Skip to main content

The Cedar Project: high incidence of HCV infections in a longitudinal study of young Aboriginal people who use drugs in two Canadian cities



Factors associated with HCV incidence among young Aboriginal people in Canada are still not well understood. We sought to estimate time to HCV infection and the relative hazard of risk factors associated HCV infection among young Aboriginal people who use injection drugs in two Canadian cities.


The Cedar Project is a prospective cohort study involving young Aboriginal people in Vancouver and Prince George, British Columbia, who use illicit drugs. Participants’ venous blood samples were drawn and tested for HCV antibodies. Analysis was restricted to participants who use used injection drugs at enrolment or any of follow up visit. Cox proportional hazards regression was used to identify independent predictors of time to HCV seroconversion.


In total, 45 out of 148 participants seroconverted over the study period. Incidence of HCV infection was 26.3 per 100 person-years (95% Confidence Interval [CI]: 16.3, 46.1) among participants who reported using injection drugs for two years or less, 14.4 per 100 person-years (95% CI: 7.7, 28.9) among participants who had been using injection drugs for between two and five years, and 5.1 per 100 person-years (95% CI: 2.6,10.9) among participants who had been using injection drugs for over five years. Independent associations with HCV seroconversion were involvement in sex work in the last six months (Adjusted Hazard Ratio (AHR): 1.59; 95% CI: 1.05, 2.42) compared to no involvement, having been using injection drugs for less than two years (AHR: 4.14; 95% CI: 1.91, 8.94) and for between two and five years (AHR: 2.12; 95%CI: 0.94, 4.77) compared to over five years, daily cocaine injection in the last six months (AHR: 2.47; 95% CI: 1.51, 4.05) compared to less than daily, and sharing intravenous needles in the last six months (AHR: 2.56; 95% CI: 1.47, 4.49) compared to not sharing.


This study contributes to the limited body of research addressing HCV infection among Aboriginal people in Canada. The HCV incidence rate among Cedar Project participants who were new initiates of injection drug use underscores an urgent need for HCV and injection prevention and safety strategies aimed at supporting young people surviving injection drug use and sex work in both cities. Young people must be afforded the opportunity to provide leadership and input in the development of prevention programming.

Peer Review reports


Increasing levels of HCV infection among young Aboriginal people are distressing for many Aboriginal communities and service providers, not only in small and large urban centres but also in rural settings where healthcare resources are limited [1, 2]. This situation is exacerbated by the fact that the major consequences of HCV infection, including cirrhosis of the liver and hepatocellular cancer do not develop for many decades after initial infection [3]. Available data have demonstrated that Aboriginal people are not only disproportionately represented among HCV infected people in Canada but also underrepresented in community based treatment programs [4]. In British Columbia, it is estimated that incidence for HCV infection is twice as high among Aboriginal people compared to non-Aboriginal people [5] and that over half the population of Aboriginal people living with HIV are HCV co-infected, making the treatment challenges associated with being HCV and HIV co-infected far more complex [6]. Unfortunately, national HCV surveillance data for indigenous people in Canada is considered to be very limited largely because of under reporting and lack of consistent documentation of ethnic status between provinces [7, 8]. Despite these limitations the Public Health Agency of Canada has identified that HCV incidence among Aboriginal people in Canada is 5 to 6 fold higher than among non-Aboriginal people [8]. The majority of these new infections can be attributed to injection drug use and the sharing of contaminated injection equipment [7, 9].

There is also increasing evidence that HCV is disproportionately impacting Aboriginal young people. As Roy et al [10]. have suggested, recent onset of injection is a particularly vulnerable time for young people and the risk for HCV seroconversion is extremely high. In a previous study, we demonstrated that approximately 11% of our participants will transition to injection drug use per year; a rate that is twice as high as that found in a similar longitudinal investigation conducted in Montreal [11, 12]. A number of prospective studies in Canada have examined HCV infection among people who use injection drugs. However, most have been limited by the fact that they are older cohorts and characterized by high HCV prevalence and small numbers of Aboriginal people, making it difficult to assess risk factors relevant for Aboriginal specific programming.

Concerns over the paucity of available data and the potential for explosive HIV and HCV epidemics among Aboriginal young people in other areas of the province similar to those reported in the mid-1990s in Vancouver’s downtown eastside prompted the initiation of a two city cohort study to address the specific HIV and HCV related vulnerabilities of Aboriginal young people who use illicit drugs. To our knowledge, this is the only longitudinal study of young and ‘at risk’ indigenous peoples of its kind in North America. Follow-up of the cohort allowed us to estimate the incidence of HCV infection among young people enrolled in the Cedar Project and identify risk factors associated with seroconversion among study participants.


The Cedar Project is an ongoing prospective study of young Aboriginal people who use drugs in Vancouver and Prince George, Canada. Previous studies have described the methodology of the Cedar study in detail including the proportion of Aboriginal young people living in BC, participant recruitment and questionnaire design [13]. Briefly, young people who self identified as Aboriginal people were considered to be the descendants of the First Nation Peoples of North America and include Métis, Aboriginal, First Nations, Inuit and status and non-status Indians. Participants living primarily in the downtown areas of both cities were recruited through referral by health care providers, community outreach and word of mouth. Eligibility criteria for study entry included age 14 to 30 years and to have smoked or injected illicit drugs, aside from marijuana, in the month prior to enrolment. Saliva screens (Oral-screen, Avitar Onsite Diagnostics) were used to confirm drug use. All participants met with one First Nations study coordinator who explained procedures, sought informed consent and confirmed study eligibility. At enrolment, participants completed a detailed interviewer-administered questionnaire to elicit information on socio-demographic characteristics, non-injection and injection drug use, injection practices, sexual vulnerability and service utilization. Participants were followed-up every six months for subsequent interviews. Venous blood samples were drawn and tested for HIV and HCV-antibodies at each visit, and each participant had private interviews including pre- and post-test counselling with trained nurses. Participants were requested but not required to return for their HIV/HCV serostatus test results and given a twenty dollar stipend at each study visit.

Since they were established in 2010, we have enthusiastically embraced the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans, with particular attention to Section 9, which pertains to research involving Aboriginal participants. Our First Nations collaborators and investigators were involved in the conception, design and interpretation of this study and approved this manuscript for publication. The University of British Columbia/Providence Health Care Research Ethics Board has also approved the study.

Outcome variables and covariates

The main outcome of interest in this study was HCV antibody seroconversion among participants who reported injection drug use between January 2003 and January 2009. We used algorithms for HCV serologic testing similar to those used in other studies conducted in this region [14]. In brief, AxSYM HCV version 3.0 (Abbott Laboratories, Chicago, Ill.) was used to screen all plasma samples. Negative samples did not undergo further testing. All positive samples underwent further testing with the recombinant Ortho HCV 3.0 ELISA test system (Ortho Clinical Diagnostic Inc., Rochester, NY). Samples that tested positive with both assays were classified as positive. Samples that tested positive by the AxSYM HCV test and negative by the Ortho HCV test were classified as negative. Because of the known association of the HCV virus with parenteral drug use, HCV incidence rates were estimated by three categories using the variable time since initiation of injection drug use. The variable was coded for relatively equal distribution between participants who had been injecting for <2 years (n = 40), those who had been injecting for 2–5 years (n = 40) and those who had been injecting for over 5 years (n = 66).

The following fixed dichotomous baseline covariates were used in the analysis: interviewed in Vancouver; sex; identifying as gay, lesbian, bisexual or two-spirited; having at least one parent who had attended residential school; ever having been placed into foster care; ever having attempted suicide; and ever having experienced sexual abuse. Sexual abuse was defined as any type of sexual activity into which participants had either been forced or coerced (including childhood sexual abuse, molestation, rape and sexual assault). Nonfixed (occurred in the past six months) covariates included age, being in a relationship, having lived on the streets for a period of three nights or more, having been in jail or prison overnight or longer, having been denied shelter because of drug use, having been involved in sex work, having any sexually transmitted infection, having been incarcerated overnight or longer, presence of antibodies to HIV, time since initiation of injection drug use, daily vs. less than daily use of injection cocaine, daily vs. less than daily use of injection opioids (including heroin, morphine, methadone, dilaudid or talwin and speedballs (combination of cocaine and heroin)), daily vs. less than daily use of injection methamphetamine, rig sharing, having overdosed, and inconsistent use of condoms during insertive sex (vaginal, anal) with casual, regular or client partners. Sexual assault was defined as having experienced sexual violence in the past six months. Sex work was defined as receiving money, shelter, food or drugs in exchange for sex. Sexual relationships that lasted less than three months were defined as casual sexual partners, more than three months were defined as regular partners, and clients were relationships where sex was exchanged for money, food, drugs or shelter.

The Cedar Project cohort includes 605 participants in total, however this study included only participants who reported injection drug use, were HCV negative at baseline, reported injection drug use and who returned for at least one of eight follow-up interviews up to December 2008 (n = 148). HCV incidence was calculated as incidence density. HCV incidence was calculated separately for groups including participants from Vancouver and Prince George, all participants together, and for participants who had been using injection drugs for less than two years, those who had been using injection drugs for between two and five years, and those who had been using injection drugs for five or more years. The date of seroconversion was estimated using the midpoint between the last negative and the first positive antibody test result. Cumulative incidence rates of HCV infection were calculated using Kaplan Meier methods. In these analyses time 0 was defined as the date of enrolment. We assessed the proportionality assumptions using the log minus log curve for the fixed covariates used in the model and observed no violations of assumptions. Participants who consistently remained HCV seronegative were considered to be right censored at the time of their most recent test result. Annual rates of HCV seroconversion were calculated with actuarial methods per 100 person years. Relative risks and 95% confidence intervals were obtained for risk factors of interest.

Cox proportional hazards regression were used to examine the independent effect of both fixed and time-dependent covariates on time to HCV seroconversion. Adjusted and unadjusted time dependent Cox regression models were used to identify risk associations with HCV seroconversion with Hazard Ratios and 95% confidence intervals were obtained for risk factors of interest. Backward stepwise Cox proportional hazards model included all variables that were statistically associated with HCV seroconversion at a p <0.10 significance level in unadjusted analyses. The adjusted model controlled for the significant covariates to determine which of those risk factors are independently associated with HCV seroconversion. All reported p-values are two-sided.

Overall, 605 (305 in Vancouver and 300 in Prince George) young Aboriginal people were recruited and screened for enrolment in the Cedar Project study. Among them, 292 (48%) were women and the mean age was 23.5 years (Standard Deviation (SD): 4.0). A total of 335 (55.4%) participants reported that they had used injection drugs before enrolment, and 42 (6.9%) reported that they had initiated injection drug use in the time after enrolment. The mean age of first having injected drugs was 20.2 years (SD: 4.6). Among the 377 participants who had injected drugs over the study period, 175 were HCV seronegative at time of their baseline interview. Out of 175 participants, 148 completed at least one follow-up visit, yielding a follow-up rate of 85%. In total, 148 participants were therefore eligible for inclusion in the HCV incidence analysis.


In total, 148 participants were eligible for inclusion in the analysis. Descriptive baseline statistics are provided in Table 1. The median age of participants at baseline was 23 years (standard deviation: 3.9), 53.4% were women and 57.4% were located in Vancouver. In addition, 11.5% identified as gay/lesbian/bisexual/transgender or two-spirited, 52.1% reported that they had ever been sexually abused and 68.2% had ever been taken from their biological parents into the child welfare system. In total, these 148 participants contributed 338.6 person years of observation over the study period. The mean length of follow-up time was 2.6 years (SD: 1.6) for all participants, 1.3 years (SD: 1.1) for those who became HCV positive and 3.2 years (SD: 1.5) for those who remained HCV negative. Table 2 demonstrates the incidence of HCV among Cedar Project participants overall, and among those who reported using injection drugs for 2 years or less, between 2-5 years and over 5 years. Overall, 45 participants seroconverted during the observation period yielding an incidence density of 11.6 cases per 100 person years (95% Confidence Interval (CI): 8.5%, 17.1%). Incidence of HCV infection was higher in Prince George than in Vancouver (14.8 vs. 9.6 per 100 person years), but this difference was not statistically significant (Log-rank test, p = 0.186). Incidence of HCV infection was 26.3 per 100 person-years (95% CI: 16.3, 46.1) among participants who reported using injection drugs for two years or less, 14.4 per 100 person-years (95% CI, 7.7, 28.9) among participants who had been using injection drugs for between two and five years, and 5.1 per 100 person-years (95% CI: 2.6,10.9) among participants who had been in using injection drugs for over five years.

Table 1 Unadjusted and adjusted* backward stepwise Cox regression models for vulnerabilities associated with HCV incidence among Cedar participants who used injection drugs (n = 148)
Table 2 HCV incidence among Cedar Project participants who had been using injection drugs for less than 2 years, 2–5 years and over 5 years

Figure 1 demonstrates the survival estimates for time to HCV seroconversion among participants who had only been injecting for two years or less, those who had been using injection drugs for between two and five years, and those who had been injecting for over five years. For those newest to injection drug use, the cumulative HCV incidence increased sharply to approximately 38% within the first year of follow-up and was over 50% by the third year of follow-up.

Figure 1

Kaplan Meier Curves of HCV incidence rates by length of time participants reported use of injection drugs (2 years or less, 2–5 years, and over 5 years).

Results from unadjusted and adjusted Cox regression analyses for factors associated with HCV incidence are displayed in Table 1. In unadjusted analyses, risk for HCV seroconversion was significantly associated with having been involved in sex work in the last six months (Unadjusted Hazard Ratio (UHR): 1.79; 95% CI: 1.16, 2.53). Risk for seroconversion appeared to decline with duration of injecting, as the hazard for HCV was significantly higher for participants who reported having been injecting drugs for less than two years (UHR: 4.57; 95% CI: 2.91, 9.51), and for those who had been injecting for between two and five years (UHR: 2.43; 95% CI: 1.09, 5.45) compared to those who had been injecting for five or more years. HCV risk also appeared to rise with increased frequency of injection, as participants who reported daily cocaine injection in the last six months (UHR: 3.94; 95% CI: 2.49, 6.24) and daily opioid injection in the last six months (UHR: 2.06; 95% CI: 1.43, 2.98) had significantly higher rates of HCV incidence compared to participants who were injecting cocaine or opioids less than daily. In addition, participants who reported unsafe injection practices in the last six months including sharing rigs (UHR: 3.35; 95% CI: 2.09, 5.39), reusing one’s own rig (UHR: 2.17; 95% CI: 1.48, 3.19) and having a difficult time finding new rigs (UHR: 2.16; 95% CI: 1.31, 3.57) had significantly higher risk for HCV seroconversion.

In the adjusted backward stepwise Cox regression model, independent associations with HCV seroconversion among Cedar Project participants who used injection drugs were involvement in sex work in the last six months (Adjusted Hazard Ratio (AHR): 1.59; 95% CI: 1.05, 2.42), having been using injection drugs for less than two years (AHR: 4.14; 95% CI: 1.91, 8.94) and for between two and five years (AHR: 2.12; 95%CI: 0.94-4.77), daily cocaine injection in the last six months (AHR: 2.47; 95% CI: 1.51, 4.05) and sharing rigs in the last six months (AHR: 2.56; 95% CI: 1.47, 4.49).


Our findings have illustrated that young Aboriginal people are at very high risk of HCV infection early in their injection careers. The declining risk with longer durations of injection was not surprising. It is likely that a form of survivorship bias is operative here. The analysis was based on those who were HCV negative at recruitment, therefore highest risk individuals in the longer-using groups would have seroconverted to HCV prior to the study, leaving lower risk groups for inclusion in this analysis. However, it is shocking that approximately 26% of participants became infected with HCV within two years of initiating injection drug use in two cities with established harm reduction programs. It is clear from this observation that the timeframe in which to provide access to meaningful preventative interventions after these young people initiate injection drug use is very short and that harm reduction programs must do a better job of reaching them [11, 15, 16].

This study also demonstrated that participants who reported frequent drug injection and syringe sharing over the study period had over twice the risk for HCV infection. Poly-drug use was common in this group. More than half of those who reported daily cocaine injection also reported daily opiate injection (data not shown). It is noteworthy that daily cocaine injection remained associated with HCV infection in the multivariable model while daily opiate injection did not. This is consistent with a previous study in Vancouver that demonstrated acquisition of HIV among injection drug users was directly related to frequent use of injection cocaine as opposed to opiates, particularly as a consequence of ‘cocaine binges’ [17]. We find it very concerning that despite scaling up harm reduction efforts, high intensity injection cocaine and syringe sharing continues to be exposing Cedar Project participants to high risk for HCV infection in both the northern and southern urban communities. Increased efforts must be made to engage young people who are new to injection drug use in harm reduction service provision, including injection equipment, addiction treatment and HIV and HCV testing services. Moreover, while early intervention with young people who have recently transitioned to injection drug use is immediately required, programming aimed at prevention of injection drug use must also be prioritized. In both Vancouver and Prince George, the complex interplay between the impact of colonization, residential schools, racialized care, and generations of mistrust of both provincial and federal authorities must be acknowledged [18]. When designing new programming service providers must be mindful of how the past can shape the response to prevention initiatives [19] and nurture flexible, trust-based relationships that seek to build upon young Aboriginal people’s resiliency in the face of intergenerational and lifetime traumas [20]. Any efforts to alleviate the immense impact of drug related harm but be inclusive of the perspectives of those young people who have learned how to ‘remain safe’ and have avoided infection via injection drug use [21]. Furthermore, young people must be afforded the opportunity to provide leadership in programme design intended to reflect their needs.

An independent association was also found in this study between recent involvement in sex work and HCV seroconversion. These results provide evidence that the risk for HCV among participants who had been involved in sex work was 59% higher compared to those who had not been involved in sex work. Recent studies conducted in British Columbia’s lower mainland have demonstrated that impoverished Aboriginal women involved in sex work and concomitant illicit drug use continue to be exposed to alarming levels of drug related harm, infectious disease and violent predation [2224]. Sadly, these findings are consistent with other settings internationally where women exchanging sex for basic needs including drug dependence, are exposed to alarming levels of violence and infectious disease [25]. These data indicate the critical need for scaling up services aimed at reducing drug or sex related harm for young Aboriginal women, particularly in Northern and remote communities. It is important to highlight that many young Aboriginal women involved in sex work are intimately involved with men who are usually older and who also use injection drugs [23, 26]. Indeed research has demonstrated that for women who rely on their intimate partners for drug acquisition, preparation and injection, the distribution of power and control in intimate relationships often lies with drug injecting men who control the money and the drugs [27, 28]. Combined, these factors lead to a greater likelihood of unsafe sex and the female partner more likely coming “second on the needle.”

Several limitations of this study should be acknowledged. This study is based on self-reported behavioural data obtained from a non-probability sample of street-involved individuals. Consequently, there is potential for recall bias, socially desirable reporting, and misclassification of exposure variables in this study. Responses to questions concerning drug use and sexual behaviors may be influenced by the participant’s knowledge of their HCV antibody status. In addition, recall problems may exist with reporting of past traumatic life events. The effect of memory on our estimates of risk for these factors is difficult to assess. Additionally, although data were analyzed using time-dependent variables, we cannot make conclusions regarding temporal sequences between HCV risk patterns and infection. The number of participants who had never used injection drugs and seroconverted to HCV positive over the study period was very low (n = 5) we were therefore unable to examine the risks for HCV incidence among those participants. Finally, the fact that HCV incidence was lower among participants who had been injecting drugs longer may be demonstrating a survivorship bias. Therefore, perhaps the most at-risk participants who had been injecting longest became HCV positive prior to entering the study. Nevertheless, this study does show alarming rates of HCV infection early in the injection career of young Aboriginal people in Vancouver and Prince George. Despite these limitations, we believe these data provide important epidemiological information about a high-risk Aboriginal population that has not been previously studied.


Results presented in this study suggest that even in the presence of established harm reduction initiatives in both Vancouver and Prince George, including fixed and mobile needle distribution sites, young Aboriginal people who use drugs are at sustained risk for HCV infection. In addition, the new initiates to injection drug use were at highest risk, particularly those young people who were frequently injecting cocaine, sharing rigs and involved in sex work. In the absence of post-exposure prophylaxis or an effective HCV vaccine, primary prevention programs must focus on safe injection practices and reducing the number of people who initiate injection drug use. Indeed, such high incident rates among new initiates in this study underscore the importance of carefully examining the effectiveness of current harm reduction initiatives in both rural and urban settings. On September 30, 2011, the Supreme Court of Canada made a unanimous decision ordering the federal government to refrain from its attempts to close Vancouver’s supervised injection clinic [29]. It has been speculated that this landmark decision will provide other Canadian cities with the authority to open their own safe injection clinics [30]. Although not statistically significant, the present study indicated a higher incidence of HCV in the northern city of Prince George than Vancouver. Based on the estimates we have obtained in this study, we speculate similar rates of HCV infection will be observed in smaller, northern communities throughout British Columbia. In previous studies, we identified Vancouver’s safe injection facility as an integral source for harm reduction programming among Cedar Project participants who were already fully entrenched in injection drug use and HCV positive [31]. Taken together, these findings underscore the urgent need for expansion of safe drug use facilities to other locations in BC, including the North. Furthermore, current policies and practices guiding addiction treatment delivery may be reinforcing the marginalization of street-involved young Aboriginal people because they fail to address historical and social injustices that influence resilience, particularly racial discrimination [3234]. Treatment delivery for optimal adherence among young, HCV positive Aboriginal people who inject drugs must be individually tailored, enriched with ancillary psychosocial supports and provided within a culturally safe setting [7, 35]. These findings may be applicable to at-risk young Indigenous people globally, for example in Australia, where similar patterns of vulnerabilities have been identified [36]. With significant increases in resources, acknowledging the intergenerational trauma related to the residential school system may be one way that Aboriginal leadership and addiction specialists and other practitioners can begin to mitigate the potential impact of the epidemic currently threatening their communities.


The study was supported by a grant from the Institute for Aboriginal Peoples Health, of the Canadian Institutes for Health Research (CIHR), which has no role in the preparation of data or manuscripts. PMS is the recipient of the CIHR New Investigator Career Award. MEP and NC are supported by CIHR doctoral research awards. WMC is the spokesperson for the Shuswap Nation Tribal Council. MTS is the Chief Scientific Officer for the Michael Smith Foundation for Health Research.


  1. 1.

    Hansen D: Hep C cases linked to residential schools. 2010, Vancouver: Vancouver Sun, B2-B2

    Google Scholar 

  2. 2.

    Ko HH, et al: Liver disease in the indigenous populations of the Arctic, sub-Arctic, and Pacific Northwest. BC Med J. 2006, 48: 216-221.

    Google Scholar 

  3. 3.

    Wong T, Lee SS: Hepatitis C: a review for primary care physicians. CMAJ Can Med Assoc J: J l'Assoc Med Can. 2006, 174: 649-659. 10.1503/cmaj.1030034.

    Article  Google Scholar 

  4. 4.

    Cooper CL: Outcomes of peginterferon alpha-2a and ribavirin hepatitis C therapy in Aboriginal Canadians. Can J Gastroenterol J Can Gastroenterol. 2008, 22: 677-680.

    Article  Google Scholar 

  5. 5.

    Buxton JA, et al: HCV co-infection in HIV positive population in British Columbia, Canada. BMC Publ Health. 2010, 10: 225-225. 10.1186/1471-2458-10-225.

    Article  Google Scholar 

  6. 6.

    Miller CL, et al: HIV and hepatitis C outbreaks among high-risk youth in Vancouver demands a public health response. Can J Public Health. 2005, 96: 107-108.

    PubMed  Google Scholar 

  7. 7.

    Fischer B, Haydon E, Rehm J, Krajden M, Reimer J: Injection drug use and the hepatitis C virus: considerations for a targeted treatment approach--the case study of Canada. J Urban Health Bull N Y Acad Med. 2004, 81: 428-447. 10.1093/jurban/jth128.

    Article  Google Scholar 

  8. 8.

    Public Health Agency of Canada: Epi-Update: Hepatitis C virus (HCV) among Aboriginal people surveyed by three national enhanced surveillance systems in Canada. 2010, Ottawa: Centre for Communicable Disease and Infection Control

    Google Scholar 

  9. 9.

    Miller CL, et al: Opportunities for prevention: Hepatitis C prevalence and incidence in a cohort of young injection drug users. Hepatology. 2002, 36: 737-742. 10.1053/jhep.2002.35065.

    Article  PubMed  Google Scholar 

  10. 10.

    Roy E, Boudreau J-F, Boivin J-F: Hepatitis C virus incidence among young street-involved IDUs in relation to injection experience. Drug Alcohol Depend. 2009, 102: 158-161. 10.1016/j.drugalcdep.2009.01.006.

    Article  PubMed  Google Scholar 

  11. 11.

    Miller CL, et al: The Cedar Project: risk factors for transition to injection drug use among young, urban Aboriginal people. Can Med Assoc J. 2011, 183: 1147-1154. 10.1503/cmaj.101257.

    Article  Google Scholar 

  12. 12.

    Roy E, Boudreau JF, Leclerc P, Boivin JF, Godin G: Trends in injection drug use behaviours over 10 years among street youth. Drug Alcohol Depend. 2007, 89: 170-175. 10.1016/j.drugalcdep.2006.12.025.

    Article  PubMed  Google Scholar 

  13. 13.

    Spittal PM, et al: The Cedar Project: Prevalence and Correlates of HIV Infection among Young Aboriginal People who use Drugs in Two Canadian Cities. Int J Circumpolar Health. 2007, 66: 225-240.

    Article  Google Scholar 

  14. 14.

    Patrick DM, et al: Incidence of hepatitis C virus infection among injection drug users during an outbreak of HIV infection. Can Med Assoc J. 2001, 165: 889-895.

    CAS  Google Scholar 

  15. 15.

    Clatts MC, Colón-López V, Giang LM, Goldsamt LA: Prevalence and incidence of HCV infection among Vietnam heroin users with recent onset of injection. J Urban Health Bull N Y Acad Med. 2010, 87: 278-291. 10.1007/s11524-009-9417-9.

    Article  Google Scholar 

  16. 16.

    Maher L, et al: Incidence and risk factors for hepatitis C seroconversion in injecting drug users in Australia. Addiction. 2006, 101: 1499-1508. 10.1111/j.1360-0443.2006.01543.x.

    Article  PubMed  Google Scholar 

  17. 17.

    Tyndall MW, et al: Intensive injection cocaine use as the primary risk factor in the Vancouver HIV-1 epidemic. AIDS (London, England). 2003, 17: 887-893. 10.1097/00002030-200304110-00014.

    Article  Google Scholar 

  18. 18.

    Craib K, Spittal PM, Patel SH, Christian WM, Moniruzzaman A, Pearce ME, Pearce ME, Demerais L, Sherlock C, Schechter M, For the Cedar Project Partnership: Prevalence and incidence of hepatitis C virus infection among Aboriginal young people who use drugs: results from the Cedar Project. Open Med. 2009, 3: 220-227.

    Google Scholar 

  19. 19.

    Browne AJ: Discourses influencing nurses' perceptions of First Nations patients. Can J Nur Res Rev Can Rech Sci Infirmieres. 2005, 37: 62-87.

    Google Scholar 

  20. 20.

    Tousignant M, Sioui N: Resilience and Aboriginal Communities in Crisis: Theory and Interventions. J Aboriginal Health. 2009, November: 43-61.

    Google Scholar 

  21. 21.

    Mateu-Gelabert P, et al: How can hepatitis C be prevented in the long term?. Int J Drug Policy. 2007, 18: 338-340. 10.1016/j.drugpo.2007.06.001.

    Article  PubMed  PubMed Central  Google Scholar 

  22. 22.

    Mehrabadi A, Craib KJ, Patterson K, Adam W, Moniruzzaman A, Ward-Burkitt B, Schechter MT, Spittal PM, for the Cedar Project Partnership: The Cedar Project: a comparison of HIV-related vulnerabilities amongst young Aboriginal women surviving drug use and sex work in two Canadian cities. Int J Drug Policy. 2008, 19: 159-168. 10.1016/j.drugpo.2007.07.005.

    Article  PubMed  Google Scholar 

  23. 23.

    Spittal PM, et al: Surviving the sex trade: a comparison of HIV risk behaviours among street-involved women in two Canadian cities who inject drugs. AIDS Care. 2003, 15: 187-195. 10.1080/0954012031000068335.

    CAS  Article  PubMed  Google Scholar 

  24. 24.

    Shannon K, et al: Survival sex work involvement as a primary risk factor for hepatitis C virus acquisition in drug-using youths in a canadian setting. Arch Pediatr Adolesc Med. 2010, 164: 61-65. 10.1001/archpediatrics.2009.241.

    Article  PubMed  PubMed Central  Google Scholar 

  25. 25.

    Romero-Daza N, Weeks M, Singer M: "Nobody gives a damn if I live or die": violence, drugs, and street-level prostitution in inner-city Hartford, Connecticut. Med Anthropol. 2003, 22: 233-259. 10.1080/01459740306770.

    Article  PubMed  Google Scholar 

  26. 26.

    Evans-Campbell T, Lindhorst T, Huang B, Walters KL: Interpersonal violence in the lives of urban American Indian and Alaska Native women: implications for health, mental health, and help-seeking. Am J Public Health. 2006, 96: 1416-1422. 10.2105/AJPH.2004.054213.

    Article  PubMed  PubMed Central  Google Scholar 

  27. 27.

    Doherty MC, Garfein RS, Monterroso E, Brown D, Vlahov D: Correlates of HIV infection among young adult short-term injection drug users. AIDS (London, England). 2000, 14: 717-726. 10.1097/00002030-200004140-00011.

    CAS  Article  Google Scholar 

  28. 28.

    Miller CL, et al: Females experiencing sexual and drug vulnerabilities are at elevated risk for HIV infection among youth who use injection drugs. J Acquir Immune Defic Syndr. 2002, 30: 335-341.

    Article  PubMed  Google Scholar 

  29. 29.

    Canada (Attorney General): Canada (Attorney General) v. PHS Community Services Society. 2011, Ottawa: Supreme Court of Canada

    Google Scholar 

  30. 30.

    Makin K, Dhillon S, Perez I: Supreme Court ruling opens doors to drug injection clinics across Canada. 2011, Ottawa: The Globe & Mail

    Google Scholar 

  31. 31.

    Moniruzzaman A, Patel SH, Miller C, Bingham B, Spittal PM: The Cedar Project: Factors associated with using Vancouver’s Safe Injection Site among young Aboriginal people who use injection drugs. 2010, Toronto: Canadian Public Health Association Annual Conference, Oral presentation

    Google Scholar 

  32. 32.

    Browne AJ: Clinical Encounters Between Nurses and First Nations Women in A Western Canadian Hospital. Soc Sci Med. 2007, 64: 2167-2176.

    Article  Google Scholar 

  33. 33.

    Dell CA, Lyons T: Harm Reduction Policies and Programs for Persons of Aboriginal Descent. 2007, Ottawa, Ontario: Canadian Centre on Substance Abuse

    Google Scholar 

  34. 34.

    Harris R, et al: Effects of self-reported racial discrimination and deprivation on Māori health and inequalities in New Zealand: cross-sectional study. Lancet. 2006, 367: 2005-2009. 10.1016/s0140-6736(06)68890-9.

    Article  PubMed  Google Scholar 

  35. 35.

    Smye V, Browne AJ: 'Cultural safety' and the analysis of health policy affecting aboriginal people. Nurs Res. 2002, 9: 42-56.

    Google Scholar 

  36. 36.

    Iverson J, Wand H, Gonnermann A, Maher L: Gender differences in hepatitis C antibody prevalence and risk behaviours amongst people who inject drugs in Australia 1998–2008. Int J Drug Policy. 2010, 21: 471-476. 10.1016/j.drugpo.2010.04.004.

    Article  Google Scholar 

Pre-publication history

  1. The pre-publication history for this paper can be accessed here:

Download references


We are indebted to the study participants for their continued participation in the Cedar Project. Special thanks to the Cedar Project Partnership; the Prince George Native Friendship Centre, Carrier Sekani Family Services, Healing Our Spirit, Positive Living North, The Red Road Aboriginal HIV/AIDS Network, Central Interior Native Health, Vancouver Native Health Society, Splatsin Secwepemc Nation, Neskonlith Indian Band, and Adams Lake Indian Band for their conviction and for holding us accountable to the voices of Aboriginal young people. Our study staff, Vicki Thomas, Sharon Springer, Amanda Wood, Randy Dodginghorse, Janene Erickson, Matt Quenneville, and Nancy Laliberte must be thanked for their continued conviction and contributions.

Author information



Corresponding author

Correspondence to Patricia M Spittal.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

PMS wrote the initial draft of the manuscript was responsible for interpretation of the findings. MEP revised subsequent drafts of the manuscript and contributed to the statistical interpretation of the findings. AKM conducted the statistical analyses and helped draft the manuscript. NC, MT, WMC and MTS were responsible for the interpretation of the findings and revisions to the manuscript. All authors read and approved the final version of this manuscript.

Authors’ original submitted files for images

Below are the links to the authors’ original submitted files for images.

Authors’ original file for figure 1

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Spittal, P.M., Pearce, M.E., Chavoshi, N. et al. The Cedar Project: high incidence of HCV infections in a longitudinal study of young Aboriginal people who use drugs in two Canadian cities. BMC Public Health 12, 632 (2012).

Download citation


  • Cocaine
  • Injection Drug
  • Aboriginal People
  • Harm Reduction
  • Adjust Hazard Ratio