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Controversial Ebola vaccine trials in Ghana: a thematic analysis of critiques and rebuttals in digital news



Communication is of paramount importance in responding to health crises. We studied the media messages put forth by different stakeholders in two Ebola vaccine trials that became controversial in Ghana. These interactions between health authorities, political actors, and public citizens can offer key lessons for future research. Through an analysis of online media, we analyse stakeholder concerns and incentives, and the phases of the dispute, to understand how the dispute evolved to the point of the trials being suspended, and analyse what steps might have been taken to avert this outcome.


A web-based system was developed to download and analyse news reports relevant to Ebola vaccine trials. This included monitoring major online newspapers in each country with planned clinical trials, including Ghana. All news articles were downloaded, selecting out those containing variants of the words “Ebola,” and “vaccine,” which were analysed thematically by a team of three coders. Two types of themes were defined: critiques of the trials and rebuttals in favour of the trials. After reconciling differences between coders’ results, the data were visualised and reviewed to describe and interpret the debate.


A total of 27,460 articles, published between 1 May and 30 July 2015, were collected from nine different newspapers in Ghana, of which 139 articles contained the keywords and met the inclusion criteria. The final codebook included 27 themes, comprising 16 critiques and 11 rebuttals. After coding and reconciliation, the main critiques (and their associated rebuttals) were selected for in-depth analysis, including statements about the trials being secret (mentioned in 21% of articles), claims that the vaccine trials would cause an Ebola outbreak in Ghana (33%), and the alleged impropriety of the incentives offered to participants (35%).


Perceptions that the trials were “secret” arose from a combination of premature news reporting and the fact that the trials were prohibited from conducting any publicity before being approved at the time that the story came out, which created an impression of secrecy. Fears about Ebola being spread in Ghana appeared in two forms, the first alleging that scientists would intentionally infect Ghanaians with Ebola in order to test the vaccine, and the second suggesting that the vaccine might give trial participants Ebola as a side-effect – over the course of the debate, the latter became the more prominent of the two variants. The incentives were sometimes criticised for being coercively large, but were much more often criticised for being too small, which may have been related to a misperception that the incentives were meant as compensation for the trials’ risks, which were themselves exaggerated.


The rumours captured through this research indicate the variety of strong emotions drawn out by the trials, highlighting the importance of understanding the emotional and social context of such research. The uncertainty, fear, and distrust associated with the trials draw from the contemporary context of the Ebola outbreak, as well as longstanding historical issues in Ghana. By analysing the debate from its inception, we can see how the controversy unfolded, and identify points of concern that can inform health communication, suggesting that this tool may be valuable in future epidemics and crises.

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In 2014 the Ebola outbreak in West Africa became a global health emergency, spurring an international effort to trial candidate Ebola vaccines and other potential prevention and control measures. The European Union Innovative Medicines Initiative (IMI) funded several projects to help combat the epidemic, one of them EBODAC (EBOla Vaccine Deployment, Acceptance and Compliance).

Within its broader communication and community engagement mandate, EBODAC addressed the risk of misinformation and controversies undermining the trial of a prime-boost Ebola vaccine regimen, developed by Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen). Rumours were already hindering the Ebola response in the affected countries [1], [2] and the early detection and analysis of emerging rumours around the vaccine trials was considered a priority for EBODAC [3].

In February 2015, the EBODAC consortium launched a system for real-time monitoring and analysis of online newspapers in Sierra Leone, and in April 2015 the media monitoring system was extended to include Ghana, Uganda and Kenya, where Phase I trials for Ebola vaccines were also being planned.

In late May 2015, a controversy was reported in Ghanaian newspapers and became inflamed into a public debate, finally resulting in the suspension of both the planned Phase 1 trial for the Janssen Ebola vaccine at the University of Health and Allied Sciences (UHAS) in Hohoe, Volta region, and a planned Phase 2 trial for the GlaxoSmithKline (GSK) Ebola vaccine in Hohoe and in Kintampo. This controversy was exacerbated by the fact that, when these critical articles first became public, both the Minister of Health and the trial lead investigator were travelling outside Ghana – a fact which should be borne in mind while reviewing this analysis.

At the time the controversy broke out, the Ghana Food and Drugs Authority (FDA) was considering both vaccine trials for approval. Five months after the suspension, both vaccine trials were finally approved by Parliament [4]. To date, however, neither trial has proceeded since receiving this approval.

This article examines the messages and perspectives put forth by different stakeholders in the controversial vaccine trials in Ghana through the use of a media monitoring and analysis system. The study analyses the stakeholder concerns and incentives, and the phases and dynamics of the dispute. It provides a unique methodological approach to studying complex interactions between public health authorities, political actors, and public citizens, offering lessons for future research.

Historical research controversies and their implications

History offers several examples of the importance of addressing stakeholder concerns in public health initiatives, since failure to do so can undermine health research and programmes, even when these concerns are rumour-driven [5,6,7,8].

In Nigeria in 2003, for example, Northern states boycotted polio vaccination campaigns, because of a complex set of factors including the memory of a controversial trial of the antibiotic Trovan in 1996, in which 11 children died [9]. Although the deaths were deemed to be unrelated to the antibiotic, the incident led to a multitude of lawsuits both in Nigeria and the USA, one of which ended in an out-of-court settlement of 75 million USD related to ethical misconduct, paid to the state of Kano in 2009 [10].

The Trovan trial left a lasting distrust in Kano. In 2003 a leader of the polio boycott justified his opposition to the vaccination campaign by referring to, “…the Pfizer scandal, when our people were used as guinea pigs with the approval of the federal ministry of health, and the approval of all the relevant UN agencies” [11]. A Kano farmer interviewed in 2005 put the issue more bluntly:

“We cannot trust the white man or our federal government because many years ago they were in partnership… Our government does not have our interests at heart, that is why these people can come in any time they want and do whatever they want” [12].

This perception that the government responds more to international interests than to its own people was reinforced by the fact that polio vaccines were being provided free by the Global Polio Eradication Initiative (GPEI), while services for other pressing health needs were lacking [13, 14]. The polio boycott, which allowed polio cases to quadruple between 2002 and 2006, re-seeded the disease in multiple countries that had already eliminated it, and cost the GPEI 500 million USD [15]. This case illustrates how important it is to recognize and address stakeholder concerns early, as they can influence public trust, with serious public health consequences in the long term.


To monitor news in each country with planned vaccine trials – Sierra Leone, Ghana, Uganda, and Kenya – the project team selected online newspapers in each country. The selection was based on a qualitative assessment of expected impact and maximum variation to ensure detection of any news regarding the planned trials. Services like Google News AlertFootnote 1 were considered for monitoring new articles meeting specific criteria, but in several of the target countries the major search engines indexed only a few of these news outlets, and these services were therefore not appropriate. Instead a PHP-basedFootnote 2 system was set up to monitor the front page of the outlets for new articles every hour, downloaded any new articles and scanned the articles for variants of the keywords “Ebola” and “Vaccination”. The system also forwarded all articles containing relevant keywords to the Ebola vaccine program communication crisis team.

Using a thematic analysis [16] approach, three independent coders (LL, WS, PEK) reviewed a subset of articles and were assigned to identify between 5 and 15 themes. Findings from a previous study [17] investigating online vaccine sentiments were used as a starting point for the codebook, which was further adapted to the Ghana context. The team met to compare their proposed themes and 24 were initially agreed upon, but after a change in coders (ES, WS, PEK) an additional three themes were added, for a total of 27 themes [see: Appendix 1].

Theme inclusion criteria were: a) they should be repeated in at least two different news outlets; and b) they should be able to be reduced to declarative statements about the trials or their proponents/opponents.

Two overarching types of themes were defined: (1) “critiques” which directly or indirectly argue that the trials should not take place, and (2) “rebuttals” refuting the critiques, sometimes introducing new arguments in favour of the trials.

Based on the codebook, a web-based coding interface was developed allowing the coders to mark example text and attach relevant coding tags to the text [see: Appendix 2]. When all coders had completed the first round of scoring, the coders unanimously agreed on 87% of the coding decisions. This gave an inter-rater reliability (IRR) score of 0.62, calculated using Fleiss’ kappa, which can be considered a high level of agreement [18]. The main reason for calculating IRR here is to improve reliability. Inter-rater disagreement can arise from actual disagreement, but when dealing with large amounts of data, it is often based on misreading or overlooking themes that are present.

In the second round, where one coder disagreed with the other two, s/he was presented with the other raters’ coding, accompanied by a relevant text extract from the article, and asked whether s/he agreed. If s/he still disagreed it was sent back to the others. This was repeated, and virtually all discrepancies were reconciled. After two rounds of the reconciliation process there were only five disagreements left, giving an IRR which was very close to 1.0. In these remaining five cases the coders agreed that the coding decisions were fundamentally subjective [see: Appendix 3 for more details on the coding procedure].


A total of 27,460 articles from nine different newspapers were collected on-line from Ghana in the time period from May 1st to July 30th 2015. Of these, 150 articles in six different newspapers contained the keywords. Eleven of the 150 articles were excluded because they referred only indirectly to the trials, or not at all. The final dataset included 139 articles (Fig. 1) [see: Appendix 3 for a list of analysed articles].

Fig. 1
figure 1

Study design flow chart. Flow chart shows data sources and exclusion by keyword search and thematic analysis

The 139 reports analysed were collected from six news outlets (Fig. 2) in which we identified 385 instances of critiques and 279 instances of rebuttals.

Fig. 2
figure 2

Overall count of articles included from each publisher, with theme proportions. Diagrams show the proportion of negative and positive themes (critiques and rebuttals) in articles from each publisher, with size scaled to represent the number of articles included from each news outlet (shown also in tabular form beneath)

Because the codebook specified more negative themes than positive themes, no conclusions should be drawn about overall ratio of positive versus negative sentiment. Instead, we gain insights by tracking groups of related themes over time, how they evolved, identifying which critiques were more prevalent, and which rebuttals were issued in response. There were three key areas of critique: (1) the allegation that the trials were secret; (2) the belief that the trials would lead, in one way or another, to Ebola cases in Ghana; and (3) the argument that the trials were providing inappropriate incentive packages for participants.

Figure 3 shows the major organisations, listed in order from most-mentioned to least-mentioned, referenced in the media reports about the trials. Blue bars indicate the number of articles mentioning a given organisation shown against grey background bars representing the total number of included articles published on a given day. The Ghana FDA was named in the very first articles in mid-May and remained a key actor throughout the debate, whereas the Ministry of Health and World Health Organisation (WHO) became more involved in mid-June. Early and ardent critics of the trials, such as the Coalition for Ghana’s Independence Now (CGIN) and the National Democratic Congress (NDC), were most involved in early June, whereafter their salience faded. Meanwhile the Ghana Academy of Arts and Sciences (GAAS) maintained a low but persistent media presence through to early July.

Fig. 3
figure 3

Daily count of stakeholder mentions. Number of articles mentioning institutional stakeholders daily (blue bars), compared to total relevant articles daily (grey bars). Quantified by keyword search, conducted after completion of thematic analysis

Figure 4 shows the prevalence of positive and negative themes over time. The first article in our dataset was published 21 May 2015 by Starr FM Online, the website for the Ghanaian radio station Starr FM. This article broke the story, presented as an “undercover” investigation into a secret trial, which remained a common theme throughout the controversy (see section "Secret trial and insufficient public information"). It also drew attention to the incentives offered for participation in the trial, which likewise remained relevant for many weeks (see section "Incentives").

Fig. 4
figure 4

Daily combined count of critiques and rebuttals, exact and moving average. Legend: Circles indicate exact count of critiques (red) and rebuttals (green) appearing daily. Line plots show a 7-day moving average, calculated to show overall trend in critiques and rebuttals per day

The story went seemingly unnoticed for more than a week, until a press release was issued by the CGIN.Footnote 3 The statement (see Additional file 1), first published by Starr FM Online (30.05), claimed that the trial researchers would infect healthy Ghanaians with Ebola in order to test the vaccine (see section "The fear that vaccine trials will bring Ebola").

The story received increasing coverage over the following week, until the Volta regional office of the NDC political party issued a statement opposing the trials, which was then raised in Parliament. At this point, critiques spiked dramatically, and rebuttals followed.

As shown in Fig. 5, a variety of themes were prominent in the ensuing weeks, including arguments that the trials were “unnecessary” because Ghana was unaffected by the Ebola outbreak, that other diseases were more important (Starr FM Online, 08.06a), and that the trials should be conducted in a country other than Ghana.

Fig. 5
figure 5

Overall count of theme mentions. Number of articles mentioning each theme, colour-coded to distinguish critiques (red) and rebuttals (green)

Rebuttals tended to be broader statements, making the case that the risk to participants was small and that there had been no deviation from established protocols (GhanaWeb, 08.06a), emphasising the global importance of developing an Ebola vaccine (GhanaWeb, 08.06a), and also that Ghana had an interest in the publicity and economic benefits of hosting such research (Modern Ghana, 16.06b). They also pointed out that the vaccines had already undergone some safety checks as they had been tested in other countries (GhanaWeb, 08.07).

The issue of “ignorance” emerged in a prolonged back-and-forth between Professor Alex Dodoo and the Ghanaian Parliament, during which Dodoo was summoned to explain his alleged criticism of Members of Parliament (MPs) as “ignorant” regarding the procedures of clinical trials.Footnote 4 While this prompted considerable reaction, most of the related articles were as much about Parliament itself as they were about Professor Dodoo’s comments.

A chronological overview of the major events can be found in Appendix 1. To give a visual summary of the coded data, a timeline of theme density is shown in Fig. 6.

Fig. 6
figure 6

Daily count of individual themes, shaded by number of articles per day mentioning a given theme. Themes were conceived as “statements about the trials,” and divided into two categories: critiques of the trials (red) and rebuttals on behalf of the trials (green). a Themes discussed in section "Secret trial and insufficient public information": Descriptions of the trials as “secret” or “clandestine” were most prevalent in the first half of the controversy, but following Parliamentary discussions, this theme was superseded by the more restrained judgements that the trials had provided “insufficient information” to politicians and had failed to “sensitise” the general public. Trial representatives began responding in mid-June that information had been provided and public sensitisation would be done. b Themes discussed in section "The fear that vaccine trials will bring Ebola": Early concerns about the trials’ safety included two related but distinct fears – first, that trial participants might contract Ebola from the vaccine, and second, that because Ghana had no Ebola cases, the researchers must have intended to introduce Ebola into the population for the purpose of testing the vaccines. Rebuttals included repeated explanations of why the trial vaccines could not infect participants, as well as several assurances that Ebola was not being introduced to the country, however most rebuttals focused more on the idea that the trials were “following all protocols” and safe in a general sense. c Themes discussed in section "Incentives": Incentives – 200 Ghanaian Cedis (GH₵) and a mobile phone – were a target for extensive criticism, both from those who felt these were valuable enough to be coercive, and also from those who perceived the trials to be very risky and consequently viewed the incentives as insultingly small. Rebuttals included the clarification that phones were intended to facilitate communication between researchers and participants, and the money was to compensate participants for their time. d Uncategorised themes


Secret trial and insufficient public information

Secrecy was a strong and recurrent theme (Fig. 6a), and 29 (21%) of 139 articles contained statements about the trials being a secret. The initial Starr FM Online article of 21 May included the passage, “Investigations by Starr FM under-cover team have made public a clandestine attempt by authorities to use midwifery students at Hohoe in the Volta region for human experiment on the Ebola vaccine in a country with no Ebola case.” The CGIN press release brought greater attention to this article, and this specific passage is repeated in a total of 19 articles up until 8 June.

Descriptions of the trials as “secret” or “clandestine” were most prevalent in the first half of the controversy, but following Parliamentary discussions, this theme was superseded by the more restrained judgements that the trials had provided “insufficient information” to politicians and had failed to “sensitise” the general public. Trial representatives began responding in mid-June that information had been provided and sensitisation would be done.

This softer criticism, that the trials had provided “insufficient information,” appeared in 39 (28%) of the articles. In an article titled, “House orders ‘secret’ Ebola vaccination stopped,” MPs’ objections focused on a lack of consultation with politicians and the general public:

“(…) the Deputy Minister of Education, Samuel Okudzeto Ablakwa, said it was unacceptable for the ministry to carry out such a sensitive exercise without proper communication and sensitisation. He said the exercise (…) did not have political approval from the government, and appealed to his colleagues not to put the blame on the government.” (Ghanaian Times, 11.06).

Speaking before Parliament, Health Minister Alex Segbefia struck a contrite tone, admitting the need for better public engagement but asserting that approval had been sought from all the appropriate institutions:

“He said standard protocol had been followed prior to the approval for the vaccination to take place, but he conceded that despite the rigorous nature of the approval process, the stakeholder consultation that needed to have been done was not thorough enough.” (GhanaWeb, 16.06a).

In an interview published the following day, however, Susan Adu Amankwah (a researcher unaffiliated with either trial) ridiculed parliamentarians’ expectation of being personally consulted:

“The protocol of the trial had gone through the FDA … [in accordance with] the law that they [MPs] themselves passed – the Public Act 815 so the government knew about it. If the government is not represented by the FDA, if the state is not represented by the FDA, then I don’t know who the FDA is.” (GhanaWeb, 17.06b).

Even as new public education efforts got underway, the secrecy claim continued to reappear, such as when the NPP party Ashanti Regional Chairman used it to direct blame at Ghana’s president,

“… wondering how government, under the leadership of President John Dramani Mahama, could allow such an exercise to be conducted in his homeland, without the necessary education and approval.” (Ghanaian Chronicle, 22.06b).

In an article titled “When Scientists Become Too Secretive,” author Cameron Duodo was clearly unconvinced by the legalistic argument that the trials had received proper approval:

“… scientists of the Ghana Food and Drugs Authority (FDA) blithely authorised Ghanaian scientists, working for a foreign pharmaceutical company to carry out trials of an Ebola vaccine, without so much as a word to the Ghanaian public, to prepare their minds for the trials.” (Ghanaian Times, 30.06).

This narrative of an immoral experiment lent itself to historical comparisons, including the Tuskegee Syphilis Experiment (Modern Ghana 08.06), its Guatemalan counterpart (Ghanaian Chronicle, 25.06), and medical crimes perpetrated under the racist regimes of Nazi Germany and Apartheid South Africa (Ghanaian Times, 30.06). While such references were relatively sparse, Ghana’s colonial past is a recurring theme throughout the debate, particularly in the “incentives” issue.

Lastly, long after the peak of the debate, a key traditional leader in the Hohoe region professed his longstanding support for the trials, and his bemusement at the national controversy:

“The Paramount Chief of Gbi Traditional Area, Togbe Gabusu, … wondered why the Ebola vaccine trial should generate so much controversy. “I have never doubted this because when they [researchers] came, they called all the traditional heads. They met us talked to us and we were satisfied before the hullabaloo came. We have a Research Centre in town here, it has been here for [many] years…and they have been working. So why this?”, the Paramount Chief wondered.” (Modern Ghana, 17.07).

The idea that the trials were “secret” was initially propagated by the Starr FM Online article, in which local students described being approached about participating in an upcoming trial, and in which interviewees affiliated with the UHAS research centre “pleaded anonymity,” and insisted they “could not disclose” information. It seems likely that the interviewees were attempting to adhere to perfectly ordinary non-disclosure agreements, considering that the trials were still under review. This may have added an unintentionally conspiratorial air to their comments.

The Starr FM Online article also instigated the idea of secrecy by the mere fact that it was the first place where the trials were widely publicised. In the words of commentator Cameron Duodu,

“if you … try, even if metaphorically, to “smuggle” the project into the country, you will ensure that the first that is heard of it is through the news broadcast by a local radio station, then you are asking for trouble” (Ghanaian Times, 30.06).

The mere fact that the public was not aware of the trials lent credibility to the claims in the Starr FM Online article. Then again, the trials were forbidden to conduct any public education prior to receiving ethics approval, so its absence was not so much a mistake, but rather a vulnerability inherent in the established protocol for conducting research, which may need to be revised.

The fear that vaccine trials will bring Ebola

One of the most common critiques was that the vaccine trials would lead to Ebola cases in Ghana. Out of 139 articles in our dataset, 47 (33%) claimed that the vaccine would cause an Ebola outbreak in Ghana, while 27 articles (19%) said this would not happen. The critique came in two distinct forms: first, a suspicion that trial researchers would intentionally expose people to Ebola virus in order to test the vaccine, and second, a fear that the vaccine itself would cause participants to contract Ebola. Rebuttals included direct responses to both of these critiques, and overarching statements that the trials were safe and protocols had been followed. Figure 6b shows when each of the critiques appears, and when each is countered.

The claim is first mentioned in Starr FM Online (30.05), and is a direct quote from a press release issued by CGIN:

Ebola outbreak, which is 100% sure to happen in Ghana should this human trials be allowed to go on, will be the greatest national security threat our country will ever face. The manufacturers of the so-called Ebola vaccine will look on till a larger number of Ghanaians are killed by the disease here in Ghana before the vaccine will be released and this would happen to make government buy the vaccine at any price…there is and will be no way by which Ghana can go through this Ebola virus human experiment without Ebola being spread country wide.” (Starr FM Online, 30.05).

Thus the original claim was that Ebola had to be introduced to be able to test the vaccine. After a fierce debate, in which the CGIN statement was referenced in the majority of the monitored newspapers, the first statements defending the trials found their way into the media more than a week later:

The Food and Drugs Authority (FDA) has refuted claims that the impending Ebola vaccine trial in Ghana will harm persons who will be used as subjects for the exercise. ”(Starr FM Online, 08.06).

According to FDA documents, the vaccines to be tested in Ghana are made using a common cold virus called an adenovirus that “does not make people sick”. The vaccines contain extracts that do not cause the disease from the Ebola virus.” (GhanaWeb, 09.06).

After the trials were suspended by the Minister of Health on 9 June (after being ordered to do so by Parliament) the debate continued and the GAAS issued a press statement on 12 June stating that it was “unsafe to undertake the trials in Ghana”. The statement included a list of ten technical questions, including:

“What assurances do we have that the chimpanzee-derived live adenovirus vector used in the GSK vaccine construct, although non-replicating for now, will remain dormant and not itself cause a disease to compromise the health of the people of Ghana?” (GhanaWeb, 15.06a).

Several writers demanded that “The World Health Organization Must Respond to the Queries of the Ghana Academy of Arts and Sciences,” (GhanaWeb, 27.06). On 26 June UHAS issued a press statement [19] rebutting the scientific questions point-by-point. Principal Investigator Professor Fred Binka also gave rebuttals in person at a sensitisation forum, and offered to undergo vaccination himself (Modern Ghana, 22.06). However, newspapers continued re-printing the GAAS critiques as late as 5 July, without acknowledging these rebuttals. Only one article reported on the UHAS response, and not until 8 July.

Moreover, the GAAS was portrayed as a mouthpiece of the people: “Ghanaians, through the Ghana Academy of Arts and Sciences (GAAS), have posed Ten Queries which WHO is required to take extremely seriously and reply to.” (GhanaWeb, 27.06), in contrast to portrayals of the Ghana FDA as “…a body grandiosely semi-labelling itself after an illustrious American name sake…” (GhanaWeb, 15.06).

So, it appears that the initial fear about scientists intentionally introducing Ebola was gradually replaced by the concern that the vaccine itself could cause disease, and this narrative became somewhat more scientifically sophisticated after the GAAS’ list of questions became a focal point. There were other passages, such as “The Ho West MP added that MPs from the region have been inundated with phone calls from panic-stricken constituents who believe that this trial is aimed at spreading the dreaded Ebola disease in the Volta Region. ”(GhanaWeb, 15.06b), that indicate a perception that people would be infected prior to vaccination. However, most quotes between 16-22 June are related to whether the adenovirus vector might mutate into a virulent form of the Ebola virus and infect trial participants.


The debate around incentives was challenging to respond to: most complained that the incentives for trial participation were insufficient, but others simultaneously claimed they were inappropriately large, and in general the allegations made no distinction between the GSK trial (which was to offer participants money and a mobile phone) and the Janssen trial (which was not). The incentives were perceived as compensation for the trial’s dangers (as opposed to compensation for the cost of travel and time lost), and these dangers were thought to be great, leading to the conclusion that the incentives were too little. There were far fewer concerns about the incentives being coercively large compared with the many allegations that they were insultingly paltry. The claim that these incentives violated international standards for participant compensation, in some places attributed to WHO (see for instance GhanaWeb, 10.06d), added to the sense of insult. Rebuttals were issued to the effect that the incentives were for practical purposes (money for transport and phones for follow-up communication), but it is evident that the density of these rebuttals was sparser than that of the critiques.

The “incentives” theme appeared early in the debate peaking in the month of June (see Fig. 6c). It is one of the most frequent themes, with 49 of 139 articles (35%) mentioning it, and received relatively few rebuttals.

Incentives – 200 Ghanaian Cedis (GH₵)Footnote 5 and a mobile phone – were a target for extensive criticism, both from those who felt these were valuable enough to be coercive, and also from those who perceived the trials to be very risky and consequently viewed the incentives as insultingly small. Rebuttals included the clarification that phones were intended to facilitate communication between researchers and participants, and the money was to compensate participants for their time and transport.

As with secrecy, the topic of incentives is central in the initial Starr FM Online article:

“Documents cited by indicate that the students have been promised [GH₵] 200 each and mobile phones.” They will also receive other compensations (…) “I’m really scared and a lot of my colleagues are apprehensive too,” a student confided in . “Currently, they are compiling our names for the trial but we don’t know whether the vaccine is safe or not; whether we’ll contract the disease or otherwise. Nobody is explaining anything to us.” (Starr FM Online, 21.05).

The incentives are described neutrally, yet appear alongside fearful quotes. Similar references appeared in late May and early June, until the Volta office of the NDC party released a statement condemning the trials and portraying the incentives in a decidedly negative light:

“We are appealing to all Voltarians to remain calm and should not risk their lives for [GH₵] 200 and mobile phone,” a statement signed by the NDC regional chairman Kwadwo Gyapong, secretary Simon Amegashie-Viglo and regional organiser Henry Kojo Ametefee said. (Starr FM Online, 08.06a).

In an opinion piece published the following day, writer Michael Bokor issued a strong condemnation:

“Clearly, using Ghanaians as guinea pigs for this Ebola vaccine experiment is insulting and misguided. It is unethical, immoral, and despicable, especially if we consider what is being used as an inducement for participants.” (Modern Ghana, 09.06b).

Not all articles were so critical, and at least one correctly reported that the phone was provided “to facilitate communication and monitoring” (Modern Ghana, 10.06c).

When the issue was brought before Parliament, however, the Majority Chief Whip proposed “to invite the foreign pharmaceutical companies to do some explanations, because entering into a community and using mobile phones and [GHC] 200 to entice people for such a dangerous research is simply unacceptable.” (Ghanaian Times, 11.06). Harsh opinion articles followed, arguing both that “volunteers in other countries will not take less than US$2,000 or £1,000 per a single trial, in Ghana volunteers are being offered £40 ([GHC] 200) plus a cheap or substandard mobile (cell) phone likely to be of Chinese-made” (Modern Ghana, 12.06b), and also that that the incentives were coercively high and that participants:“… should not be influenced in their decision by psychological or financial pressures of any sort.” (Ghanaian Times, 16.06).

These contradictory criticisms presented an obvious challenge for defending the incentives. Early rebuttals focused on the practicality of the incentives:

“…the [GHC] 200.00 was supposed to cater for the transportation of the volunteers while the mobile phone was to help health personnel assess the health of the volunteers once the vaccine has been administered on them.” (Modern Ghana, 10.06b).

WHO country representative for Ghana Dr. Magda Rabalo managed to address the issue of the amount provided in the incentive package during a forum in Accra:

“…the ethics committee of trials said such moneys should not be too much or too little to manipulate people to volunteer… It also noted that WHO does not define how much participant should be paid and that compensations differ from country to country.” (Vibeghana (TV), 20.06).

Finally, several weeks later, an interview with Dr. Ama Kyerewaa Edwin, member of the Ghana Health Service Ethics Committee, clarified the actual compensation being given:

“... [participants] are not paid for volunteering but you will be compensated for your time and traveling in and out of the research Centre. … Persons who offer themselves for the Ebola vaccine trial in Ghana will be given a comprehensive international insurance cover against any unintended consequences,” (Starr FM Online, 08.07).


This analysis only looks at English-language online media in a lower-middle-income country. It does not include print-only publications, radio or television broadcasts, and is therefore only analysing a subset of the media. However, we find few, if any, references in the online material to print-only sources.

In using these data to study a public debate, we assume that the timing and quantity of news coverage around a specific theme reflects the salience of that theme in the public consciousness. However, topics reported also reflect other factors, like editorial bias and preference for sensational stories.

As noted in the Results section, we make no attempt to draw conclusions from the aggregate amount of positive and negative themes observed in the dataset. A weighted analysis might account for the different number of positive and negative themes defined in the codebook. However, this would mask the fact that the themes do not measure discrete units of “positivity” and “negativity” but rather points and counterpoints in a narrative, which don’t combine additively. This may be an interesting subject for future research, nonetheless.

In our study we assume all articles to have equal influence. If the dataset were larger, it would be reasonable to attribute a weight based on the number of readers or geographic reach of a publication to estimate their potential influence.

Our analysis is based on manually coding themes. All coding was done using online tools, annotating the live data directly. Compared to traditional qualitative analysis, it is effective. However, it still means all articles matching specific keywords need to be read manually. Advancements in machine learning approaches might make it possible in the future to develop tools that will automate part of the coding in order to better provide real time monitoring to help health communication teams.


The rumours identified in this dataset highlight the vital importance of understanding the emotional context of public concerns: a story of secret vaccine trials in Ghana, or scientists intentionally infecting Ghanaians with Ebola, is only credible in the context of deep mistrust. Indeed, the trials debate is marked, from beginning to end, by the overwhelming fear engendered by the Ebola outbreak, as well as a pervasive anxiety to distance Ghana from the disease, even at the expense of research that could help protect against it. Since the trials themselves were partly sponsored by Western pharmaceutical companies, opposing them could be portrayed as a show of independence from the influence of former colonial powers. In this way, critics tapped into long-running historical themes, as well as the visceral fear of the Ebola epidemic.

By analysing the debate from its inception, we can track the evolution of issues from their initial appearance in alarming news articles, to examples of extreme claims becoming more sober, as seen in the transition from claims of a “secret trial” towards more moderate complaints that too little sensitisation and stakeholder consultation had been done. As early opponents like the CGIN dropped out of the news, attention focused on high-profile figures, and in this process, these public figures may have felt that they needed to justify their initial position to avoid embarrassment. This could explain the overall increase in the sophistication of arguments against the trials, while the initial emotions remained at the heart of the debate. As shown in this analysis, even marginal critics can mobilize a widespread and sophisticated opposition movement to derail important public health programmes, if they are taken up by high-profile opinion leaders. The situation in Ghana demonstrates the importance of early and constant engagement with both supporters and critics of trials, bringing them into conversations and ensuring that their fears, concerns and perspectives are heard and considered from the very beginning of the process. We recommend early engagement as a way to minimise the risk of individuals and communities feeling excluded, or their concerns dismissed, provoking perceptions of secrecy and potentially leading high-profile opinion leaders to take up their arguments on a wider scale.

It is noteworthy that although some of the initial critiques remained major themes throughout the debate, others, such as the conspiratorial allegation that “Ebola is a business,” did not last as long. Not unlike an infectious disease outbreak, beginning with an isolated index case and followed by a larger flare-up, some strains of these rumours proved more contagious than others. New arguments and angles also emerged as more people joined the debate. For example, the controversy clearly resonated with racial and colonial themes, as evidenced by the repeated references to historical instances of unethical experimentation on African bodies. This should serve as a stark reminder that past injustices can still undermine trust in the present. In addition, researchers should work to build trusting relationships within the communities where they are working by being consistently open and transparent as early as possible. This is particularly vital when considering sensitive issues or protocol requirements such as taking blood or the use of incentives that may be particularly sensitive given histories of extraction in the region.

Although regulations sometimes prevent trials from sharing public information about a specific trial prior to receiving ethical approval, this doesn’t necessarily preclude the possibility of a more general, government-led national discussion on the need for an Ebola vaccine, the strong value that such a vaccine would have for Ghana’s national security, and the long-term economic and diplomatic benefits of taking part in the international effort. Such a generalised national dialogue - avoiding the specifics of any one candidate vaccine trial - should be considered, especially when the disease in question is so emotionally fraught, and so relevant to the whole nation. We also recommend the involvement of community representatives in the development of clinical trial protocols, in order to ensure that trial designs are both scientifically valid and also acceptable to the communities within which they are occurring.

One of the other major challenges is making the collected information comprehensible and useable to decision makers. To achieve this, effective visualisation techniques are vital. Some of these techniques are demonstrated in this article, and many of these can be generated on-demand in real time. For stakeholders involved in a major health crisis, real-time insights can be vital, given the limited amount of time available for decision-making. It is our hope that these techniques can be incorporated into a reliable tool for assessing public information needs in future epidemics and similarly emotive national crises.



  2. PHP (PHP: Hypertext Preprocessor) is an open source general-purpose scripting language that is especially suited for web development.

  3. The document in question was written by Tawiah Evans, a former journalism student who operates the CGIN with a number of other activists based in Accra.

  4. “Prof Dodoo, on the airwaves, had described MPs as ignorant for making misleading and unfounded comments on the Ebola vaccine trial in the country following MPs’ opposition to the vaccine trial.” (Modern Ghana,17.06c)

  5. 200GH₵ is the equivalent of approximately 48USD/44EUR. According to the World Bank, the minimum monthly wage for a 19-year old or apprentice in Ghana was around 28USD (118GH₵) in 2013 (



Coalition for Ghana’s Independence Now


Ghana Academy of Arts and Sciences

Ghana FDA:

Ghana Food and Drug Authority


Global Polio Eradication Initiative




Inter-Rater Reliability


Janssen Pharmaceutical Companies of Johnson & Johnson


Member of Parliament


National Democratic Congress


World Health Organisation


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We wish to thank Prof. Alex Dodoo for his advice and feedback.


The project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under the grant agreement EBODAC (grant nr. 115,847). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and European Federation of Pharmaceutical Industries and Associations (EFPIA).

Availability of data and materials

The dataset supporting the conclusions of this article is included within the article.

Author information

Authors and Affiliations



PK, WS, HL, and LL designed the study. PK collected the articles for the data analysis. PK, WS and ES coded the articles. All authors contributed to and have approved the final manuscript.

Corresponding author

Correspondence to Per Egil Kummervold.

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Not applicable.

Competing interests

HL has served on the Merck Vaccine Strategic Advisory Board, and is the director of the Vaccine Confidence Project (VCP), which has received funds from Merck and GSK to convene research symposia and has advised GSK on vaccine hesitancy issues. WS also is a researcher with the VCP. The other authors declare that they have no competing interests.

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Additional file

Additional file 1:

CGIN Press Release - May 29th 2015. (PDF 283 kb)


Appendix 1

Table 1 Final coding guidelines

Appendix 2

Procedure for coding and resolving disagreements

The following procedure were followed for each article after initial coding:

  • A theme that all coders included was marked as “present”.

  • A theme none of the coders included was marked as “not present”.

  • A theme Coder 1 marked but not Coder 2 or Coder 3 was marked as “Challenge for Coder 1”.

    • [Repeated for Coder 2 and Coder 3]

  • A theme Coder 2 and Coder 3 marked but not Coder 1 was marked as “Challenge for Coder 1”.

    • [Repeated for Coder 2 and Coder 3]

After initial coding all themes in the article then one of the following statuses:

  • Theme is present

  • Theme is not present

  • Challenge for Coder 1, Coder 2 or Coder3

Coder 1 was then presented with the following choice:

  • Coder 2 and Coder 3 marked this as theme X. They based this on the following quotes. Do you agree or disagree?

  • Only you coded this as theme X. You did base it on the following quote. Do you still agree?

  • [Repeated for Coder 2 and Coder 3]

As long as the article was marked as a challenge, it was hidden for the agreeing coders. In cases where the challenge was not solved by agreement, it was sent back to the other coders, and the process repeated. The majority coders would then see one of message like:

  • Coder 1 insists this should (not) be coded as theme X. Do you agree?

Appendix 3

Table 2 Analysed articles and major incidents

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Kummervold, P.E., Schulz, W.S., Smout, E. et al. Controversial Ebola vaccine trials in Ghana: a thematic analysis of critiques and rebuttals in digital news. BMC Public Health 17, 642 (2017).

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