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Outcomes of a community-led online-based HIV self-testing demonstration among cisgender men who have sex with men and transgender women in the Philippines during the COVID-19 pandemic: a retrospective cohort study

Abstract

Introduction

The Philippines, which has the fastest rising HIV epidemic globally, has limited options for HIV testing and its uptake remains low among cisgender men who have sex with men (cis-MSM) and transgender women (TGW), especially amid the COVID-19 pandemic. As HIV self-testing (HIVST) and technology-based approaches could synergize to expand uptake of HIV testing, we aimed to evaluate the outcomes of a community-led online-based HIVST demonstration and to explore factors associated with HIVST-related behaviours and outcomes.

Methods

We did a secondary data analysis among cis-MSM and TGW who participated in the HIVST demonstration, who were recruited online and tested out-of-facility, in Western Visayas, Philippines, from March to November 2020. We reviewed data on demographics, sexuality-, and context-related variables. Using multivariable logistic regression, we tested for associations between the aforementioned covariates and two primary outcomes, opting for directly-assisted HIVST (DAH) and willingness to secondarily distribute kits.

Results

HIVST kits were distributed to 647 individuals (590 cis-MSM, 57 TGW), 54.6% were first-time testers, 10.4% opted DAH, and 46.1% were willing to distribute to peers. Reporting rate was high (99.3%) with 7.6% reactivity rate. While linkage to prevention (100%) and care (85.7%) were high, pre-exposure prophylaxis (PrEP) (0.3%) and antiretroviral therapy (ART) (51.0%) initiation were limited. There were no reports of adverse events. Those who were employed, had recent anal intercourse, opted for DAH, not willing to secondarily distribute, and accessed HIVST during minimal to no quarantine restriction had significantly higher reactivity rates. Likelihood of opting for DAH was higher among those who had three or more partners in the past year (aOR = 2.01 [CI = 1.01–4.35]) and those who accessed during maximal quarantine restrictions (aOR = 4.25 [CI = 2.46–7.43]). Odds of willingness to share were higher among those in urban areas (aOR = 1.64 [CI = 1.15–2.36]) but lower among first-time testers (aOR = 0.45 [CI = 0.32–0.62]).

Conclusions

HIVST could effectively reach hard-to-reach populations. While there was demand in accessing online-based unassisted approaches, DAH should still be offered. Uptake of PrEP and same-day ART should be upscaled by decentralizing these services to community-based organizations. Differentiated service delivery is key to respond to preferences and values of key populations amid the dynamic geographical and sociocultural contexts they are in.

Peer Review reports

Introduction

The limited demand for HIV testing among the key populations (KP) has challenged the Philippines to reverse its HIV epidemic, where annual incidence of new infections and AIDS-related death increased by 237 and 315%, respectively, over the past decade [1]. Although estimated national prevalence is at 0.2%, the epidemic is concentrated among KP with prevalence disproportionately higher among people who inject drugs (PWID) (29.0%), cisgender men who have sex with men (cis-MSM) (5.0%), transgender women (TGW) (4.9%), and female sex workers (0.6%) [2]. Improvements in the first 95% of the UNAIDS 95–95-95 targets were noted in the recent years until the COVID-19 pandemic has decreased HIV tests done by 61% in 2020, ultimately leading to 68% of estimated people living with HIV (PLHIV) knowing their status in 2021 [a], similar to the proportion estimated 5 years ago [2].

The diagnosis gap is a known driver of the HIV epidemic [3]. The low uptake of HIV testing among cis-MSM and TGW has been attributed to meager options for testing in the Philippines [4, 5], limited currently to facility-based and community-based testing. The former is the more prevalent model [6] and involves using rapid diagnostic test (RDT) kits, available only in Department of Health (DOH)-accredited stand-alone laboratories, hospitals, and clinics, and is only facilitated by medical technologists specifically trained for HIV [7]. Whereas community-based testing is carried out by trained lay providers during community visits and outreach programs using RDT kits. To address the low uptake amid the limited choices, expanding options may be key to upscaling access and uptake of HIV testing. The World Health Organization (WHO) has recommended HIV self-testing (HIVST), which involves the use of RDT kits for individuals to perform and interpret on their own [8]. This may remove barriers in the current HIV testing in the Philippines, including geographical distance, lack of confidentiality or privacy, conflicting schedules, and stigma [4, 5, 9,10,11,12]. HIVST has been shown to be safe and effective at increasing uptake and frequency of HIV testing without compromising condom use, social safety, and enrollment to treatment [13]. In the Philippines, limited evidence shows acceptability and preference of blood-based over fluid-based tests among cis-MSM and TGW [14, 15].

An equally important approach is the use of technology-based interventions—this is the concurrent use of technology to expand reach, accelerate scale-up, and facilitate cost-efficient and instantaneous service delivery, responding to the inherent restrictions in face-to-face services [16]. Examples of these are online-based interventions, which if used with HIVST seem to synergistically remove barriers to HIV testing among cis-MSM especially among first-time testers [17, 18]. Even though the proportion of Filipinos accessing the internet (67.0%) and using social media (80.7%) are higher than the global average [19], this approach has not been maximized, yet has been increasingly used during the COVID-19 pandemic [20].

We aimed to describe the outcomes of a community-led online-based HIVST demonstration project done in Western Visayas, Philippines, particularly, in terms of reach, reporting and reactivity rates, and successful linkage to services. Furthermore, we aimed to explore the demographic, sexuality-, and context-related factors associated with HIVST-related behavior and preferences, particularly opting for DAH and willingness to share HIVST kits to their partners and peers.

Methods

Study design, setting, and participants

We did a multiple-center, retrospective cohort analysis of participants recruited in a community-led online-based HIVST demonstration in Western Visayas, Philippines, implemented from March to November 2020. The STROBE statement checklist of items was used to guide the development of this research [21].

Western Visayas is in the center of the Philippines and is composed of six provinces separated in three different islands. Its two highly urbanized cities (Bacolod City and Iloilo City) are HIV high burden areas [1]. HIVST was demonstrated in the region in 2020 by the DOH Western Visayas because, firstly, two thirds of new HIV cases in the Philippines are detected outside Metro Manila and the Western Visayas is among the areas with highest HIV incidence, contributing 6.2% of newly diagnosed cases in 2019 nationally [22], and secondly, almost one fourth of PLHIV in the region has not been diagnosed in 2019 [22].

The demonstration project was implemented by different CBOs led by the main study site, Family Planning Organization of the Philippines-Iloilo (FPOP-Iloilo)-Rajah Community Center. Both online and offline recruitment campaigns were conducted, using social media platforms and face-to-face invites in social and sexual networks, respectively. As the HIVST demonstration was only limited among individuals within the Western Visayas region, the campaigns were targeted among cis-MSM and TGW in the said region. These campaigns led interested individuals to an online sign-up sheet. All adults residing in the six provinces in Western Visayas who signed-up were eligible to receive the HIVST services from implementing CBOs which started to distribute INSTI® HIV Self-Test kits (BioLytical Laboratories, Richmond, British Columbia, Canada) in March 2020. While extreme lockdowns were implemented due to the unprecedented COVID-19 pandemic, the online-based nature of the program allowed continuity of provision of HIVST.

Using convenience sampling, we performed a secondary data analysis among people who opted and consented for the HIVST demonstration who fit the following inclusion criteria as follows: (1) self-identified as cis-MSM or TGW, (2) 18 years old and above, and (3) opted for online-based services. The following were excluded: (1) assigned female at birth, (2) assigned male at birth and identified as heterosexual, (3) opted for offline services, and (4) those who eventually disclosed that they were known PLHIV.

Procedures

When signing up online, the participants were provided with pre-test and programmatic information. Upon providing their electronically recorded consent, data on demographics, sexual risk and behavior, and HIV testing related behavior and preference were collected through self-reporting. Thereafter, the participants were reached by the implementers through phone calls to verify the intent and data they provided. Participants accessed the HIVST package, either through pick-up or courier, containing the HIVST kit itself, instructional materials (containing information on HIV, on how to use, interpret, and dispose of the kit, on accessing the support hotline, and linkage to appropriate HIV-related services), and condoms and lubricants. Participants were followed-up through phone calls within two days upon access to determine the outcomes, to provide post-test counseling and support on linking them to appropriate services. For validation purposes, the participants were asked to show the outcome of the HIVST kit by sending a photo or through a video call. In rare cases when the result was invalid (n = 4), they were offered retesting using their preferred strategy (DAH or unassisted) but with a different HIVST kit.

Those who tested reactive were referred directly to HIV treatment facilities and follow-up calls were conducted at two weeks, four weeks, and then every four weeks until ART initiation or twelve weeks, whichever came first, to determine self-reported linkage to the cascade of HIV care services. Those who neither responded to follow-ups nor reported their cascade outcomes within twelve weeks were tagged as lost to follow-up. Verification of the self-reported cascade outcomes were legislatively possible only if they were eventually enrolled in the main study site, FPOP-Iloilo. Meanwhile, those who tested non-reactive were routinely provided with risk reduction counseling and were offered to be enrolled in the HIV preexposure prophylaxis (PrEP) program of FPOP-Iloilo (the only provider in the region during the span of the study) as part of the post-test counseling. The project officers in each CBO were designated to collect all the data using a standardized data collection sheet.

We created a research dataset for the purposes of the secondary analysis from the deidentified dataset from the implementers, which included participants who fit the study inclusion and exclusion criteria. We cleaned the dataset and ensured that recoding would preserve the original data as much as possible. The following outcomes were included: (1) HIVST result (reactive or non-reactive), (2) whether they opted for directly assisted (DAH) (i.e., in-person demonstration and / or supervision by a provider) or unassisted HIVST [8], (3) whether they were willing to distribute the kits to their partners or peers (i.e., secondary distribution of HIVST kits) or not [8], (4) linkage to appropriate HIV services, i.e., enrollment to care (confirmatory testing and treatment) among those reactive and prevention services (risk reduction counseling, condoms and lubricants, and/or PrEP) among those non-reactive, and (5) reports of adverse events such as suicidal attempts, coercion, and social harm [8, 23, 24]. Included covariates were (1) demographics (age, gender identity, and employment), (2) sexuality-related variables including (a) anal sex within the past 3 months, (b) number of male partners for the past 12 months, (c) history of HIV testing, i.e., first-time tester or not [25], and (d) source of information regarding the HIVST program, and (3) context-related variables such as (a) time, measured in the date of access of the HIVST service, and (b) place of residence. These variables were determined a priori [25, 26]. Some quantitative variables were transformed into categories, particularly, (1) age, grouped into less than or equal to 24 or 25 and over, signifying the young KP group [8], (2) number of male sexual partners in the past 12 months, grouped based on the median number based on national biobehavioral surveillance [4]. Some qualitative variables were recoded: (1) the extent of quarantine restrictions into “None to minimal” or “Maximal”, based on the date and location of the individual participation, and (2) the place of residence classified into either urban or rural.

Statistical analysis

Descriptive statistics were done to summarize the predictors. We performed Chi-square and Fisher exact tests to compare baseline characteristics, stratified by reported HIV test result. To describe the outcomes of the HIVST demonstration, we determined the prevalence at each component of the testing cascade. Moreover, we performed multivariate logistic regression using complete case analyses and backward elimination to determine predictors associated with our outcomes of interest: (1) opting for DAH and (2) willingness to distribute. Predictors found to be statistically associated in the initial bivariate analyses using p < 0.25 were included in the final multivariate analyses. Chi-square tests were used to assess collinearity of potential predictors. We used c statistics and Hosmer-Lemeshow statistics to assess predictive power and model fit. We used p < 0.05 to determine significant outputs in Chi-square and Fisher exact tests and crude (cOR) and adjusted odds ratio (aOR). All analyses were performed using R version 4.0.3.

Ethical approval

The study adhered to the principles of the Declaration of Helsinki and the ethical approval (NEC Code: 2021–004) was provided by the National Ethics Commission of the Philippine Council on Health Research and Development, Department of Science and Technology, Republic of the Philippines.

Results

From March to November 2020, 768 HIVST kits were distributed (Fig. 1). Due to missing documentation, 33 participants were not assessed for eligibility. Among those assessed, 88 were excluded based on the inclusion and exclusion criteria. Eventually, 647 participants were included in the analysis.

Fig. 1
figure 1

Flow diagram of the retrospective cohort study. HIVST – HIV self-testing, PLHIV – people living with HIV

Median age of the participants was 26 (interquartile range 23–30) years. Majority self-identified as cis-MSM (91.2%), and most were employed (77.6%) and residing in an urban area (69.1%) (Table 1). Many (70.2%) had three or more sexual partners in the past 12 months and 51.8% had anal sexual intercourse in the past 3 months.

Table 1 Sociodemographic factors, sexual risk and behavior, and HIV testing-related behavior and preferences of the HIVST demonstration project participants, disaggregated into reported HIV testing result

Among those distributed with HIVST kits, more than half (54.6%) had never tested previously for HIV, most (89.6%) preferred unassisted HIVST, and almost half (46.1%) were willing to distribute kits to their sexual partners and peers. Furthermore, reporting rate of HIVST result was high at 99.3%.

Of the 643 who reported their HIVST outcomes, 49 (7.6%) tested reactive. The proportions of testing reactive were significantly higher among those employed (p = 0.023), who had anal intercourse in the past 3 months (p = 0.021), who opted for DAH (p = 0.018), not willing to distribute the HIVST kits (p < 0.000), and who accessed HIVST during none to minimal quarantine restrictions (p = 0.017) compared to their corresponding counterparts. There was no significant difference in the proportion of those tested reactive between first-time testers and those with a history of HIV testing (p = 0.743). Moreover, among those who tested reactive, 42 (85.7%) were eventually linked to care and 25 (51.0%) were initiated on ART during the study period (Table 2). Among those non-reactive, all 594 participants (100%) were provided prevention services through routine provision of risk reduction counseling and condoms and lubricants. Only 2 (0.3%) were successfully linked to PrEP services. Lastly, there were no reports of adverse events in the program.

Table 2 HIV self-testing demonstration study outcomes

Only a few (10.4%) opted for DAH (Table 3). The likelihood of opting for DAH was higher among those who had three or more partners in the past year (aOR = 2.01 [CI = 1.01–4.35], p = 0.049) and among those who accessed HIVST during maximal quarantine restrictions (aOR = 4.25 [CI = 2.46–7.43], p < 0.00).

Almost half (46.1%) were willing to distribute the HIVST kits to their partners and peers (Table 4). The likelihood of willingness to share was higher among those residing in urban (aOR = 1.64 [CI = 1.15–2.36], p = 0.007), whereas it was lower among first-time testers (aOR = 0.45 [CI = 0.32–0.62], p < 0.00).

Table 3 Predictors of opting directly assisted HIVST
Table 4 Predictors of willingness to distribute HIVST to sexual partners and peers

Discussion

We found that online-based HIVST reached many first-time testers among cis-MSM and TGW, similar with previous studies [27,28,29,30,31]. Reporting and linkage to care and prevention rates were high but ART and PrEP initiation were sub-optimal. Reactivity rate and HIVST preferences were associated with participants’ vulnerabilities and context.

It is striking that there seemed to be no difference in reactivity rate between first-time and ever testers, especially considering that in the Philippines all of those who come for HIV testing are routinely provided with risk reduction counselling [7, 32] which would be expected to decrease their risk for HIV. Our finding suggests that the aforementioned may have had marginal impact, as noted in other studies [33]. Nonetheless, HIV testing is a good avenue to educate KP regarding HIV and their risks. Hence, the DOH should not only consider reviewing its risk reduction counseling strategy but also advocate for and upscale all aspects of combination prevention [34], particularly pre- and post-exposure prophylaxis, condom use, and addressing stigma and discrimination, which have been determined as national priority interventions for HIV prevention [35].

Although only a minority in our cohort (10.4%) opted for DAH, the following findings have important implications for policy. Firstly, reactivity among those who opted for DAH was significantly higher compared to unassisted, similar with another study [36]. Moreover, we found that those with three or more sexual partners in the past year had twice higher odds of opting for DAH. There is evidence on the presence of anxiety related to the HIVST process, particularly linkage to care, and this translates to a desire for assistance among cis-MSM [14], TGW [14, 31], and other KP [37, 38]. Secondly, while it may be intuitive that testing for the first-time is associated with higher odds of DAH as seen in previous studies [14, 25, 39], it was the opposite in our bivariate model. Participants may have been enticed by the privacy, convenience, and independence that HIVST offers. Lastly, we found that stricter COVID-19-related quarantine restrictions were associated with higher likelihood of DAH. We could only speculate that the perceived limited access to healthcare services amid a time of public health crisis and uncertainty may have reinforced dependence on health providers and peers especially given that PLHIV and KP are at increased risk of vulnerability to both HIV and COVID and its physical, mental, and social comorbidities [40, 41]. Therefore, as DAH was associated with better retention [42] and higher ART initiation [43], even during the COVID-19 pandemic [44], implementation of HIVST in the Philippines should provide and expand options for direct assistance that go beyond in-person demonstration and also include emotional support [45]. This could involve capacitating community-based testing providers and “seeds” to provide demonstrations and peer support to their communities and networks [46, 47], respectively, and kits being delivered by trained providers themselves. Moreover, ensuring DAH may be crucial if the Philippines introduces oral fluid-based test, to address lack familiarity as Filipino KPs are more accustomed to blood-based tests.

Secondary distribution has been shown to increase the reach, positivity yield, and cost-efficiency of HIV testing among cis-MSM [26, 46, 48]. Like other studies which showed increased distribution [26, 49], we found that willingness to distribute was higher among those with prior HIV testing. This is reassuring as we also found that online-based HIVST can effectively reach to first-time testers, consistent with other studies [17, 18]. Hence, in the Philippines, where less than half (43%) of cis-MSM and TGW were ever tested for HIV [4], technology-based HIVST has the potential to increase the proportion of ever tested for HIV [17, 18] and, consequently, facilitate initial and repeat testing among their networks though secondary distribution [30, 50]. We also found that residing in urban areas was associated with increased odds of willingness to distribute. This may be due to the dense clustering of KP [51], higher access to queer culture [52] and HIV education [53], and higher acceptability of HIV interventions [51]. This is opportune as urban areas are priority sites for sustainable and effective HIV response [54]; as willingness was high, secondary distribution of HIVST kits could augment current HIV testing practices through approaches like index testing and sexual and social network testing [46, 47]. There is plenty of evidence that secondary distribution [55] and technology-assisted models [18, 55] play a role in increasing testing uptake among cis-MSM and TGW, whereas community-based models were found to be more effective among young people and male partners of females in antenatal clinics [55]. The knowledge gap on effective distribution models among other KPs, like PWID, people in prisons, and female sex workers, may be attributed to the disproportionately limited studies among these vulnerable groups. Hence, further studies are required to fully respond to their values and preferences on HIV testing.

Despite high rates of uptake, reporting, and referral to services, we found suboptimal initiation of antiretroviral interventions. Apart from the limitations brought by COVID-19, suboptimal initiation may be explained by the fact that only one in eleven CBOs in the demonstration was capable of prescribing ART or PrEP, similar to the experience in Thailand [43]. However, when treatment was also CBO-led, as in the HIVST demonstration in Vietnam, higher initiation rates was noted [56]. Furthermore, despite that rapid ART initiation has been recommended by the WHO since 2017, the current HIV treatment guidelines in the Philippines in 2018 did not mention this [b] and may explain the low ART initiation rate. Meanwhile, poor PrEP initiation may be explained by cost [57], especially that, unlike ART, PrEP is neither state-sponsored nor covered by health insurance in the Philippines. Overall, the benefits of online-based HIVST could not be maximized without concurrent innovations in treatment and prevention. Although a few treatment and PrEP facilities are CBOs or have partner CBOs in the Philippines, continuing the endeavor by the DOH to further decentralize HIV-related services to CBOs should be prioritized. Likewise, technology-supported interventions or seamless online-to-offline transition during ART or PrEP prescribing, linkage to care, and retention, should be considered and further studied. Lastly, local treatment guidelines should be revised to allow rapid ART initiation.

The primary strength of this study was the technology-based delivery of the demonstration project; this allowed numerous and precise data points to be used to explore associations. Furthermore, to our knowledge, this is the first association study to consider the potential influence of quarantine restrictions on HIV service delivery in the Philippines. Meanwhile, it is important to acknowledge some study limitations. Firstly, as this study is a secondary data analysis, we were bound to the limitations of the primary data collection such as high potential for information bias, as much of the data was collected through self-reporting which is particularly vulnerable to social desirability bias. However, verification was done whenever possible. Moreover, likewise with a previous study [58], the willingness to distribute HIVST kits were collected at baseline and, hence, may be influenced by the uncertainty of their HIV status. Secondly, the online-based convenience sampling may have led to self-selection bias. Generalizing the findings of our study must be done with caution. Lastly, there are limitations of in the use of stepwise backward elimination. Although it prevents overfitting and allow different combinations of variables [59,60,61,62], there is considerable variance when different samples are used [62] and there is potential for inappropriate variables to be included in the model [59, 60, 62]. We did, however, ensure that there were sufficient events per variable [60, 63] and that we explored a priori predictors, respectively. Thus, we are confident that the models predict the outcomes within the context of the study.

Conclusions

We have shown that a community-based online-based HIVST intervention is safe and has the potential to increase uptake of HIV testing and linkage to appropriate service among cis-MSM and TGW, yet initiation of ART and PrEP were low. The study emphasized the importance of providing different options for HIVST which suite their values and preferences of KP. Geographical, temporal, and sociocultural contexts are important considerations in ensuring differentiated services are provided.

Availability of data and materials

Due to ethical reasons, the dataset created and analyzed is not publicly available as it contains potentially sensitive information. For further inquiries, email may be sent to the corresponding author, Dr. Patrick C. Eustaquio via patrick@loveyourself.ph.

Abbreviations

AIDS:

Acquired immune deficiency syndrome

aOR:

Adjusted odds ratio

ART:

Antiretroviral therapy

CBO:

Community-based organization

CI:

Confidence interval

cis-MSM:

Cisgender men who have sex with men

cOR:

Crude odds ratio

COVID-19:

Coronavirus disease in 2019

DAH:

Directly-assisted HIV self-testing

DOH:

Department of Health

FPOP:

Family Planning Organization of the Philippines

HIV:

Human immunodeficiency virus

HIVST:

HIV self-testing

KP:

Key population

PLHIV:

People living with human immunodeficiency virus.

PrEP:

Pre-exposure prophylaxis

STROBE:

Strengthening the reporting of observational studies

TGW:

Transgender women

UNAIDS:

Joint United Nations Programme on HIV/AIDS

WHO:

World Health Organization

References

  1. Department of Health Epidemiology Bureau. A briefer on the Philippine HIV estimates 2020. Manila: Department of Health; 2021.

    Google Scholar 

  2. Joint United Nations Programme on HIV/AIDS. UNAIDS Data 2020. Geneva: UNAIDS; 2020.

    Google Scholar 

  3. Fisher M, Pao D, Brown AE, Sudarshi D, Gill ON, Cane P, et al. Determinants of HIV-1 transmission in men who have sex with men: a combined clinical, epidemiological and phylogenetic approach. AIDS. 2010;24(11):1739–47.

    PubMed  Google Scholar 

  4. Department of Health Epidemiology Bureau. 2018 integrated HIV Behavioral and serologic surveillance (IHBSS). Manila: Department of Health; 2020.

    Google Scholar 

  5. United Nations Development Programme. Missing in action - loss of clients from HIV testing, treat- ment, care and support services: case studies of gay men and other men who have sex with men in Manila missing in action. Bangkok: United Nations Development Programme; 2017.

    Google Scholar 

  6. Ross AG, Ditangco RA, Belimac JG, Olveda RM, Mercado ES, Chau TN, et al. The dire sexual health crisis among MSM in the Philippines: an exploding HIV epidemic in the absence of essential health services. Int J Infect Dis. 2015;37:6–8.

    PubMed  Google Scholar 

  7. Department of Health. Administrative order 2017–0019 policies and guidelines in the conduct of HIV testing Services in Health Facilities. Philippines: DOH; 2017.

    Google Scholar 

  8. World Health Organization. Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach. Geneva: World Health Organization; 2021.

    Google Scholar 

  9. Golub SA, Gamarel KE. The impact of anticipated HIV stigma on delays in HIV testing behaviors: findings from a community-based sample of men who have sex with men and transgender women in new York City. AIDS Patient Care STDS. 2013;27(11):621–7.

    PubMed  PubMed Central  Google Scholar 

  10. Rutstein SE, Ananworanich J, Fidler S, Johnson C, Sanders EJ, Sued O, et al. Clinical and public health implications of acute and early HIV detection and treatment: a scoping review. J Int AIDS Soc. 2017;20(1):21579.

    PubMed  PubMed Central  Google Scholar 

  11. Hatzold K, Gudukeya S, Mutseta MN, Chilongosi R, Nalubamba M, Nkhoma C, et al. HIV self-testing: breaking the barriers to uptake of testing among men and adolescents in sub-Saharan Africa, experiences from STAR demonstration projects in Malawi, Zambia and Zimbabwe. J Int AIDS Soc. 2019;22(Suppl 1):e25244.

    PubMed  PubMed Central  Google Scholar 

  12. Piamonte S. Behavioral, Normative, and Control Beliefs of Filipino Men Who Have Sex with Men on Repeat HIV Testing and Counseling. Acta Med Philipp. 2021.

  13. Witzel TC, Eshun-Wilson I, Jamil MS, Tilouche N, Figueroa C, Johnson CC, et al. Comparing the effects of HIV self-testing to standard HIV testing for key populations: a systematic review and meta-analysis. BMC Med. 2020;18(1):381.

    PubMed  PubMed Central  Google Scholar 

  14. Gohil J, Baja ES, Sy TR, Guevara EG, Hemingway C, Medina PMB, et al. Is the Philippines ready for HIV self-testing? BMC Public Health. 2020;20(1):34.

    PubMed  PubMed Central  Google Scholar 

  15. Pagtakhan R, Rosadiño J, Briñes M, Baja E. Community-led conversations on awareness and acceptability of HIV self-screening among men who have sex with men and transgender women in metropolitan Manila, Philippines. International AIDS Society Conference on HIV Science; 2019; Mexico City: International AIDS Society; 2019.

  16. Simoni JM, Kutner BA, Horvath KJ. Opportunities and challenges of digital technology for HIV treatment and prevention. Curr HIV/AIDS Rep. 2015;12(4):437–40.

    PubMed  PubMed Central  Google Scholar 

  17. LeGrand S, Muessig KE, Horvath KJ, Rosengren AL, Hightow-Weidman LB. Using technology to support HIV self-testing among MSM. Curr Opin HIV AIDS. 2017;12(5):425–31.

    PubMed  PubMed Central  Google Scholar 

  18. McGuire M, de Waal A, Karellis A, Janssen R, Engel N, Sampath R, et al. HIV self-testing with digital supports as the new paradigm: A systematic review of global evidence (2010-2021). EClinicalMedicine. 2021;39:101059.

    PubMed  PubMed Central  Google Scholar 

  19. DataReportal. Digital 2021 The Philippines 2021 [Available from: https://datareportal.com/reports/digital-2021-philippines.

  20. Quilantang MIN, Bermudez ANC, Operario D. Reimagining the future of HIV service implementation in the Philippines based on lessons from COVID-19. AIDS Behav. 2020;24(11):3003–5.

    PubMed  PubMed Central  Google Scholar 

  21. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806–8.

    Google Scholar 

  22. Department of Health Epidemiology Bureau. HIV/AIDS and ART registry of the Philippines - December 2019. Manila: Department of Health; 2019.

    Google Scholar 

  23. Mulubwa C, Hensen B, Phiri MM, Shanaube K, Schaap AJ, Floyd S, et al. Community based distribution of oral HIV self-testing kits in Zambia: a cluster-randomised trial nested in four HPTN 071 (PopART) intervention communities. Lancet HIV. 2019;6(2):e81–92.

    PubMed  Google Scholar 

  24. Brown AN, Djimeu EW, Cameron DB. A review of the evidence of harm from self-tests. AIDS Behav. 2014;18(Suppl 4):S445–9.

    PubMed  Google Scholar 

  25. Lyons CE, Coly K, Bowring AL, Liestman B, Diouf D, Wong VJ, et al. Use and acceptability of HIV self-testing among first-time testers at risk for HIV in Senegal. AIDS Behav. 2019;23(Suppl 2):130–41.

    PubMed  PubMed Central  Google Scholar 

  26. Xiao W, Yan L, Chen L, Fu G, Yang H, Yang C, et al. Sexual network distribution of HIV self-testing kits: findings from the process evaluation of an intervention for men who have sex with men in China. PLoS One. 2020;15(4):e0232094.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Wang Z, Lau JTF, Ip M, Ho SPY, Mo PKH, Latkin C, et al. A randomized controlled trial evaluating efficacy of promoting a home-based HIV self-testing with online counseling on increasing HIV testing among men who have sex with men. AIDS Behav. 2018;22(1):190–201.

    PubMed  Google Scholar 

  28. Tang W, Wei C, Cao B, Wu D, Li KT, Lu H, et al. Crowdsourcing to expand HIV testing among men who have sex with men in China: A closed cohort stepped wedge cluster randomized controlled trial. PLoS Med. 2018;15(8):e1002645.

    PubMed  PubMed Central  Google Scholar 

  29. Jamil MS, Prestage G, Fairley CK, Grulich AE, Smith KS, Chen M, et al. Effect of availability of HIV self-testing on HIV testing frequency in gay and bisexual men at high risk of infection (FORTH): a waiting-list randomised controlled trial. Lancet HIV. 2017;4(6):e241–e50.

    PubMed  Google Scholar 

  30. Zhang C, Li X, Brecht ML, Koniak-Griffin D. Can self-testing increase HIV testing among men who have sex with men: A systematic review and meta-analysis. PLoS One. 2017;12(11):e0188890.

    PubMed  PubMed Central  Google Scholar 

  31. Witzel CTWT, McCabe L, Gabriel M, WOlton A, Gafos M, Ward D, et al. Impact and acceptability of HIV self-testing for trans men and trans women: A mixed-methods subgroup analysis of the SELPHI randomised controlled trial and process evaluation in England and Wales. EClinicalMedicine. 2021;32(100700).

  32. Department of Health. Department Memorandum No. 2020–0276: Interim Guidelines on Community-based HIV Screening. Philippines: DOH; 2020.

  33. Zajac K, Kennedy CE, Fonner VA, Armstrong KS, O'Reilly KR, Sweat MD. A systematic review of the effects of Behavioral counseling on sexual risk behaviors and HIV/STI prevalence in low- and middle-income countries. AIDS Behav. 2015;19(7):1178–202.

    PubMed  PubMed Central  Google Scholar 

  34. Brody C, Sok S, Tuot S, Pantelic M, Restoy E, Yi S. Do combination HIV prevention programmes result in increased empowerment, inclusion and agency to demand equal rights for marginalised populations in low-income and middle-income countries? A systematic review. BMJ Glob Health. 2019;4(5):e001560.

    PubMed  PubMed Central  Google Scholar 

  35. Department of Health, editor. Philippine Health Sector HIV Strategic Plan. In: Department of Health, editor. Manila: Department of Health; 2020.

    Google Scholar 

  36. Girault P, Misa Wong C, Jittjang S, Fongkaew K, Cassell MM, Lertpiriyasuwat C, et al. Uptake of oral fluid-based HIV self-testing among men who have sex with men and transgender women in Thailand. PLoS One. 2021;16(8):e0256094.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Burke VM, Nakyanjo N, Ddaaki W, Payne C, Hutchinson N, Wawer MJ, et al. HIV self-testing values and preferences among sex workers, fishermen, and mainland community members in Rakai, Uganda: A qualitative study. PLoS One. 2017;12(8):e0183280.

    PubMed  PubMed Central  Google Scholar 

  38. Wulandari LPL, Kaldor J, Guy R. Uptake and acceptability of assisted and unassisted HIV self-testing among men who purchase sex in brothels in Indonesia: a pilot intervention study. BMC Public Health. 2020;20(1):730.

    PubMed  PubMed Central  Google Scholar 

  39. Phanuphak N, Anand T, Jantarapakde J, Nitpolprasert C, Himmad K, Sungsing T, et al. What would you choose: online or offline or mixed services? Feasibility of online HIV counselling and testing among Thai men who have sex with men and transgender women and factors associated with service uptake. J Int AIDS Soc. 2018;21(Suppl 5):e25118.

    PubMed  PubMed Central  Google Scholar 

  40. Waterfield KC, Shah GH, Etheredge GD, Ikhile O. Consequences of COVID-19 crisis for persons with HIV: the impact of social determinants of health. BMC Public Health. 2021;21(1):299.

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Iversen J, Sabin K, Chang J, Morgan Thomas R, Prestage G, Strathdee SA, et al. COVID-19, HIV and key populations: cross-cutting issues and the need for population-specific responses. J Int AIDS Soc. 2020;23(10):e25632.

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Tonen-Wolyec S, Kayembe Tshilumba C, Batina-Agasa S, Marini Djang'eing'a R, Hayette MP, Belec L. Comparison of practicability and effectiveness between unassisted HIV self-testing and directly assisted HIV self-testing in the Democratic Republic of the Congo: a randomized feasibility trial. BMC Infect Dis. 2020;20(1):830.

    PubMed  PubMed Central  Google Scholar 

  43. Phanuphak N, Jantarapakde J, Himmad L, Sungsing T, Meksena R, Phomthong S, et al. Linkages to HIV confirmatory testing and antiretroviral therapy after online, supervised, HIV self-testing among Thai men who have sex with men and transgender women. J Int AIDS Soc. 2020;23(1):e25448.

    CAS  PubMed  PubMed Central  Google Scholar 

  44. Maatouk I, Nakib ME, Assi M, Farah P, Makso B, Nakib CE, et al. Community-led HIV self-testing for men who have sex with men in Lebanon: lessons learned and impact of COVID-19. Health Res Policy Syst. 2021;19(Suppl 1):50.

    PubMed  PubMed Central  Google Scholar 

  45. Janssen R, Engel N, Esmail A, Oelofse S, Krumeich A, Dheda K, et al. Alone but supported: A qualitative study of an HIV self-testing app in an observational cohort study in South Africa. AIDS Behav. 2020;24(2):467–74.

    PubMed  Google Scholar 

  46. Okoboi S, Lazarus O, Castelnuovo B, Nanfuka M, Kambugu A, Mujugira A, et al. Peer distribution of HIV self-test kits to men who have sex with men to identify undiagnosed HIV infection in Uganda: A pilot study. PLoS One. 2020;15(1):e0227741.

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Lillie T, Boyee D, Kamariza G, Nkunzimana A, Gashobotse D, Persaud N. Increasing testing options for key populations in Burundi through peer-assisted HIV self-testing: descriptive analysis of routine programmatic data. JMIR Public Health Surveill. 2021;7(9):e24272.

    PubMed  PubMed Central  Google Scholar 

  48. Okoboi S, Castelnuovo B, Van Geertruyden JP, Lazarus O, Vu L, Kalibala S, et al. Cost-effectiveness of peer-delivered HIV self-tests for MSM in Uganda. Front Public Health. 2021;9:651325.

    PubMed  PubMed Central  Google Scholar 

  49. Sha YX, Y; Wang Y; Ong, J; Ni, Y; Lu, Y; Cheng, M. Comparing the effectiveness of secondary distribution of HIV self-testing to testing card referral in promoting HIV testing among men who have sex with men in China: A quasi-experimental study. medRxiv. 2021.

  50. Li S, Zhang J, Mao X, Lu T, Gao Y, Zhang W, et al. Feasibility of indirect secondary distribution of HIV self-test kits via WeChat among men who have sex with men: National Cross-sectional Study in China. J Med Internet Res. 2021;23(10):e28508.

    PubMed  PubMed Central  Google Scholar 

  51. He L, Pan X, Yang J, Ma Q, Jiang J, Wang W, et al. HIV risk behavior and HIV testing among rural and urban men who have sex with men in Zhejiang Province, China: A respondent-driven sampling study. PLoS One. 2020;15(4):e0231026.

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Preston DB, D'Augelli AR, Kassab CD, Cain RE, Schulze FW, Starks MT. The influence of stigma on the sexual risk behavior of rural men who have sex with men. AIDS Educ Prev. 2004;16(4):291–303.

    PubMed  Google Scholar 

  53. Colby D, Minh TT, Toan TT. Down on the farm: homosexual behaviour, HIV risk and HIV prevalence in rural communities in Khanh Hoa province. Vietnam Sex Transm Infect. 2008;84(6):439–43.

    CAS  PubMed  Google Scholar 

  54. Joint United Nations Programme on HIV/AIDS. Global AIDS Update 2021 - Confronting Inequalities: Lessons for Pandemic Responses from 40 Years of AIDS. 2021.

  55. Eshun-Wilson I, Jamil MS, Witzel TC, Glidded DV, Johnson C, Le Trouneau N, et al. A systematic review and network Meta-analyses to assess the effectiveness of human immunodeficiency virus (HIV) self-testing distribution strategies. Clin Infect Dis. 2021;73(4):e1018–e28.

    PubMed  PubMed Central  Google Scholar 

  56. Green KE, Vu BN, Phan HT, Tran MH, Ngo HV, Vo SH, et al. From conventional to disruptive: upturning the HIV testing status quo among men who have sex with men in Vietnam. J Int AIDS Soc. 2018;21(Suppl 5):e25127.

    PubMed  PubMed Central  Google Scholar 

  57. van Dijk M, de Wit JBF, Guadamuz TE, Martinez JE, Jonas KJ. Slow uptake of PrEP: Behavioral predictors and the influence of Price on PrEP uptake among MSM with a high interest in PrEP. AIDS Behav. 2021;25(8):2382–90.

    PubMed  PubMed Central  Google Scholar 

  58. Sharma A, Chavez PR, MacGowan RJ, McNaghten AD, Mustanski B, Gravens L, et al. Willingness to distribute free rapid home HIV test kits and to test with social or sexual network associates among men who have sex with men in the United States. AIDS Care. 2017;29(12):1499–503.

    PubMed  Google Scholar 

  59. Ratner B. Variable selection methods in regression: ignorable problem, outing notable solution. J Target Meas Anal Mark. 2010;18:65–75.

    Google Scholar 

  60. Hosmer D, Lemeshow S, Sturdivant RX. Applied logistic regression. New York: John Wiley & Sons, Inc.; 2013.

    Google Scholar 

  61. Steyerberg E. Clinical prediction models: a practical approach to development, validation, and updating: Springer Science & Business Media; 2008.

    Google Scholar 

  62. Chowdhury MZI, Turin TC. Variable selection strategies and its importance in clinical prediction modelling. Fam Med Community Health. 2020;8(1):e000262.

    PubMed  PubMed Central  Google Scholar 

  63. Austin PC, Steyerberg EW. Events per variable (EPV) and the relative performance of different strategies for estimating the out-of-sample validity of logistic regression models. Stat Methods Med Res. 2017;26(2):796–808.

    PubMed  Google Scholar 

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Acknowledgments

Data used were collected from participants in the HIVST demonstration project (iScreen) in Western Visayas, Philippines. We would like to acknowledge the vital role of different CBOs who made the HIVST demonstration project possible: Rajah Community Center, Montecarlo Clan, Cabatuan LGBT Association, La Villa Pride, GBT Janiuay, LGBTQ PAVIA Chapter, Red Seahorse, Bagani Community Center, Ogtonganon Mask Stewards, Kamini Community Center, and Red Lace Boracay. The investigating team would also like to acknowledge the following: Adrian Hort Ramos, DOH-CHD Region 6 HIV program coordinator, for providing his technical inputs in the demonstration project, Vincent Misterio, FPOP-Iloilo iScreen project coordinator, and other members of the iScreen implementation team for organizing the implementation of the HIVST demonstration project. We would also like to acknowledge Danvic Rosadiño for his technical review of the research protocol and to our peer reviewers for providing us crucial feedback on improving this manuscript.

Funding

The funding for ethics application and publication were provided by the Joint United Nations Programme on HIV/AIDS Unified Budget, Results and Accountability Framework 2020. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.

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Contributions

All authors conceived and designed the research question and analysis and provided technical inputs in the draft. RFJ and MD collected the data. PCE performed the statistical analysis while all other others contributed to the data analysis. PCE and RFJ wrote the first draft of the manuscript and all other authors provided technical inputs and contributed for the revisions. All authors have agreed on the final version of the manuscript.

Corresponding author

Correspondence to Patrick C. Eustaquio.

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Ethics approval and consent to participate

In accordance with the international standards and national guidelines, the study adhered to the principles of the Declaration of Helsinki and the research protocol received ethics approval from the National Ethics Commission of the Philippine Council on Health Research and Development, Department of Science and Technology, Republic of the Philippines (NEC Code: 2021–004). Data collection, processing, and management strictly adhered to the Republic Act 10173 Philippines Data Privacy Act of 2012 and the Republic Act 11166 HIV/AIDS Control Act. All participants voluntarily gave their electronically recorded informed consent to participate in the study.

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Not applicable.

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The authors declare that they have no competing interests.

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Eustaquio, P.C., Figuracion, R., Izumi, K. et al. Outcomes of a community-led online-based HIV self-testing demonstration among cisgender men who have sex with men and transgender women in the Philippines during the COVID-19 pandemic: a retrospective cohort study. BMC Public Health 22, 366 (2022). https://doi.org/10.1186/s12889-022-12705-z

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Keywords

  • HIV self-testing
  • Cisgender men who have sex with men
  • Transgender women
  • Community-based interventions
  • Digital health
  • Differentiated service delivery
  • Philippines
  • Low- and middle-income countries