|  | Adjusted hazard ratio (95% confidence interval)a |  | |||
---|---|---|---|---|---|---|
 |  | Continual smokers | Quitters | Sustained ex-smokers | Never smokers | p for trend |
Cardiovascular disease | Aspirin use | |||||
 No | 1.00 (reference) | 0.59 (0.31–1.13) | 0.55 (0.34–0.90) | 0.55 (0.35–0.86) | 0.013 | |
 Yes | 1.00 (reference) | 0.70 (0.42–1.16) | 0.94 (0.65–1.35) | 0.80 (0.56–1.14) | 0.361 | |
Warfarin use | ||||||
 No | 1.00 (reference) | 0.66 (0.43–1.03) | 0.71 (0.51–0.98) | 0.73 (0.54–0.99) | 0.073 | |
 Yes | 1.00 (reference) | 0.45 (0.18–1.13) | 0.85 (0.45–1.61) | 0.52 (0.28–0.97) | 0.088 | |
Total stroke | Aspirin use | |||||
 No | 1.00 (reference) | 0.63 (0.26–1.54) | 0.44 (0.21–0.91) | 0.71 (0.38–1.31) | 0.269 | |
 Yes | 1.00 (reference) | 0.83 (0.40–1.69) | 1.04 (0.61–1.77) | 0.79 (0.47–1.33) | 0.423 | |
Warfarin use | ||||||
 No | 1.00 (reference) | 0.70 (0.38–1.29) | 0.74 (0.46–1.16) | 0.78 (0.51–1.20) | 0.343 | |
 Yes | 1.00 (reference) | 0.64 (0.17–2.46) | 0.85 (0.31–2.35) | 0.54 (0.20–1.49) | 0.255 | |
Coronary heart disease | Aspirin use | |||||
 No | 1.00 (reference) | 0.53 (0.22–1.29) | 0.60 (0.31–1.14) | 0.46 (0.25–0.84) | 0.018 | |
 Yes | 1.00 (reference) | 0.62 (0.32–1.19) | 0.87 (0.55–1.38) | 0.83 (0.54–1.29) | 0.661 | |
Warfarin use | ||||||
 No | 1.00 (reference) | 0.64 (0.36–1.15) | 0.68 (0.44–1.04) | 0.74 (0.50–1.10) | 0.197 | |
 Yes | 1.00 (reference) | 0.32 (0.10–1.03) | 0.67 (0.32–1.42) | 0.41 (0.20–0.86) | 0.053 |