implemented 7-19 months after Avahan was introduced in different districts, and an independent analysis retrospectively assessing condom use confirmed that condom use increased notably after Avahan was introduced . Condom use may also be high due to the indirect impacts of Avahan (e.g., through increased peer awareness of condoms or increased condom availability ). Improved condom availability was also a key feature of the intervention . This facilitated condom use simply by increasing access, but also likely by increasing social acceptance of condoms through increased visibility and presence. Other interventions incorporating these program elements have shown success in improving condom use among FSWs [10, 11, 32].
Results from this study are supported by other studies showing similar results. These include observational studies suggesting that condom use as reported by clients  and FSWs [30, 34] increased after the introduction of the intervention, as well as studies suggesting that condom availability to FSWs increased substantially since the intervention began . Increases in condom use among high-risk groups could have important implications for HIV and STI prevalence in Karnataka. Sentinel surveillance and observational studies have found decreasing trends in terms of HIV and STIs among FSWs in Karnataka state since the intervention was introduced [34, 35]. Moreover, results are also consistent with mathematical modelling indicating that the increase in condom use after initiation of the intervention was consistent with decreasing HIV epidemiological trends over multiple rounds of survey data collection in Karnataka state [36, 37]. There is evidence to suggest that increased condom levels can be sustained over time in this population . Nevertheless, continued monitoring of condom use levels and assessments of the impact of observed increases in condom use on reducing HIV and STIs is important for a long-term and comprehensive understanding of the impact of the intervention.
While a higher probability of CCU with all clients in the most recent day worked and occasional clients was observed for FSWs with increased exposure to the intervention, the same patterns were not observed among FSWs for CCU with their most recent repeat client, non-paying partner and their husband or cohabiting partner. Moreover, CCU with FSWs’ husband or cohabiting partner decreased significantly with increasing numbers of condom demonstrations seen by intervention staff in the previous month, when testing for trends. It is not clear why this was observed, but of note, CCU with FSWs’ husband or cohabiting partner was very low and the absolute proportions did not vary substantially according to the number of condom demonstrations seen (10.1% to 13.8%). The reasons for low condom use within non-commercial and regular commercial sexual partnerships of FSWs are complex. These may include power disparities that favour the male partner [4, 38, 39], including an economic dependence on longer-term male partners [40, 41]. The use of condoms may not be acceptable in non-commercial relationships, if there is greater longevity, trust and intimacy within the partnership; the use of condoms may also be perceived as a symbol of infidelity and foster mistrust . Women may agree to not use condoms with repeat clients in exchange for these partners providing a stable form of longer-term income or because they feel they can assess if their partner is not infected with HIV after they have seen him several times. Further research is required to better understand condom use with non-commercial and regular commercial partners of FSWs; in particular, understanding gender-based interpersonal factors that influence condom use and preferences by both partners, as well as environmental factors (e.g. favourable societal views of condoms) that could be incorporated into interventions to increase condom use. The female condom could play an increasing role in HIV prevention within these partnerships. In addition, recent promising findings of the effectiveness of microbicides indicate that microbicides could play an important role in HIV prevention as an alternative to condoms for women whose partner does not use condoms .
There are several limitations to this study. This study is based on self-reported data from cross-sectional surveys collected in three districts and is not experimental in design. This study was based on data collected only from FSWs and should be considered alongside studies that show consistent results in other populations (e.g., clients), using other data sources to assess exposure to the intervention, and in similar settings. The condom use outcomes used in this study did not specify a timeframe. However, the questions were intended to capture recent (e.g., condom use with the last 10 clients) or current average behaviour. We relied on self-reported answers to questions that may be perceived as sensitive (e.g. consistency of condom use), and the questions are therefore susceptible to social desirability bias . This may have overestimated the relationship between intervention exposure and CCU, and it is possible that women with increased condom use are more likely or able to be accessed by intervention-related services and programs rather than the other way around. However, we believe that this is unlikely, since the total sample size was relatively large, particularly for a marginalized and hidden population, and the cluster sampling design was used to make the sample as representative as possible, with complex survey methods accounting for the sampling design. Additionally, our results suggest not only a relationship between exposure to the intervention and increased condom use, but a dose-response relationship between increased exposure to the intervention and increased condom use with all clients and occasional clients.
The impact of increases in condom use among FSWs and their clients on the HIV epidemic in southern India should continue to be assessed. Large-scale HIV prevention programs targeted at groups with high HIV risk could in theory also have an indirect impact on HIV prevalence within general populations ; however, results from mathematical modelling suggest that the current observed decrease in antenatal clinic HIV prevalence in India was likely not caused by the FSW-targeted intervention, although it is likely too early to assess the impact of the intervention on bridge groups or groups with low risk for HIV . Since many clients of FSWs have other longer-term and/or non-paying partners such as wives, as well as other FSW partners, and since condom use is low in these partnerships, clients provide an important transmission “bridge” between FSWs and the general population [45, 47]. Since condom use tends to be relatively low among FSWs’ repeat clients and non-paying partnerships, these partners can also provide a transmission bridge to FSWs .
If the intervention’s influence on condom use varies by type of commercial sex client (e.g. occasional compared to repeat clients) and the patterns of sexual structure vary geographically (e.g., districts such as Bangalore have higher fractions of occasional clients and lower numbers of repeat clients per month), we would expect to observe different intervention effects across the three districts in Karnataka. CCU with non-paying partners was also much lower in Bangalore (12.8%) compared to the other two districts (45.7% and 41.6% respectively), indicating that the importance of these partnerships in this district may be more pronounced, and should be considered in this district more than others when planning interventions. Exploring the relative role of different patterns of FSW-client sexual structure and variation in the numbers of different types of partners on HIV transmission in Karnataka, India, using simulation studies, would be useful to further improve the impact of the intervention [3, 24, 49–51].
In summary, study findings suggest that the exposure to a large-scale HIV preventive intervention among FSWs was associated with increased condom use with occasional clients, with a dose-response relationship, but that it did not seem to influence condom use with repeat clients, non-paying partners and with the husband or cohabiting partner. Future research should be directed toward understanding why condom use remains relatively low with non-commercial partners and new strategies should be investigated and developed specifically to increase condom use by these partners.
Rhodes T: The 'risk environment': a framework for understanding and reducing drug-related harm. Int J Drug Policy. 2002, 13: 85-94. 10.1016/S0955-3959(02)00007-5. [http://www.sciencedirect.com/science/article/pii/S0955395902000075]
Rhodes T, Singer M, Bourgois P, Friedman SR, Strathdee SA: The social and structural production of HIV risk among injecting drug users. Soc Sci Med. 2005, 61: 1026-1044. 10.1016/j.socscimed.2004.12.024.
Buzdugan R, Halli SS, Cowan FM: The female sex work typology in India in the context of HIV/AIDS. Trop Med Int Health. 2009, 14: 673-687. 10.1111/j.1365-3156.2009.02278.x.
Shannon K, Kerr T, Allinott S, Chettiar J, Shoveller J, Tyndall MW: Social and structural violence and power relations in mitigating HIV risk of drug-using women in survival sex work. Soc Sci Med. 2008, 66: 911-921. 10.1016/j.socscimed.2007.11.008.
Harcourt C, Donovan B: The many faces of sex work. Sex Transm Infect. 2005, 81: 201-206. 10.1136/sti.2004.012468.
Shannon K, Rusch M, Shoveller J, Alexson D, Gibson K, Tyndall MW, Maka Project Partnership: Mapping violence and policing as an environmental-structural barrier to health service and syringe availability among substance-using women in street-level sex work. Int J Drug Policy. 2008, 19: 140-147. 10.1016/j.drugpo.2007.11.024.
Jana S, Rojanapithayakorn W, Steen R: Harm reduction for sex workers. The Lancet. 2006, 367: 814-
Hanenberg R, Rojanapithayakorn W, Kunasol P, Sokal D: Impact of Thailand's HIV-control programme as indicated by the decline of sexually transmitted diseases. Lancet. 1994, 344: 243-245. 10.1016/S0140-6736(94)93004-X.
Rojanapithayakorn W: The 100% condom use programme in Asia. Reprod Health Matters. 2006, 14: 41-52. 10.1016/S0968-8080(06)28270-3.
Jana S, Basu I, Rotheram-Borus MJ, Newman PA: The Sonagachi Project: a sustainable community intervention. AIDS Educ Prev. 2004, 16: 405-414. 10.1521/aeap.16.5.405.48734.
Cohen J: HIV/AIDS in India: Sonagachi sex workers stymie HIV. Science. 2004, 304: 506-10.1126/science.304.5670.506.
Avahan, the India AIDS Initiative - the Business of HIV prevention at Scale. 2008, New Delhi, India: The Bill & Melinda Gates Foundation
Piot P: Setting new standards for targeted HIV prevention: the Avahan initiative in India. Sex Transm Infect. 2010, 86 (Suppl 1): i1-i2. 10.1136/sti.2009.040428.
Sarkar S: Community engagement in HIV prevention in Asia: going from 'for the community' to 'by the community'--must we wait for more evidence?. Sex Transm Infect. 2010, 86 (Suppl 1): i2-i3. 10.1136/sti.2009.039289.
Managing HIV Prevention from the Ground Up: Avahan's Experience in Peer Led Outreach at Scale in India. 2008, New Delhi, India: The Bill & Melinda Gates Foundation
Blanchard JF, Bhattacharjee P, Kumaran S, Ramesh BM, Kumar NS, Washington RG, Moses S: Concepts and strategies for scaling up focused prevention for sex workers in India. Sex Transm Infect. 2008, 84 (Suppl 2): ii19-ii23. 10.1136/sti.2008.033134.
Steen R, Mogasale V, Wi T, Singh AK, Das A, Daly C, George B, Neilsen G, Loo V, Dallabetta G: Pursuing scale and quality in STI interventions with sex workers: initial results from Avahan India AIDS Initiative. Sex Transm Infect. 2006, 82: 381-385. 10.1136/sti.2006.020438.
Halli SS, Ramesh BM, O'Neil J, Moses S, Blanchard JF: The role of collectives in STI and HIV/AIDS prevention among female sex workers in Karnataka, India. AIDS Care. 2006, 18: 739-749. 10.1080/09540120500466937.
Beattie TS, Bhattacharjee P, Ramesh BM, Gurnani V, Anthony J, Isac S, Mohan HL, Ramakrishnan A, Wheeler T, Bradley J, et al: Violence against female sex workers in Karnataka state, south India: impact on health, and reductions in violence following an intervention program. BMC Public Health. 2010, 10: 476-10.1186/1471-2458-10-476.
Reza-Paul S, Beattie T, Syed HU, Venukumar KT, Venugopal MS, Fathima MP, Raghavendra H, Akram P, Manjula R, Lakshmi M, et al: Declines in risk behaviour and sexually transmitted infection prevalence following a community-led HIV preventive intervention among female sex workers in Mysore, India. AIDS. 2008, 22 (Suppl 5): S91-S100. 10.1097/01.aids.0000343767.08197.18.
Boily MC, Lowndes CM, Vickerman P, Kumaranayake L, Blanchard J, Moses S, Ramesh BM, Pickles M, Watts C, Washington R, et al: Evaluating large-scale HIV prevention interventions: study design for an integrated mathematical modelling approach. Sex Transm Infect. 2007, 83: 582-589. 10.1136/sti.2007.027516.
Szklo M, Nieto FJ: Epidemiology: Beyond the Basics. 1999, New York: Aspen Publishers
Ramesh BM, Moses S, Washington R, Isac S, Mohapatra B, Mahagaonkar SB, Adhikary R, Brahmam GNV, Paranjape RS, Subramanian T, Blanchard JF, IBBA Study Team: Determinants of HIV prevalence among female sex workers in four south Indian states: analysis of cross-sectional surveys in twenty-three districts. AIDS. 2008, 22 (Suppl 5): S35-S44. 10.1097/01.aids.0000343762.54831.5c.
Blanchard JF, O’Neil J, Ramesh BM, Bhattacharjee P, Orchard T, Moses S: Understanding the social and cultural contexts of female sex workers in Karnataka, India: implications for prevention of HIV infection. J Infect Dis. 2005, 191 (Suppl 1): S139-S146. 10.1086/425273.
O'Neil J, Orchard T, Swarankar RC, Blanchard JF, Gurav K, Moses S: Dhandha, dharma and disease: traditional sex work and HIV/AIDS in rural India. Soc Sci Med. 2004, 59: 851-860. 10.1016/j.socscimed.2003.11.032.
Orchard T: In this life: the impact of gender and tradition on sexuality and relationships for Devadasi sex workers in rural India. Sexuality and Culture. 2007, 11: 3-27. 10.1007/BF02853933. [http://www.springerlink.com/content/u38121502n51gt8q/]
SAS. 2002-03, Cary, NC, USA: SAS Institute Inc, 9.1-pp 9.1
Cole SR: Analysis of complex survey data using SAS. Comput Methods Programs Biomed. 2001, 64: 65-69. 10.1016/S0169-2607(00)00088-2.
Aral SO, Blanchard J, Lipshutz J: STD/HIV prevention intervention: efficacy, effectiveness and population impact. Sex Transm Infect. 2008, 84 (Suppl 2): ii1-ii3. 10.1136/sti.2008.033613.
Lowndes CM, Alary M, Verma S, Demers E, Bradley J, Jayachandran AA, Ramesh BM, Moses S, Adhikary R, Mainkar MK: Assessment of intervention outcome in the absence of baseline data: 'reconstruction' of condom use time trends using retrospective analysis of survey data. Sex Transm Infect. 2010, 86 (Suppl 1): i49-i55. 10.1136/sti.2009.038802.
Bradley J, Moses S, Blanchard JF, Rajaram S, Ramesh BM, Verma S, Alary M: Assessing reported condom use among female sex workers in southern India through examination of condom availability. Sex Transm Infect. 2010, 86 (Suppl 1): i44-i48. 10.1136/sti.2009.038398.
Kerrigan D, Telles P, Torres H, Overs C, Castle C: Community development and HIV/STI-related vulnerability among female sex workers in Rio de Janeiro, Brazil. Health Educ Res. 2007, 23: 137-145. 10.1093/her/cym011.
Lipovsek V, Mukherjee A, Navin D, Marjara P, Sharma A, Roy KP: Increases in self-reported consistent condom use among male clients of female sex workers following exposure to an integrated behaviour change programme in four states in southern India. Sex Transm Infect. 2010, 86 (Suppl 1): i25-i32. 10.1136/sti.2009.038497.
Ramesh BM, Beattie TS, Shajy I, Washington R, Jagannathan L, Reza-Paul S, Blanchard JF, Moses S: Changes in risk behaviours and prevalence of sexually transmitted infections following HIV preventive interventions among female sex workers in five districts in Karnataka state, south India. Sex Transm Infect. 2010, 86 (Suppl 1): i17-i24. 10.1136/sti.2009.038513.
HIV Fact Sheets: Based on HIV Sentinel Surveillance Data in India, 2003-2006. 2007, New Delhi, India: National AIDS Control Organization (NACO)
Pickles M, Foss AM, Vickerman P, Deering K, Verma S, Demers E, Washington R, Ramesh B, Moses S, Blanchard J, et al: Interim modelling analysis to validate reported increases in condom use and assess HIV infections averted among female sex workers and clients in southern India following a targeted HIV prevention programme. Sex Transm Infect. 2010, 86 (Suppl 1): i33-i43. 10.1136/sti.2009.038950.
Dureau J, Boily M-C, Vickerman P, Pickles M, S I, Ramesh B, Verma S, Moses S, Alary M, Kalogeropoulos K: What has been the impact of the Avahan HIV intervention on condom use among female sex workers? Insights from a fully Bayesian inference methodology. International Society for Sexually Transmitted Diseases Research; Quebec City, Canada. 2011
Wang Y, Li B, Song DM, Ding GY, Cathy E: Power relation and condom use in commercial sex behaviours. Biomed Environ Sci. 2007, 20: 302-306.
Wojcicki JM, Malala J: Condom use, power and HIV/AIDS risk: sex-workers bargain for survival in Hillbrow/Joubert Park/Berea, Johannesburg. Soc Sci Med. 2001, 53: 99-121. 10.1016/S0277-9536(00)00315-4.
Luke N: Exchange and condom use in informal sexual relationships in urban Kenya. Economic Development and Cultural Change. 2006, 54: 319-348. 10.1086/497011. [http://www.jstor.org/pss/10.1086/497011]
Luke N: Confronting the 'sugar daddy' stereotype: age and economic asymmetries and risky sexual behavior in urban Kenya. Int Fam Plan Perspect. 2005, 31: 6-14. 10.1363/3100605.
Varga CA: The condom conundrum: barriers to condom use among commercial sex workers in Durban, South Africa. Afr J Reprod Health. 1997, 1: 74-88. 10.2307/3583277.
Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, Kharsany ABM, Sibeko S, Mlisana KP, Omar Z, et al: Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010, 329: 1168-1174. 10.1126/science.1193748.
Hanck SE, Blankenship KM, Irwin KS, West BS, Kershaw T: Assessment of self-reported sexual behavior and condom use among female sex workers in India using a polling box approach: a preliminary report. Sex Transm Dis. 2008, 35: 489-494. 10.1097/OLQ.0b013e3181653433.
Vickerman P, Foss AM, Pickles M, Deering K, Verma S, Eric Demers, Lowndes CM, Moses S, Alary M, Boily MC: To what extent is the HIV epidemic driven by commercial sex? A modelling analysis. AIDS. 2010, 24: 2563-2572. 10.1097/QAD.0b013e32833e8663.
Boily MC, Pickles M, Vickerman P, Buzdugan R, Isac S, Deering KN, Blanchard JF, Moses S, Lowndes CM, Ramesh BM, et al: Using mathematical modelling to investigate the plausibility of attributing observed antenatal clinic declines to a female sex worker intervention in Karnataka state, India. AIDS. 2008, 22 (Suppl 5): S149-S164. 10.1097/01.aids.0000343773.59776.5b.
Lowndes CM, Alary M, Meda H, Gnintoungbé CA, Mukenge-Tshibaka L, Adjovi C, Buvé A, Morison L, Laourou M, Kanhonou L, Anagonou S: Role of core and bridging groups in the transmission dynamics of HIV and STIs in Cotonou, Benin, West Africa. Sex Transm Infect. 2002, 78 (Suppl 1): i69-i77. 10.1136/sti.78.suppl_1.i69.
Lowndes CM, Alary M, Gnintoungbé CAB, Bédard E, Mukenge L, Geraldo N, Jossou P, Lafia E, Bernier F, Baganizi E, et al: Management of sexually transmitted diseases and HIV prevention in men at high risk: targeting clients and non-paying sexual partners of female sex workers in Benin. AIDS. 2000, 14: 2523-2534. 10.1097/00002030-200011100-00015.
Coffee M, Lurie MN, Garnett GP: Modelling the impact of migration on the HIV epidemic in South Africa. AIDS. 2007, 21: 343-350. 10.1097/QAD.0b013e328011dac9.
Deering KN, Vickerman P, Moses S, Ramesh BM, Blanchard JF, Boily MC: The impact of out-migrants and out-migration on the HIV/AIDS epidemic: a case study from south-west India. AIDS. 2008, 22 (Suppl 5): S165-S181. 10.1097/01.aids.0000343774.59776.95.
Female Sex Workers and Their Clients in the Epidemiology and Control of Sexually Transmitted Diseases. Edited by: Blanchard JF, Moses S. 2007, New York, USA: McGraw Hill, 4
KND is supported by a Postdoctoral Fellowship (Bisby Award) from the Canadian Institutes of Health Research. We would like to thank Adamma Aghaizu for early contributions to the study. Support for this study was provided by the Bill and Melinda Gates Foundation. The views expressed herein are those of the authors and do not necessarily reflect the official policy or position of the Bill and Melinda Gates Foundation.
This article has been published as part of BMC Public Health Volume 11 Supplement 6, 2011: Learning from large scale prevention efforts – findings from Avahan. The full contents of the supplement are available online at URL.
The authors declare that they have no competing interests.
KND contributed to the conceptual design of the study, conducted the study and the analysis and drafted the manuscript; MCB, CML, PV, MP and MA participated in the conceptual design of the study and coordination, made substantial contributions in the interpretation of data; JS, MWT, SM and JB made substantial contributions in the interpretation of data and critically revised the manuscript for important intellectual content; BMR, KG, SR, RW made substantial contributions to the acquisition and management of the data. All authors read and approved the final manuscript.
Marie-Claude Boily, Catherine M Lowndes, Jean Shoveller, Mark W Tyndall, Peter Vickerman, Jan Bradley, Kaveri Gurav, Michael Pickles, Stephen Moses, Banadakoppa M Ramesh, Reynold Washington, S Rajaram and Michel Alary contributed equally to this work.
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Deering, K.N., Boily, M., Lowndes, C.M. et al. A dose-response relationship between exposure to a large-scale HIV preventive intervention and consistent condom use with different sexual partners of female sex workers in southern India. BMC Public Health 11, S8 (2011). https://doi.org/10.1186/1471-2458-11-S6-S8
- Intervention Exposure
- Intervention Staff
- Legal Empowerment
- Karnataka State
- Condom Availability