- Research article
- Open Access
Socioeconomic indicators and economic investments influence oral cancer mortality in Latin America
BMC Public Health volume 21, Article number: 377 (2021)
It is necessary to recognize the influence of socioeconomic factors on oral cancer indicators in Latin American countries. This study aimed to analyze the influence of socioeconomic indicators and economical investments on oral cancer mortality rates in Latin American countries.
This cross-sectional study considered the age-standardized mortality rate (ASR) of oral cancer within the period 2000–2015. The oral cancer mortality rate (for both sexes and age groups 40–59 and 60 years old or more), socioeconomic aspects (Gini Inequality Index, unemployment rate and Gross Domestic Product (GDP) per capita) and investments in different sectors (%GDP invested in health per capita and by the government, %GDP invested in education by the government and %GDP invested in research and development) were considered. Tweedie multivariate regression was used to estimate the effect of independent variables on the mortality rate of oral cancer, considering p < 0.05.
This study showed that being male and aged 60 or over (PR = 14.7) was associated with higher mortality rate for oral cancer. In addition, greater inequality (PR = 1.05), higher health expenditure per capita (PR =1.09) and greater investment in research and development (PR = 1.81) were associated with a higher mortality rate from oral cancer.
Socioeconomic factors and economical investments influence the mortality rate of oral cancer in Latin American countries. This emphasizes oral cancer is a socioeconomic-mediated disease.
Oral cancer has high rates of morbidity and mortality around the world, and is therefore considered a growing public health problem [1, 2]. The disease’s treatment often has a significant impact on the quality of life of individuals, which is affected by mutilations, functional limitations and chronic pain .
Oral cancer has a complex and multifactorial etiology, with tobacco and alcohol consumption being the most relevant factor [4, 5]. In recent decades, the discussion on the role of socioeconomic factors as determinants for the disease has intensified, suggesting that socioeconomically vulnerable individuals are at increased risk for oral cancer and its complications [6,7,8]. The greater exposure to risk factors, limited access to health services and consequent low frequency of early diagnosis might explain the relationship between socioeconomic factors and incidence of oral cancer [9, 10].
Latin America has shown recent advances in the health conditions of its population, with a reduction in infant mortality and an increase in life expectancy . However, strong social inequalities and segmentation in their health systems still persist, in which a large part of the population (non-wage earners) does not have full access to health services [12, 13]. In addition, the organization of health services and government investments differ between countries, contributing to great inequity in health in the region [12,13,14].
In this scenario, Latin America is characterized as a region with a high incidence of oral and oropharynx cancer . Between 2018 and 2025, a 22.4% increase in the number of new cases of the disease in the region is expected. As for mortality, the expected growth is 24.1% for the same period . Cuba, Brazil, Puerto Rico and Uruguay occupy, in that order, the first positions regarding the highest age-standardized incidence rates (ASR) . Cuba and Brazil also lead the most recent estimates regarding mortality by the disease in the region .
Therefore, it is necessary to recognize the influence of socioeconomic factors on oral cancer indicators in Latin American countries. Thus, policies to combat social inequalities and public health measures for prevention, early diagnosis and treatment can be targeted, seeking to reduce cancer rates in the population . However, it appears that several Latin American countries have adopted austerity policies, which limit investments and public spending. This situation can result in an increase in inequality and worsening in the epidemiological panorama of the population [18, 19].
Thus, the aim of this study was to analyze the influence of socioeconomic indicators and government investments on oral cancer mortality rates in Latin American countries.
An observational cross-sectional retrospective study was carried out, considering the time period between the years 2000 and 2015 (totaling 16 years analyzed). The sample units of this study were the countries located in Latin America and the Caribbean, whose data regarding mortality from oral cancer, socioeconomic aspects and government investments were available in international databases.
The data referring to the number of deaths from oral cancer (considering the category lip, oral cavity and pharynx) of each country, for both sexes and the age groups of 40–59 years and 60 years or more, were collected from the World Health Organization Cancer Mortality Database (http://www-dep.iarc.fr/WHOdb/WHOdb.htm), considering each year of the period between 2000 and 2015. The Gini inequality coefficient, unemployment rate, Gross Domestic Product (GDP) per capita, GDP percentage invested in health per capita, GDP percentage invested in health by the government, GDP percentage invested in education by the government and GDP percentage invested in research and development were extracted from the World Bank indicator system (https://data.worldbank.org/indicator).
Constitution of the model
The response variable (dependent) of this study was the oral cancer mortality rate, expressed through the standardized mortality rate. The independent variables were: sex, age, period (year), Gini inequality coefficient, unemployment rate, Gross Domestic Product (GDP) per capita, GDP percentage invested in health per capita, GDP percentage invested in health by the government, GDP percentage invested in education by the government and GDP percentage invested in research and development.
The data were put in charts and analyzed using the IBM Statistical Package for Social Sciences program (IBM SPSS, v. 24, IBM, Chicago, IL). Tweedie’s Multivariate Regression was used to estimate the effect of independent variables on the mortality rate among Latin American countries. The model was adjusted by gradually removing variables with a p-value> 0.20. The effect of the independent variables was verified through the measures of prevalence ratio (PR) and confidence interval (CI95%), considering p-value< 0.05.
Descriptive data regarding the oral cancer standardized mortality rate for each Country is presented in Table 1. Descriptive data regarding the socioeconomic parameters of Latin American countries considered for this study is presented in Table 2. Factors associated to the standardized mortality rate of oral cancer (mouth, lip and oropharynx) are presented in Table 3. The adjusted model did not account for the effect of year and unemployment rate, since those variables presented p-value> 0.20 during model adjustment. Gross Domestic Product per capita, Government Health Expenditure (as %GDP) and Government Education Investments (as %GDP) did not influence the oral cancer mortality rate within the adjusted model. Male population with 60 years or more is associated with higher mortality of oral cancer. Greater inequality (greater Gini index), higher health expenditure per capita (as %GDP) and higher investments on research and development (%GDP) are associated with higher oral cancer mortality rate among Latin American Countries.
The results of this investigation demonstrate that socioeconomic factors and government investments influence mortality by oral cancer in Latin American countries. The results of this study reaffirm the higher prevalence of oral cancer among male individuals, over 60 years old [15, 20,21,22]. Also, it revealed that social inequalities are related with the increase of oral cancer mortality in these countries. Although government investments in health and education have not influenced standardized mortality rates, investments per capita in health and spending on research and development seem to be the result of the expansion of austerity policies and less government accountability for the population’s health problems.
The choice of the evaluation period for this study is justified by the fact that the years 2000 to 2015 corresponded to the most recent time interval in which the largest number of Latin American countries presented data available on the analyzed databases. During this period, mortality by oral cancer among the countries included was stable. Previous studies have shown great variability in the trend of mortality from oral cancer in Latin America in the last decades [15, 23, 24]. This is probably due to the absence or discontinuity of records in some countries, in addition to the singularities of each country, especially regarding the distribution of risk factors in the region.
In this study, the Gross Domestic Product (GDP) showed no association with mortality from oral cancer, suggesting that this condition is not influenced by the amount of wealth in the countries. The comparison between Cuba and Brazil could illustrate this finding: despite the great difference in the economic organization and wealth of these countries, both lead the indicators of mortality from oral cancer in Latin America. However, it is important to consider that Latin countries are marked by strong socioeconomic inequalities, which was evidenced in this study through the Gini Index, which was positively associated with mortality.
Thus, although there is no difference between poor and rich countries, inequality is an important factor. The same is true for the unemployment rate, which, despite not being part of the association model, is an important indicator of inequality and may have been included in the Gini Index. A similar study found no association between this index and mortality from oral cancer in Latin America . However, the authors of the aforementioned study suggested that a regional analysis may not be able to detect this association, making it necessary to conduct national studies to better explain this relationship.
Government investments in education and health have not influenced the mortality rate and may suggest that in these countries investments in social policies and health systems are still low and insufficient, unable to meet the demands of the population and contribute to the improvement of their health condition . A positive association was verified between oral cancer mortality and health expenditure per capita, which means that the countries that spent more on health also had higher mortality. This finding suggests that health care in the private sector has higher cost for population and not adequate efficiency .
Another intriguing finding refers to the positive association between investment in research and development and mortality from oral cancer. This association was probably influenced by the fact that Brazil is the country with the highest investment in research and development, also presenting the highest mortality rate from oral cancer among the countries analyzed. Although there is investment in the sector, it does not seem to positively influence the population’s health, and it is necessary to analyze this finding individually for each country, along with its other characteristics. It is also important to reflect on the use of strategies so that the products of scientific health development in these countries become accessible to the majority of the population, thus providing a real impact on the indicators of cancer and other diseases .
Despite the recognition of socioeconomic conditions as determining factors for oral cancer, the presence of harmful habits related to lifestyle are the strongest etiological factors [4, 27]. Latin countries in which public policies for the control of tobacco and alcohol consumption have been developed have shown less advances in mortality rates from oral cancer in the last decades . Therefore, socioeconomic factors must always be analyzed in the light of the population’s habits that are involved. In addition, policies to control risk factors must be implemented in conjunction with policies to combat social inequalities. Based on that, campaigns to fight tobacco use, limit sun exposition, reduce alcohol ingestion, and extend access to healthcare should be outlined simultaneously with the reduction of social inequalities.
This study presents the proper limitations of a cross-sectional study based on data from an information system, being liable to failures due to the secondary origin of the data. However, databases and information systems considered world reference were used, seeking to ensure greater reliability. The analysis of the Latin American region also requires care in interpreting the results, since not all countries were included due to the lack of data, and the particularities of each country must be considered. As previously discussed, the presence of habits that represent risk factors for oral cancer should be studied in conjunction with socioeconomic determinants. Therefore, it is suggested to conduct further studies that consider both aspects.
The analysis of oral cancer mortality in Latin America from the perspective developed in this study proposes important reflections on the austerity policies in public health investments that are being implemented in the region. Previous experiences in European countries have demonstrated the damage these policies have to the living and health conditions of the population, worsening socioeconomic inequities, intensifying unemployment, violence, social unprotection, decreasing access and coverage of health services, among others [28, 29]. Neoliberal measures have threatened the main universal health system in the world, Brazil’s Unified Health System . The scientific debate on the new health challenges in Latin America is necessary, aiming at the preservation of achievements resulting from past social struggles, such as social protection, strengthening of health systems, improvement in health indicators and achieving international development goals .
In conclusion, this manuscript highlights socioeconomic factors and economical investments influence the mortality rate of oral cancer in Latin American countries. This emphasizes oral cancer is a socioeconomic-mediated disease. Austerity policies may play a significant role on the mortality rate of oral cancer in Latin America.
Availability of data and materials
The datasets generated during the current study can be provided by the corresponding author under reasonable request. Data were extracted from the following websites: https://www-dep.iarc.fr/WHOdb/WHOdb.htm and https://data.worldbank.org/indicator.
- 95% C.I.:
95% Confidence Interval
Age-Standardized Incidence Rates
Gross Domestic Product
World Health Organization
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancerstatistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. https://doi.org/10.3322/caac.21492.
Prado NS, Bonan RF, Leonel AC, Castro UF, Carvalho EJ, Silveira FM, et al. Awareness on oral cancer among patients attending dental school clinics in Brazil. Med Oral Patol Oral Cir Bucal. 2020;25:e89–95. https://doi.org/10.4317/medoral.23207.
Valdez JA, Brennan MT. Impact of Oral cancer on quality of life. Dent Clin N Am. 2018;62:143–54. https://doi.org/10.1016/j.cden.2017.09.001.
Bezerra NV, Leite KL, de Medeiros MM, Martins ML, Cardoso AM, Nonaka CFW, et al. Advanced-stage tongue and mouth floor cancer is related to tobacco and alcohol abuse. J Public Health. 2018;26:151–6. https://doi.org/10.1007/s10389-017-0859-3.
Sakamoto AJ, Brizon VSC, Bulgareli JV, Ambrosano GMB, Hebling E. Influence of municipal socioeconomic indices on mortality rates for oral and oropharyngealcancer in older adults in the state of São Paulo, Brazil. Rev Bras Epidemiol. 2019;22:e190013. https://doi.org/10.1590/1980-549720190013.
Conway DI, Petticrew M, Marlborough H, Berthiller J, Hashibe M, Macpherson LM. Socioeconomic inequalities and oral cancer risk: a systematic review and meta-analysis of case-control studies. Int J Cancer. 2008;122:2811–9. https://doi.org/10.1002/ijc.23430.
Freire AR, Freire DEWG, Araújo ECF, Lucena EH, Cavalcanti YW. Influence of public Oral health services and socioeconomic indicators on the frequency of hospitalization and deaths due to Oral cancer in Brazil, between 2002–2017. Int J Environ Res Public Health. 2021;18(1):238. https://doi.org/10.3390/ijerph18010238.
Lins LS, Bezerra NV, Freire AR, Almeida LD, Lucena EH, Cavalcanti YW. Socio-demographic characteristics are related to the advanced clinical stage of oral cancer. Med Oral Patol Oral Cir Bucal. 2019;24:e759–63. https://doi.org/10.4317/medoral.23105.
Shin JY, Yoon JK, Shin AK, Diaz AZ. The influence of insurance status on treatment and outcomes in oral cavity cancer: an analysis on 46,373 patients. Int J Oral MaxillofacSurg. 2018;47:1250–7. https://doi.org/10.1016/j.ijom.2018.03.022.
Herrera-Serna BY. Lara-Carrillo E, Toral-Rizo VH, Cristina do Amaral R, Aguilera-Eguía RA. Relationship between the human development index and its components with Oral cancer in Latin America. J Epidemiol Glob Health. 2019;9:223–32. https://doi.org/10.2991/jegh.k.191105.001.
Frenk J, Gómez-Dantés O. Health Systems in Latin America: the search for universal health coverage. ArchMed Res. 2018;49:79–83. https://doi.org/10.1016/j.arcmed.2018.06.002.
Cotlear D, Gómez-Dantés O, Knaul F, Atun R, Barreto ICHC, Cetrángolo O, et al. Overcoming social segregation in health care in Latin America. Lancet. 2015;385:1248–59. https://doi.org/10.1016/S0140-6736(14)61647-0.
Giovanella L, Almeida PF. Comprehensive primary care and segmented health systems in South America. Cad Saude Publica. 2017;33:e00118816Published 2017 Oct 2. https://doi.org/10.1590/0102-311X00118816.
Herrera-Serna BY, Lara-Carrillo E, Toral-Rizo VH, do Amaral RC. Efecto de lãs políticas de control de factores de riesgo sobre lamortalidad por cáncer oral em América Latina. Rev EspSalud Publica. 2019;93:e201907050 Published 2019 Jul 22.
Curado MP, Johnson NW, Kerr AR, Silva DRM, Lanfranchi H, Pereira DL, et al. Oral and oropharynx cancer in South America: incidence, mortality trends and gaps in public databases as presented to the Global Oral cancer forum. Transl Res Oral Oncol. 2016;1:1–7. https://doi.org/10.1177/2057178X16653761.
GLOBAL CANCER OSERVATORY. Cancer Tomorrow. Available online: <http://gco.iarc.fr/>. Acessed on Feb 10 2019.
Ferreira MA, Gomes MN, Michels FA, Dantas AA, Latorre MR. Social inequality in morbidity and mortality from oral and oropharyngeal cancer in the city of São Paulo, Brazil: 1997-2008. CadSaude Publica. 2012;28:1663–73. https://doi.org/10.1590/S0102-311X2012000900006.
Rossi TRA, Lorena Sobrinho JE, Chaves SCL, Martelli PJL. Economic crisis, austerity and its effects on the financing of oral health and access to public and private services. CienSaude Colet. 2019;24:4427–36. https://doi.org/10.1590/1413-812320182412.25582019.
Amorim AC, Fernandes VR, Sérgio JV. Vicente da Silva JP. Health and equity in Latin America: utopias and reality. Health Promot Int. 2019;34:i11–9. https://doi.org/10.1093/heapro/daz014.
Santos HB, dos Santos TK, Paz AR, Cavalcanti YW, Nonaka CF, Godoy GP, et al. Clinical findings and risk factors to oral squamous cell carcinoma in young patients: a 12-year retrospective analysis. Med Oral Patol Oral Cir Bucal. 2016;21:e151–6.
Perea LME, Peres MA, Boing AF, Antunes JLF. Trend of oral and pharyngeal cancer mortality in Brazil in the period of 2002 to 2013. Rev Saude Publica. 2018;52:10. https://doi.org/10.11606/S1518-8787.2018052000251.
Prado da Fonseca E, Cristina do Amaral R, Carlos Pereira A, Martins Rocha C, Tennant M. Geographical variation in Oral and oropharynx cancer mortality in Brazil: a Bayesian approach. Int J Environ Res Public Health. 2018;15:E2641. https://doi.org/10.3390/ijerph15122641.
Perdomo S, Martin Roa G, Brennan P, Forman D, Sierra MS. Head and neck cancer burden and preventive measures in central and South America. CancerEpidemiol. 2016;44:S43–52. https://doi.org/10.1016/j.canep.2016.03.012.
Chatenoud L, Bertuccio P, Bosetti C, Malvezzi M, Levi F, Negri E, et al. Trends in mortality from major cancers in the Americas: 1980-2010. Ann Oncol. 2014;25:1843–53. https://doi.org/10.1093/annonc/mdu206.
Moreno-Serra R, Anaya-Montes M, Smith PC. Potential determinants of health system efficiency: evidence from Latin America and the Caribbean. PLoS One. 2019;14:e0216620. https://doi.org/10.1371/journal.pone.0216620.
Sipido KR, Nagyova I. Health research and knowledge translation for achieving the sustainable development goals: tackling the hurdles. Eur J Pub Health. 2020;30(Suppl_1):i36–40. https://doi.org/10.1093/eurpub/ckaa032.
Warnakulasuriya S. Causes of oral cancer--an appraisal of controversies. Br Dent J. 2009;207:471–5. https://doi.org/10.1038/sj.bdj.2009.1009.
Barreto ML. Austerity comes to Latin America: lessons from the recent European experience on studying its effects on health. La austeridad visita a América Latina. SaludColect. 2018;14:681–4. https://doi.org/10.18294/sc.2018.1990.
Machado CV, Lima LD. Health policies and systems in Latin America: regional identity and national singularities. Cad Saude Publica. 2017;33:e00068617. https://doi.org/10.1590/0102-311X00068617.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. We acknowledge Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil) for MSc scholarship. Authors declare no conflicts of interest.
This manuscript was conducted without support of any funding research apart from the MSc scholarships.
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Freire, A.R., Freire, D.E.W.G., de Araújo, E.C.F. et al. Socioeconomic indicators and economic investments influence oral cancer mortality in Latin America. BMC Public Health 21, 377 (2021). https://doi.org/10.1186/s12889-021-10419-2
- Oral cancer
- Latin America
- Socioeconomic factors