This article has Open Peer Review reports available.
HIV behavioural interventions targeted towards older adults: a systematic review
© Negin et al.; licensee BioMed Central Ltd. 2014
Received: 25 January 2013
Accepted: 20 May 2014
Published: 26 May 2014
The increasing number of people living with HIV aged 50 years and older has been recognised around the world yet non-pharmacologic HIV behavioural and cognitive interventions specifically targeted to older adults are limited. Evidence is needed to guide the response to this affected group.
We conducted a systematic review of the available published literature in MEDLINE, Embase and the Education Resources Information Center. A search strategy was defined with high sensitivity but low specificity to identify behavioural interventions with outcomes in the areas of treatment adherence, HIV testing uptake, increased HIV knowledge and uptake of prevention measures. Data from relevant articles were extracted into excel.
Twelve articles were identified all of which originated from the Americas. Eight of the interventions were conducted among older adults living with HIV and four for HIV-negative older adults. Five studies included control groups. Of the included studies, four focused on general knowledge of HIV, three emphasised mental health and coping, two focused on reduced sexual risk behaviour, two on physical status and one on referral for care. Only four of the studies were randomised controlled trials and seven – including all of the studies among HIV-negative older adults – did not include controls at all. A few of the studies conducted statistical testing on small samples of 16 or 11 older adults making inference based on the results difficult. The most relevant study demonstrated that using telephone-based interventions can reduce risky sexual behaviour among older adults with control reporting 3.24 times (95% CI 1.79-5.85) as many occasions of unprotected sex at follow-up as participants. Overall however, few of the articles are sufficiently rigorous to suggest broad replication or to be considered representative and applicable in other settings.
More evidence is needed on what interventions work among older adults to support prevention, adherence and testing. More methodological rigourised needed in the studies targeting older adults. Specifically, including control groups in all studies is needed as well as sufficient sample size to allow for statistical testing. Addition of specific bio-marker or validated behavioural or cognitive outcomes would also strengthen the studies.
KeywordsOlder adults HIV Interventions Systematic review Effectiveness
HIV prevalence among those aged 50 years of age and older has been rising over the past few years. In the US, in 2005, 25% of those infected with HIV were older than 50 years of age  and recent estimates have noted that around 50% of people living with HIV will be older than 50 by 2015 . The number of adults aged 50 years and older living with HIV in the US grew by 14% a year between 2004 and 2007 . Articles have highlighted the HIV and ageing phenomenon in New York , London , Italy  and Australia . The increase has been seen partly due to widespread treatment access . The ageing trend has been increasingly recognised in sub-Saharan Africa where the majority of HIV infections occur [8–11].
The increasing trend of ageing is not only the result of longer survival due to treatment; older adults accounted for 15% of new cases of HIV in the US in 2005 . Western European data reveals that 12.9% of newly reported cases of HIV infection in 2007 were among peopled aged 50 and older compared to 10.4% in 2003 . The percentage of older adults among new infections in Eastern Europe has doubled over the same time frame .
The term “older adults” is used to describe those aged 50 years and older. It is acknowledged that in many countries, people in this age group would not be considered old or elderly. In Australia for example, most studies on the elderly focus on those aged 65 years and above or even 70 . The reasons the 50 years cut off point is used here is because the majority of HIV surveillance and reporting over the first two decades of the HIV response has only covered those aged 15–49 [15–17] as well as the accelerated ageing of HIV infected adults compared to uninfected adults .
Older adults remain sexually active well into advanced ages and condom use rates among older adults are low [19, 20]. In addition, testing rates among older adults are also lower: fewer than 15% of Americans aged over 45 years have been tested for HIV compared to 44% of all adults  and late presentation for care is also more common . Older adults – particularly older women – are at greater physiological risk for HIV transmission [23, 24]. Those aged 50 and older might also enter into new relationships in which unprotected sex is more likely given the absence of pregnancy concerns .
When examined, HIV knowledge amongst older adults has been variable; while some exhibit adequate knowledge many do not consider themselves to be at risk as HIV is considered an illness of younger people . Surveys of HIV positive older women have suggested that insufficient HIV prevention information contributes to risk taking behaviours . Because of this, there have been many urgent calls for prevention messaging and specific HIV programs targeted to older people [23, 27–30] rather than simply the application of strategies designed for younger people . This call has extended beyond developed countries to a number of countries in Africa [32, 33].
Strengthening the argument for research focussed on HIV positive older adults are the specific problems faced by this cohort . Older HIV positive adults face the additional burden of physical and psychological comorbidities  and accelerated senescence . Concurrently, HIV positive older adults experience the double stigma of illness and ageism while having fewer support mechanisms from family, friends and community .
Given this situation, a number of academics have lamented the paucity of specific studies conducted among older adults with regard to HIV prevention , testing, adherence  and other social and behavioural areas  for older adults with HIV. There are hypotheses of what would help treatment adherence or the effectiveness of prevention education among older adults including nutrition, mental stimulation, physical activity and better training among physicians  but evidence regarding these approaches is patchy and few translated into programmatic use. Orel and colleagues  found that in 2004, 15 US States had HIV-related educational materials that were specifically targeted to older adults yet limited evidence is available on their impact on raising awareness and preventing new infections.
The literature provides reviews of the available evidence on HIV behavioural interventions targeted to a range of other affected groups including sex workers [43, 44], children , men who have sex with men , drug users  and in occupational settings . Based on these reviews and others, there is mixed evidence on what constitutes effective HIV prevention interventions. Peer education interventions have been found to have some positive impact on risk behaviour in some settings  but not others . Routine opt-out testing protocols have demonstrated increased HIV testing uptake in some settings . Internet and text message interventions have shown some positive impact [51, 52].
Yet no compilation of evidence exists for older adults despite the recognised trend of an ageing HIV cohort globally. This paper systematically reviews the available published evidence on non-pharmacologic HIV behavioural interventions specifically targeted to older adults with a specific emphasis on treatment adherence, HIV testing uptake, increased HIV knowledge, reduced risk behaviour as well as social and physical support.
The systematic review adheres to the PRISMA guidelines. Searches were conducted on 6 February 2012 and again on 4 June 2012 in MEDLINE, Embase and the Education Resources Information Center (ERIC). A search strategy was defined with high sensitivity but low specificity. The search strategy consisted of free-text and Medical Subject Headings (MeSH) terms. Search terms for older adults included the following: “elderly”, “older adults”, “aged”, “ageing”, “geriatric”, “mature adults” and “senior citizen”. The terms HIV, AIDS and HIV/AIDS were included. Additional search terms to identify interventions or trials included “intervention”, “trial”, “evaluation”, “intervention studies”, “randomized controlled trials”, “evaluation studies”, “program evaluation” and “prevention”, “testing” and “adherence” to ensure capture of relevant articles. Between each of the three categories of terms, an “AND” term was included so that only articles including information on HIV and older adults and relevant interventions were included in the results. Additionally, references of identified publications and published reviews were hand searched for potential additional relevant articles.
There were no restrictions on language or year of publication or country. We included studies that reported specifically on those aged 50 years and older or that reported age groups in which the majority of respondents were in that age group (i.e. 45+). Studies that included participants aged, for example, 25–52 were excluded if there was no specific sub-group reporting on those aged 50 and older or in which a majority of respondents were aged 50 and older.
Data were then extracted from each relevant study into an excel spreadsheet. Extracted information included year, location of study, brief description, study type, sample size, study population, review of methods, primary outcome measure and focus topic of the study. Major themes were identified in the relevant studies. The study adheres to the PRISMA guidelines for systematic reviews.
After removing duplicates, the search revealed 1229 articles. After a review of titles and then abstracts, ten articles met study criteria. An addition two articles were identified through searching reference lists and were included in the review providing twelve articles in total.
Summary of included articles
Control group (Y/N)
Among HIV-Negative Older Adults
Small 2009 
Individuals aged 50 years and older N = 50
Both quantitative and qualitative data were gathered during each session and included a pre-survey and immediate post-37-item-survey, a focus group, and an HIV educational curriculum.
Four HIV education training sessions each lasting three hours covering the following topics: (a) Introduction and Overview, (b) Identifying Myths and Stereotypes, (c) HIV Facts, and (d) Provision of Resources.
Interest in HIV prevention and education (composite of two questions)
HIV knowledge was not significantly (p = .273) higher in the posttest (mean = 10.92) than in the pretest (mean = 10.32)
Substantive knowledge about HIV and AIDS remained low among respondents, and there was no significant change in knowledge after the administration of the modified curriculum
Purposive sampling USA
Substantive HIV knowledge (composite of 15 questions)
Orel et al. 2010 
11 participants of 89 aged 60 and older completed both questionnaires N = 11 USA
Before and after questionnaires
“No One is Immune Project” –six-hour education and prevention workshop held at senior centre. Post-test questionnaire administered immediately after workshop.
45-item HIV/AIDS Knowledge Questionnaire
Increase in % answering correct
Workshop increased knowledge of HIV among older adults
● HIV can be spread by mosquitoes (48 to 98)
● you cannot get HIV when getting a tattoo (25 to 78)
● women are always tested for HIV during their pap smears (12 to 100)
● No data provided on overall changes in scores
Altschuler et al. 2004 
Adults aged 50 years and older USA N = 40
Verbal feedback after educational program
3 hour educational program. Curriculum includes overview, myths and stereotypes, facts and resources.
Group feedback on HIV awareness, HIV perceptions and ability to speak to health care providers
Participants identified learning that HIV was relevant to their lives; feeling empowered to speak up to their health care providers; positive impression being able to discuss a taboo topic.
Qualitative results suggest that education program can help individuals discuss HIV with partners.
Rose 1996 
Individuals aged >60 recruited at senior citizen meal sites USA
Pre and post-test cross-sectional survey
20-30 minute age-specific AIDS education program delivered at meal site and educational pamphlet. Consisted of statistics and facts about HIV, prevention measures and case studies of elderly people with HIV. Post-test administered immediately following education program.
Questionnaire measured HIV knowledge and perceptions of susceptibility to HIV (Likert scales)
Significant increase in total knowledge about AIDS (p < 0.001), perceived susceptibility (p < 0.01) and perceived severity (p < 0.001)
Age specific education program significantly increased HIV-related knowledge at senior citizen meal sites
Pre-intervention N = 458
Post-intervention N = 318
Among HIV-Positive Older Adults
Lovejoy et al. 2011 
HIV-infected adults 45-plus years old who reported engaging in at least one occasion of unprotected sex in the 3 months prior to enrolment N = 100 USA
Randomised controlled trial
Telephone delivered motivational interviewing (MI) (client-focused and directive form of counselling) to reduce risky sexual behaviour
Yes (N = 23)
Episodes of unprotected sex in past 3 months
Participants in the 4-session MI arm engaged in the fewest occasions of unprotected sex at 3 and 6 month follow-up. Controls had on average 3.24 times as many occasions of unprotected sex (95% CI 1.79-5.85). Furthermore, 1-session MI participants had four times as many unprotected sex acts as 4-session MI participants at 3-month (OR = 3.98 [2.38–6.67]) and 6-month (OR = 4.39 [2.56–7.46]) follow-up.
Four sessions of telephone-delivered MI reduces sexual risk behaviour among HIV-positive older adults
3 arms – 4-sessions (N = 39), 1 session (N = 38) or nothing/control (N = 23).
Ruiz and Kamerman 2010 
Referral for care
HIV-positive patients aged >60 years N = 57 USA
Functional screening for detection of comorbidities and referral for further care if failed in 3 or more domains
Referrals for comorbid conditions
17 patients were referred due to problems in multiple domains including cognitive dysfunction (10), problems in daily living (8), nutritional issues (6), depression (5), and mobility (5)
Screening for comorbidities among HIV-positive older adults can facilitate referral for further care likely to improve quality of care and outcomes
Illa et al. 2010 
HIV-positive, 45 or older, sexually active in last 12 months
Randomised controlled trial
Project ROADMAP (re-educating older adult in maintaining AIDS prevention).
Sexual risk (number of partners, partner HIV status, sexual acts, condom use)
Inconsistent condom use with partners of negative or unknown serostatus reduced from 9% at baseline to 1.3% at 6 month follow-up among intervention group (p = .003); reduced from 4% to 3% with control group (p = .999)
Group psycho-educational sessions reduced unprotected sexual acts with partners of unknown or negative serostatus
Intervention group: educational brochure and four psycho-educational group sessions designed for HIV-positive older adults. Sessions focused on information, motivation, behavioural skills and risk reduction behaviours. Control: educational brochure only.
N = 241 (149 intervention group and 92 in control group) USA
HIV knowledge (33 item measure) Sexual self-efficacy
Heckman et al. 2001 
HIV-positive individuals aged 50 years and older attending AIDS service organizations
Pilot pre- and post-test cohort study
Coping improvement group intervention
Severity of HIV-related Life Problem Scale
Increased social wellbeing (2.20 to 2.41, p < 0.05)
Group sessions focusing on coping strategies had limited impact on coping and stress but increased social wellbeing among HIV-positive older adults
Ways of coping Questionnaire Functional assessment of HIV Infection Scale
Marginal non-significant change in coping (p < 0.10)
Marginal non-significant decrease in stress associated with AIDS-related loss and health concerns (p <0.10)
Provision of Social relations
Marginal non-significant increase in support from friends (p < 0.10)
Heckman et al. 2006 
HIV-positive individuals aged 50 years and older recruited from AIDS service organizations with diagnosis of depression or dysthymia N = 90 USA
Randomised controlled trial with delayed treatment control Embedded cohort study Assessed pre, post (within 1 week of completion) and at3 months
12, 90 minute sessions, telephone delivered weekly coping improvement group intervention to reduce psychological distress 1) Immediate treatment (n = 44) 2) Delayed treatment (control) (n = 46)
Yes, delayed treatment, control group
Geriatric depression scale (GDS) Symptom checklist 90-revised (SCL-90-R)
Intervention group reported fewer psychological symptoms (p = 0.05), less life stressor burden (p = 0.058), less use of avoidant coping strategies (p = 0.05) and marginally higher levels of coping self-efficacy (p = 0.10) compared to controls with no effect on depressive symptoms, loneliness or use of engagement coping Within cohorts IG: significant decrease in depressive symptoms (p < 0.003) psychological symptoms (p < 0.001), life-stressor burden (p < 0.03) and avoidance coping (p < 0.04) at 3 months Delayed group: significant decrease in psychological symptoms (p < 0.03), life stressor burdens (p < 0.001), loneliness (p < 0.03) and greater coping self-efficacy (p < 0.04) following intervention
Telephone delivered coping group sessions among HIV-positive people with depression were effective in reducing psychological symptoms and stress
HIV-related life-stressor burden scale UCLA Loneliness Scale (10-item)
The Ways of Coping Checklist (WOCC)
Coping self-efficacy Scale
Heckman et al. 2011 
HIV-positive individuals aged 50 years or older with Beck Depression Inventory-II score 10 or more and Modified mini-mental state examination score of 75 or greater. N = 295 USA
Randomised controlled trial 3 arms
1) 12 90 minute sessions face-to-face coping improvement (FFCI) group intervention (n = 104)
Geriatric Depression Screening Scale
Both FFCI and IPSG participants reported fewer depressive symptoms than controls post-intervention, 4- and 8-month follow-up. This effect was not always statistically significant (p’s < 0.01-0.1). IPSG reported fewer depressive symptoms compared to control.
An age-appropriate coping improvement group intervention was effective in reducing depressive symptoms in HIV + older adults. The effect was more pronounced amongst subjects suffering greater levels of depressive symptoms.
Completed using audio-computer assisted self interviews (A-CASI)
2) 12 session interpersonal support group (IPSG) intervention (n = 105)
3) Individual therapy upon request (ITUR) control (n = 86). Subjects had access to standard psychosocial services available in the community.
Effect size greater for subset of participants with mild, mod and severe depression at baseline
Souza et al. 2008 
Subjects HIV+, older than 60 (Mean 65.6+/- 2.9), sedentary at baseline. 3 subsequently excluded due to >3/12 absence from training program N = 11.
Prospective Case series study
1 year resistance training program 4 exercises targeting major muscle groups 3 sets 8-12 reps at light, mod and heavy resistance respectively 2 sessions/week, one year
Anthropometric indices: Body mass, circumferences and skin folds Body composition (DEXA) Strength and functional tests: Sub-maximum weight lifted Two functional tests performed every 4 months assessing walking speed, and sit-to-stand performance.
No significant change in weight Strength improvements of between
Following one year of progressive resistance training HIV positive older adults showed significant improvements in strength and functional capacity, no changes in body composition and improved immunological indices.
74-97% (p’s = 0.003-0.021)
Functional tests: decreased times for sit-stand (2.00 to 1.57 s, p = 0.003) and walking 2.4 m (9.25 to 6.58 s, p = 0.003)
All subjects medical able to complete training and not using cortico- or anabolic steroids Brazil
Souza et al. 2011 
Subjects HIV+, age > = 60 (M = 64.4 +/- 3.0) Ave. 9 year history of HIV, recruited at Hospital in Sao Paulo, Brazil N = 11 with 21 controls All subjects medically able to complete training and not using cortico- or anabolic steroids
Progressive resistance exercise 2 sessions per week for 1 year.
Yes, age, activity and gender matched HIV–controls (N = 21)
Strength and functional tests: Sub-maximum load monitored bi-monthly Functional test of walk and sit-stand speeds. Anthropometric and metabolic indices: Weight; BMI Lipid and glycaemic profiles (values registered in clinical record immediately before and after training program)
Although weaker at baseline, HIV + subjects increased weight lifted from 1.52 to 2.33 times baseline, a significantly greater improvement than controls (1.21-1.48, p < 0.01) HIV + lighter, significantly lower BMI (p = 0.007 pre and p = 0.004 post) Faster at walking tests (significant, p = 0.036 pre-, not significant post-training). HIV + significantly faster at sit-to-stand after training than controls (p = 0.005) Fasting BSL significantly improved in both groups (p’s = 0.027-0.037).
Progressive resistance exercise training produced increased strength and functional gains in older adults living with HIV, with gains superior to those seen in age-matched HIV- controls. An effect was also seen on metabolic indices.
Five exercises utilised major muscle groups
3 sets 12/10/8 repetitions at sub-maximum load
Of the included studies, none were focused on improving treatment adherence and none had increased HIV testing uptake as an outcome measure. The four articles conducted among HIV-negative participants aimed to improve general HIV knowledge to facilitate HIV prevention. Within the studies among HIV-positive participants, the main outcome measure of Lovejoy and colleagues  and Illa and colleagues  articles was reduced sexual risk behavior. The three Heckman et al. articles [35, 37, 55] focused on mental health and coping assessments while the two Souza et al. papers [36, 56] emphasized physical status and strength. Improved referral for care was the outcome measure of the last relevant article .
The included studies do highlight areas for action in developing prevention and adherence interventions specifically for older adults. With respect to improving knowledge, Rose demonstrated that delivery of an age-specific AIDS education program was effective in improving HIV knowledge (p < 0.001) and perceptions of susceptibility (p < 0.01) among older HIV-negative Americans compared to a control group not receiving the education program . While Orel and colleagues  and Altschuler and colleagues  both showed that education sessions improved HIV-related knowledge among older adults, Small’s workshop did not have a significant impact .
Other interventions targeted HIV-infected older adults to reduce risk behaviour. The ROADMAP (Reeducating Older Adult in Maintaining AIDS Prevention) project ran group educational sessions to reduce high-risk sexual behaviours . After sessions that included practicing condom use skills and role playing condom negotiation, participants in the intervention group (N = 149) reported reduced inconsistent condom use (9% at baseline to 1% at 6 month follow-up; p = 0.003) compared with the control group (N = 92) (4% at baseline to 3% at follow-up; p = .0999). Another study used telephone-based interventions to reduce risky sexual behaviour with controls reporting on average 3.24 times (95% CI 1.79-5.85) as many occasions of unprotected sex at follow-up .
Supporting older adults to cope with HIV infection was the focus of three papers [35, 37, 55]. Heckman and colleagues reported that group sessions with trained facilitators that included a focus on coping mechanisms and how to deal with stress are effective in reducing depressive symptoms in HIV-positive older adults (p values ranging from 0.01 to 0.1 for variety of measures; see Table 1) .
Weekly resistance exercise training sessions trialed in Sao Paulo, Brazil [36, 56], among HIV-positive older adults, produced increased strength and functional gains superior to those seen in age-matched HIV-negative controls. Those receiving the intervention (N = 11) increased weight lifted compared to controls (N = 21) (p < 0.01) and were faster at sit-to-stand after training (p = 0.005) .
Discussion and conclusion
This systematic review of behavioural HIV interventions specifically targeted to older adults reveals the absolute paucity of published literature on this topic despite the increases in the number of people living with HIV aged 50 years and older and the increasing prevalence in this group globally. Though there have been many calls for more evidence that specifically address the vulnerabilities and characteristics of older adults, only twelve articles were found that included some evaluation of an intervention for this population. Limited conclusions can be drawn due to the small sample of relevant studies. The diversity of behavioural and cognitive interventions applied in the studies limits the ability to generalise from the results available; a number of interventions focused on knowledge building, others on sexual behaviour and others on coping.
Only four of the studies were randomised controlled trials and seven – including all of the studies among HIV-negative older adults – did not include controls at all. A few of the studies conducted statistical testing on small samples of 16 or 11 older adults making inference based on the results difficult. A number of the studies – especially those among HIV-negative individuals focused on general HIV awareness and interest as opposed to behaviour change. More methodological rigour is needed in the studies targeting older adults. Specifically, including control groups in all studies is needed as well as sufficient sample size to allow for statistical testing. Addition of specific bio-marker or validated behavioural or cognitive outcomes would also strengthen the studies.
The majority of articles identified from the searches and ultimately excluded from this review describe behaviours of older adults rather than evaluating an intervention . For example, there were articles that described specific intervention projects targeted to older adults – for example the Florida Senior HIV Intervention Project – but which did not provide any evidence of success or evaluation of the program . Other papers did not report on those aged 50 and older. For example, one paper provided data for the age group 30–59 but was not included in the review because it did not report on older adults specifically .
Despite the limited number of papers providing evidence on this topic, some lessons do emerge from the review. Due to concerns over stigma and the perception of being low risk, researchers have suggested approaches for older adults through the lens of sexuality and sexual health rather than HIV directly . Providing information on, for example, the impact of medications on sexuality may provide an appropriate time to discuss safe sex and HIV.
Though there is an erroneous ageist assumption that older people are not able to make behaviour changes , a number of ideas were expressed as possible avenues to reach older adults with HIV services including using older adults as peer educators  and providing training in sexuality counselling to social workers working with this age group . Others advocate for the increased use of internet and mobile phone based HIV programs to reach the elderly who might be uncomfortable discussing HIV in more public settings . A number of authors called for more education of physicians on the topic to ensure that HIV counselling and also testing are carried out among older adults [65, 66].
This systematic review has a number of limitations. The review focused specifically on interventions reporting outcomes among older adults and therefore might have missed interventions designed for adults of all ages that are effective among older adults. The review only included published papers documenting interventions that had been evaluated thus eliminating a large set of publications that only describe interventions. The review is also subject to publication bias and selective reporting as is common in systematic reviews.
The review only searched for studies specifically on HIV. There are a number of other studies on medication adherence generally among older adults [67–69] or on sexual health interventions that might be relevant to HIV that were not included here.
Given the trends within the HIV community, much more rigorous evidence is needed on how best to provide services for those aged 50 years and older. A number of interventions were mentioned in articles, but without evidence of impact, suggesting that there are opportunities for evaluations to add to the base of knowledge in this area . Some particular understudied challenges for older adults include: 1) through which channels is it best to reach older adults; 2) what types of messaging are most appropriate for this population; and 3) what content resonates with older adults. Interventions might be targeted to older adults themselves or to health professionals and other providers of services to older adults. Specific evaluated interventions are needed in the areas of testing, supporting adherence, reducing risky sexual behaviours are all areas where the evidence base is currently insufficient. More operational research is needed to scrutinise the “how” of service delivery for older adults  and how to provide it at scale. The other major research challenge will be building an evidence base for older adults living in low and middle income countries where very little currently exists. The American studies are likely not to be applicable to other parts of the world and therefore new research will be critical as the HIV cohort in Africa and Asia ages into the future.
JN was partially supported by an Australian National Health and Medical Research Council Capacity Building Grant. AM was funded by a Fellowship from the University of Sydney, Australia.
- Gebo KA: HIV infection in older people. BMJ. 2009, 338: b1460-10.1136/bmj.b1460.View ArticlePubMedGoogle Scholar
- Effros RB, Fletcher CV, Gebo K, Halter JB, Hazzard WR, Horne FM, Huebner RE, Janoff EN, Justice AC, Kuritzkes D, Nayfield SG, Plaeger SF, Schmader KE, Ashworth JR, Campanelli C, Clayton CP, Rada B, Woolard NF, High KP: Aging and infectious diseases: workshop on HIV infection and aging: what is a known and future research direction. Clin Infect Dis. 2008, 47 (4): 542-553. 10.1086/590150.View ArticlePubMedPubMed CentralGoogle Scholar
- Justice AC: HIV and aging: time for a new paradigm. Curr HIV/AIDS Rep. 2010, 7 (2): 69-76. 10.1007/s11904-010-0041-9.View ArticlePubMedGoogle Scholar
- Shippy RA, Karpiak SE: The aging HIV/AIDS population: fragile social networks. Aging Ment Health. 2005, 9 (3): 246-254. 10.1080/13607860412331336850.View ArticlePubMedGoogle Scholar
- Elford J, Ibrahim F, Bukutu C, Anderson J: Over fifty and living with HIV in London. Sex Transm Infect. 2008, 84 (6): 468-472. 10.1136/sti.2008.031187.View ArticlePubMedGoogle Scholar
- Orchi N, Balzano R, Scognamiglio P, Navarra A, De Carli G, Elia P, Grisetti S, Sampaolesi A, Giuliani M, De Filippis A, Puro V, Ippolito G, Girardi E, SENDIH group: Ageing with HIV: newly diagnosed older adults in Italy. AIDS Care. 2008, 20 (4): 419-425. 10.1080/09540120701867073.View ArticlePubMedGoogle Scholar
- Pitts M, Grierson J, Misson S: Growing older with HIV: a study of health, social and economic circumstances for people Living with HIV in Australia over the age of 50 years. AIDS Patient Care STDS. 2005, 19 (7): 460-465. 10.1089/apc.2005.19.460.View ArticlePubMedGoogle Scholar
- Negin J, Cumming RG: HIV infection in older adults in sub-Saharan Africa: extrapolating prevalence from existing data. Bull World Health Organ. 2010, 88 (11): 847-853. 10.2471/BLT.10.076349.View ArticlePubMedPubMed CentralGoogle Scholar
- Hontelez JA, Lurie MN, Newell ML, Bakker R, Tanser F, Barnighausen T, Baltussen R, de Vlas SJ: Ageing with HIV in South Africa. AIDS. 2011, 25 (13): 1665-1667. 10.1097/QAD.0b013e32834982ea.View ArticlePubMedGoogle Scholar
- Mills EJ, Barnighausen T, Negin J: HIV and aging–preparing for the challenges ahead. N Engl J Med. 2012, 366 (14): 1270-1273. 10.1056/NEJMp1113643.View ArticlePubMedGoogle Scholar
- Shisana O, Human Sciences Research Council: South African National HIV Prevalence, Incidence, Behaviour and Communication Survey, 2008: A Turning Tide Among Teenagers. 2009, Cape Town: HSRC PressGoogle Scholar
- Simone MJ, Appelbaum J: HIV in older adults. Geriatrics. 2008, 63 (12): 6-12.PubMedGoogle Scholar
- Lazarus JV, Nielsen KK: HIV and people over 50 years old in Europe. HIV Med. 2010, 11 (7): 479-481.PubMedGoogle Scholar
- Cumming RG, Handelsman D, Seibel MJ, Creasey H, Sambrook P, Waite L, Naganathan V, Le Couteur D, Litchfield M: Cohort Profile: the Concord Health and Ageing in Men Project (CHAMP). Int J Epidemiol. 2009, 38 (2): 374-378. 10.1093/ije/dyn071.View ArticlePubMedGoogle Scholar
- UNAIDS: AIDS at 30: nations at the crossroads. 2011, Geneva: Joint United Nations Programme on HIV/AIDSGoogle Scholar
- UNAIDS: Monitoring the Declaration of Commitment on HIV/AIDS: guidelines on construction of core indicators: 2010 reporting. 2009, Geneva, Switzerland: UNAIDSGoogle Scholar
- Demographic and Health Surveys. [http://www.measuredhs.com/]
- Work Group for the HIV and Aging Consensus Project: Summary report from the Human Immunodeficiency Virus and Aging Consensus Project: treatment strategies for clinicians managing older individuals with the human immunodeficiency virus. J Am Geriatr Soc. 2012, 60 (5): 974-979.View ArticleGoogle Scholar
- Lindau ST, Schumm LP, Laumann EO, Levinson W, O’Muircheartaigh CA, Waite LJ: A study of sexuality and health among older adults in the United States. N Engl J Med. 2007, 357 (8): 762-774. 10.1056/NEJMoa067423.View ArticlePubMedPubMed CentralGoogle Scholar
- Schick V, Herbenick D, Reece M, Sanders SA, Dodge B, Middlestadt SE, Fortenberry JD: Sexual behaviors, condom use, and sexual health of Americans over 50: implications for sexual health promotion for older adults. J Sex Med. 2010, 7 (Suppl 5): 315-329.View ArticlePubMedGoogle Scholar
- Akers AY, Bernstein L, Doyle J, Corbie-Smith G: Older women and HIV testing: examining the relationship between HIV testing history, age, and lifetime HIV risk behaviors. Sex Transm Dis. 2008, 35 (4): 420-423. 10.1097/OLQ.0b013e3181644b39.View ArticlePubMedGoogle Scholar
- Iwuji CC, Churchill D, Gilleece Y, Weiss HA, Fisher M: Older HIV-infected individuals present late and have a higher mortality: Brighton, UK cohort study. BMC Public Health. 2013, 13: 397-10.1186/1471-2458-13-397.View ArticlePubMedPubMed CentralGoogle Scholar
- Orel NA, Spence M, Steele J: Getting the message out to older adults: Effective HIV health education risk reduction publications. J Appl Gerontol. 2005, 24 (5): 490-508. 10.1177/0733464805279155.View ArticleGoogle Scholar
- Drew O, Sherrard J: Sexually transmitted infections in the older woman. Menopause Int. 2008, 14 (3): 134-135.PubMedGoogle Scholar
- Rose MA: Effect of an AIDS education program for older adults. J Community Health Nurs. 1996, 13 (3): 141-148. 10.1207/s15327655jchn1303_1.View ArticlePubMedGoogle Scholar
- Neundorfer MM, Harris PB, Britton PJ, Lynch DA: HIV-risk factors for midlife and older women. Gerontologist. 2005, 45 (5): 617-10.1093/geront/45.5.617.View ArticlePubMedGoogle Scholar
- Bhavan KP, Kampalath VN, Overton ET: The aging of the HIV epidemic. Curr HIV/AIDS Rep. 2008, 5 (3): 150-158. 10.1007/s11904-008-0023-3.View ArticlePubMedGoogle Scholar
- Lovejoy TI, Heckman TG, Sikkema KJ, Hansen NB, Kochman A, Suhr JA, Garske JP, Johnson CJ: Patterns and correlates of sexual activity and condom use behavior in persons 50-plus years of age living with HIV/AIDS. AIDS Behav. 2008, 12 (6): 943-956. 10.1007/s10461-008-9384-2.View ArticlePubMedPubMed CentralGoogle Scholar
- Winningham A, Corwin S, Moore C, Richter D, Sargent R, Gore-Felton C: The changing age of HIV: sexual risk among older African American women living in rural communities. Prev Med. 2004, 39 (4): 809-814. 10.1016/j.ypmed.2004.03.005.View ArticlePubMedGoogle Scholar
- Strombeck R, Levy JA: Educational strategies and interventions targeting adults age 50 and older for HIV/AIDS prevention. Res Aging. 1998, 20 (6): 912-936. 10.1177/0164027598206014.View ArticleGoogle Scholar
- UNAIDS: HIV and Aging: A Special Supplement to the UNAIDS Report on the global AIDS Epidemic. 2013, Geneva, Switzerland: UNAIDSGoogle Scholar
- Philip-Ephraim EE, Gyuse AN, Udonwa NE, Peters EJ, Anyanechi CC: Knowledge and perception of HIV prevention through condom use among midlife and older adults in Calabar, Nigeria. West Indian Med J. 2010, 59 (4): 429-433.PubMedGoogle Scholar
- Negin J, Nemser B, Cumming R, Lelerai E, Ben Amor Y, Pronyk P: HIV attitudes, awareness and testing among older adults in Africa. AIDS Behav. 2012, 16 (1): 63-68. 10.1007/s10461-011-9994-y.View ArticlePubMedGoogle Scholar
- Sankar A, Nevedal A, Neufeld S, Berry R, Luborsky M: What do we know about older adults and HIV? A review of social and behavioral literature. AIDS Care. 2011, 23 (10): 1187-1207. 10.1080/09540121.2011.564115.View ArticlePubMedPubMed CentralGoogle Scholar
- Heckman TG, Sikkema KJ, Hansen N, Kochman A, Heh V, Neufeld S, Aids: A randomized clinical trial of a coping improvement group intervention for HIV-infected older adults. J Behav Med. 2011, 34 (2): 102-111. 10.1007/s10865-010-9292-6.View ArticlePubMedGoogle Scholar
- Souza PM, Jacob-Filho W, Santarem JM, Zomignan AA, Burattini MN: Effect of progressive resistance exercise on strength evolution of elderly patients living with HIV compared to healthy controls. Clinics (Sao Paulo). 2011, 66 (2): 261-266. 10.1590/S1807-59322011000200014.View ArticleGoogle Scholar
- Heckman TG, Kochman A, Sikkema KJ, Kalichman SC, Masten J, Bergholte J, Catz S: A pilot coping improvement intervention for late middle-aged and older adults living with HIV/AIDS in the USA. AIDS Care. 2001, 13 (1): 129-139. 10.1080/09540120020018233.View ArticlePubMedGoogle Scholar
- Mack KA, Bland SD: HIV testing behaviors and attitudes regarding HIV/AIDS of adults aged 50–64. Gerontologist. 1999, 39 (6): 687-694. 10.1093/geront/39.6.687.View ArticlePubMedGoogle Scholar
- Wutoh AK, Elekwachi O, Clarke-Tasker V, Daftary M, Powell NJ, Campusano G: Assessment and predictors of antiretroviral adherence in older HIV-infected patients. J Acquir Immune Defic Syndr. 2003, 33 (Suppl 2): S106-114.View ArticlePubMedGoogle Scholar
- Williams E, Donnelly J: Older Americans and AIDS: some guidelines for prevention. Soc Work. 2002, 47 (2): 105-111. 10.1093/sw/47.2.105.View ArticlePubMedGoogle Scholar
- Vance DE, Burrage JW: Promoting successful cognitive aging in adults with HIV: strategies for intervention. J Gerontol Nurs. 2006, 32 (11): 34-41.PubMedGoogle Scholar
- Orel NA, Wright JM, Wagner J: Scarcity of HIV/AIDS risk-reduction materials targeting the needs of older adults among state departments of public health. Gerontologist. 2004, 44 (5): 693-696. 10.1093/geront/44.5.693.View ArticlePubMedGoogle Scholar
- Wariki WM, Ota E, Mori R, Koyanagi A, Hori N, Shibuya K: Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in low- and middle-income countries. Cochrane Database Syst Rev. 2012, 2: CD005272-PubMedGoogle Scholar
- Ota E, Wariki WM, Mori R, Hori N, Shibuya K: Behavioral interventions to reduce the transmission of HIV infection among sex workers and their clients in high-income countries. Cochrane Database Syst Rev. 2011, 12: CD006045-PubMedGoogle Scholar
- Bain-Brickley D, Butler LM, Kennedy GE, Rutherford GW: Interventions to improve adherence to antiretroviral therapy in children with HIV infection. Cochrane Database Syst Rev. 2011, 12: CD009513-PubMedGoogle Scholar
- Wei C, Herrick A, Raymond HF, Anglemyer A, Gerbase A, Noar SM: Social marketing interventions to increase HIV/STI testing uptake among men who have sex with men and male-to-female transgender women. Cochrane Database Syst Rev. 2011, 9: CD009337-PubMedGoogle Scholar
- Meader N, Li R, Des Jarlais DC, Pilling S: Psychosocial interventions for reducing injection and sexual risk behaviour for preventing HIV in drug users. Cochrane Database Syst Rev. 2010, 1: CD007192-PubMedGoogle Scholar
- Ojo O, Verbeek JH, Rasanen K, Heikkinen J, Isotalo LK, Mngoma N, Ruotsalainen E: Interventions to reduce risky sexual behaviour for preventing HIV infection in workers in occupational settings. Cochrane Database Syst Rev. 2011, 12: CD005274-PubMedGoogle Scholar
- Simoni JM, Nelson KM, Franks JC, Yard SS, Lehavot K: Are peer interventions for HIV efficacious? A systematic review. AIDS Behav. 2011, 15 (8): 1589-1595. 10.1007/s10461-011-9963-5.View ArticlePubMedPubMed CentralGoogle Scholar
- Creek TL, Ntumy R, Seipone K, Smith M, Mogodi M, Smit M, Legwaila K, Molokwane I, Tebele G, Mazhani L, Shaffer N, Kilmarx PH: Successful introduction of routine opt-out HIV testing in antenatal care in Botswana. J Acquir Immune Defic Syndr. 2007, 45 (1): 102-107. 10.1097/QAI.0b013e318047df88.View ArticlePubMedGoogle Scholar
- Kang M, Skinner R, Usherwood T: Interventions for young people in Australia to reduce HIV and sexually transmissible infections: a systematic review. Sex Health. 2010, 7 (2): 107-128. 10.1071/SH09079.View ArticlePubMedGoogle Scholar
- Noar SM, Black HG, Pierce LB: Efficacy of computer technology-based HIV prevention interventions: a meta-analysis. AIDS. 2009, 23 (1): 107-115. 10.1097/QAD.0b013e32831c5500.View ArticlePubMedGoogle Scholar
- Lovejoy TI, Heckman TG, Suhr JA, Anderson T, Heckman BD, France CR: Telephone-administered motivational interviewing reduces risky sexual behavior in HIV-positive late middle-age and older adults: a pilot randomized controlled trial. AIDS Behav. 2011, 15 (8): 1623-1634. 10.1007/s10461-011-0016-x.View ArticlePubMedGoogle Scholar
- Illa L, Echenique M, Saint Jean G, Bustamante-Avellaneda V, Metsch L, Mendez-Mulet L, Eisdorfer C, Sanchez-Martinez M: Project roadmap: reeducating older adults in maintaining AIDS prevention–a secondary intervention for older HIV-positive adults. AIDS Educ Prev. 2010, 22 (2): 138-147. 10.1521/aeap.2010.22.2.138.View ArticlePubMedGoogle Scholar
- Heckman TG, Barcikowski R, Ogles B, Suhr J, Carlson B, Holroyd K, Garske J: A telephone-delivered coping improvement group intervention for middle-aged and older adults living with HIV/AIDS. Ann Behav Med. 2006, 32 (1): 27-38. 10.1207/s15324796abm3201_4.View ArticlePubMedGoogle Scholar
- Souza PM, Jacob-Filho W, Santarem JM, Silva AR, Li HY, Burattini MN: Progressive resistance training in elderly HIV-positive patients: does it work?. Clinics (Sao Paulo). 2008, 63 (5): 619-624. 10.1590/S1807-59322008000500009.View ArticleGoogle Scholar
- Ruiz M, Kamerman LA: Nutritional screening tools for HIV-infected patients: implications for elderly patients. J Int Assoc Physicians AIDS Care (Chic). 2010, 9 (6): 362-367. 10.1177/1545109710384504.View ArticleGoogle Scholar
- Orel NA, Stelle C, Watson WK, Bunner BL: No one is immune: a community education partnership addressing HIV/AIDS and older adults. J Appl Gerontol. 2010, 29 (3): 352-370. 10.1177/0733464809337412.View ArticlePubMedGoogle Scholar
- Altschuler J, Katz AD, Tynan M: Developing and implementing an HIV/AIDS educational curriculum for older adults. Gerontologist. 2004, 44 (1): 121-126. 10.1093/geront/44.1.121.View ArticlePubMedGoogle Scholar
- Small LF: What older adults know about HIV/AIDS: lessons from an HIV/AIDS education program. Educ Gerontol. 2009, 36 (1): 26-45. 10.1080/03601270903058317.View ArticleGoogle Scholar
- Agate LL, Mullins JM, Prudent ES, Liberti TM: Strategies for reaching retirement communities and aging social networks: HIV/AIDS prevention activities among seniors in South Florida. J Acquir Immune Defic Syndr. 2003, 33 (Suppl 2): S238-242.View ArticlePubMedGoogle Scholar
- Wawer MJ, Sewankambo NK, Serwadda D, Quinn TC, Paxton LA, Kiwanuka N, Wabwire-Mangen F, Li C, Lutalo T, Nalugoda F, Gaydos CA, Moulton LH, Meehan MO, Ahmed S, Gray RH: Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial. Rakai Project Study Group. Lancet. 1999, 353 (9152): 525-535. 10.1016/S0140-6736(98)06439-3.View ArticlePubMedGoogle Scholar
- Coon DW, Lipman PD, Ory MG: Designing effective HIV/AIDS social and behavioral interventions for the population of those age 50 and older. J Acquir Immune Defic Syndr. 2003, 33 (Suppl 2): S194-205.View ArticlePubMedGoogle Scholar
- Ybarra ML, Bull SS: Current trends in Internet- and cell phone-based HIV prevention and intervention programs. Curr HIV/AIDS Rep. 2007, 4 (4): 201-207. 10.1007/s11904-007-0029-2.View ArticlePubMedGoogle Scholar
- Chiao EY, Ries KM, Sande MA: AIDS and the elderly. Clin Infect Dis. 1999, 28 (4): 740-745. 10.1086/515219.View ArticlePubMedGoogle Scholar
- Skiest DJ, Keiser P: Human immunodeficiency virus infection in patients older than 50 years: A survey of primary care physicians’ beliefs, practices, and knowledge. Arch Fam Med. 1997, 6 (3): 289-294. 10.1001/archfami.6.3.289.View ArticlePubMedGoogle Scholar
- Morrell RW, Park DC, Kidder DP, Martin M: Adherence to antihypertensive medications across the life span. Gerontologist. 1997, 37 (5): 609-619. 10.1093/geront/37.5.609.View ArticlePubMedGoogle Scholar
- McDonald-Miszczak L, Maki SA, Gould ON: Self-reported medication adherence and health status in late adulthood: the role of beliefs. Exp Aging Res. 2000, 26 (3): 189-207. 10.1080/036107300404859.View ArticlePubMedGoogle Scholar
- Barat I, Andreasen F, Damsgaard EM: Drug therapy in the elderly: what doctors believe and patients actually do. Br J Clin Pharmacol. 2001, 51 (6): 615-622. 10.1046/j.0306-5251.2001.01401.x.View ArticlePubMedPubMed CentralGoogle Scholar
- Herbst JH, Glassman M, Carey JW, Painter TM, Gelaude DJ, Fasula AM, Raiford JL, Freeman AE, Harshbarger C, Viall AH, Purcell DW: Operational research to improve HIV prevention in the United States. J Acquir Immune Defic Syndr. 2012, 59 (5): 530-536. 10.1097/QAI.0b013e3182479077.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/14/507/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.