- Research article
- Open Access
Low-income community knowledge, attitudes and perceptions regarding antibiotics and antibiotic resistance in Jelutong District, Penang, Malaysia: a qualitative study
BMC Public Health volume 19, Article number: 1292 (2019)
Understanding community perspectives on antibiotics and antibiotic resistance (ABR) is a key component in designing educational interventions to combat ABR at the community level in Malaysia. Therefore, this study aimed to explore community residents’ knowledge, attitudes and perceptions regarding antibiotics and ABR in Jelutong District, Penang, Malaysia. Moreover, it intended to identify areas of focus to be addressed when designing an educational intervention to increase residents’ knowledge and change their attitudes and perceptions.
A qualitative approach was adopted to gain a deeper understanding of community residents’ knowledge, attitudes and perceptions regarding antibiotics and ABR. A purposive sampling was employed. Twenty-two residents (aged ≥18 years) were interviewed with the aid of a semi-structured interview guide. All interviews were audio recorded, transcribed verbatim and thematically analysed.
The majority of the participants asserted that antibiotics could be effective against viral infections. Moreover, many participants were unaware that antibiotics have adverse effects. Some acquired antibiotics from a community pharmacy without a prescription, took antibiotics given to them by their family or friends, or took leftover antibiotics prescribed for a previous illness. A few indicated that they would request antibiotics from their physician when they had viral infections. More than half of the participants discontinued taking antibiotics when their symptoms improved. The majority stated that ABR occurs when the body becomes used to antibiotics. Most participants were unaware of the causes, consequences and prevention of ABR. In fact, they were not concerned about it. As a result, only a few perceived themselves as having responsibility for preventing this problem.
The community residents had misconceptions about antibiotics and ABR, negative attitudes towards antibiotics and negative perceptions of ABR. The areas of focus that need to be addressed when designing an educational intervention to increase the general public knowledge and change their attitudes and perceptions are the appropriate use of antibiotics and their adverse effects; the importance of adhering to antibiotic therapy; and the definition, causes, consequences and prevention of ABR.
Antibiotic resistance (ABR) is a global public health problem that threatens the treatment and prevention of bacterial infections and undermines advanced medical procedures such as cancer chemotherapy, organ transplantations and surgeries [1,2,3]. ABR can occur anywhere, including in the community, particularly where infections are common and can spread rapidly [1, 4]. Misuse and overuse of antibiotics is accelerating the emergence and spread of ABR [2, 5, 6]. Self-medication with antibiotics and dispensing of antibiotics without a prescription is common in low- and middle-income countries (LMICs) [7,8,9,10]. Inappropriate prescribing of antibiotics and suboptimum adherence to antibiotic therapy is not only a frequent occurrence in LMICs, but also in high-income countries [11,12,13,14]. Such practices could be due to lack of public awareness regarding ABR and inadequate implementation of regulations on antibiotic prescribing and dispensing .
The World Health Organization (WHO), concerned with this growing threat, has developed a global action plan for ABR and urges all nations to increase public knowledge of antibiotics and ABR through effective education and communication . To design effective educational interventions, it is essential to understand public knowledge, attitudes and perceptions regarding antibiotics and ABR . Previous qualitative studies have explored public attitudes towards and perceptions of antibiotics and ABR in European countries , India , New Zealand , Sweden , Australia , Sri Lanka , South Africa , Albania , Indonesia  and the United Kingdom (UK) [26,27,28,29,30]. Overall, these studies indicated that the general public and patients had inadequate knowledge and misconceptions about antibiotics and ABR. Moreover, a considerable proportion of the patients had negative attitudes towards antibiotics and negative perceptions of ABR. For example, some studies showed low knowledge of the differences between viral and bacterial infections among the patients [24, 29]. In addition, the study from Australia showed that the patients’ understanding of ABR is poor and the participants had misconceptions about several aspects of ABR . The study from Sweden reported that the participants considered ABR as a slowly emerging health issue rather than a significant current public health issue that is getting worse . However, the level of knowledge of antibiotics and ABR and the issues surrounding the use of antibiotics can vary from one country to another due to the differences in healthcare systems, educational interventions and public awareness [31, 32].
Based on an extensive search of the literature using several electronic databases (ProQuest, PubMed, Scopus, Web of Science and Wiley Online Library), there is a paucity of data regarding community residents’ knowledge, attitudes and perceptions in relation to antibiotics and ABR in Malaysia. Moreover, it is inappropriate to extrapolate the findings from public attitudes and perceptions conducted in other countries to the local situation because of differences in healthcare systems, contexts and cultures . Therefore, the study aimed to explore community residents’ knowledge, attitudes and perceptions regarding antibiotics and ABR in Jelutong District, Penang, Malaysia. In addition, it intended to identify areas of focus to be addressed when designing an educational intervention to increase the general public knowledge and change their attitudes towards and perceptions. The findings of the study will provide guidance to policymakers and other stakeholders for developing educational interventions that effectively enhance community residents’ knowledge and change their attitudes and perceptions in relation to antibiotics and ABR in Malaysia. Furthermore, it will offer a framework for a national action plan to combat ABR at the community level.
A qualitative phenomenological approach was employed in this study because it allows the researchers greater freedom in exploring participants’ knowledge, attitudes and perceptions regarding antibiotics and ABR [33,34,35,36]. In addition, it is effective for gaining insight into individual experiences, attitudes and perceptions [37, 38]. Moreover, it helps in understanding the meaning, common features or essences of an experience or episode [39, 40].
This study was conducted at 1Malaysia Community in Makloom Street, Jelutong between 4 October and 6 December 2016. Jelutong is an urban district located in North-east Penang. The total number of 1Malaysia Community residents (aged ≥18 years) was approximately 1200 in 2016 . The residents came from different age groups, were multi-ethnic and had varying educational and socioeconomic backgrounds. Most lived in flats in low-rise blocks in Makloom Street, while others lived in landed properties along this street.
The study site (i.e. population) was selected based on several factors. First, the School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM) has good rapport with 1Malaysia Community in Makloom Street. This helped the authors gain access to the field. Second, the community residents showed an interest in the research topic and supported the study. Third, the residents are from different age groups and ethnic, educational and socioeconomic backgrounds. This offered the authors the opportunity to gain a heterogeneous sample. Finally, there was no pre-established relationship between the authors and the participants prior to the study commencing. Thus, participants’ responses would not be distorted and any pre-conceptions would be eliminated from the authors’ understanding of the study phenomena.
Participants were included in the study if they were residents of 1Malaysia Community; were 18 years of age and over; were aware of the term ‘antibiotics’; and were able to speak, read and write in English or Malay. Healthcare professionals, those who did not meet the inclusion criteria or those unwilling to participate were excluded from the study.
Sampling strategy and sample size
Purposive sampling was adopted in the study because it is the primary sampling technique used in qualitative studies [42,43,44]. In addition, it helps achieve a representative and heterogeneous sample. Thus, a full spectrum of views can be adequately obtained to reflect the sample’s diversity [45, 46]. The selection of participants was based on age, ethnicity, education level and monthly household income.
Before the data collection began, the first author (LI) met the leader of 1Malaysia Community to inform him of the study, seek his endorsement and discuss any concerns. Since the first author did not know any of the community residents prior to the study commencing, she requested the community leader to nominate those who fulfilled all the study criteria and had the potential to provide rich and relevant data [47,48,49].
The interviewer (LI) met the nominees and provided them with verbal and written information about the study. Those who agreed to participate were asked to contact the interviewer to arrange an interview. The recruitment continued until data saturation was achieved [50,51,52,53], as indicated by data replication or redundancy . In this study, the data collected in the last two interviews were found to be repetitive. Therefore, the sample size of the study was 22 participants. None of the selected participants refused to take part or dropped out of the study.
A semi-structured interview guide (see Additional file 1) was used to explore participants’ knowledge, attitudes and perceptions regarding antibiotics and ABR. The guide was developed based on an extensive literature review [8, 12, 13, 17,18,19,20,21,22,23], and was validated by a panel of experts consisting of two senior academics with expertise in pharmacy practice and a senior academic with expertise in infectious diseases. Minor revisions were made according to their feedback. The guide was then piloted among three community residents. Afterwards it was translated into Malay, the national language of Malaysia, by a certified translator and translated back into English by another independent, certified translator to ensure validity and accuracy. The first author compared the back-translated version with the original version to ensure that an equivalence of meaning between the two languages was achieved [54, 55]. Subsequently, the Malay version was piloted among another three community residents. Minor amendments were made as a consequence of the pilot interviews. Data collected from the pilot interviews were not included in the analysis.
Prior to the interviews, written informed consent was sought and the participants were asked to complete a demographic survey concerning their age, gender, ethnicity, marital status, education level, employment status, monthly household income, the last time they had taken antibiotics and the number of antibiotic courses they had taken in the previous year. Afterwards the interviewer, who is experienced in conducting qualitative interviews and is well-versed in English and Malay, conducted the face-to-face, semi-structured interviews with the aid of the interview guide. Based on the participants’ preference, half of the interviews (n = 11) were conducted in English and the other half (n = 11) were conducted in Malay. As the relationship with the participants had not yet been established, the interviewer began the interviews by introducing herself and asking some introductory questions to build a rapport with them. The interviews focused on participants’ knowledge, attitudes and perceptions regarding antibiotics and ABR. Appropriate probing questions were asked when necessary. To extricate further ideas from the participants, they were given the freedom to express additional opinions on antibiotics and ABR at the end of the interviews. The interviews were held in 1Malaysia Community hall at a time convenient for the participants. Each interview lasted between 30 and 40 min. Field notes were made during and after each interview. None of the interviews were repeated.
All interviews were audio recorded using a digital voice recorder with the participants’ consent. The recordings were then anonymised and transcribed verbatim by a professional transcriber who is familiar with medical terminology and fluent in English and Malay. The interviewer checked all the transcripts against the audio recordings for accuracy and completeness. When necessary, amendments were made, and then a copy of the transcript was returned to the interviewed participant for verification. All participants endorsed the transcripts without making any corrections. The Malay transcripts (n = 11) were then translated into English for analysis.
All English transcripts (n = 22) were thematically analysed by the first author (LI) and an independent researcher with expertise in qualitative research. The analysis began with data familiarisation, a process that involved reading the transcripts repeatedly and noting down ideas. Subsequently, the information pertinent to participants’ knowledge, attitudes and perceptions regarding antibiotics and ABR was identified and coded based on deductive and inductive approaches. These codes were then collated into themes and sub-themes. The first author subsequently discussed the coding, themes and sub-themes with the independent researcher to enhance the data reliability. Afterwards they were reviewed by the co-authors (AAA, MAH and FS). Any discrepancies were resolved by discussion until a consensus was reached. The first author was then presented the findings to the study participants and obtained their feedback to ensure that their perspectives were accurately and clearly represented.
Participants’ demographic characteristics
Twenty-two participants (P1–P22) were interviewed. Slightly more than half (n = 12) were females. The ages of all participants ranged from 18 to 70 years (Median [Q1-Q3] = 48 [32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64]). They came from a diverse range of ethnic, educational and socioeconomic backgrounds. All participants (n = 22) reported that they had previously taken antibiotics. The majority (n = 13) reported having taken antibiotics within the previous 6 months, while half (n = 11) stated that they had only taken one course of antibiotics in the previous year. Table 1 presents the participants’ demographic characteristics.
Four major themes were identified: knowledge of antibiotics; attitudes towards antibiotics; knowledge of ABR; and perceptions of taking responsibility for combating ABR (Table 2).
Theme 1: knowledge of antibiotics
To explore participants’ knowledge of antibiotics, the interviewer asked them about their understanding of the term ‘antibiotics’ and antibiotic use. The interviewer also asked participants about the adverse effects of antibiotics.
Understanding the term ‘antibiotics’ and antibiotic use
The participants had different understandings of the term ‘antibiotics’ and antibiotic use. The majority had a misconception that antibiotics are medicines that kill viruses and can hasten recovery from viral infections:
‘Antibiotics are medicines that kill viruses. They are medicines used to speed up recovery from colds and coughs.’ (P7)
‘Antibiotics are medicines that kill small living things called viruses. They can cure colds and sore throats quickly.’ (P11)
Some participants understood antibiotics as medicines that reduce fevers:
‘As far as I’m concerned, antibiotics are medicines that bring down a high temperature.’ (P2)
‘All I know is that antibiotics are medicines used to reduce fevers.’ (P22)
A few participants understood antibiotics as medicines that relieve pain and reduce inflammation:
‘I’m completely certain that antibiotics are medicines that ease pain and swelling.’ (P3)
‘To my knowledge, antibiotics are the same as painkillers. They reduce pain and swelling.’ (P21)
Two participants stated that antibiotics are medicines that kill bacteria and can be used to treat bacterial infections:
‘Antibiotics are medicines that kill germs called bacria [bacteria]. They are effective for the treatment of bacria [bacterial] infections such as umonia [pneumonia].’ (P1)
‘Antibiotics are medicines that kill bacteria. They can be used to treat skin infections and urine [urinary tract] infections.’ (P15)
One participant indicated that antibiotics are medicines that prevent any illnesses from becoming severe:
‘Antibiotics are pills that prevent all kinds of illnesses from getting worse.’ (P9)
Knowledge of the adverse effects of antibiotics
Most participants were unaware that antibiotics have adverse effects; none had experienced adverse effects while taking antibiotics:
‘I really don’t know whether or not antibiotics have side effects. I’ve never experienced any of them.’ (P2)
‘I’m not sure if antibiotics can cause side effects. I have never had side effects from the medicine.’ (P7)
Only a few participants were aware of some adverse effects of antibiotics such as diarrhoea, stomach discomfort and rashes. They stated that they would seek further consultation with their physician if adverse effects occurred:
‘As far as I’m concerned, antibiotics can cause side effects such as stomach discomfort. If I experience any side effects, I would go back to my doctor.’ (P14)
‘Yes, antibiotics have side effects. If I’m not mistaken, they can cause diarrhoea and rashes. If that happens, I would return to my doctor.’ (P17)
Theme 2: attitudes towards antibiotics
To explore participants’ attitudes towards antibiotics, the interviewer asked them how they acquired antibiotics. Participants were also asked about their responses to physicians’ decisions to prescribe antibiotics and their adherence to antibiotic therapy.
Attitudes towards acquiring antibiotics
The majority of participants reported that they acquired antibiotics from a physician and were advised how to take them:
‘I never request antibiotics from my doctor. He prescribes them and advises me how to take the medicine.’ (P12)
‘My doctor prescribes me antibiotics and advises me how to take them.’ (P22)
Some participants acquired antibiotics from a community pharmacy before consulting a physician, as they wanted to recover quickly from viral infections. They said that they would consult the physician if symptoms persisted:
‘When I have a cold, I buy antibiotics in a [community] pharmacy without a prescription because they help me get better. If there is no improvement after taking them, I’ll see a doctor.’ (P7)
‘When I have a sore throat, I go to a [community] pharmacy and ask for antibiotics as I want to get better quickly. If my condition doesn’t improve after taking them, I’ll see a doctor for advice.’ (P10)
A few participants took antibiotics given to them by their family or friends, as they believed that antibiotics are effective for treating colds and sore throats:
‘I take an antibiotic given by my mum. She said the medicine is effective against colds. I try it and it works.’ (P4)
‘When my throat is a bit painful, my girlfriend gives me antibiotics. She said they are good for sore throats. I believe what she said and take the medicine according to her advice.’ (P11)
Two participants indicated that they took leftover antibiotics prescribed for a previous illness when similar symptoms arose, as they wanted to save the time it would take to visit a primary-care clinic:
‘If I have similar symptoms, I don’t want to see a doctor because of a long wait in the clinic. I would rather take leftover antibiotics prescribed for my past illness.’ (P8)
‘When I have the same symptoms, I usually take leftover antibiotics prescribed for my previous illness. I can’t stand the long waiting time in the clinic.’ (P16)
Attitudes towards physicians’ decisions to prescribe antibiotics
When asked about their responses to physicians’ decisions to prescribe antibiotics, the majority stated that they would abide by their physician’s decisions and would not request antibiotics, as they trust the physician:
‘I trust my doctor. If she doesn’t prescribe antibiotics, I won’t ask for such medicines. I’ll take any medicines given by her.’ (P5)
‘I have confidence in my doctor. Whether or not he prescribes antibiotics, I’ll abide by his decision. I won’t demand antibiotics.’ (P19)
Some participants stated that they would not express their expectations openly to their physician nor request antibiotics, as they wanted to establish a good relationship with the physician:
‘Although I want antibiotics, I don’t dare to ask my doctor to prescribe the medicine. I would rather build a good relationship with the doctor.’ (P2)
‘Deep down, I wish to take antibiotics when I’m not feeling well. But, if my doctor doesn’t prescribe the medicine, I won’t request them. I prefer to have a good relationship with the doctor.’ (P9)
A few participants indicated that they would make their expectations explicit and request antibiotics from their physician when they had viral infections, as they believed the medicine promotes rapid recovery. They also said that they would consult another physician if their request was not granted:
‘If I have a cold or sore throat, I’ll certainly expect antibiotics from my doctor as the medicine will help me get over it faster. If he refuses to prescribe antibiotics, I’ll see another doctor.’ (P4)
‘When I have a cold, I ask my doctor to prescribe antibiotics because I want to get well quickly. If he is reluctant to do so, I’ll consult another doctor.’ (P11)
Attitudes towards adhering to antibiotic therapy
When asked about how they took antibiotics, more than half of the participants stated that they adhered to antibiotic regimens. However, they discontinued taking the antibiotics when their symptoms improved, as they were unaware of the importance of taking the full prescribed course. They believed that they had recovered from the infection when they felt better:
‘I follow the instructions on the label. But, I stop taking the antibiotics when I feel better. Why should I finish the prescribed course when I have recovered from the infection? I don’t understand!’ (P7)
‘I take antibiotics according to the instructions on the label. But, I stop taking them when I feel better. Honestly, I don’t see the point why I should take the full prescribed course when symptoms have cleared up.’ (P16)
Some participants reported that they occasionally missed a few doses of antibiotics because of their hectic lifestyle. Nevertheless, they were aware of what they should do if they missed a dose and completed the prescribed course:
‘I occasionally miss one or two doses of antibiotics as I am busy with many things, but I always complete the prescribed course. If I miss a dose, I take the missed dose as soon as I remember, and then continue with the regular [dosage] schedule. I never take a double dose to compensate for the missed dose.’ (P2)
‘I try my best to follow the instructions on the label. But, sometimes I forget to take one or two doses because I have a very busy life. If I miss a dose and it is almost time for the next dose, I skip the missed dose and then continue with the regular [dosage] schedule until I finish them all. I never take a double dose to make up for the missed dose.’ (P19)
Only a few participants stated that they adhered to antibiotic regimens and completed the prescribed course to ensure that all bacteria had been killed:
‘I take antibiotics according to the doctor’s instructions and finish the prescribed course. Hopefully, all bacteria are killed.’ (P15)
‘I follow the doctor’s instructions on how to take antibiotics. I finish them all, even if I feel better because I want to make sure all bacteria are killed.’ (P18)
Those who did not complete the prescribed course were asked what they would do with the leftover antibiotics. Most participants indicated that they kept them in a cupboard and eventually disposed them of in a dustbin; they had no intention of saving them for future use:
‘I put the leftover antibiotics in a drawer until a later clear out. When I’m free, I throw them away in a dustbin. I won’t take them at a later date.’ (P13)
‘I keep the leftover antibiotics in a cabinet, but I won’t take them next time I’m not well. Eventually I’ll throw them out in a rubbish bin.’ (P21)
Two participants reported that they did keep the leftover antibiotics for future use:
‘I keep the leftover antibiotics and take them now and then when I have similar symptoms.’ (P8)
‘I keep the leftover antibiotics in a cupboard and use them in the future.’ (P16)
Theme 3: knowledge of ABR
To explore participants’ knowledge of ABR, the researcher asked them about their understanding of the term ‘ABR’ and its causes, consequences and prevention.
Understanding the term ‘ABR’
Most participants had heard of the term ‘ABR’, but only two understood it as a condition where bacteria become resistant to antibiotics:
‘In my opinion, antibiotic resistance occurs when bacteria are able to resist the effects of antibiotics.’ (P1)
‘As far as I’m concerned, antibiotic resistance is a condition where bacteria are able to protect themselves from the effects of antibiotics.’ (P5)
Three participants were unaware of the term:
‘Antibiotic resistance? What’s that? I don’t have a clue!’ (P4)
‘Huh? This is the first I’ve heard of the term [antibiotic] resistance.’ (P10)
‘What? I’m not aware of the term [antibiotic] resistance.’ (P22)
The majority stated that ABR occurs when the body becomes used to antibiotics:
‘Antibiotic resistance is a condition where the body becomes used to antibiotics.’ (P6)
‘My understanding of antibiotic resistance is that it occurs when the body gets used to antibiotics.’ (P8)
Other participants understood ABR as follows:
antibiotics losing their potency before killing bacteria:
‘I think antibiotic resistance occurs when antibiotics lose their potency before killing bacteria.’ (P21)
the body becoming incompatible with antibiotics:
‘The body is not compatible with antibiotics. That’s what antibiotic resistance is.’ (P13)
the illness becoming too strong for antibiotics to manage:
‘As far as I know, antibiotic resistance is a condition where an illness is becoming stronger than antibiotics.’ (P16)
a hereditary illness:
‘Based on my understanding, antibiotic resistance is a hereditary illness. If none of our family members is affected by antibiotic resistance, we won’t suffer from it.’ (P19)
Knowledge of the causes of ABR
Although most participants noted an association between antibiotic use and ABR, they expressed uncertainty about the causes of ABR:
‘I guess there is a link between antibiotic use and antibiotic resistance. But, I’m not sure how antibiotic resistance arises.’ (P3)
‘I don’t really know the root of antibiotic resistance. Perhaps there is a connection between antibiotic use and [antibiotic] resistance.’ (P6)
Some participants stated that inappropriate prescribing of antibiotics, including unnecessary prescription of this medicine, can lead to ABR:
‘In my opinion, unnecessary antibiotic prescriptions can contribute to antibiotic resistance.’ (P12)
‘I guess over-prescription of antibiotics can lead to antibiotic resistance.’ (P14)
A few participants attributed ABR to the irresponsible use of antibiotics such as not adhering to antibiotic regimens and not completing the prescribed course:
‘I think antibiotic resistance is likely to occur if we don’t take antibiotics according to the instructions on the label.’ (P15)
‘Antibiotic resistance may occur if we don’t finish the prescribed course of antibiotics.’ (P18)
Two participants indicated that inadequately implementing the regulations on antibiotic availability could contribute to ABR. They reported that some community pharmacists dispensed antibiotics over the counter (OTC), although in Malaysia, regulations prohibit dispensing antibiotics without a prescription:
‘When I picked up my dad’s medication from a [community] pharmacy, I saw something was not right. The pharmacist sold antibiotics under the counter. You know, such actions can lead to antibiotic resistance.’ (P17)
‘I notice some [community] pharmacists sell antibiotics without a prescription, even though the law says otherwise. I think such things can contribute to antibiotic resistance.’ (P20)
Knowledge of the consequences of ABR
Most participants were unaware of the consequences of ABR. Moreover, they were not concerned about it:
‘I don’t know the consequences of antibiotic resistance. Anyway, it doesn’t concern me at all!’ (P10)
‘I can’t think of the consequences of [antibiotic] resistance. In fact, I’m not concerned about it.’ (P13)
Only two participants were aware of some consequences of ABR, including infections being more difficult to treat and the higher cost of treatment:
‘As far as I know, illnesses are harder to treat because of [antibiotic] resistance.’ (P1)
‘I’m sure the cost of treatment will increase because of antibiotic resistance.’ (P5)
Knowledge of the prevention of ABR
Most participants were unaware of how ABR can be prevented. They also indicated that they were not at risk of contracting antibiotic-resistant infections and had a limited role in avoiding the emergence and spread of ABR:
‘I’m just an ordinary person. I’m not sure how antibiotic resistance can be prevented. I guess there is nothing I can do about it. Anyway, I don’t think antibiotic resistance will affect me.’ (P2)
‘I don’t know how we can prevent antibiotic resistance. I guess I can do nothing to slow down the spread of the resistance. Somehow, I believe that I’m not at risk of getting an antibiotic-resistant infection.’ (P6)
Conversely, only a few participants stated that responsible use of antibiotics, such as adhering to antibiotic regimens and completing the prescribed course, can prevent ABR:
‘I suppose taking antibiotics exactly as your doctor tells you can prevent antibiotic resistance.’ (P15)
‘Finishing the prescribed course of antibiotics can prevent antibiotic resistance.’ (P18)
Other participants had some suggestions about how physicians, pharmacists and policymakers should prevent ABR. A few proposed that physicians should only prescribe antibiotics when they are needed, and should educate patients about ways to prevent ABR:
‘In my view, doctors should prescribe antibiotics when patients really need them. Besides, they should explain what we should do to prevent [antibiotic] resistance.’ (P12)
‘In my opinion, doctors should give advice on how we can prevent antibiotic resistance. Most importantly, they should only prescribe antibiotics when patients need them.’ (P14)
Two participants pointed out that policymakers should take steps to enforce the law on prescribing and dispensing antibiotics:
‘I suppose the government should enforce the law so that antibiotics won’t be freely available in [community] pharmacies.’ (P17)
‘The government should do something so that doctors won’t simply prescribe antibiotics and [community] pharmacists stop selling the medicine without a prescription.’ (P20)
Only one participant stated that pharmacists should educate patients on how to use antibiotics responsibly to prevent ABR:
‘Pharmacists should provide an adequate explanation of how to take antibiotics appropriately and how to avoid [antibiotic] resistance.’ (P19)
Theme 4: perceptions of taking responsibility for combating ABR
When asked about the stakeholders who should take responsibility for combating ABR, the majority felt that physicians play a vital role in combating this major public health problem, as they are medical experts and have the authority to prescribe antibiotics:
‘Apart from being trained in medical science, doctors are also qualified to prescribe antibiotics. Hence, they should take responsibility for combating antibiotic resistance.’ (P5)
‘In my view, doctors play a key role in combating antibiotic resistance because they are experts in the field.’ (P8)
Some participants indicated that pharmacists should also take responsibility for combating ABR, because they are members of the healthcare team and dispense medicines:
‘Pharmacists are part of the medical team. Their job is to prepare all sorts of medicines including antibiotics. So they should take responsibility for combating antibiotic resistance.’ (P3)
‘As pharmacists prepare medicines for patients, there is no doubt in my mind that they should take responsibility for combating antibiotic resistance.’ (P9)
Only a few participants perceived themselves as having responsibility for preventing ABR, because they believed that they were at risk of contracting antibiotic-resistant infections:
‘As a consumer, I get the feeling that I could be affected by antibiotic resistance. Therefore, I should take action to prevent this problem.’ (P15)
‘I think all patients, including myself, have responsibility for combating [antibiotic] resistance because all of us are at risk of getting an antibiotic-resistant infection.’ (P18)
Two participants emphasised that policymakers play a key role in combating ABR, as they develop policies and enforce the law:
‘First and foremost, the government develops policies and has the power to enforce the law. Consequently, it plays a major role in combating antibiotic resistance.’ (P17)
‘The government is the one who develops policies and therefore it has to take the lead in combating antibiotic resistance.’ (P20)
This qualitative study yields important findings regarding community residents’ knowledge, attitudes and perceptions in relation to antibiotics and ABR. It also identifies areas of focus that need to be addressed when developing an educational intervention to increase their knowledge and change their attitudes and perceptions.
The study revealed that only a few participants were aware that antibiotics are medicines used to treat bacterial infections. The majority asserted that antibiotics are effective for treating viral infections, while others understood them as medicines that reduce fevers and inflammation, relieve pain, or prevent any illnesses from becoming severe. This aligns with the findings of other Malaysian studies, whereby the majority of the public surveyed in the States of Selangor (68%)  and Penang (67%)  stated that antibiotics are effective against viral infections. Similarly, a large number (64–71%) of the public surveyed in Indonesia , Namibia , Nigeria , Pakistan , Saudi Arabia , South Korea , the United States  and across many countries  also indicated that antibiotics are medicines that kill viruses.
This could be attributed to several factors. First, the study participants might not be adequately informed by healthcare professionals about what antibiotics should be used for and when they should be used . Second, physicians and pharmacists often use the term ‘germs’ rather than ‘bacteria’ or ‘viruses’ when educating the public about infections [57, 65, 66]. Finally, frequent antibiotic prescribing for upper respiratory tract infections (URTIs) could contribute to public misconceptions that antibiotics are the first-line therapy for such conditions and can rapidly improve their symptoms [57, 67, 68]. As a result, the public is inclined to expect or request antibiotics from physicians when they have symptoms of URTIs [67,68,69]. In this study, a few participants indicated that they would make their expectations explicit and request antibiotics from their physician when they had viral infections. Conversely, some noted that they would not express these expectations openly nor request antibiotics, as they would rather maintain a good relationship with their physician. This is similar to the findings of a UK study conducted by Butler et al. , whereby one-third of the public expected antibiotics from a physician when they had colds or sore throats, but only one participant made this expectation explicit. Others viewed the physician–patient relationship as important, and were thus reluctant to request antibiotics from their physician. Lam et al.  also reported that 22% of the public surveyed in Hong Kong expected their physician to prescribe antibiotics for viral infections. However, they did not make their expectations explicit. Healthcare professionals play a key role in educating patients about the appropriate use of antibiotics. This could be done during the clinical consultation by providing explanations as to why antibiotics are not needed (e.g. viral infections) . In fact, at the clinical consultation level, discussing the benefits and harms of antibiotics in a balanced way is a useful strategy to enhance patients’ understanding of antibiotics. The discussion could include the indication of the antibiotics and the potential harms associated with ABR on the patient and the community [21, 73]. Therefore, the key role of healthcare professionals is central in the rational use of antibiotics.
This study revealed that most participants were unaware of the common adverse effects of antibiotics, while other Malaysian studies showed that slightly more than half of the public surveyed in Penang (54%)  and the Federal Territory of Putrajaya (52%)  did not know that antibiotics have adverse effects. Similarly, Barber et al.  found that 55% of the public surveyed in the Philippines were unaware of the adverse effects of antibiotics. This might indicate that pharmacists are not educating patients about the common adverse effects of antibiotics and possible allergic reactions, how these can be minimised and what action they should take when these adverse effects occur [76, 77]. Inaccurate or inadequate information could influence public attitudes towards antibiotics. Some patients may be reluctant to take antibiotics because they fear adverse effects [78,79,80].
Most of the study participants acquired antibiotics from their physician. This could be due to the fact that in Malaysia, most medicines are available free of charge in public hospitals and primary-care clinics [81, 82]. Private practice physicians also have the legal right to prescribe and dispense medicines. Consequently, most patients obtain medicines from hospitals or primary-care clinics rather than community pharmacies [83, 84]. Some participants reported that they acquired antibiotics from a community pharmacy before consulting a physician, as they wanted to recover quickly from viral infections. This aligns with the findings of a public survey conducted in Kenya, whereby 22% of participants with acute respiratory tract infections acquired antibiotics from a community pharmacy before seeking the advice of a physician . In this study, a few participants took antibiotics given to them by their family or friends, as they believed that antibiotics are effective for treating colds and sore throats. This practice has also been reported in Indonesia , Nigeria , Palestine  and other LMICs . Similar to studies conducted in Indonesia , Jordan [88,89,90], the UK  and other LMICs , a few participants in the present study reported that they took leftover antibiotics prescribed for a previous illness when similar symptoms arose, because they wanted to save the time it would take to visit a primary-care clinic. Self-medication with antibiotics is a cause for concern because in Malaysia, antibiotics are classified as prescription-only medicines—therefore, dispensing them without a prescription is prohibited . In addition, this practice not only contributes to the emergence and spread of ABR, but can also mask the diagnosis of infectious diseases and the development of chronic diseases. It may also result in adverse drug reactions and high treatment costs, since non-prescribed antibiotic use is usually associated with inappropriate medicine selection and suboptimal dosing or treatment duration [92,93,94,95,96,97]. Thus, the public must gain a better understanding of why antibiotics should only be taken when they have been prescribed to a specific individual for a particular illness ; pharmacists should recommend OTC medicines rather than antibiotics for minor illnesses such as colds [10, 98]; and policymakers should take steps to strengthen implementation of regulations on dispensing antibiotics [18, 98, 99].
The WHO  suggests that patients should adhere to antibiotic regimens and take the full prescribed course. This study showed that more than half of the participants took antibiotics according to the instructions on the label. However, they intentionally stopped taking the medicine when their symptoms improved, because they believed that they had recovered from the infection when they felt better. This is consistent with the findings of other Malaysian studies, whereby the majority of the public surveyed in the State of Pahang (69%)  and the Federal Territory of Kuala Lumpur (55%)  did not complete their prescribed course of antibiotics. Similarly, more than half (57–71%) of the public surveyed in India [101,102,103] and Saudi Arabia [104, 105] discontinued taking antibiotics when they felt better. On the contrary, less than one-third (30%) of the public surveyed in Hong Kong , Oman  and Qatar  stopped taking antibiotics when their symptoms improved. This suggests that pharmacists should educate patients about the importance of taking a full prescribed course of antibiotics . Providing clear instructions and adequate explanations will positively influence their adherence to antibiotic therapy .
This study revealed that some participants occasionally missed a few doses of antibiotics because of their hectic lifestyle. Forgetting to take antibiotics indicates that participants had forgotten that they were feeling unwell or believed their condition was not severe, meaning that antibiotics were not needed or their condition had improved to the point that it was no longer necessary to take antibiotics [28, 110].
Most of the study participants disposed of leftover antibiotics in a dustbin; none returned them to pharmacists or physicians. This aligns with the findings of other Malaysian studies, whereby the majority of the public surveyed in Kuala Lumpur (79%)  and Pahang (64%)  disposed of leftover antibiotics in a rubbish bin. Tong et al.  also reported that the most common method for disposing of leftover medicines was placing them in a dustbin (43%). Disposing of leftover antibiotics in this manner can cause harm to children, pets and individuals who intentionally search household trash seeking medicines. Moreover, these antibiotics could enter the environment through landfill leachates and eventually contaminate water systems, resulting in ABR [112,113,114,115]. Hence, pharmacists should encourage patients to return leftover antibiotics to any public hospital or primary-care clinic when their physician advises them to stop taking their prescribed course . Further, they should educate patients regarding the consequences of improper antibiotic disposal.
The study revealed that most participants had heard of the term ‘ABR’, but only a few correctly understood the term as a condition where bacteria become resistant to antibiotics. The majority understood the term as the body becoming used to antibiotics, whereas others understood it as antibiotics losing their potency before killing bacteria, the body becoming incompatible with antibiotics, the illness becoming too strong for antibiotics to manage or a hereditary illness. This is consistent with the findings of qualitative studies carried out in European countries , India  and the UK , and the findings of public surveys conducted in Kuwait , Sweden  and across many countries , whereby the majority of participants (56–87%) asserted that ABR occurs when the body becomes used to antibiotics. This common misconception could raise public concerns about personal overuse of antibiotics and deter them from completing a prescribed course [19, 28].
Although most of the study participants were aware of a correlation between antibiotic use and ABR, they remained uncertain about the causes of this problem. Some attributed ABR to external factors, such as inappropriate prescribing or dispensing of antibiotics without a prescription, rather than internal factors, such as non-adherence to antibiotic therapy. In addition, they believed that they were not at risk of contracting antibiotic-resistant infections, despite the fact that antibiotic-resistant bacteria can spread readily from one person to another and affect anyone [119, 120]. As a consequence, they neither perceived themselves as being responsible for preventing ABR, nor indicated that they play an important role in avoiding the problem. This is similar to the findings from other qualitative studies conducted in the UK [26, 27], whereby most of the public perceived the causes of ABR as due to external rather than internal factors. As a result, they believed that others should take action to prevent ABR. This is a cause for concern, as all stakeholders, including the public, should take responsibility for combating this problem [3, 5, 119, 121].
The study showed that most participants were unaware of the consequences of ABR, and not concerned about this issue. Similar findings have been reported in the UK [26, 27], whereby the majority of the public was unclear about the impact of ABR on individuals and the community. Conversely, a public survey conducted in the UK  indicated that 81% of participants were concerned about ABR after participating in public education campaigns on antibiotics.
Study strengths and limitations
The purposive and maximum variation sampling was employed in this study. In fact, this sampling strategy can achieve representativeness and capture the heterogeneity in the population. Thus, the study managed to capture a wide range of community residents’ views, knowledge, attitudes and perceptions regarding antibiotics and ABR. Hence, it provided a greater insight into the study phenomena . In addition, a rigorous approach was used to ensure the data validity and reliability by verifying the transcripts and study findings from the participants, and by involving an independent researcher in the analysis [123,124,125]. The small sample size might be seen as a limitation when judged by quantitative standards. However, the adequacy of sample in qualitative research is determined by data saturation—which is the gold standard method that determines the adequacy of the sample size in qualitative research . In addition, our sample size is comparable to other studies, particularly the studies that used the same methodology (i.e. qualitative study) and the same topic [20, 21, 24,25,26, 30]. As with most interview studies, it is possible that the study participants gave socially desirable responses or were unwilling to share their experiences, attitudes and perceptions openly . To minimise this, the authors reassured the participants that no consequences would arise from anything they revealed during the interviews . Moreover, as the majority had a misconception about the term antibiotics, they could have confused antibiotics with other medicines when talking about their previous experiences with antibiotics. However, we were aware of this issue and tried to minimise it by in-depth discussions to ensure that the participants were discussing their experiences with antibiotics. Additionally, the interviews were conducted in a professional manner—no one else was present and participant confidentiality was maintained. As the study was conducted in Penang, the findings may not be generalised throughout Malaysia. However, since the study participants were from different age groups, ethnic, educational and socioeconomic backgrounds, it is likely that diverse communities in other parts of Malaysia would have a similar lack of knowledge about antibiotics and ABR. Overall, we believe that the findings are robust and might be transferable to similar populations or settings in Malaysia. However, more studies to replicate the results in different settings, populations or contexts are needed as other aspects and issues surrounding the use of antibiotics might be uncovered.
The findings indicate that the majority of community residents lacked knowledge about antibiotics and ABR, had negative attitudes towards antibiotics and had negative perceptions of ABR. Therefore, there is an urgent need to develop and implement educational interventions to address key gaps in their knowledge, correct common misconceptions and shift their attitudes and perceptions. The areas of focus that need to be addressed include the appropriate use of antibiotics and their adverse effects; the importance of adhering to antibiotic therapy; and the definition, causes, consequences and prevention of ABR.
Availability of data and materials
The datasets generated or analysed during the study are available from the corresponding author on reasonable request.
Low-and Middle-Income Countries
Over the Counter
Upper Respiratory Tract Infections
Universiti Sains Malaysia
World Health Organization
Centers for Disease Controls and Prevention (CDC). Antibiotic resistance threats in the United States. [http://www.cdc.gov/drugresistance/threat-report-2013/] Acessed 30 Aug 2019.
Laxminarayan R, Duse A, Wattal C, Zaidi AM, Wertheim HL, Sumpradit N. Antibiotic resistance—the need for global solutions. Lancet Infect Dis. 2013;13(12):1057–98.
World Health Organization (WHO). Global action plan on antimicrobial resistance [http://apps.who.int/iris/bitstream/10665/193736/1/9789241509763_eng.pdf?ua=1] Acessed 30 Aug 2019.
World Health Organization (WHO). Antimicrobial resistance: global report on surveillance [http://www.who.int/drugresistance/documents/surveillancereport/en/] Acessed 30 Aug 2019.
Tackling drug-resistant infections globally: final report and recommendations [https://amr-review.org/sites/default/files/160525_Final%20paper_with%20cover.pdf] Acessed 30 Aug 2019.
Public Health England. English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) 2010 to 2014 [https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/477962/ESPAUR_Report_2015.pdf ] Acessed 30 Aug 2019.
Godman B, Acurcio FA, Guerra AA, Faridah MY, Bishop I, Campbell S, Eriksson I, Finlayson AE, Furst J, Garuoliene K, et al. Initiatives among authorities to improve the quality and efficiency of prescribing and the implications. J Pharm Care Health Syst. 2014;1:13.
Islahudin F, Tamezi AA, Shah NM. Knowledge, attitudes and practices about antibiotic use among the general public in Malaysia. Southeast Asian J Trop Med Public Health. 2014;45(6):1474–82.
Ocan M, Obuku EA, Bwanga F, Akena D, Richard S, Ogwal-Okeng J, Obua C. Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries. BMC Public Health. 2015;15(1):742.
World Health Organization (WHO). Pharmacists have decisive role in combating antibiotic resistance [http://www.euro.who.int/__data/assets/pdf_file/0003/263109/Press-release,-Pharmacists-have-decisive-role-in-combating-antibiotic-resistance,-says-new-WHO-European-survey.pdf?ua=1] Acessed 30 Aug 2019.
Alili-Idrizi E, Dauti M, Malaj L. Validation of the parental knowledge and attitude towards antibiotic usage and resistance among children in Tetovo, the republic of Macedonia. Pharm Pract (Granada). 2014;12(4):467.
Gualano MR, Gili R, Scaioli G, Bert F, Siliquini R. General population's knowledge and attitudes about antibiotics: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf. 2015;24(1):2–10.
Al-Haddad MS. General public knowledge, source of knowledge and practice towards antibiotics in the state of Penang, Malaysia. Arch Pharm Pract. 2012;3(3):233–41.
Zarb P, Goossens H. Human use of antimicrobial agents. Rev Sci Tech. 2012;31(1):121–33.
World Health Organization (WHO). Worldwide country situation analysis: response to antimicrobial resistance [http://www.who.int/drugresistance/documents/situationanalysis/en/] Acessed 30 August 2019.
Lavery JV, Tinadana PO, Scott TW, Harrington LC, Ramsey JM, Ytuarte-Nunez C, James AA. Towards a framework for community engagement in global health research. Trends Parasitol. 2010;26(6):279–83.
Brookes-Howell L, Elwyn G, Hood K, Wood F, Cooper L, Goossens H, Ieven M, Butler CC. The body gets used to them: patients’ interpretations of antibiotic resistance and the implications for containment strategies. J Gen Intern Med. 2011;27(7):766–72.
Chandy SJ, Mathai E, Thomas K, Faruqul AR, Holloway K, Lundburg CS. Antibiotic use and resistance: perceptions and ethical challenges among doctors, pharmacists and the public in Vellore, South India. Indian J Med Ethics. 2013;10(1):20–7.
Norris P, Chamberlain K, Dew K, Gabe J, Hodgetts D, Madden H. Public beliefs about antibiotics, infection and resistance: a qualitative study. Antibiotics. 2013;2(4):465–76.
Ancillotti M, Eriksson S, Veldwijk J, Fahlquist JN, Andersson DI, Godskesen T. Public awareness and individual responsibility needed for judicious use of antibiotics: a qualitative study of public beliefs and perceptions. BMC Public Health. 2018;18(1):1153.
Bakhit M, Del Mar C, Gibson E, Hoffmann T. Exploring patients’ understanding of antibiotic resistance and how this may influence attitudes towards antibiotic use for acute respiratory infections: a qualitative study in Australian general practice. BMJ Open. 2019;9(3):e026735.
Tillekeratne LG, Bodinayake CK, Dabrera T, Nagahawatte A, Arachchi WK, Sooriyaarachchi A, Stewart K, Watt M, Østbye T, Woods CW. Antibiotic overuse for acute respiratory tract infections in Sri Lanka: a qualitative study of outpatients and their physicians. BMC Fam Pract. 2017;18(1):37.
Watkins JA, Wagner F, Gómez-Olivé FX, Wertheim H, Sankoh O, Kinsman J. Rural south African community perceptions of antibiotic access and use: qualitative evidence from a health and demographic surveillance system site. Am J Trop Med Hyg. 2019;100(6):1378–90.
Kaae S, Malaj A, Hoxha I. Antibiotic knowledge, attitudes and behaviours of Albanian health care professionals and patients–a qualitative interview study. J Pharm Policy Pract. 2017;10(1):13.
Widayati A, Suryawati S, Crespigny C, Hiller JE. Beliefs about the use of nonprescribed antibiotics among people in Yogyakarta City, Indonesia: a qualitative study based on the theory of planned behaviour. Asia Pac J Public Health. 2015;27(2):NP402–13.
Brooks L, Shaw A, Sharp D, Hay AD. Towards a better understanding of patients’ perspectives of antibiotic resistance and MRSA: a qualitative study. Fam Pract. 2008;25(5):341–8.
Hawkings NJ, Wood F, Butler CC. Public attitudes towards bacterial resistance: a qualitative study. J Antimicrob Chemother. 2007;59(6):1155–60.
Hawkings NJ, Butler CC, Wood F. Antibiotics in the community: a typology of user behaviours. Patient Educ Couns. 2008;73(1):146–52.
Hawking MK, Lecky DM, Lundgren PT, Aldigs E, Abdulmajed H, Ioannidou E, Paraskeva-Hadjichambi D, Khouri P, Gal M, Hadjichambis AC. Attitudes and behaviours of adolescents towards antibiotics and self-care for respiratory tract infections: a qualitative study. BMJ Open. 2017;7(5):e015308.
Van Hecke O, Butler CC, Wang K, Tonkin-Crine S. Parents’ perceptions of antibiotic use and antibiotic resistance (PAUSE): a qualitative interview study. J Antimicrob Chemother. 2019;74(6):1741–7.
Godman B, Fadare J, Kibuule D, Irawati L, Mubita M, Ogunleye O, Oluka M, Paramadhas BDA, de Oliveira CJ, de Lemos LLP. Initiatives across countries to reduce antibiotic utilisation and resistance patterns: impact and implications. In: Drug resistance in bacteria, fungi, malaria, and cancer. edn. Cham: Springer; 2017. p. 539–76.
World Health Organization (WHO). Antibiotic resistance: multi-country public awareness survey [http://apps.who.int/medicinedocs/documents/s22245en/s22245en.pdf] Accessed 30 Aug 2019.
Berg BL, Lune H. Qualitative research methods for the social sciences 8th edn. London: Pearson Education, Inc; 2011.
Hassali MA, Saleem F, Farooqui M, Aljadhey H. Strengthening pharmacy practice research: the need for combining both qualitative and quantitative methodology. J Pharm Care Health Syst. 2014;1(3):112.
Tonna AP, Edwards RM. Is there a place for qualitative research methods in pharmacy practice? Eur J Hosp Pharm Sci Pract. 2013;20:97–9.
Kairuz T, Crump K, O'brien A. An overview of qualitative research. Pharm J. 2007;277:312–4.
Husserl E. Ideas: general introduction to pure phenomenology. 1st ed. London and New York: Routledge; 2012.
Lester S. An introduction to phenomenological research 1st edn. Taunton: Stan Lester Developments; 1999.
Sokolowski R. Introduction to phenomenology 1st edn. Cambridge: Cambridge University Press; 2000.
Starks H, Trinidad SB. Choose your method: a comparison of phenomenology, discourse analysis and grounded theory. Qual Health Res. 2007;17(10):1372–80.
Background and definition [http://www.penerangan.gov.my/index.php/en/programmes/1malaysia-community/background-and-definition] Acessed 30 Aug 2019.
Etikan I, Musa SA, Alkassim RS. Comparison of convenience sampling and purposive sampling. Am J Theor Appl Stat. 2016;5(1):1–4.
Maxwell JA. Designing a qualitative study. In: Bickman L, Rog DJ, editors. Handbook of applied social research methods. 2nd ed. United States of America: Sage Publications, Inc; 2009. p. 214–53.
Teddlie C, Yu F. Mixed methods sampling. J Mixed Methods Res. 2007;1(1):77–100.
Cote L, Turgeon J. Appraising qualitative research articles in medicine and medical education. Med Teach. 2005;27(1):71–5.
Giacomini MK, Cook DJ. Users’ guides to the medical literature: XXIII. Qualitative research in health care a. are the results of the study valid? JAMA. 2000;284(3):357–62.
Hennink M, Hutter I, Bailey A. Qualitative research methods. 1st ed. London: Sage Publications, Inc.; 2011.
McKenna SA, Main DS. The role and influence of key informants in community-engaged research: a critical perspective. Action Res. 2013;11(2):113–24.
Silverman D. Doing qualitative research 4th edn. Great Britain: Sage Publications, Inc; 2013.
Bowen GA. Naturalistic inquiry and the saturation concept: a research note. Qual Res. 2008;8(1):137–52.
Creswell JW. Educational research: planning, conducting, and evaluating quantitative and qualitative research 4th edn. Pearson Education, Inc: United States of America; 2012.
Curry LA, Nembhard IM, Bradley EH. Qualitative and mixed methods provide unique contributions to outcomes research. Circulation. 2009;119(10):1442–52.
Fossey E, Harvey C, McDermott F, Davidson L. Understanding and evaluating qualitative research. Aust N Z J Psychiatry. 2002;36:717–32.
Chen H, Boore J. Translation and back-translation in qualitative nursing research: methodological review. J Clin Nurs. 2009;19:234–9.
Hendrickson SG, Harrison TC, Lopez NA, Zegarra-Coronado AG, Ricks T. Translation cost, quality and adequacy. J Nurs Scholarsh. 2013;45(2):185–91.
Chan GC, Tang SF. Parental knowledge, attitudes and antibiotic use for acute upper respiratory tract infection in children attending a primary healthcare clinic in Malaysia. Singap Med J. 2006;47(4):266–70.
Oh AL, Hassali MA, Al-Haddad MS, Sulaiman SA, Shafie AA, Awaisu A. Public knowledge and attitudes towards antibiotic usage: a cross-sectional study among the general public in the state of Penang, Malaysia. J Infect Dev Ctries. 2011;5(5):338–47.
Widayati A, Suryawati S, de Crespigny C, Hiller JE. Knowledge and beliefs about antibiotics among people in Yogyakarta City, Indonesia: a cross sectional population-based survey. Antimicrob Resist Infect Control. 2012;1(1):38.
Pereko DD, Lubbe MS, Essack SY. Public knowledge, attitudes and behaviour towards antibiotic usage in Windhoek, Namibia. South Afr J Infect Dis. 2015;30(4):134–7.
Auta A, Banwat SB, David S, Dangiwa DA, Ogbole E, Tor-anyiin AJ. Antibiotic use in some Nigerian communities: knowledge and attitudes of consumers. Trop J Pharm Res. 2013;12(6):1087–92.
Naseem S, Iffat W, Shakeel S, Tariq S. Knowledge about antibiotic use amongst the public: a cross sectional study in Karachi. Infect Dis J Pak. 2016;25(3):49–54.
Abobotain AH, Sheerah HA, Alotaibi FN, Joury AU, Mishiddi RM, Siddiqui AR, Saeed A. Socio-demographic determinants of antibiotic misuse in children: a survey from the central region of Saudi Arabia. Saudi Med J. 2013;34(8):832–40.
Kim SS, Moon S, Kim EJ. Public knowledge and attitudes regarding antibiotic use in South Korea. J Korean Acad Nurs. 2011;41(6):742–9.
Filipetto FA, Modi DS, Weiss LB, Ciervo CA. Patient knowledge and perception of upper respiratory infections, antibiotic indications and resistance. Patient Prefer Adherence. 2008;2:35–9.
Kandelaki K, Lundborg CS, Marrone G. Antibiotic use and resistance: a cross-sectional study exploring knowledge and attitudes among school and institution personnel in Tbilisi, Republic of Georgia. BMC Res Notes. 2015;8(1):1–8.
Rousounidis A, Papaevangelou V, Hadjipanayis A, Panagakou S, Theodoridou M, Syrogiannopoulos G, Hadjichristodoulou C. Descriptive study on parents’ knowledge, attitudes and practices on antibiotic use and misuse in children with upper respiratory tract infections in Cyprus. Int J Environ Res Public Health. 2011;8(8):3246–62.
Rezal RS, Hassali MA, Alrasheedy AA, Saleem F, Yusof FA, Godman B. Physicians’ knowledge, perceptions and behaviour towards antibiotic prescribing: a systematic review of the literature. Expert Rev Anti-Infect Ther. 2015;13(5):665–80.
Hassali MA, Kamil TK, Yusof FA, Alrasheedy AA, Yusoff ZM, Saleem F, SK AL-T, Wong ZY, Aljadhey H, Godman B. General practitioners’ knowledge, attitude and prescribing of antibiotics for upper respiratory tract infections in Selangor, Malaysia: findings and implications. Expert Rev Anti-Infect Ther. 2015;13(4):511–20.
Kalungia AC, Burger J, Godman B, Costa JO, Simuwelu C. Non-prescription sale and dispensing of antibiotics in community pharmacies in Zambia. Expert Rev Anti-Infect Ther. 2016;14(12):1215–23.
Butler CC, Rollnick S, Pill R, Maggs-Rapport F, Stott N. Understanding the culture of prescribing: qualitative study of general practitioners’ and patients’ perceptions of antibiotics for sore throats. Br Med J. 1998;317(7159):637–42.
Lam TP, Lam KF, Ho PL, Yung R. Knowledge, attitude and behaviour toward antibiotics among Hong Kong people: local-born versus immigrants. Hong Kong Med Jl. 2015;21(6):S41–7.
Radyowijati A, Haak H. Improving antibiotic use in low-income countries: an overview of evidence on determinants. Soc Sci Med. 2003;57(4):733–44.
McCullough A, Parekh S, Rathbone J, Del Mar C, Hoffmann T. A systematic review of the public's knowledge and beliefs about antibiotic resistance. J Antimicrob Chemother. 2015;71(1):27–33.
Lim KK, Teh CC. A cross sectional study of public knowledge and attitude towards antibiotics in Putrajaya, Malaysia. South Med Rev. 2012;5(2):26–33.
Barber DA, Casquejo E, Ybanez PL, Pinote MT, Casquejo L, Pinote LS, Estorgio M, Young AM. Prevalence and correlates of antibiotic sharing in the Philippines: antibiotic misconceptions and community-level access to non-medical sources of antibiotics. Tropical Med Int Health. 2017;22(5):567–75.
National Health Service (NHS). Respiratory tract infections [http://www.nhs.uk/Conditions/Respiratory-tract-infection/Pages/Introduction.aspx] Acessed 30 Aug 2019.
NPS. Understanding side effects [http://www.nps.org.au/topics/how-to-be-medicinewise/side-effects-interactions/understanding-side-effects] Acessed 30 Aug 2019.
Dawood OT, Hassali MA, Saleem F. A qualitative study exploring medicines use pattern and practice among general public in Malaysia. Pharm Pract (Granada). 2016;14(2):740.
Filho AI, Lima-Costa MF, Uchoa E. Bambui project: a qualitative approach to self-medication. Cad Saude Publica. 2004;20(6):1661–9.
Fried TR, Tinetti ME, Towle V, O’Leary JR, Iannone L. Effects of benefits and harms on older persons’ willingness to take medication for primary cardiovascular prevention. Arch Intern Med. 2011;171(10):923–8.
Babar ZU, Ibrahim MI, Singh H, Bukahri NI, Creese A. Evaluating drug prices, availability, affordability and price components: implications for access to drugs in Malaysia. PLoS Med. 2007;4(3):e82.
Ministry of Health Malaysia. Malaysian national medicines policy [http://www.pharmacy.gov.my/v2/sites/default/files/document-upload/buku-dunas.pdf] Acessed 30 Aug 2019.
Shafie AA, Hassali MA, Azhar S, See OG. Separation of prescribing and dispensing in Malaysia: a summary of arguments. Res Soc Adm Pharm. 2012;8(3):258–62.
Tiong J, Mai CW, Gan PW, Johnson J, Mak V. Separation of prescribing and dispensing in Malaysia: the history and challenges. Int J Pharm Pract. 2016;24(4):302–5.
Bigogo G, Audi A, Aura B, Aol G, Breiman RF, Feikin DR. Health-seeking patterns among participants of population-based morbidity surveillance in rural western Kenya: implications for calculating disease rates. Int J Infect Dis. 2010;14(11):e967–73.
Sapkota AR, Coker ME, Rosenberg Goldstein RE, Atkinson NL, Sweet SJ, Sopeju PO, Ojo MT, Otivhia E, Ayepola OO, Olajuyigbe OO, et al. Self-medication with antibiotics for the treatment of menstrual symptoms in Southwest Nigeria: a cross-sectional study. BMC Public Health. 2010;10(1):610.
Sawalha AF. Self-medication with antibiotics: a study in Palestine. Int J Risk Saf Med. 2008;20(4):213–22.
Al-Azzam S, Al-Husein B, Alzoubi F, Masadeh M. Self-medication with antibiotics in Jordanian population. Int J Occup Med Environ Health. 2007;20(4):373–80.
Darwish DA, Abdelmalek S, Dayyih WA, Hamadi S. Awareness of antibiotic use and antimicrobial resistance in the Iraqi community in Jordan. J Infect Dev Ctries. 2014;8(5):616–23.
Sawair FA, Baqain ZH, Abu Karaky A, Abu Eid R. Assessment of self-medication of antibiotics in a Jordanian population. Med Princ Pract. 2009;18(1):21–5.
Poisons act 1952 (revised 1989) [http://www.pharmacy.gov.my/v2/sites/default/files/document-upload/poisons-act-1952-act-366.pdf] Acessed 30 Aug 2019.
Abdulhak A, Al-Tannir M, Almansor M, Almohaya M, Onazi A, Marei M, Aldossary O, Obeidat S, Obeidat M, Riaz M, et al. Non prescribed sale of antibiotics in Riyadh, Saudi Arabia: a cross sectional study. BMC Public Health. 2011;11(1):538.
Belkina T, Warafi AA, Eltom EH, Tadjieva N, Kubena A, Vlcek J. Antibiotic use and knowledge in the community of Yemen, Saudi Arabia and Uzbekistan. J Infect Dev Ctries. 2014;8(4):424–9.
Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis. 2011;11(9):692–701.
Shehab N, Patel PR, Srinivasan A, Budnitz DS. Emergency department visits for antibiotic-associated adverse events. Clin Infect Dis. 2008;47(6):735–43.
Togoobaatar G, Ikeda N, Ali M, Sonomjamts M, Dashdemberel S, Mori R, Shibuya K. Survey of non-prescribed use of antibiotics for children in an urban community in Mongolia. Bull World Health Organ. 2010;88(12):930–6.
Volpato DE, Souza BV, Rosa LD, Melo LH, Daudt CS, Deboni L. Use of antibiotics without medical prescription. Braz J Infect Dis. 2005;9:288–91.
FIP statement of policy: control of antimicrobial medicines resistance [http://apps.who.int/medicinedocs/documents/s19755en/s19755en.pdf] Acessed 30 Aug 2019.
How to stop antibiotic resistance? Here's a WHO prescription [http://www.who.int/mediacentre/commentaries/stop-antibiotic-resistance/en/] Acessed 30 Aug 2019.
Fatokun O. Exploring antibiotic use and practices in a Malaysian community. Int J Clin Pharm. 2014;36:564–9.
Radhakrishnan A. Jaykar Balasundaram, Arul Balasubramaniam, Gunasekaran G: evaluation of general public’s knowledge and perception of appropriate antibiotics use in Salem District. Indian J Pharm Pract. 2017;10(2):108–10.
Kurniawan K, Posangi J, Rampengan N. Association between public knowledge regarding antibiotics and self-medication with antibiotics in Teling Atas community health center, East Indonesia. Med J Indones. 2017;26(1):62–9.
Khalifeh M, Moore N, Salameh P. Public knowledge and attitude towards antibiotic use in Lebanon. Am J Epidemiol Infect Dis. 2017;5(2):35–41.
Abujheisha KY, Al-Shdefat R, Ahmed N, Fouda MI. Public knowledge and behaviours regarding antibiotics use: a survey among the general public. Int J Med Res Health Sci. 2017;6(6):82–8.
El Zowalaty ME, Belkina T, Bahashwan SA, El Zowalaty AE, Tebbens JD, Abdel-Salam HA, Khalil AI, Daghriry SI, Gahtani MA, Madkhaly FM, et al. Knowledge, awareness, and attitudes toward antibiotic use and antimicrobial resistance among Saudi population. Int J Clin Pharm. 2016;38(5):1261–8.
Wun YT, Lam TP, Lam KF, Ho PL, Yung WH. The public’s perspectives on antibiotic resistance and abuse among Chinese in Hong Kong. Pharmacoepidemiol Drug Saf. 2013;22(3):241–9.
Jose J, Jimmy B, AlSabahi AS, Al Sabei GA. A study assessing public knowledge, belief and behaviour of antibiotic use in an Omani population. Oman Med J. 2013;28(5):324–30.
Moienzadeh A, Massoud T, Black E. Evaluation of the general public’s knowledge, views and practices relating to appropriate antibiotic use in Qatar. Int J Pharm Pract. 2015;1(1):1–7.
Jin J, Sklar GE, Oh VMS, Li SC. Factors affecting therapeutic compliance: a review from the patient’s perspective. Ther Clin Risk Manag. 2008;4(1):269–86.
Myers LB, Midence K. Adherence to treatment in medical conditions. 1st ed. India: Harwood academic publishers; 1998.
Tong AY, Peake BM, Braund R. Disposal practices for unused medications around the world. Environ Int. 2011;37(1):292–8.
US Food and Drug Agency (FDA). Disposal of unused medicines: what you should know [http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/EnsuringSafeUseofMedicine/SafeDisposalofMedicines/ucm186187.htm] Acessed 30 Aug 2019.
Kummerer K. Significance of antibiotics in the environment. J Antimicrob Chemother. 2003;52(1):5–7.
Antimicrobials in agriculture and the environment: reducing unnecessary use and waste [https://amr-review.org/sites/default/files/Antimicrobials%20in%20agriculture%20and%20the%20environment%20-%20Reducing%20unnecessary%20use%20and%20waste.pdf] Acessed 30 Aug 2019.
Rosenblatt-Farrell N. The landscape of antibiotic resistance. Environ Health Perspect. 2009;117(6):A244–50.
Minstry of Health Mlaysia. Return your medicines programme [http://www.pharmacy.gov.my/v2/en/content/return-your-medicines-program.html] Acessed 30 Aug 2019.
Awad AI, Aboud EA. Knowledge, attitude and practice towards antibiotic use among the public in Kuwait. PLoS One. 2015;10(2):e0117910.
Vallin M, Polyzoi M, Marrone G, Rosales-Klintz S, Tegmark Wisell K, Stålsby Lundborg C. Knowledge and attitudes towards antibiotic use and resistance: a latent class analysis of a Swedish population-based sample. PLoS One. 2016;11(4):e0152160.
AURA 2016: First Australian report on antimicrobial use and resistance in human health [https://www.safetyandquality.gov.au/wp-content/uploads/2016/06/AURA-2016-First-Australian-Report-on-Antimicroibal-use-and-resistance-in-human-health.pdf] Acessed 30 Aug 2019.
Antibiotic resistance patient safety atlas [https://gis.cdc.gov/grasp/PSA/] Acessed 30 Aug 2019.
Merrett GL, Bloom G, Wilkinson A, MacGregor H. Towards the just and sustainable use of antibiotics. J Pharm Policy Pract. 2016;9(1):31.
McNulty C, Boyle P, Nichols T, Clappison P, Davey P. Don’t wear me out: the public's knowledge of and attitudes to antibiotic use. J Antimicrob Chemother. 2007;59(4):727–38.
Anney VN. Ensuring the quality of the findings of qualitative research: looking at trustworthiness criteria. J Emerg Trends Educ Res Policy Stud. 2014;5(2):272–81.
Noble H, Smith J. Issues of validity and reliability in qualitative research. Evid Based Nurs. 2015;18(2):34–5.
Smith F. Research methods in pharmacy practice. 1st ed. London: Pharmaceutical Press; 2002.
Guest G, Bunce A, Johnson L. How many interviews are enough? An experiment with data saturation and variability. Field Methods. 2006;18(1):59–82.
Cope AL, Wood F, Francis NA, Chestnutt IG. General dental practitioners’ perceptions of antimicrobial use and resistance: a qualitative interview study. Br Dent J. 2014;217(5):E9.
The authors would like to thank all the community residents who participated in this study.
The study was supported by a research university grant from USM (grant number: 1001/PFARMASI/816263). The study sponsor had no involvement in study design; data collection, analysis and interpretation; or in writing the manuscript and decision to submit it for publication.
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The study was approved by the Joint Ethics Committee of the School of Pharmaceutical Sciences, USM–Lam Wah Ee Hospital on Clinical Studies (approval number: USM–HLWE/IEC/2016 (0010)). Written informed consent to participate in the study was obtained from the participants.
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Irawati, L., Alrasheedy, A.A., Hassali, M.A. et al. Low-income community knowledge, attitudes and perceptions regarding antibiotics and antibiotic resistance in Jelutong District, Penang, Malaysia: a qualitative study. BMC Public Health 19, 1292 (2019). https://doi.org/10.1186/s12889-019-7718-9
- Antibiotic resistance
- Qualitative study