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Gender-based violence and engagement in biomedical HIV prevention, care and treatment: a scoping review



While gender-based violence (GBV) has been shown to increase women’s risk of HIV acquisition, the role of GBV in the HIV testing to care continuum is less clear. Clarifying how GBV may act as a barrier to accessing HIV services, treatment and care - such as anti-retroviral treatment (ART) or pre-exposure prophylaxis (PrEP) - will not only provide insights into how to best meet individual women’s HIV care needs, but also inform public health oriented HIV epidemic control strategies.


Through a comprehensive scoping review, we synthesized and analyzed existing evidence regarding the influence of GBV on engagement in PrEP and the HIV care continuum among women living with HIV, including members of key populations (female sex workers, transgender women and women who use drugs). We explored PubMed, Scopus and Web of Science for peer-reviewed studies published in 2003–2017. Of the 279 sources identified, a subset of 51 sources met the criteria and were included in the scoping review.


Studies were identified from 17 countries. The majority of studies utilized quantitative cross-sectional designs (n = 33), with the rest using longitudinal (n = 4), qualitative (n = 10) or mixed methods (n = 4) designs. Taken together, findings suggest that GBV impedes women’s uptake of HIV testing, care, and treatment, yet this can vary across different geographic and epidemic settings. Substantial gaps in the literature do still exist, including studies on the impact of GBV on engagement in PrEP, and research among key populations.


This scoping review contributes to our knowledge regarding the role GBV plays in women’s engagement in PrEP and the HIV care continuum. Findings reveal the need for more longitudinal research to provide insights into the causal pathways linking GBV and HIV care and treatment outcomes. Research is also needed to illuminate the impact of GBV on PrEP use and adherence as well as the impact of GBV on engagement along the HIV care continuum among key populations. It is critical that programs and research keep pace with these findings in order to reduce the global burden of GBV and HIV among women.


Gender-based violence (GBV), defined as violence perpetrated against an individual based on their gender/gender identity [1, 2], is an important global health and human rights concern. GBV includes physical, sexual and psychological/emotional violence and can be perpetrated by a variety of actors, including intimate partners (referred to as intimate partner violence (IPV)), family members, community members, and representatives of the state (e.g. law enforcement officials) [1,2,3]. GBV is a common experience for women globally, with estimates suggesting that 1 in 3 women experience some form of GBV in their lifetime, primarily from an intimate partner [4]. Marginalized populations including female sex workers (FSW), transgender women, and women who use drugs experience even higher rates of GBV, often perpetrated by intimate partners and non-partners such as representatives of the state [5,6,7].

GBV is associated with several acute and long-lasting health consequences [8], including HIV [9, 10]. Globally, women are disproportionately affected by HIV—particularly in the epidemic’s epicenter in sub-Saharan Africa-- and HIV is the leading cause of death among women of reproductive age [11]. FSW, transgender women, and women who inject drugs are at even greater risk for HIV acquisition and HIV-related morbidity and mortality, due to their marginalized status in society, and the associated barriers they face in accessing HIV services [11]. Because of this, members of these populations have been identified as ‘key populations’ by international HIV organizations including the Joint United Nations Programme on HIV/AIDS (UNAIDS) [12].

A large body of evidence has demonstrated an inextricable link between GBV and HIV among women [9, 10]. Women who experience GBV are more likely to engage in HIV risk behaviors such as condomless sex and are more likely to be living with HIV [9, 10, 13]. Similarly, evidence suggests that women living with HIV (WLHIV) are at increased risk for experiencing violence [14,15,16]. However, the role of GBV in the HIV care continuum (which includes HIV testing, and appropriate care and treatment for HIV or to prevent transmission via PrEP) is less clear. It is critical to clarify how GBV may act as a barrier to accessing HIV testing, linking to and staying engaged in HIV care and treatment, as well as PrEP, not only to address violence against individual women and meet their HIV care needs, but to also achieve public health-oriented HIV epidemic control goals. In 2015, for example, the World Health Organization (WHO) published guidelines which promoted the use of anti-retroviral treatment (ART) by anyone diagnosed with HIV, given the protective effects of early treatment initiation [17,18,19]. Further, in 2017, UNAIDS adopted the ‘epidemic control’ paradigm whereby the global HIV response is now working towards 90% awareness of HIV status, 90% of those with HIV on treatment, and 90% of those on treatment virally suppressed [20]. Also in 2017, WHO finalized guidelines promoting pre-exposure prophylaxis (PrEP) - a formulation of antiretrovirals (ARVs) that prevents HIV acquisition even if exposed to HIV [21, 22] - for all those at substantial risk of HIV, including members of key populations [18]. In response, a massive global effort to encourage HIV testing and treatment has been rolled out, as testing is the entry-point to HIV care and ART for those living with HIV, as well as PrEP for those at substantial risk of HIV. Key to the success of both HIV treatment and PrEP use is the regular adherence to the medications [23].

Over the past several years, a limited body of evidence has documented GBV as a barrier to women’s engagement in the HIV care continuum. For example, a 2015 systematic review and meta-analysis by Hatcher and colleagues [24] – conducted before the guidelines mentioned above were established - explored the effects of IPV on ART use, ART adherence (measured via self-report and viral load), and retention in HIV care among WLHIV. The review identified 13 cross-sectional studies, primarily from the United States, and the meta-analysis demonstrated that IPV was associated with lower ART use, lower self-reported ART adherence, and lower odds of viral suppression [24]. This review did not include the literature exploring the effect of GBV on HIV testing or PrEP, and none of the identified studies included key populations. The authors noted the need for future research to explore the effect of GBV on the care continuum for these populations [24].

In light of the new global test and start guidelines [18], research is needed to summarize the evidence regarding the role GBV plays in engagement in the HIV testing to care continuum and PrEP among women, including members of key populations. Such a review can provide important insights into areas for future research and possible avenues for intervention. Accordingly, building upon the findings of the 2015 systematic review, we conducted an updated review of the evidence linking GBV to engagement in the HIV care continuum and PrEP using a ‘scoping’ methodology. A scoping review provides a more comprehensive review of the literature than a systematic review by looking broadly across study designs (for more detail, see the methods section) [25]. The present study aimed to expand upon the prior systematic review in two ways. First, we examined the evidence regarding the relationship between GBV and HIV testing as well as PrEP use and adherence, in addition to care and treatment. Second, we sought to identify studies that assessed the effect of GBV on engagement in the HIV care continuum and PrEP among members of key populations, including FSW, transgender women, and women who use drugs.


Scoping review

We conducted a scoping review, which enables researchers to summarize what is known about a certain topic for dissemination to policy makers and practitioners, and to identify gaps in the existing literature [25]. In contrast to systematic reviews, which are guided by a research question focused on a particular study design (typically restricted to quantitative methods), scoping reviews aim to “identify all relevant literature regardless of study design” [25](p.22). Additionally, scoping reviews call for an iterative process of refining search terms as the researcher becomes more familiar with the literature, to ensure the review is comprehensive [25].

Identifying the research questions and relevant literature

This scoping review was guided by Arksey and O’Malley’s (2005) methodological framework [25], and examined the known relationship between GBV and engagement in the HIV care continuum and PrEP among women, including members of key populations (FSW, female drug users, and transgender women). When examining the care continuum, we included HIV testing, linkage to and engagement in care, ART adherence and viral suppression. The team identified a search strategy based on a review of the literature and medical subject heading (MeSH) terms. We explored the three search engines (PubMed, Scopus and Web of Science) for studies published in peer-reviewed journals in English between January 2003 and November 2017. We began our search in 2003 given that the WHO and UNAIDS began their initiative to roll out ART in low and middle income countries during that year [26]. Table 1 outlines the search terms used for each search engine. For each database, we conducted separate searches for each population given that individual searches in some cases yield different (and more) articles than a combined search.

Table 1 Search terms

Selecting the literature

We reviewed the titles and abstracts of all identified sources. The team created post hoc exclusion criteria at this point to further narrow the review. Developing post-hoc exclusion criteria is a hallmark of the scoping review methodology. It is recommended to maximize the likelihood that researchers identify all relevant criteria as they familiarize themselves with the literature [25]. We excluded articles that were opinion pieces, protocols describing study designs, and literature reviews (although we did include individual studies that were referred to in literature reviews that met our inclusion criteria). We also excluded papers that explored violence and only the acceptability or awareness of HIV services, as our focus was on the influence over behaviors. Finally, if papers included data from both male and female participants, we excluded those that did not disaggregate the results by sex. The articles of the remaining sources were reviewed in full. Reference sections of all included sources were hand searched for additional relevant sources not already identified by the database search. Relevant sources were included in the full review.

Charting, collating and summarizing the information

The first author created a matrix to chart relevant information about all the sources reviewed. Specifically, the chart included details about the study design, sample size, population and relevant findings. In accordance with Arksey and O’Malley’s framework [25], the research team held meetings to discuss the overall themes emerging from the reviewed literature and to identify gaps in the literature that warranted further exploration.


As shown in Fig. 1, the team identified 226 non-duplicate sources to review from the database search. An additional 53 sources were added after reviewing the reference sections of the sources identified by the database search. Of these 279 sources, a subset of 51 sources were included in the scoping review (Table 2). Studies were from 17 countries: 10 countries from Africa (Uganda, Kenya, Zambia, Malawi, Ethiopia, South Africa, Tanzania, Cameroon, Tunisia and Cote D’Ivoire), three countries from Asia (Nepal, India, Malaysia), two countries from South America (Dominican Republic and Bolivia), and North America (United States (U.S.) and Canada). The majority of studies identified utilized quantitative cross-sectional designs (n = 33), four used quantitative longitudinal designs, ten were qualitative and four were mixed methods. Below, we outline the evidence regarding the effects of experiences of violence on women’s engagement in the HIV care continuum and PrEP.

Fig. 1

Flow diagram of review process

Table 2 Summary of published literature on GBV as a barrier to women’s uptake of HIV prevention and treatment services and behaviors

GBV and its implications for engagement in the HIV care continuum and PrEP

HIV testing

The review yielded 19 quantitative studies (three longitudinal and 16 cross-sectional studies), one qualitative study and one mixed method study that explored the relationship between violence and HIV testing among women. Three studies were conducted among members of key populations (two studies were among women who use drugs and one was among FSW). We did not find any studies that examined the relationship between GBV and HIV testing among transgender women.

Results were mixed. A number of the studies found that experiences of violence were associated with reduced HIV testing among women [30, 33, 34, 36, 39]. Qualitative studies described how fear of a violent reaction from one’s partner in the event of a positive test result contributed to reduced rates of HIV testing [43, 44]. A cross-sectional study by Turan et al. (2011) supported these findings by demonstrating that anticipated stigma (defined as break-up of marriage/relationship and physical violence from a partner) upon testing positive for HIV was associated with refusing to test for HIV [27].

Two studies among key populations also found a negative relationship between GBV and HIV testing [39, 65]. A cross-sectional study among women who use drugs in Malyasia found that experiences of adulthood violence from a partner were associated with failure to test for HIV [39]. Another study among substance-using black South African women found that those who experienced physical violence were less likely to be aware of their HIV-positive status [65].

At the same time, five additional studies, all from the U.S., found experiences of violence to be associated with increased HIV testing [31, 35, 37, 38, 40]. One of these studies was a longitudinal study, which found that experiences of intimate partner violence (IPV) in the past 12 months at baseline was significantly associated with increased odds of receiving a test for sexually transmitted infections (STIs) (including HIV) during a two-year follow up period [40].

Seven studies found no significant relationship between experiences of violence and uptake of HIV testing among women [28, 29, 32, 41, 42, 44, 62]. Two of these studies utilized longitudinal designs. Conroy et al. (2015) found that physical and sexual violence at baseline was not significantly associated with receiving a subsequent HIV test during a 16-month follow up period among women in heterosexual couples in Malawi [41]. A cross-sectional study among FSW in Côte d’Ivoire also found no significant relationship between physical or sexual violence and uptake of HIV testing [62].

Linkage to and engagement in HIV care

The review yielded thirteen studies (six quantitative, five qualitative, and two mixed-methods studies) that explored the relationship between GBV and linkage to and engagement in HIV care among WLHIV. Two of these studies were conducted among FSW. We did not find any studies that examined this relationship among women who use drugs, or transgender women.

The research suggests that experiences of violence are associated with reduced linkage to HIV care among WLHIV [48, 71, 73], including FSW [61]. A cross-sectional study among WLHIV in Kenya found that women were less likely to link to HIV care if they anticipated a violent reaction from their partner upon learning the woman’s HIV-positive serostatus [48]. This was supported by qualitative research from Uganda and Kenya, which found that women avoided disclosing their HIV-positive status to their partner because they feared a violent reaction [73]. Women revealed that non-disclosure was a major barrier to uptake of HIV care because they did not want to inadvertently disclose their status to their partner by seeking care [73].

There is also some evidence to suggest that GBV prevents WLHIV from staying engaged in HIV care, once they have already enrolled [52, 70,71,72]. A cross-sectional study among WLHIV in Canada found that experiences of IPV were associated with increased interruptions in HIV care longer than one year [52]. Qualitative evidence suggests that women skip their HIV care appointments due to fear that attending such appointments will unintentionally alert their partner to their HIV-positive status and result in violence [70]. Having partners who threaten women with violence or prevent them from attending their HIV care appointments may also prevent WLHIV from staying engaged in HIV care [70, 72]. Furthermore, women who experience violence may miss their appointments due to depression, physical illness, or injury caused by violence, and shame of being abused [70, 71].

Three other studies found no significant relationship between experiences of violence and engagement in HIV care among WLHIV [45, 46, 53]. All three studies were cross-sectional and from the U.S. Additionally, a mixed methods study among FSW in Kenya found that GBV did not limit women’s engagement in HIV care [75]. Findings from this study suggest that women utilized a number of different strategies to stay engaged in HIV care including not disclosing their HIV status to their partner and seeking support from their friends.

Antiretroviral therapy initiation and adherence

We identified 29 studies that explored the relationship between GBV and ART initiation and adherence among WLHIV. Eighteen studies were quantitative (17 cross-sectional and one longitudinal), 9 were qualitative, and two utilized mixed methods. Six of these studies were conducted among members of key populations: three among FSW [61, 62, 75], two among women who use drugs [50, 64], and one among transgender women [63].

Taken together, evidence suggests that WLHIV who experience violence are significantly less likely to initiate [60] and adhere to ART [14, 49, 51, 52, 56, 58, 61, 64, 66, 68, 69, 72, 73], and ultimately achieve viral suppression [50, 51, 55, 57, 63]. In terms of ART initiation, a longitudinal study among WLHIV in the U.S. found that women who experienced physical or sexual violence were significantly more likely to be non-ART users after a three-month follow-up period [60]. In a cross-sectional study, Espino et al. (2015) found that African American women in the U.S. with a history of violence were significantly less likely to be virally suppressed than women without a history of violence [57]. Hampanda et al. (2016) found that violence from a partner was associated with reduced adherence to PMTCT during and after pregnancy among pregnant and post-partum WLHIV in Zambia, also assessed cross-sectionally [49].

When looking specifically at key populations, a cross-sectional study among FSW living with HIV in the Dominican Republic found that experiencing violence from a non-paying intimate partner was associated with not currently being on ART and missing a recent ART dose [61]. Kalokhe et al. (2012) found that experiences of IPV was associated with significantly lower current ART use among female crack cocaine users in the U.S. [64]. Another study found that women of color from the U.S. with higher levels of substance abuse, binge drinking, IPV, poor mental health, and sexual risk taking had reduced odds of viral suppression [50]. Finally, Machtinger et al. (2012) found that recent trauma (defined as having been abused, threatened, or the victim of violence in the past 30 days) was associated with having a detectable viral load among both cis-gendered and transgender women [63] .

Qualitative studies shed light on potential mechanisms through which GBV can lead to poor ART adherence. Evidence suggests that women may choose to keep their HIV-positive status a secret from their partner because they fear their partner may become violent upon learning their HIV status [14, 73, 66, 68, 74]. As a consequence, women hide their pills and have to take their medication in secret [14, 68, 73, 74]. This sometimes leads to missed doses of ART [14, 73, 74]. Additional qualitative research has revealed that some women’s partners throw away their ART medication, or otherwise prevent them from taking their ART medication, which limits their adherence [70, 72]. Other research has demonstrated that WLHIV who experience violence from their partners can skip treatment due to depression or feelings of hopelessness [67,68,69].

Although the majority of evidence in the literature suggests a negative association between violence and ART use and adherence, we did find six studies among WLHIV that did not follow this trend [45, 46, 54, 59, 62, 75]. For example, a cross-sectional study of WLHIV attending an HIV clinic in Baltimore, Maryland did not find a significant association between GBV and current ART use, CD4 cell count, or HIV-1 RNA levels (which were used as a proxy for ART adherence) [54]. The authors argue that this finding may be due the fact that women in the sample were recruited from an HIV clinic and, therefore, all participants were engaged in HIV care and treatment [54]. As another example, a mixed methods study among FSW living with HIV in Kenya found that GBV was associated with significantly lower risk of a detectable viral load [75]. Women participating in the qualitative component described how they used different strategies, such as keeping their status secret from their abusive partner, to ensure that they were not prevented from accessing care [75]. Additionally, a cross-sectional study among FSW in Cote D’Ivoire did not find a statistically significant relationship between experiences of violence (physical or sexual) and ART adherence [62].

Pre-exposure prophylaxis (PrEP)

We found only one study that examined the relationship between GBV and PrEP use and adherence. Roberts et al. (2016) conducted a mixed-methods study among serodiscordant couples in Uganda, which found that HIV-negative women who experienced IPV in the past three months had a significantly increased risk of low adherence to PrEP by pill count and by plasma tenofovir, compared to women who had not experienced violence [76]. In qualitative interviews, HIV-negative women described how conflict in their homes made it difficult for them to remember to take their PrEP pills [76]. Others reported escaping their homes after a violent episode and forgetting to take their PrEP pills with them, and, as a result, they missed some doses [76].

We were unable to find studies that examined the relationship between experiences of violence and PrEP use among FSW, transgender women, or women who use drugs.


Taken together, findings from this wide-ranging examination of recent literature suggest that GBV impedes women’s engagement in biomedical HIV prevention, care, and treatment services. We see a similar relationship for female members of key populations, with a small but growing evidence base. Several studies suggest that women who experience violence are less likely to link to HIV care [48, 61, 71, 73], initiate and adhere to ART [14, 49, 51, 52, 56, 58, 60, 61, 64, 66, 68, 69] and less likely to achieve viral suppression [50, 51, 55, 57, 63]. Qualitative evidence suggests women avoid disclosing their HIV-positive status to their partner because they fear their partner may become violent upon learning their HIV status [14, 66, 68, 73, 74]. Such non-disclosure, was highlighted as a barrier to engagement in HIV care and treatment, due to fear of inadvertently alerting one’s partner to one’s HIV positive status, and potentially experiencing violence [14, 68, 73, 74]. Other research suggests a mental health pathway linking experiences of GBV to sub-optimal engagement in HIV care and treatment [67,68,69].

However, evidence specifically regarding the relationship between GBV and uptake of HIV testing varied across settings. Several studies from high-income countries, for example, found that GBV was associated with increased testing [31, 35,36,37,38, 40], while most studies from low and middle-income countries revealed no significant relationship between GBV and HIV testing [28, 29, 32, 41, 42]. While these studies were for the most part cross-sectional, and therefore do not indicate whether experiences of GBV led to increased testing or vice versa, it is feasible that the positive relationship between experiences of GBV and HIV testing found in high-income countries may in fact reflect increased perceived risk of HIV among survivors [77] and an interest in ascertaining HIV status, as well as enhanced infrastructure in these settings to address and respond to GBV.

There were several notable remaining gaps in the literature. We only found one study that examined the relationship between experiences of GBV and engagement in PrEP [76]. This study was from Uganda, and there were no such studies from higher-income countries, where PrEP is more accessible and established as an HIV prevention strategy. Additional research is needed, including longitudinal studies, to further understand the role that GBV plays in engagement in PrEP. The need for such evidence will become increasingly pronounced as PrEP is introduced and scaled up in the Global South.

Information about the effects of GBV on engagement along the HIV care continuum for female key populations living with HIV was also limited, and thus additional research is sorely needed. Furthermore, we did not find any study that explored the relationship between GBV and PrEP use among female key populations. It is critical to understand how experiences of GBV may influence these populations’ access to PrEP, especially given their heightened risk for both GBV and HIV [6, 7, 11, 78], and the 2017 WHO guidelines highlighting the need for PrEP among these populations [18].

It is also important to note the dearth of longitudinal studies that have explored the relationship between GBV and women’s engagement in biomedical HIV prevention, care and treatment. This review identified only four longitudinal studies. Three of these studies examined the relationship between GBV and HIV testing, and one assessed the effect of GBV on ART use. We did not identify any longitudinal studies that examined the relationship between experiences of GBV and linkage to and engagement in HIV care as well as PrEP use or adherence. Longitudinal studies are urgently needed to better understand the effect of GBV on engagement in biomedical HIV prevention, care and treatment to inform future intervention work.

Given the existing evidence highlighted in this review suggesting that GBV is an important barrier to engagement in the HIV care continuum, programmatic responses are urgently needed. However, our review only identified one paper describing an evaluation of a program that explicitly sought to address GBV with the goal of improving any HIV care continuum outcomes [79]. Collins et al. (2017) used a quasi-experimental design to assess the effects of a muti-component intervention, “Creating Lasting Family Connections,” among African American women in the U.S. [79]. This intervention sought to address factors that place African American women at increased risk for HIV including substance use and violence. Intervention modules promoted positive relationship and parenting skills, conflict resolution skills, offered guidance on how to incorporate substance use and violence prevention messages into activities with children, and improved knowledge about HIV transmission and substance abuse. Participants in the intervention were significantly more likely to test for HIV, and significantly less likely to report IPV in the past 3 months, relative to the comparison group [79]. We did not come across literature describing evaluations that found effects on engagement in HIV care or treatment, or uptake and adherence to PrEP among HIV negative women.

We do acknowledge that a number of studies have evaluated the effects of interventions that have sought to address GBV and HIV risk [80,81,82,83]. Researchers could draw upon related lessons learned to address GBV and engagement in HIV care and treatment. For example, several past interventions have aimed to mitigate and transform inequitable gender dynamics (such as support for ‘toxic’ masculinities, and unequal power in relationships) that can lead to GBV and HIV risk behaviors [81, 83, 84]. Future research could explore the impact of promoting gender equitable norms on both GBV and engagement in the HIV care continuum and PrEP. Other researchers have integrated GBV screening into HIV testing services to identify survivors of violence, who might otherwise not report their experience, and offer support and information [85, 86]. It is also possible that HIV care appointments could provide an important opportunity for health care providers or counselors to screen women for GBV and strategize ways to prevent future violence and stay engaged in HIV care and treatment.

This scoping review was limited to articles written in English, and as such we may have excluded relevant articles written in other languages. Additionally, while we recognize that both women and men experience GBV, this review is focused on violence experienced by women, and the HIV service experiences of women. As such, this study does not address what is known about GBV and engagement in the HIV care continuum and PrEP among men, including men who have sex with men. This area certainly warrants further research.


The linkages between GBV and HIV acquisition have been documented since the early 2000s. This review presents the latest evidence on how GBV can also impede the uptake of HIV testing, care and treatment and PrEP. Findings suggest that the relationship between experiences of GBV and sub-optimal engagement in the HIV care continuum is also significant, although it can vary by geographic context and epidemic setting. However, this review highlighted important gaps in the literature including a dearth of research on the role GBV plays in PrEP use and adherence, limited research on the effect of GBV on engagement in HIV care and treatment and PrEP among members of key populations, and very few longitudinal studies. Future research should prioritize addressing these gaps in the literature.

The global HIV response continues to evolve at an extraordinary pace, with new biomedical strategies creating the potential for epidemic control on the foreseeable horizon. It is critical, however, that programs and research keep pace with these changes by continuing to train a critical lens on gender inequity—and GBV as a particularly severe sequela—as a persistent driver of HIV. Only by continuing to place women at the center of the global HIV response will we achieve the ambitious UNAIDS HIV epidemic control goals.

Availability of data and materials

Not applicable.



Antiretroviral therapy




Female sex workers


Gender based violence


Intimate partner violence


Pre-exposure prophylaxis


United States


Joint United Nations Program on HIV/AIDS


World Health Organization


Women living with HIV


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JP, EW and EY conceived this review. AL conducted the review with guidance from JP, EW, and EY. AL drafted the manuscript and all authors edited the manuscript.

Correspondence to Anna M. Leddy.

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Leddy, A.M., Weiss, E., Yam, E. et al. Gender-based violence and engagement in biomedical HIV prevention, care and treatment: a scoping review. BMC Public Health 19, 897 (2019) doi:10.1186/s12889-019-7192-4

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  • Gender-based violence
  • Intimate partner violence
  • Pre-exposure prophylaxis
  • HIV care and treatment