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Successful aging defined by health-related quality of life and its determinants in community-dwelling elders
© Li et al.; licensee BioMed Central Ltd. 2014
Received: 8 August 2013
Accepted: 18 September 2014
Published: 28 September 2014
Successful aging in old age is important. However, the determinants of successful aging vary across populations due to cultural differences, and only a limited number of studies have addressed these determinants in Taiwan population. This study aimed to evaluate successful aging via better physical and mental functions as well as to explore associated determinants in an elderly Taiwan population that had no impaired cognitive function.
A community-based cross-sectional survey was conducted in January 2009 in Taichung, Taiwan. A total of 903 elderly persons (≥65 years) without impaired cognitive function were enrolled. Those with physical and mental component scores in the top tertile of the Short-Form 36 were considered to be aging successfully. All participants completed a structured questionnaire and the comprehensive geriatric assessment measurements of the five components of frailty defined by Fried et al. Crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the relationship between associated factors and successful aging using logistic regression analysis.
The prevalence of successful aging was 10.4% in elders. A higher proportion of successful aging was found in non-frail (16.9%) and pre-frail elders (7.2%) than in frail elders (0.9%). Multivariate logistic regression showed pre-frail elders to be associated with lower prevalence of successful aging relative to non-frail elders (OR: 0.45; 95% CI: 0.24–0.84). Relative to those aged ≤70 years, elders aged 71–75 years were associated with a lower prevalence of successful aging (OR: 0.27; 95% CI: 0.13–0.58). Successful aging was also more likely among those able to visit relatives and friends (OR: 3.86, 95% CI: 1.09–13.61) and among those without a history of falling (OR: 4.95; 95% CI: 1.79–13.74), pain (OR: 4.04; 95% CI: 2.18–7.50), or sleep disorders (OR: 2.36; 95% CI: 1.30–4.27).
Successful aging was associated with age, frail status, chronic health-related problems and psychosocial support. However, whether or not these associations are causal requires further exploration.
The proportion of the elderly population aged ≥65 years has continued to dramatically increase worldwide from 8% in 1950 to 11% in 2009 . A similar tendency has occurred in Taiwan, as the number of elderly people increased by approximately 2% each year throughout the 1990s. The proportion of elderly Taiwanese is projected to further increase almost threefold from 10% in 2009 to 36% by 2050. Because the aging process is associated with increased susceptibility to chronic conditions, disabilities, psychosocial problems and comorbidities [2, 3], it is important that this aging population is able to enter late stages of life in relatively good health.
An extensive review of 28 quantitative studies reported that there are several methods to operationally define and measure successful aging . The prevalence and definitions of successful aging were found to vary among studies . As the number of included domains increased, definitions of successful aging tended to become more complex ; there was, however, a consensus regarding the multidimensional nature of successful aging [4–6]. The Study of Health Assessment and Risk in Ethnic groups also reported a cross-national variation in the prevalence of successful aging among 14 European countries. The authors suggested that self-reported health measures may be the most appropriate measures for comparing cross-national differences to avoid diagnostic differences across countries . Multidimensional, standardized, and self-rated instruments are more practical and are more easily comparable among different countries and populations.
The Short Form-36 (SF-36) is a multidimensional scale and a well-established instrument that measures health concepts and self-reported health-related quality of life . Using SF-36 to define successful aging is acceptable because it represents overall health status in two key measures—the physical component summary (PCS) and the mental component summary (MCS) scores. These two scores reflect the status of physical, mental, and social well-being that are generally used to define health status . The aim of this study was to explore the prevalence of successful aging, as gauged by SF-36, as well as to identify determinants of successful aging among community-dwelling elders.
Population and participants
We conducted a population-based cross-sectional study in June 2009 with a target population of all residents aged ≥65 years residing in eight administrative neighborhoods of Taichung, Taiwan. Taichung is located in west-central Taiwan and has a population of just over one million people, making it the third largest city on the island; its area spans 163.4 km2, and the population density is 6,249/km2 (2009). There were 3,997 elderly residents in these eight administrative neighborhoods of Taichung, accounting for 4.5% of the population. Data for this study were obtained from individuals’ records compiled by the Bureau of Households; details of this study’s sampling method are described elsewhere . This research was approved by the Human Research Committee of China Medical University Hospital, and written informed consent was obtained from each participant. A total of 1,347 elderly residents of Taichung participated in this study, yielding an overall response rate of 49.0%. Among these participants, 256 elderly residents completed only the first stage of the screening test for the frailty assessment and did not submit responses to the SF-36 questionnaire. A total of 903 elders were included in the final data analysis after excluding those diagnosed with dementia (n = 18), those lacking Mini-Mental State Examination (MMSE) information (n = 5), those with MMSE scores less than 14 points (n = 8), those who had incomplete frailty-related components (n = 87), and those with incomplete SF-36 information (n = 70).
Measurements from the SF-36 instrument were applied to identify whether the elderly residents of Taichung were aging successfully. The SF-36 is a short questionnaire with 36 items that measures the following eight multi-item variables: physical functioning (PF, 10 items), social functioning (SF, 2 items), role limitations due to physical problems (RP, 4 items), role limitations due to emotional problems (RE, 3 items), mental health (MH, 5 items), vitality (VT, 4 items), pain (BP, 2 items), and general perception of health (GH, 5 items). The scores for each variable item were coded, summed, and transformed into a score ranging from 0 (worst measured health state) to 100 (best measured health state). The SF-36 PCS and MCS scales were derived from the standard SF-36 scoring algorithms. Elders with both PCS and MCS in the highest tertile, indicating the best states of physical and mental health, were considered to be successfully aging. The cutoff scores of the top tertile were 53.00 for the PCS and 59.28 for the MCS.
Socioeconomic factors, health-related practices, visual and hearing capacity, and psychosocial support
Data on health-related practices, psychosocial support, and socioeconomic factors (including age, gender, education, marital status and money use) were collected through self-administered questionnaires. Visual and hearing capacities were categorized as good, general, and bad/blind or bad/deaf. Health-related practices, such as tobacco use and alcohol consumption, were categorized as never and former/current. Regular exercise was categorized as “yes” or “no”. Psychosocial support was assessed using two statements: “Someone is listening when you talk” and “You see relatives/friends when you want”.
Frailty status and chronic illness and problems
We adopted the definition of frailty proposed by Fried et al. , consisting of five components: unintended weight loss, weakness, poor endurance and energy, slowness, and low physical activity level. In this study, unintended weight loss was defined as weight loss 33 kg over the course of the previous year; weakness was defined as grip strength in the lowest quintile at baseline, based on the subgroups of gender and body mass index. Poor endurance and energy were evaluated by self-reported exhaustion and by two questions from the Center for Epidemiological Studies-Depression scale . Slowness was measured for each gender and height subgroup and was defined as the slowest quintile to walk a distance of 15 feet and was divided into gender and height subgroups . Low physical activity level was measured for each gender and was defined as the lowest quintile of kilocalories spent every week (using weighted scores), based on responses from each participant. Subjects exhibiting none of the above components were considered robust; those with one or two components were considered pre-frail; and those with more than two components were considered frail.
Self-reported personal medical histories—including diabetes mellitus, hypertension, heart disease, stroke, arthritis, hyperlipidemia, gout, hyperuricemia, cataract, and fall histories—were collected. Pain problems and sleep disorders were also collected as “yes” or “no” binary responses.
Continuous variables were reported as mean ± standard deviation (SD), and categorical variables were reported as numbers and percentages. Student’s t-test was used to compare the eight dimensions and the two component summaries of SF-36 among elders who were and were not aging successfully. Univariate logistic regression was used to explore the associations of sociodemographic factors, psychosocial support, visual and hearing capacities, health-related practices, and chronic health problems with successful aging. Variables found to be statistically significant by univariate logistic regression analysis were selected to further evaluate their relative contributions using four multivariate logistic regression models. First, the sociodemographic and psychosocial support factors were evaluated by multivariate logistic regression. Health-related practices and visual and hearing capacities were then added to the second model; chronic illness and fall history were then added to the third model; and pain, sleep disorders, and frailty were finally added to the fourth model. All calculations were repeated for sensitivity analysis. The cutoff point of both the PCS and the MCS for defining successful aging was changed from the highest tertile to the seventieth percentile and the fourth quartile. All reported p-values were those of two-sided tests; significance was defined as p < 0.05. All analyses were performed using SAS version 9.2 statistical software (SAS Institute Inc., Cary, NC, USA).
Comparison of eight dimensions and two component summaries of SF-36 between successfully aging and not successfully aging elders
Not successfully aging
(n = 809)
(n = 94)
Prevalence and odds ratio of successful aging defined by health-related quality of life among socio-demographic factors, visual and hearing capacity, and health-related practices
≥ 13 years
Visual and hearing capacity
Someone is listening when you talk
You see relatives/friends when you want
Prevalence and odds ratios of successful aging defined by health-related quality of life among chronic illness, problems, and frailty status
Nested logistic regression analysis was used to further examine the interrelatedness of factors significantly associated with successful aging. Among socioeconomic and psychosocial support factors, the odds of successful aging were significantly lower for the very elderly and for those with insufficient income. After accounting for the effects of visual capacity, hearing capacity, and exercise habits on successful aging, the significance of age remained unchanged while the strength of the financial resources association diminished. Meanwhile, we observed increased odds of successful aging for elders with general or good visual capacity and for those who exercised regularly. After chronic illness and history of falling were added into the regression model, successfulness of aging was statistically associated with an age range of 71–75 years; regular exercise; and the absence of heart disease, arthritis, and fall histories.
Nested logistic regression analysis of successful aging defined by health-related quality of life
71–75 vs ≤70
>75 vs ≤70
Women vs Men
≤6 years vs Illiterate
7–12 years vs Illiterate
≥ 13 years vs Illiterate
Just enough vs Enough
Not enough vs Enough
You see relatives/friends when you want
Yes vs No
General vs Bad/Blind
Good vs Bad/Blind
General vs Bad/Deaf
Good vs Bad/Deaf
Yes vs No
No vs Yes
No vs Yes
No vs Yes
No vs Yes
No vs Yes
No vs Yes
No vs Yes
No vs Yes
Pre-fail vs Non-frail
Frail vs Non-frail
Adjusted McFadden’s R2
Likelihood ratio test†
p < 0.001
p < 0.001
p < 0.001
The sensitivity analysis results showed that age, fall history, and pain were still significantly associated with successful aging when using the highest cutoff value at the seventieth percentile for both the PCS and the MCS. Successful aging associations with sleep disorders and visiting relatives and friends were strong but insignificant. Using the highest quartile as a cut-off value, only fall history and pain were significantly associated with successful aging. All elders who were frail were found to be unsuccessfully aging; however, the factor of frailty could not be added to the final multivariate model due to problems with statistical convergence.
The prevalence of successful aging, as was defined using SF-36, was 10.4% in community-dwelling elders in a metropolitan population of Taiwan. Elders with chronic diseases or other health-related problems had a lower prevalence of successful aging compared with those without such health issues. All elderly people who had had a stroke, for example, were considered to be unsuccessfully aging. Elders more likely to be successfully aging, however, were ≤70 years old; were are able to visit relatives or friends whenever they wished; and had no history of falling, pain, or sleep disorders.
We adopted the five components of frailty defined by Fried et al.  that included objective, performance-based measures. A previous study had reported that frailty in elders is an important clinical state that is distinct from normal aging and a strong predictor for disability . In this study, frailty was found to be an independent determinant of successful aging. Among frail elders, only one (0.93%) was found to be successfully aging; and even after PCS and MCS cutoff values were increased from tertile to a higher percentile, no other frail elders were found to be successfully aging. These results indicated that gauging successful aging using SF-36 is not only easy but also reflects actual health conditions. A noteworthy additional study by Theou et al., however, reported that frailty in elders can be reversed by structured exercise training .
The prevalence of successful aging among previous community-based studies ranges from 0.4% to 95% based on various definitions [5, 6, 12, 14–20]. In general, those studies using a single-item, self-rating scale reported a higher and more variable prevalence of successful aging, ranging from 50.3% to 90.2% [6, 15, 18]. The focus of many studies on successful aging has shifted from disease status and functional decline to multidimensional health status, which encompasses physical, functional, psychological, and social health . Early published reports defined successful aging using only one or two dimensions of health, such as the absence of chronic diseases, longer longevity, independent physical functioning, social life engagement, and mental health [14, 16, 17, 19]. However, more recent studies have focused on the concept that successful aging is more multifaceted and complex [5, 7]. Studies using the absence of major disease as one of the domains to define successful aging in elders reported a lower prevalence of successful aging [15, 18, 20] compared with those not using this domain [5, 7, 12, 15]. To obtain a comparable prevalence of successful aging among elders and to explore the associated determinants, there is a need for a simple, standardized and multidimensional tool to be used across studies. In a study conducted in Hong Kong, higher PCS and MCS scores in SF-36 reflected better overall physical, functional, psychological, and social health in Chinese elders . Consequently, higher PCS and MCS scores in SF-36 among elders were used to define successful aging in this study.
Age is a commonly identified determinant of successful aging. Consistent with the results reported in previous studies [5, 23, 24], younger age was one determinant of successful aging among elders in this study. We also found that the ability to see relatives and friends at will (as a variable related to social support) was an independent determinant for successful aging among the elderly. Pruchno et al.  reported that unsuccessfully aging elders have less social support compared with successful agers. Our findings on the associations among sleep disorders, fall histories, and successful aging were similar to those in prior research . Elderly persons with sleep disorders were at a higher risk of unsuccessfully aging compared with those without sleep disorders. This finding provides evidence supporting a previous study by Andrews et al.  that defined the concept of high functioning and found that elders without sufficient sleep were less likely to be in the high functioning category. In our findings, a history of falling was associated with a lower likelihood of successful aging, as those with such a history tend to restrict outdoor activity out of a fear of falling . In general, the fear of falling has tended to impede elderly participation in healthy activities and leads to decreased mobility, resulting in diminished quality of life [27, 28].
Previous studies have reported that chronic diseases—such as arthritis, diabetes, stroke, and hypertension—were all associated with successful aging. [5, 16] We found that these diseases were not independent risk factors of unsuccessful aging because their effects were explained by falls, frailty, pain, and sleep problems. Among these chronic diseases, stroke had a major impact on successful aging; all elders who had a history of stroke in this study were found to be unsuccessfully aging. Strokes were not, however, added to the final multivariate model due to problems with statistical convergence. We observed lower physical component scores in elders with stroke histories compared with those without stroke histories; no significant differences were observed in mental component scores. Consistent with the findings of Okonkwo et al. , the difference in PCS scores between subjects with and without a stroke history in this study was approximately twofold that in MCS scores. In contrast to our findings on stroke effects, Haley et al.  indicated that an incident of stroke has a negative impact in both mental and physical health over a three-year period. One possible explanation for these different findings is that the elders in our present study had already coped with their conditions, allowing for better mental health.
In present study, we used Cohen’s d in the chi-square value formula (, where N is total sample size)  to calculate the effect size of significant factors. Our results indicated a mid-size effect of both pain (d = 0.47) and frailty (d = 0.38). The effect sizes of other factors (including age, seeing relatives and friends at will, fall histories, and sleep disorders) were small, between 0.2 and 0.3. The two determinants of pain problems and frailty were found to have greater relative association with successful aging.
The present study has certain limitations that should be taken into account when interpreting the results. First, owing to the nature of the cross-sectional study, we cannot explore the possible causal relationships between the health conditions considered in this study and successful aging. Second, the findings of our work are not generalizable to rural elders because this study sample was a group of metropolitan elders. Finally, the prevalence of successful aging in urban elders may have been overestimated due to the exclusion of elders who were diagnosed with dementia, had cognitive impairment, and were unable complete the SF-36 questionnaire. Our study’s elders reflected the general global measures of physical and mental dysfunction, rather than those of specific disabilities or impairments .
The following conclusions can be drawn from the present study: the higher proportion of successful aging in elders was found among those who were relatively younger, had social support, not frail, and had no pain, sleep impairment, and fall history. These findings revealed the importance of considering suitable intervention to improve the frailty, pain, and sleep problems among the elders. However, the causal relationships between these factors and successful aging will require further investigations.
This research was supported by the Taiwan National Health Research Institutes Grant (NHRI-EX99-9838PI, NHRI-EX100-9838PI, NHRI-EX101-9838PI), Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW103-TDU-B-212-113002), and China Medical University Hospital (DMR-100-075).
- Kinsella K, He W: An Aging World: 2008. Washington, DC: US Government Printing Office; 2009. US Census Bureau. International Population Reports, PS95/09-1.Google Scholar
- Molton IR, Jensen MP: Aging and disability: biopsychosocial perspectives. Phys Med Rehabil Clin N Am. 2010, 21 (2): 253-265. 10.1016/j.pmr.2009.12.012.View ArticlePubMedGoogle Scholar
- Finlayson ML, Peterson EW: Falls, aging, and disability. Phys Med Rehabil Clin N Am. 2010, 21 (2): 357-373. 10.1016/j.pmr.2009.12.003.View ArticlePubMedGoogle Scholar
- Depp CA, Jeste DV: Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies. Am J Geriatr Psychiatry. 2006, 14 (1): 6-20. 10.1097/01.JGP.0000192501.03069.bc.View ArticlePubMedGoogle Scholar
- Ng TP, Broekman BF, Niti M, Gwee X, Kua EH: Determinants of successful aging using a multidimensional definition among Chinese elderly in Singapore. Am J Geriatr Psychiatry. 2009, 17 (5): 407-416. 10.1097/JGP.0b013e31819a808e.View ArticlePubMedGoogle Scholar
- Pruchno RA, Wilson-Genderson M, Cartwright F: A two-factor model of successful aging. J Gerontol B Psychol Sci Soc Sci. 2010, 65 (6): 671-679.View ArticlePubMedGoogle Scholar
- Hank K: How “successful” do older Europeans age? Findings From SHARE. J Gerontol B Psychol Sci Soc Sci. 2011, 66 (2): 230-236.View ArticlePubMedGoogle Scholar
- Ware JE, Gandek B: Overview of the SF-36 health survey and the international quality of life assessment (IQOLA) Project. J Clin Epidemiol. 1998, 51 (11): 903-912. 10.1016/S0895-4356(98)00081-X.View ArticlePubMedGoogle Scholar
- World Health Organization: Constitution of the World Health Organization. 1948, Geneva, Switzerland: WHO Basic DocumentsGoogle Scholar
- Lin CC, Li CI, Chang CK, Liu CS, Lin CH, Meng NH, Lee YD, Chen FN, Li TC: Reduced health-related quality of life in elders with frailty: a cross-sectional study of community-dwelling elders in Taiwan. PLoS One. 2011, 6 (7): e21841-10.1371/journal.pone.0021841.View ArticlePubMedPubMed CentralGoogle Scholar
- Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G: Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001, 56 (3): M146-M157. 10.1093/gerona/56.3.M146.View ArticlePubMedGoogle Scholar
- Almeida OP, Norman P, Hankey G, Jamrozik K, Flicker L: Successful mental health aging: results from a longitudinal study of older Australian men. Am J Geriatr Psychiatry. 2006, 14 (1): 27-35. 10.1097/01.JGP.0000192486.20308.42.View ArticlePubMedGoogle Scholar
- Theou O, Stathokostas L, Roland KP, Jakobi JM, Patterson C, Vandervoort AA, Jones GR: The effectiveness of exercise interventions for the management of frailty: a systematic review. J Aging Res. 2011, 2011: 569194-View ArticlePubMedPubMed CentralGoogle Scholar
- Garfein AJ, Herzog AR: Robust aging among the young-old, old-old, and oldest-old. J Gerontol B Psychol Sci Soc Sci. 1995, 50 (2): S77-S87.View ArticlePubMedGoogle Scholar
- Montross LP, Depp C, Daly J, Reichstadt J, Golshan S, Moore D, Sitzer D, Jeste DV: Correlates of self-rated successful aging among community-dwelling older adults. Am J Geriatr Psychiatry. 2006, 14 (1): 43-51. 10.1097/01.JGP.0000192489.43179.31.View ArticlePubMedGoogle Scholar
- von Faber M, Bootsma-van der Wiel A, van Exel E, Gussekloo J, Lagaay AM, van Dongen E, Knook DL, van der Geest S, Westendorp RG: Successful aging in the oldest old: who can be characterized as successfully aged?. Arch Intern Med. 2001, 161 (22): 2694-2700. 10.1001/archinte.161.22.2694.View ArticlePubMedGoogle Scholar
- Strawbridge WJ, Cohen RD, Shema SJ, Kaplan GA: Successful aging: predictors and associated activities. Am J Epidemiol. 1996, 144 (2): 135-141. 10.1093/oxfordjournals.aje.a008900.View ArticlePubMedGoogle Scholar
- Strawbridge WJ, Wallhagen MI, Cohen RD: Successful aging and well-being: self-rated compared with Rowe and Kahn. Gerontologist. 2002, 42 (6): 727-733. 10.1093/geront/42.6.727.View ArticlePubMedGoogle Scholar
- Burke GL, Arnold AM, Bild DE, Cushman M, Fried LP, Newman A, Nunn C, Robbins J: Factors associated with healthy aging: the cardiovascular health study. J Am Geriatr Soc. 2001, 49 (3): 254-262. 10.1046/j.1532-5415.2001.4930254.x.View ArticlePubMedGoogle Scholar
- McLaughlin SJ, Connell CM, Heeringa SG, Li LW, Roberts JS: Successful aging in the United States: prevalence estimates from a national sample of older adults. J Gerontol B Psychol Sci Soc Sci. 2010, 65B (2): 216-226. 10.1093/geronb/gbp101.View ArticlePubMedGoogle Scholar
- Phelan EA, Anderson LA, LaCroix AZ, Larson EB: Older adults’ views of “successful aging”–how do they compare with researchers’ definitions?. J Am Geriatr Soc. 2004, 52 (2): 211-216. 10.1111/j.1532-5415.2004.52056.x.View ArticlePubMedGoogle Scholar
- Lam CL, Tse EY, Gandek B, Fong DY: The SF-36 summary scales were valid, reliable, and equivalent in a Chinese population. J Clin Epidemiol. 2005, 58 (8): 815-822. 10.1016/j.jclinepi.2004.12.008.View ArticlePubMedGoogle Scholar
- Pruchno RA, Wilson-Genderson M, Rose M, Cartwright F: Successful aging: early influences and contemporary characteristics. Gerontologist. 2010, 50 (6): 821-833. 10.1093/geront/gnq041.View ArticlePubMedGoogle Scholar
- Newman AB, Arnold AM, Naydeck BL, Fried LP, Burke GL, Enright P, Gottdiener J, Hirsch C, O’Leary D, Tracy R: “Successful aging”: effect of subclinical cardiovascular disease. Arch Intern Med. 2003, 163 (19): 2315-2322. 10.1001/archinte.163.19.2315.View ArticlePubMedGoogle Scholar
- Andrews G, Clark M, Luszcz M: Successful aging in the Australian longitudinal study of aging: applying the MacArthur model cross–nationally. J Soc Issues. 2002, 58 (4): 749-765. 10.1111/1540-4560.00288.View ArticleGoogle Scholar
- Fletcher PC, Guthrie DM, Berg K, Hirdes JP: Risk factors for restriction in activity associated with fear of falling among seniors within the community. J Patient Saf. 2010, 6 (3): 187-191. 10.1097/PTS.0b013e3181f1251c.View ArticlePubMedGoogle Scholar
- Vellas BJ, Wayne SJ, Romero LJ, Baumgartner RN, Garry PJ: Fear of falling and restriction of mobility in elderly fallers. Age Ageing. 1997, 26 (3): 189-193. 10.1093/ageing/26.3.189.View ArticlePubMedGoogle Scholar
- Brouwer B, Musselman K, Culham E: Physical function and health status among seniors with and without a fear of falling. Gerontology. 2004, 50 (3): 135-141. 10.1159/000076771.View ArticlePubMedGoogle Scholar
- Okonkwo OC, Roth DL, Pulley L, Howard G: Confirmatory factor analysis of the validity of the SF-12 for persons with and without a history of stroke. Qual Life Res. 2010, 19 (9): 1323-1331. 10.1007/s11136-010-9691-8.View ArticlePubMedPubMed CentralGoogle Scholar
- Haley WE, Roth DL, Kissela B, Perkins M, Howard G: Quality of life after stroke: a prospective longitudinal study. Qual Life Res. 2011, 20 (6): 799-806. 10.1007/s11136-010-9810-6.View ArticlePubMedGoogle Scholar
- Dunst CJ, Hamby DW, Trivette CM: Guidelines for calculating effect sizes for practice-based research syntheses. Centerscope. 2004, 3 (1): 1-10.Google Scholar
- Parker SG, Bechinger-English D, Jagger C, Spiers N, Lindesay J: Factors affecting completion of the SF-36 in older people. Age Ageing. 2006, 35 (4): 376-381. 10.1093/ageing/afl003.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/14/1013/prepub
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