The combined effect of smoking tobacco and drinking alcohol on cause-specific mortality: a 30 year cohort study

Numerous studies have shown the serious adverse effects of lifelong tobacco smoking, with countless more showing increased mortality rates from chronic heavy drinking. Regular light drinking appears to have little effect on overall mortality and may be protective against coronary heart disease[1]. In reality, many people both drink and smoke[2]. The neurochemical mechanisms of action of nicotine and alcohol appear to be mutually reinforcing[3]. Drinking and smoking together is strongly socially patterned[4], being normative behaviour in pubs, bars and clubs worldwide until the recent introduction in some countries of smoking restrictions in public places[5]. Despite this, few studies have examined the combined effects of smoking and drinking on mortality[6–9]. In this paper, we studied cause specific mortality in 5771 men whose reported smoking and drinking behaviours were recorded at initial screening and who have been followed up for 30 years.

The Collaborative study was conducted between 1970 and 1973 on 6022 employed men and 1006 employed women from a variety of 27 factories and other workplaces in Scotland[10]. The response rate was 70% for the workplaces for which response rates were available (87% of the sample). The participants completed a questionnaire and attended a clinic for a physical examination. On the questionnaire, participants reported their occupation and also their father's occupation, from which social class and father's social class, according to the contemporaneous Classification of Occupations, were obtained[11]. They reported the number of siblings[12], age finishing whole-time education and whether the participant was a regular car driver. Postcode of residence was used to obtain the Carstairs deprivation category, based on four census variables[13]. The categories range from 1 (most affluent) to 7 (most deprived). Bronchitis was derived from the MRC questionnaire[14] and angina from the Rose angina questionnaire[15]. Smoking habit was classified as never smoker, ex-smoker or current smoker. Pipe or cigar smokers only were included with the current smokers. Ex-smokers had given up smoking for at least a year, otherwise they were classified as current smokers. This was defined by the study team in 1970 and is used in this paper for stability or comparison purposes. Current and ex-smokers also reported number of cigarettes smoked per day (with ex-smokers reporting the daily amount smoked for as long as a year), whether they inhaled, at what age they started smoking and ex-smokers reported their age when they gave up smoking. Years of smoking were calculated to date of screening. Participants reported the quantity of spirits, beer and wine usually consumed per week. The answers were converted to units of alcohol assuming a measure of spirit to be one unit, a pint of beer to be two units and a bottle of wine to be six units, the appropriate conversions at the time[16]. Alcohol consumption was classified as none, 1-14 units per week and 15 or more units per week. Participants were allocated to one of nine groups, depending on both their alcohol consumption (none, 1-14 units/week, 15+ units/week) and smoking habit (never, ex, current).

At the screening examination, blood pressure was recorded, height and weight were measured, enabling body mass index (BMI) to be calculated in kg/m², an electrocardiogram was taken and plasma cholesterol and forced expiratory volume in one second (FEV1) were measured[10]. Ischaemia on electrocardiogram was defined as any of Minnesota codes 1.1-1.3, 4.1-4.4, 5.1-5.3 and 7[17]. Percent predicted FEV1 was defined as the actual FEV1 as a percentage of the expected FEV1. The expected FEV1 was obtained from linear regressions of age and height, derived from a healthy subset of the population [18].

The current study used men aged between 35 and 64 years at screening. There were 243 men outside this age range. Women were not included due to lack of events and small numbers of women. There were 6 men who were lost to follow-up and were excluded from the study. Smoking data were missing for two men. The analyses were thus conducted on 5771 men with complete data. The 42 men who had embarked were included in analyses to the date of their embarkation.

Cox proportional hazards models were used to obtain relative rates of mortality by smoking and alcohol consumption category, with the proportionality assumption being tested by inspection of Schoenfeld residuals. Never smokers who reported drinking no alcohol were taken as the reference group. The models were adjusted firstly for age, and then for other risk factors. For the risk factor adjustment, the small numbers of missing values of cholesterol (40), BMI (1), percent predicted FEV1 (5) and father's social class (112) were imputed using the means for continuous variables or modes for categorical variables. Adjustment was not made for blood pressure levels, due to strong evidence that alcohol intake increases blood pressure and therefore that such adjustment would be for a variable in the causal pathway between alcohol intake and mortality[19]. Interactions by smoking category and alcohol category were tested using likelihood ratio tests. Means and percentages of risk factors were standardised by 5 year age groups. Stata release 10 was used. At the time of the study, ethical permissions were not required.

Table 4 and Figure 1 show the percentages of men in manual and non-manual social classes who were in each smoking and drinking category. They show that men in manual social classes were much more likely to be smokers and heavy drinkers and less likely to be non-smokers who drank moderately or not at all.

	Smoking status
Drinking status	Never	Ex	Current
None
Manual	170 (6%)	181 (6.4%)	415 (14.6%)
Non manual	319 (11%)	290 (10%)	457 (15.7%)
1-14 units/week
Manual	129 (4.5%)	196 (6.9%)	593 (20.8%)
Non manual	232 (8%)	347 (11.9%)	675 (23.2%)
15+ units/week
Manual	108 (3.8%)	213 (7.5%)	845 (29.6%)
Non manual	56 (1.9%)	167 (5.7%)	367 (12.6%)

The mortality analyses were repeated using 4597 men who were current or ex-smokers who had complete data on details of their smoking habit. The relative rates were additionally adjusted for the number of cigarettes smoked per day, whether inhaled or not, the age started smoking and the years smoked to screening. These extra adjustments had only a small effect (Additional file 1: Table S4 and S5).

Smoking and drinking 15+ units/week was the riskiest behaviour for all the causes of death considered in this study. Men in this category smoked more cigarettes/day than current smokers in the other drinking categories, suggesting that excess drinking and heavy smoking occur together, and the extra number of cigarettes/day may be contributing to the excess mortality. Smoking had stronger effects than alcohol for most of the causes investigated. Current smokers had consistently high mortality rates. Ex-smokers had lower mortality than current smokers, showing the beneficial effects of smoking cessation, but they had higher mortality than never smokers, especially due to respiratory disease and smoking-related cancer. This demonstrates the long-lasting effects of smoking, even after stopping. We have previously shown that consuming 15 units or more per week of alcohol was associated with increased mortality from several causes[20]. We now show that both smoking and drinking 15 or more units/week increased mortality from some of the above causes and also smoking-related cancer. For the specific causes, there was a protective effect of alcohol seen in CHD mortality, particularly for never smokers, but for stroke mortality, both smoking and alcohol were important. Adjusting for a wide range of confounders attenuated the relative rates but the effects of alcohol and smoking still remained. There could also have been residual confounding due to unmeasured variables such as diet. The interaction terms were not found to be significant: this could have been due to lack of power rather than to no effect. The numbers of deaths from stroke, alcohol-related and respiratory causes were small for never smokers, and may have had insufficient power to detect associations in this cohort.

Lower socioeconomic position and low educational attainment were strongly related to both alcohol consumption and smoking in this cohort. For example, 30% of the manual men were both smokers and heavy drinkers compared with only 13% of the non-manual men. On the other hand, only 11% of the manual men were never smokers who drank less than 15 units per week or not at all, compared with 19% of the non-manual men. Given the increased mortality rates associated with both smoking and heavy drinking, this will inevitably contribute to socioeconomic health inequalities. We also recently showed that in this cohort a combination of heavy drinking and obesity had a supra-additive impact on mortality from liver disease[21], further underlining the consequences of multiple risk factors and their potential effect on health inequalities if they are socially patterned. A study of 16,980 men and women in the Netherlands in 1991-8 showed much lower prevalences of smoking and excessive alcohol consumption but similar socioeconomic differences[22]. Smoking and excessive alcohol consumption ranged from 3.5% in the highest educated men and women to 6.1% in the lowest. In a study of 22,457 middle-aged men and women from Norfolk, United Kingdom in 1993-7, there were more current smokers in lower social classes but the proportion drinking 14 or more units of alcohol per week was greater in higher social classes, unlike the current study[23]. A study of tobacco and hazardous or harmful alcohol use in 39,290 participants from Thailand in 2004 found the strongest predictor of harmful or hazardous alcohol consumption was smoking and the strongest predictor of smoking was harmful or hazardous alcohol use in both men and women[24]. That study found no relationship between both smoking and excess alcohol consumption with education, but suggested that men in middle income groups were more likely to both smoke and use excess alcohol. The message here seems to be that social patterning of drinking and smoking is culturally specific. Other than recognising the adverse consequences of combining both, their social patterning cannot be generalised from one country or even one region to another.

There have been other studies of the effects of smoking and alcohol consumption on mortality, but they did not have such a long follow-up as in the current study, nor were they able to investigate the effects on as many different causes of death.

Our results for all cause mortality were similar to those from a large study of 18,244 middle-aged Chinese men, screened in1986-9, although the follow-up time was only 6.7 years on average and smoking and alcohol definitions were different[6]. Within each drinking category, risk of death was higher for smokers and increased with amount smoked. Within each smoking category, there was a suggestion that drinkers of 1-28 drinks/week had a lower risk of death than non-drinkers or heavy drinkers. The highest risk was seen in the heaviest drinkers who also smoked. A 1986 study of 30,518 women aged 55-69 in the United States, with 14 years of follow-up analysed the relationship between alcohol and mortality and cancer incidence by each smoking category separately[7]. Alcohol consumption was inversely associated with all cause and CHD mortality for never and ex-smokers, and was positively associated with cancer incidence for current and ex-smokers. There were no clear associations with cancer mortality. Attention was drawn to the lack of a protective effect of alcohol on CHD mortality in smokers: this was also observed in the current study. A study of 64,515 Chinese men aged from 30 to 89 screened between 1996 and 2000, with an average of 4.6 years of follow-up related alcohol and smoking to mortality in a similar way to the current study[8]. The highest all cause mortality was seen in the heavy drinkers and heavy smokers. There was a protective effect of moderate drinking for all cause and cardiovascular disease (CVD) mortality which was stronger in non-smokers than ever smokers. Heavy drinking was associated with increased cancer mortality and there was no protective effect seen in moderate drinking for cancer mortality, even in the non-smokers.

Other studies have looked at incidence of disease rather than mortality. In a study of stroke incidence in 1991-2 of 45,449 Swedish women aged 30-50, with an average of 11 years of follow-up, current smokers who did not drink alcohol had a four-fold increased risk of stroke compared with never smokers who did not drink[9]. Current smokers who did drink alcohol had lower relative risks than current smokers who did not drink alcohol; however, the numbers of women and cases of stroke were low in the higher alcohol category (≥ 70 g/week) in that study (3,793 women with 17 stroke cases), raising the possibility that an adverse effect of heavy drinking could have been missed. There was some evidence of a protective effect of moderate drinking in never smokers. No such protective effect of alcohol was seen with stroke mortality in the current study, but this could be because they were older, were men and stroke mortality rather than incidence was being investigated. A pooled analysis found positive relationships between alcohol and lung cancer among non-smoking men only although the absolute risk of lung cancer was small in that group[25]. There were no relationships seen for smokers, former smokers or non-smoking women. In a large study of women in 1996-2001, increasing alcohol intake was strongly associated with the incidence of upper aerodigestive tract cancers in current smokers, but not in never or former smokers[26].

The current study showed that alcohol and smoking both contribute to mortality risk. However this may not necessarily be the case for all causes. A large study of UK women in 1996-2001 showed that alcohol consumption reduced, but smoking increased the risk of gallbladder disease death or hospital admission[27]. That study also showed large effects of both smoking and alcohol on death or hospital admission for cirrhosis[27].

Smoking and drinking 15+ units/week was the riskiest behaviour for all causes of death.

CH was supported for this study by NHS Health Scotland. The funding body had no role in the study design; in the collection, analysis and interpretation of data; writing of the manuscript; or the decision to submit the manuscript for publication.