Organization WH. The world health report 2008 : primary health care now more than ever. The World Health Report 2008: primary health care - now more than ever. 2008;25(7):617.
Google Scholar
Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet (London, England). 2012;380(9836):37–43.
Article
Google Scholar
Ng SK, Tawiah R, Sawyer M, Scuffham P. Patterns of multimorbid health conditions: a systematic review of analytical methods and comparison analysis. Int J Epidemiol. 2018;47(5):1687–704.
Article
PubMed
Google Scholar
van den Akker M, et al. Comorbidity or multimorbidity: comorbidity or multimorbidity: European journal of general practice. Eur J Gen Pract. 1996;2(2):65–70.
Salive ME. Multimorbidity in older adults. Epidemiol Rev. 2013;35:75–83.
Article
PubMed
Google Scholar
Prince MJ, Wu F, Guo Y, Gutierrez Robledo LM, O'Donnell M, Sullivan R, et al. The burden of disease in older people and implications for health policy and practice. Lancet (London, England). 2015;385(9967):549–62.
Article
Google Scholar
Wang HH, Wang JJ, Wong SY, Wong MC, Li FJ, Wang PX, et al. Epidemiology of multimorbidity in China and implications for the healthcare system: cross-sectional survey among 162,464 community household residents in southern China. BMC Med. 2014;12:188.
Article
PubMed
PubMed Central
Google Scholar
Condelius A, Edberg AK, Jakobsson U, Hallberg IR. Hospital admissions among people 65+ related to multimorbidity, municipal and outpatient care. Arch Gerontol Geriatr. 2008;46(1):41–55.
Article
PubMed
Google Scholar
Wehling M. Multimorbidity and polypharmacy: how to reduce the harmful drug load and yet add needed drugs in the elderly? Proposal of a new drug classification: fit for the aged. J Am Geriatr Soc. 2009;57(3):560–1.
Article
PubMed
Google Scholar
Marengoni A, von Strauss E, Rizzuto D, Winblad B, Fratiglioni L. The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study. J Intern Med. 2009;265(2):288–95.
Article
CAS
PubMed
Google Scholar
Fortin M, Lapointe L, Hudon C, Vanasse A, Ntetu AL, Maltais D. Multimorbidity and quality of life in primary care: a systematic review. Health Qual Life Outcomes. 2004;2:51.
Article
PubMed
PubMed Central
Google Scholar
Fortin M, Bravo G, Hudon C, Lapointe L, Almirall J, Dubois MF, et al. Relationship between multimorbidity and health-related quality of life of patients in primary care. Qual Life Res Int J Qual Life Asp Treat Care Rehab. 2006;15(1):83–91.
Google Scholar
Bähler C, Huber CA, Brüngger B, Reich O. Multimorbidity, health care utilization and costs in an elderly community-dwelling population: a claims data based observational study. BMC Health Serv Res. 2015;15:23.
Article
PubMed
PubMed Central
Google Scholar
Fortin M, Dubois MF, Hudon C, Soubhi H, Almirall J. Multimorbidity and quality of life: a closer look. Health Qual Life Outcomes. 2007;5:52.
Article
PubMed
PubMed Central
Google Scholar
Gu J, Chao J, Chen W, Xu H, Zhang R, He T, et al. Multimorbidity and health-related quality of life among the community-dwelling elderly: a longitudinal study. Arch Gerontol Geriatr. 2018;74:133–40.
Article
PubMed
Google Scholar
Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel JP, et al. The world report on ageing and health: a policy framework for healthy ageing. Lancet (London, England). 2016;387(10033):2145–54.
Article
Google Scholar
DuGoff EH, Canudas-Romo V, Buttorff C, Leff B, Anderson GF. Multiple chronic conditions and life expectancy: a life table analysis. Med Care. 2014;52(8):688–94.
Article
PubMed
Google Scholar
Singh K, Patel SA, Biswas S, Shivashankar R, Kondal D, Ajay VS, et al. Multimorbidity in south Asian adults: prevalence, risk factors and mortality. J Public Health (Oxford, England). 2019;41(1):80–9.
Article
Google Scholar
Frith E, Ramulu PY, Ashar B, Loprinzi PD. Association of single and multiple medical conditions with work status among adults in the United States. J Lifestyle Med. 2019;9(1):15–26.
Article
PubMed
PubMed Central
Google Scholar
Violán C, Foguet-Boreu Q, Roso-Llorach A, Rodriguez-Blanco T, Pons-Vigués M, Pujol-Ribera E, et al. Burden of multimorbidity, socioeconomic status and use of health services across stages of life in urban areas: a cross-sectional study. BMC Public Health. 2014;14:530.
Article
PubMed
PubMed Central
Google Scholar
Pefoyo AJ, Bronskill SE, Gruneir A, Calzavara A, Thavorn K, Petrosyan Y, et al. The increasing burden and complexity of multimorbidity. BMC Public Health. 2015;15:415.
Article
PubMed
Google Scholar
Laires PA, Perelman J. The current and projected burden of multimorbidity: a cross-sectional study in a southern Europe population. Eur J Ageing. 2019;16(2):181–92.
Article
CAS
PubMed
Google Scholar
Foundation R. Chronic care: making the case for ongoing care: Robert Wood Johnson Foundation; 2010.
Google Scholar
Britt HC, Harrison CM, Miller GC, Knox SA. Prevalence and patterns of multimorbidity in Australia. Med J Aust. 2008;189(2):72–7.
Article
PubMed
Google Scholar
de Santos Machado V, Valadares AL, Costa-Paiva LH, Osis MJ, Sousa MH, Pinto-Neto AM. Aging, obesity, and multimorbidity in women 50 years or older: a population-based study. Menopause (New York, NY). 2013;20(8):818–24.
Article
Google Scholar
Hu X, Huang J, Lv Y, Li G, Peng X. Status of prevalence study on multimorbidity of chronic disease in China: systematic review. Geriatr Gerontol Int. 2015;15(1):1–10.
Article
PubMed
Google Scholar
Prados-Torres A, Calderón-Larrañaga A, Hancco-Saavedra J, Poblador-Plou B, van den Akker M. Multimorbidity patterns: a systematic review. J Clin Epidemiol. 2014;67(3):254–66.
Article
PubMed
Google Scholar
Wang R, Yan Z, Liang Y, Tan EC, Cai C, Jiang H, et al. Prevalence and patterns of chronic disease pairs and multimorbidity among older Chinese adults living in a rural area. PLoS One. 2015;10(9):e0138521.
Article
PubMed
PubMed Central
Google Scholar
Fabbri E, An Y, Zoli M, et al. Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers. J Gerontol. 2015;70(1):63.
Article
CAS
Google Scholar
Nagel G, Peter R, Braig S, et al. The impact of education on risk factors and the occurrence of multimorbidity in the EPIC-Heidelberg cohort. BMC Public Health. 2008;8:384.
Barnett K, Mercer SW, Norbury M, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380:37–43.
Article
PubMed
Google Scholar
Fabbri E, Zoli M, Gonzalez-Freire M, Salive ME, Studenski SA, Ferrucci L. Aging and multimorbidity: new tasks, priorities, and Frontiers for integrated Gerontological and clinical research. J Am Med Dir Assoc. 2015;16(8):640–7.
Article
PubMed
PubMed Central
Google Scholar
Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011;10(4):430–9.
Article
PubMed
Google Scholar
Wang SB, D'Arcy C, Yu YQ, Li B, Liu YW, Tao YC, et al. Prevalence and patterns of multimorbidity in northeastern China: a cross-sectional study. Public Health. 2015;129(11):1539–46.
Article
CAS
PubMed
Google Scholar
Fortin M, Stewart M, Poitras ME, Almirall J, Maddocks H. A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med. 2012;10(2):142–51.
Article
PubMed
PubMed Central
Google Scholar
Uijen AA, van de Lisdonk EH. Multimorbidity in primary care: prevalence and trend over the last 20 years. Eur J Gen Pract. 2008;14(Suppl 1):28–32.
Article
PubMed
Google Scholar
Schäfer I, Hansen H, Schön G, Höfels S, Altiner A, Dahlhaus A, et al. The influence of age, gender and socio-economic status on multimorbidity patterns in primary care. First results from the multicare cohort study. BMC Health Serv Res. 2012;12:89.
Article
PubMed
PubMed Central
Google Scholar
van Oostrom SH, Picavet HS, van Gelder BM, Lemmens LC, Hoeymans N, van Dijk CE, et al. Multimorbidity and comorbidity in the Dutch population - data from general practices. BMC Public Health. 2012;12:715.
Article
PubMed
PubMed Central
Google Scholar
Agborsangaya CB, Lau D, Lahtinen M, Cooke T, Johnson JA. Multimorbidity prevalence and patterns across socioeconomic determinants: a cross-sectional survey. BMC Public Health. 2012;12:201.
Article
PubMed
PubMed Central
Google Scholar
Booth HP, Prevost AT, Gulliford MC. Impact of body mass index on prevalence of multimorbidity in primary care: cohort study. Fam Pract. 2014;31(1):38–43.
Article
PubMed
Google Scholar
Zhang Y, Zhou L, Liu S, Qiao Y, Wu Y, Ke C, et al. Prevalence, correlates and outcomes of multimorbidity among the middle-aged and elderly: findings from the China health and retirement longitudinal study. Arch Gerontol Geriatr. 2020;90:104135.
Article
PubMed
Google Scholar
Ruel G, Shi Z, Zhen S, Zuo H, Kröger E, Sirois C, et al. Association between nutrition and the evolution of multimorbidity: the importance of fruits and vegetables and whole grain products. Clin Nutr (Edinburgh, Scotland). 2014;33(3):513–20.
Article
CAS
Google Scholar
Nunes BP, Flores TR, Mielke GI, Thumé E, Facchini LA. Multimorbidity and mortality in older adults: a systematic review and meta-analysis. Arch Gerontol Geriatr. 2016;67:130–8.
Article
PubMed
Google Scholar
Rizzuto D, Melis RJF, Angleman S, Qiu C, Marengoni A. Effect of chronic diseases and multimorbidity on survival and functioning in elderly adults. J Am Geriatr Soc. 2017;65(5):1056–60.
Article
PubMed
Google Scholar
Ryan A, Wallace E, O'Hara P, Smith SM. Multimorbidity and functional decline in community-dwelling adults: a systematic review. Health Qual Life Outcomes. 2015;13:168.
Article
PubMed
PubMed Central
Google Scholar