World Health Orgaization (2021).Cardiovascular Diseases [https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)]
Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, et al. Heart disease and stroke statistics-2020 Update: a report from the American Heart Association. Circulation. 2020;141(9):e139–596.
Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–81.
Andersson C, Vasan RS. Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol. 2018;15(4):230–40.
Kristensen PL, Wedderkopp N, Møller NC, Andersen LB, Bai CN, Froberg K. Tracking and prevalence of cardiovascular disease risk factors across socio-economic classes: A longitudinal substudy of the European Youth Heart Study. BMC Public Health. 2006;6:20.
Patterson KAE, Ferrar K, Gall SL, Venn AJ, Blizzard L, Dwyer T, Cleland VJ. Cluster patterns of behavioural risk factors among children: Longitudinal associations with adult cardio-metabolic risk factors. Prev Med. 2020;130:105861.
Webber LS, Srinivasan SR, Wattigney WA, Berenson GS. Tracking of serum lipids and lipoproteins from childhood to adulthood The Bogalusa Heart Study. Am J Epidemiol. 1991;133(9):884–99.
Rademacher ER, Jacobs DR, Moran A, Steinberger J, Prineas RJ, Sinaiko A. Relation of Blood Pressure and Body Mass Index During Childhood to Cardiovascular Risk Factor Levels in Young Adults. J Hypertens. 2009;27(9):1766–74.
Wilson PW: Overview of established risk factors for cardiovascular disease. UpToDate Updated. 2018;13.
Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third national health and nutrition examination survey, 1988–1994. Arch Pediatr Adolesc Med. 2003;157(8):821–7.
Ruiz JR, Castro-Piñero J, Artero EG, Ortega FB, Sjöström M, Suni J, Castillo MJ. Predictive validity of health-related fitness in youth: a systematic review. Br J Sports Med. 2009;43(12):909–23.
Andersson C, Nayor M, Tsao CW, Levy D, Vasan RS. Framingham Heart Study: JACC Focus Seminar, 1/8. J Am Coll Cardiol. 2021;77(21):2680–92.
Ruiz JR, Huybrechts I, Cuenca-García M, Artero EG, Labayen I, Meirhaeghe A, Vicente-Rodriguez G, Polito A, Manios Y, González-Gross M, et al. Cardiorespiratory fitness and ideal cardiovascular health in European adolescents. Heart. 2015;101(10):766–73.
Adegboye AR, Anderssen SA, Froberg K, Sardinha LB, Heitmann BL, Steene-Johannessen J, Kolle E, Andersen LB. Recommended aerobic fitness level for metabolic health in children and adolescents: a study of diagnostic accuracy. Br J Sports Med. 2011;45(9):722–8.
Lobelo F, Pate RR, Dowda M, Liese AD, Ruiz JR. Validity of Cardiorespiratory Fitness Criterion-Referenced Standards for Adolescents. Med Sci Sports Exerc. 2009;41(6):1222–9.
Ruiz JR, Ortega FB, Rizzo NS, Villa I, Hurtig-Wennlöf A, Oja L, Sjöström M. High cardiovascular fitness is associated with low metabolic risk score in children: the European youth heart study. Pediatr Res. 2007;61(3):350–5.
Moreira C, Santos R, Ruiz JR, Vale S, Soares-Miranda L, Marques AI, Mota J. Comparison of different VO2max equations in the ability to discriminate the metabolic risk in Portuguese adolescents. J Sci Med Sport. 2011;14(1):79–84.
Cox HC, Bellis C, Lea RA, Quinlan S, Hughes R, Dyer T, Charlesworth J, Blangero J, Griffiths LR. Principal component and linkage analysis of cardiovascular risk traits in the Norfolk isolate. Hum Hered. 2009;68(1):55–64.
Stavnsbo M, Resaland GK, Anderssen SA, Steene-Johannessen J, Domazet SL, Skrede T, Sardinha LB, Kriemler S, Ekelund U, Andersen LB, et al. Reference values for cardiometabolic risk scores in children and adolescents: Suggesting a common standard. Atherosclerosis. 2018;278:299–306.
Carlson JJ, Eisenmann JC, Pfeiffer KA, Jager KB, Sehnert ST, Yee KE, Klavinski RA, Feltz DL. (S)Partners for Heart Health: a school-based program for enhancing physical activity and nutrition to promote cardiovascular health in 5thgrade students. BMC Public Health. 2008;8(1):420.
Humphreys LG, Montanelli RG Jr. An investigation of the parallel analysis criterion for determining the number of common factors. Multivar Behav Res. 1975;10(2):193–205.
Revelle WR. psych: Procedures for Personality and Psychological Research. 2017.
Meigs JB, D’Agostino RB, Wilson PW, Cupples LA, Nathan DM, Singer DE. Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study. Diabetes. 1997;46(10):1594–600.
Zanolin ME, Tosi F, Zoppini G, Castello R, Spiazzi G, Dorizzi R, Muggeo M, Moghetti P. Clustering of cardiovascular risk factors associated with the insulin resistance syndrome: assessment by principal component analysis in young hyperandrogenic women. Diabetes Care. 2006;29(2):372–8.
de Quadros TMB, Gordia AP, Silva LR. Anthropometry and clustered cardiometabolic risk factors in young people: a systematic review. Rev Paul Pediatr. 2017;35(3):340–50.
Petkeviciene J, Klumbiene J, Kriaucioniene V, Raskiliene A, Sakyte E, Ceponiene I. Anthropometric measurements in childhood and prediction of cardiovascular risk factors in adulthood: Kaunas cardiovascular risk cohort study. BMC Public Health. 2015;15(1):218.
Schwarz PEH, Li J, Lindstrom J, Tuomilehto J. Tools for predicting the risk of type 2 diabetes in daily practice. Horm Metab Res. 2009;41(2):86–97.
Hardin DS. Screening for type 2 diabetes in children with acanthosis nigricans. Diabetes Educ. 2006;32(4):547–52.
Jones LH, Ficca M. Is acanthosis nigricans a reliable indicator for risk of type 2 diabetes? J Sch Nurs. 2007;23(5):247–51.
Rendon MI, Cruz PD, Sontheimer RD, Bergstresser PR. Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin. J Am Acad Dermatol. 1989;21(3):461–9.
Stuart CA, Pate CJ, Peters EJ. Prevalence of acanthosis nigricans in an unselected population. Am J Med. 1989;87(3):269–72.
Maguolo A, Maffeis C. Acanthosis nigricans in childhood: A cutaneous marker that should not be underestimated, especially in obese children. Acta Paediatr. 2020;109(3):481–7.
National Heart L, Institute aB. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents - Full report. 2012.
Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 1998;338(23):1650–6.
Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977;62(5):707–14.
Mahdy Ali K, Wonnerth A, Huber K, Wojta J. Cardiovascular disease risk reduction by raising Hdl cholesterol-current therapies and future opportunities. Br J Pharmacol. 2012;167(6):1177–94.
Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, Wood AM, Lewington S, Sattar N, Packard CJ, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302(18):1993–2000.
Assmann G, Schulte H, Funke H, von Eckardstein A. The Emergence of Triglycerides as a Significant Independent Risk Factor in Coronary Artery Disease. Eur Heart J. 1998;19 Suppl M:M8-14.
Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk. 1996;3(2):213–9.
Abdel-Maksoud M, Sazonov V, Gutkin SW, Hokanson JE. Effects of Modifying Triglycerides and Triglyceride-rich Lipoproteins on Cardiovascular Outcomes. J Cardiovasc Pharmacol. 2008;51(4):331–51.
Ja M, Cj G, Ps H, S Y, P W. Pediatric triglycerides predict cardiovascular disease events in the fourth to fifth decade of life. Metabolism: clinical and experimental 2009.
Andersen LB, Wedderkopp N, Hansen HS, Cooper AR, Froberg K. Biological cardiovascular risk factors cluster in Danish children and adolescents: the European Youth Heart Study. Prev Med. 2003;37(4):363–7.
Castro-Piñero J, Perez-Bey A, Segura-Jiménez V, Aparicio VA, Gómez-Martínez S, Izquierdo-Gomez R, Marcos A, Ruiz JR, Up, Group DS. Cardiorespiratory fitness cutoff points for early detection of present and future cardiovascular risk in children: a 2-year follow-up study. Mayo Clin Proc. 2017;92(12):1753–62.
Ruiz JR, Cavero-Redondo I, Ortega FB, Welk GJ, Andersen LB, Martinez-Vizcaino V. Cardiorespiratory fitness cut points to avoid cardiovascular disease risk in children and adolescents; what level of fitness should raise a red flag? A systematic review and meta-analysis. Br J Sport Med. 2016;50:1451–8.
Kvaavik E, Klepp K-I, Tell GS, Meyer HE, Batty GD. Physical fitness and physical activity at age 13 years as predictors of cardiovascular disease risk factors at ages 15, 25, 33, and 40 years: extended follow-up of the Oslo Youth Study. Pediatrics. 2009;123(1):e80-86.
Pileggi C, Carbone V, Nobile CGA, Pavia M. Blood pressure and related cardiovascular disease risk factors in 6–18 year-old students in Italy. J Paediatr Child Health. 2005;41(7):347–52.
Magnussen CG, Smith KJ. Pediatric blood pressure and adult preclinical markers of cardiovascular disease. Clin Med Insights Blood Disord. 2016;9:1–8.