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Age-specific symptom prevalence in women 35–64 years old: A population-based study
© Bardel et al; licensee BioMed Central Ltd. 2009
Received: 22 May 2008
Accepted: 26 January 2009
Published: 26 January 2009
Symptom prevalence is generally believed to increase with age. The aim of this study was to evaluate the age specific prevalence of 30 general symptoms among Swedish middle-aged women.
A cross-sectional postal questionnaire study in seven Swedish counties in a random sample of 4,200 women 35–64 years old, with 2,991 responders. Thirty general symptoms included in the Complaint Score subscale of the Gothenburg Quality of Life Instrument were used.
Four groups of age specific prevalence patterns were identified after adjustment for the influence of educational level, perceived health and mood, body mass index, smoking habits, use of hormone replacement therapy, and use of other symptom relieving therapy. Only five symptoms (insomnia, leg pain, joint pain, eye problems and impaired hearing) increased significantly with age. Eleven symptoms (general fatigue, headache, irritability, melancholy, backache, exhaustion, feels cold, cries easily, abdominal pain, dizziness, and nausea) decreased significantly with age. Two symptoms (sweating and impaired concentration) had a biphasic course with a significant increase followed by a significant decrease. The remaining twelve symptoms (difficulty in relaxing, restlessness, overweight, coughing, breathlessness, diarrhoea, chest pain, constipation, nervousness, poor appetite, weight loss, and difficulty in urinating) had stable prevalence with age.
Symptoms did not necessarily increase with age instead symptoms related to stress-tension-depression decreased.
The burden of morbidity increases with increasing age, while the prevalence of symptoms seems to be less age dependent. If symptom prevalence mirrors disease prevalence then symptom prevalence should also increase with age. However, although symptoms may indicate disease they may also be attributable to the physiological effects of anxiety or other emotions arising from a personal problem . Moreover, in addition to age, symptom reporting may be influenced by socioeconomic and lifestyle factors, such as educational level, physical activity, profession, income level, and social interaction [2–5].
Several studies have shown that women of all ages report more symptoms, take more of both prescription and non-prescription medication and consult physicians more often than men [6–8]. One possible explanation may be that women are more attentive to their wellbeing (physical and psychological), and therefore seek medical attention based on perception of their symptoms. Middle-aged women often present a variety of complaints at the onset of the menopause. It has been claimed that the menopausal syndrome is related more to personal characteristics than to the menopause per se, and that women in menopausal transition with several complaints of other origin than vasomotor may be suffering from underlying depression .
Complaint Score is a subscale of the Gothenburg Quality of Life instrument and contains a list of 30 symptoms. The subscale is intended to measure the tendency to report symptoms based on the assumption that symptom reporting reflects wellbeing. The instrument has been widely used during the last 30 years among men and women. It has been shown that symptom prevalence does not necessarily increase with age . We decided to test the hypothesis that some symptoms increase with age whereas other have a decreasing or stable tendency in young to middle-aged women sampled from the general population.
A random sample of 4200 women aged 35–64 years was drawn from the population register of the seven counties comprising the Uppsala-Örebro Health Care Region in central Sweden, a region large enough to be representative of Sweden. A postal questionnaire was sent to these women and 2991 (71.2%) responded. The age distribution of responders (49.6 ± 8.5 years) and non-responders (49.8 ± 8.7 years) was similar.
The questionnaire consisted of two parts. The first part contained information on height and weight, social background, lifestyle, medical history, gynaecological and obstetric history, and quality of life. Educational level was classified as compulsory education only, vocational training, high school, or college/university education. The women were classified according to their smoking habits as never-smokers, ex-smokers and current smokers. Body mass index was calculated as weight (kg)/height (m)2. The gynaecologic/obstetric data include number of pregnancies, ever use of contraceptives, menstrual status and ever undergone a hysterectomy or ooforectomy.
The Gothenburg Quality of Life Instrument was used to measure quality of life aspects . For this report the Complaint Score and Well-being sub-scales were used. The Complaint Score is a list of 30 general symptoms. The women were asked to indicate which of the symptoms they had experienced during the past three months. Possible responses were "yes" or "no". At test-retest of the instrument a Spearman correlation coefficient of 0.54 was found even with seven years between test and retest and probably much higher with shorter interval. Of the well-being subscale questions, those on work situation, perceived health, physical fitness, mood, energy, patience, self-esteem, and being appreciated at home or outside the home were used in this study. The responses were given on seven-point interval scales ranging from "poor" (= 1) to "excellent, could not be better" (= 7). The corresponding test-retest correlation coefficient as above was 0.49 for mood and 0.46 for health.
The second part of the questionnaire focused on drugs prescribed during the past 12 months. For each prescription, information was collected on drug trade name, indication, dosage, duration of medication, and whether or not the woman was taking the drug currently. All prescribed drugs reported were coded according to the Anatomical Therapeutic Chemical Classification System (ATC) . For this report, information on hormone replacement therapy (ATC codes G03C and G03F) and symptom relieving therapy (tranquilizers, hypnotics, antidepressants and painkillers with ATC codes N02A, N02B, N05B, N05C, N06A, M01A and M03B) was used. The study was approved by the Research Ethics Committee at Uppsala University.
Statistical analyses were conducted using the SAS  programme package. First, preliminary analyses of symptom prevalence in relation to age were performed with univariate and multivariate logistic regression analyses, with symptom reporting (yes/no) as the dependent variable, and age and 18 other potential outcome affecting variables (education, physical fitness, smoking habits, body mass index, perceived work situation, health, mood, energy, self-esteem, patience, appreciated at home or outside the home, number of pregnancies, ever use of contraceptives, hormone replacement therapy, other symptom relieving medication, menstrual status, and hysterectomy or ooforectomy ever performed), as independent variables with backward elimination of non-significant variables. In addition, a square term for age and a number of potential interaction terms were tested.
A final set of independent variables (covariates) common for all symptoms and significantly related to most of them was then defined. In addition to age it included perceived health, perceived mood, educational level, body mass index, smoking habits, use of hormone replacement therapy, and use of other symptom relieving medication, and age squared for curvilinear functions. No interaction terms survived the preliminary analyses.
Based on the final logistic regression analyses, age specific symptom prevalence estimates, adjusted for the influence of the final set of covariates listed above, were computed. The fit of adjusted functions to crude data regarding functional form was excellent for all 30 symptoms. The adjustments only affected the prevalence levels and only moderately.
A power analysis was performed regarding the age effect on one symptom each in the prevalence increase, decrease and no change group. The power, given a study population of 2900, an alpha level of 0.01, and the slopes found in the study, was 99.9% for general fatigue and 90% for insomnia. For nervousness, where there was no significant change with age, more than 30,000 subjects would have been needed to reach 80% statistical power to detect an age related prevalence change.
All tests were two-tailed. In the preliminary analyses p < 0.05 was used. In the final analyses p < 0.01 for symptom trend across age was used to account for multiple testing.
mean or %
49.6 ± 8.5
Compulsory school only
Vocational school/high school
College or university
Body mass index (kg/(m2))
Moderately good or good (4–6)
Moderately good or good (4–6)
Hormone replacement therapy
Symptom relieving therapy
Symptom prevalence data.
p across age *)
Twelve symptoms, difficulty relaxing, restlessness, overweight, coughing, breathlessness, diarrhoea, chest pain, constipation, nervousness, poor appetite, weight loss, and difficulty urinating, had a stable prevalence with age, ranging from 41.3% to 1.9%. An example from this group, coughing, is also shown on the graph in Figure 2.
Two symptoms, impaired concentration and sweating, had biphasic prevalence. Impaired concentration increased from 28% among the youngest women, to a peak value of 32% at ages 45–49 and then decreased to 22% at age 60–64. Sweating had an even more pronounced biphasic course starting at 14% among the youngest, reaching a maximum level of 38% at ages 50–54 years and then decreasing to 28% among the oldest subjects. The prevalence course for sweating is shown in Figure 2.
The remaining eleven symptoms, general fatigue, headache, irritability, melancholy, backache, exhaustion, feeling cold, crying easily, abdominal pain, dizziness, and nausea, all showed a significantly decreasing prevalence with age. For many of the symptoms the prevalence at age 60–64 was half or less of what it was among the youngest women. General fatigue, shown in Figure 2, ranged from 83.4% among the youngest to 47.8% among the oldest women. Corresponding levels for headache were 74.2% and 35.5%, respectively, Table 2. Irritability ranged from 66.1% to 30.5% and backache from 55.2% to 39.6%.
The study revealed that the symptoms examined could be grouped into four prevalence patterns. Only five symptoms increased with age, twelve symptoms had stable prevalence, two had a biphasic course (first increasing and then decreasing) and eleven symptoms had decreasing prevalence with age after adjustment for the influence of the final set of covariates on symptom prevalence, thereby making prevalence estimates in various age groups more accurate and comparable.
This study was performed in a random population sample of women aged 35–64 years. The response rate was satisfactory (71%). However, the 29% non-responders may imply a potential selection bias in the estimation of the proportion of women reporting symptom, if responders and non-responder had different characteristics. The distribution of socioeconomic variables and drug use among the responders was similar to that of national samples in Sweden [13, 14]. The size of the potential bias caused by non-response was estimated in a previous publication  and found to be of relatively little importance. Symptom reporting may have been affected by recall bias. However, the recall period of the last 3 months was short and the age range was such that younger and older women may be expected to have similar recall capacity.
The most commonly reported symptoms by the women in this study irrespective of age were general fatigue, headache, irritability, melancholy and backache, occurring in over or around 50% of the subjects. Furthermore, one third or more of the women had symptoms such as insomnia, restlessness, exhaustion and crying easily. Gorman has reviewed gender differences in the epidemiology and clinical presentations of depression . In the United States, 1 out of 5 women suffered from an episode of major depression at some time in her life. Depression was about twice as common among women as among men. Women were more likely to have atypical symptoms of depression such as hypersomnia and hyperphagia, or to have co-morbid anxiety disorders or to attempt suicide than men.
It has previously been shown by Tibblin et al., that there are different symptom prevalence patterns with age . They studied 30 general symptoms in women and men and found generally higher symptom prevalence in women, using the same symptom questionnaire as used in this study. Three symptom patterns were found: increasing, decreasing, and biphasic prevalence, whereas four patterns, increasing, decreasing, biphasic, and stable were seen in the present study. The study by Tibblin et al. was performed some twenty years ago and no adjustments were made to make the age groups more comparable, which might explain the differences found in the two studies .
Five symptoms increased with age. It is a well-established fact  and is part of the normal ageing process, that hearing and vision deteriorate with age. Sleep disturbance has also been found by others to increase with age. It has been shown in a longitudinal study, that sleep duration decreased by 0.4 hours per night for women aged 38–66 years and that sleep problems increased by 30% for women aged 38–84 years [17, 18].
In this study it was seen that leg pain as well as joint pain increased with age. This might partly be explained by increasing weight in those age groups. However, differences in body mass index between the groups were adjusted for, making overweight a less likely cause of these symptoms. Alternately, leg pain and joint pain could be signs of other musculoskeletal disorders, like osteoarthritis or rheumatoid arthritis, both of which have increasing prevalence with age [19, 20].
One third of the symptoms studied had stable prevalence patterns. This is in contrast to prior findings where increasing, decreasing and biphasic courses have been reported . We found stable prevalence patterns for difficulty in relaxing and nervousness, in contrast to the similar symptoms in the decreasing group. However, difficulty in relaxing and nervousness may indicate a personality trait rather than an age-related development. Also, symptoms like coughing, breathlessness and chest pain showed a similar unchanged pattern of relatively low prevalence, ranging from 12.2% to 23.7% among women ages 35 to 39 years indicating a more innocent nature of the symptoms than what it might have been in older age groups.
The prevalence of overweight, constipation, weight loss, and difficulty in urinating were also stable with age. Some of these symptoms, such as poor appetite, weight loss and difficulty in urinating, are commonly associated with serious diseases including diabetes and cancer, while constipation is common among the elderly. In this study overweigh ranged with age from 32.5% to 34.1%. This is broadly in line with what others found .
Two commonly considered groups of symptoms in women during the menopausal transition are psychological and vasomotor symptoms [22–27]. However, many symptoms believed to be related to the menopause also occur before and after this phase . Only two symptoms in our study showed a biphasic pattern, possibly suggesting their association with the menopausal transition. Impaired concentration had a peak, with a maximum prevalence of 32.2% at the ages of 45–49 years, which is in agreement with findings reported by Tibblin et al. . Increased prevalence of sweating was seen between the ages of 40 and 59, which is in line with what others have found [26, 28].
Eleven symptoms had decreasing prevalence patterns with age: general fatigue, headache, irritability, melancholy, backache, exhaustion, feeling cold, crying easily, abdominal pain, dizziness and nausea. The prevalence for headache ranged from 74.2% among the youngest women to 35.4% among the oldest women in our study. It is known that headache prevalence decreases after 50 years of age , both for migraine and other types of headache .
A decrease in the prevalence of backache from 55.2% to 39.6% with age was seen in this study. Low back pain mostly occurs in an individual's most productive years, with a peak in the age interval 35–59 years [30–32], which is in line with the results presented. Abdominal pain and nausea decreased with age as well. These two symptoms were less common at the older end of the age range than at the younger end. In a recent UK primary care study the incidence of abdominal pain in women was seen to decrease between the ages of 35 and 60, where after which a slight increase could be seen .
The findings from the present study may be useful for public health administrators in forming health policies. They may also be used in a clinical setting where doctors are giving advice to their patients. Since the major part of the symptoms become less prevalent with age, other strategies than pharmacological treatment may come into perspective.
Four prevalence courses across age were found. Few symptoms increased by age. The majority were either stable or decreased. Of those that decreased, the majority are generally associated with stress, strain or depression. The reasons why these symptoms generally decrease with age may be that women at the lower end of the age range have a larger burden with family, children and career than older women have, when the children may be grown up and their careers may be more stable. Symptoms do not necessarily increase with age, indicating that they may have other causes than ageing or disease.
This study was supported by grants from The Swedish Foundation for Health Care Sciences and Allergy Research, from the Epidemiology Department of AstraZeneca R&D Mölndal, and from Uppsala University.
- Tibblin G, Bengtsson C, Furunes B, Lapidus L: Symptoms by age and sex. The population studies of men and women in Gothenburg, Sweden. Scand J Prim Health Care. 1990, 8: 9-17. 10.3109/02813439008994923.View ArticlePubMedGoogle Scholar
- Furunes B, Bengtsson C, Lapidus L: Subjectively experienced symptoms in relation to socio-economic factors in women. Eur J Epidemiol. 1996, 12: 617-24. 10.1007/BF00499461.View ArticlePubMedGoogle Scholar
- Stadberg E, Mattsson LA, Milsom I: The prevalence and severity of climacteric symptoms and use of different treatment regimens in a Swedish population. Acta Obstet Gynecol Scand. 1997, 76: 442-48. 10.3109/00016349709047826.View ArticlePubMedGoogle Scholar
- Ivarsson T, Spetz AC, Hammar M: Physical exercise and vasomotor symptoms in postmenopausal women. Maturitas. 1998, 29: 139-46. 10.1016/S0378-5122(98)00004-8.View ArticlePubMedGoogle Scholar
- Hunter MS: Predictors of menopausal symptoms: psychosocial aspects. Baillieres Clin Endocrinol Metab. 1993, 7: 33-45. 10.1016/S0950-351X(05)80269-1.View ArticlePubMedGoogle Scholar
- Pennebaker JW: The psychology of physical symptoms. 1982, Berlin: Springer VerlagView ArticleGoogle Scholar
- Ladwig KH, Marten-Mittag B, Formanek B, Dammann G: Gender differences of symptom reporting and medical health care utilization in the German population. Eur J Epidemiol. 2000, 16: 511-18. 10.1023/A:1007629920752.View ArticlePubMedGoogle Scholar
- Kandrack MA, Grant KR, Segall A: Gender differences in health related behaviour: some unanswered questions. Soc Sci Med. 1991, 32: 579-90. 10.1016/0277-9536(91)90293-L.View ArticlePubMedGoogle Scholar
- Maartens LW, Leusink GL, Knottnerus JA, Pop VJ: Hormonal substitution during menopause: what are we treating?. Maturitas. 2000, 34: 113-18. 10.1016/S0378-5122(99)00093-6.View ArticlePubMedGoogle Scholar
- Tibblin G, Tibblin B, Peciva S, Kullman S, Svärdsudd K: "The Göteborg quality of life instrument" – an assessment of well-being and symptoms among men born 1913 and 1923. Methods and validity. Scand J Prim Health Care Suppl. 1990, 1: 33-38.PubMedGoogle Scholar
- Nordic Statistics on Medicines 1975–1977, parts I & II. 1977, Helsinki and Oslo: Nordic Council on MedicinesGoogle Scholar
- SAS Institute Inc: SAS, Ver.6.12. 1989, Cary, NC: SAS Institute IncGoogle Scholar
- Burman K: Läkemedelsstatistik 1996. 1996, Stockholm, Sweden: Text & TryckGoogle Scholar
- Statistical yearbook 1996. Stockholm. 1995Google Scholar
- Bardel A, Wallander MA, Svärdsudd K: Hormone replacement therapy and symptom reporting in menopausal women: a population-based study of 35–65-year-old women in mid-Sweden. Maturitas. 2002, 41: 7-15. 10.1016/S0378-5122(01)00254-7.View ArticlePubMedGoogle Scholar
- Gorman JM: Gender differences in depression and response to psycho-tropic medication. Gend Med. 2006, 3: 93-109. 10.1016/S1550-8579(06)80199-3.View ArticlePubMedGoogle Scholar
- Björkelund C, Bengtsson C, Lissner L, Rödström K: Women's sleep: longitudinal changes and secular trends in a 24-years perspective. Results of the population study of women in Gothenburg, Sweden. Sleep. 2002, 25: 894-96.PubMedGoogle Scholar
- Wallander MA, Johansson S, Ruigómez A, García Rodríguez LA, Jones R: Morbidity associated with sleep disorder in primary care: a longitudinal cohort study. Prim Care Companion J Clin Psychiatry. 2007, 9 (5): 338-345.View ArticlePubMedPubMed CentralGoogle Scholar
- Symmons DP, Barrett EM, Bankhead CR, Scott DG, Silman AJ: The incidence of rheumatoid arthritis in the United Kingdom: results from the Norfolk Arthritis Register. Br J Rheumatol. 1994, 33: 735-39. 10.1093/rheumatology/33.8.735.View ArticlePubMedGoogle Scholar
- Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, Sowers M, McAlindon T, Spector TD, Poole AR, Yanovski SZ, Ateshian G, Sharma L, Buckwalter JA, Brandt KD, Fries JF: Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med. 2000, 133: 635-46.View ArticlePubMedGoogle Scholar
- Lindqvist P, Andersson K, Sundh V, Lissner L, Björkelund C, Bengtsson C: Concurrent and separate effects of body mass index and waist-to-hip ratio on 24-year mortality in the Popoulation Study of Women in Gothenburg: evidence of age-dependency. Eur J Epidemiol. 2006, 21 (11): 789-94. 10.1007/s10654-006-9074-1.View ArticlePubMedGoogle Scholar
- Greendale GA, Lee NP, Arriola ER: The menopause. Lancet. 1999, 353 (9152): 571-80. 10.1016/S0140-6736(98)05352-5.View ArticlePubMedGoogle Scholar
- Hammar M, Berg G, Lindgren R: Vilka somatiska symptom uppträder vid hormonbortfall kring och efter menopausen och hur vanliga är dessa? (What somatic symptoms occur at hormone reduction around and after the menopause, and how common are they/authors transation). Subtitutionsbehanding i klimakteriet: aktuella synpunkter (Substitution treatment in the menopause: current views). Edited by: Sjöberg NO. 1998, Stockholm, Sweden: Swedish Society of MedicineGoogle Scholar
- Hunter M, Battersby R, Whitehead M: Relationships between psychological symptoms, somatic complaints and menopausal status. Maturitas. 1986, 8 (3): 217-28. 10.1016/0378-5122(86)90029-0.View ArticlePubMedGoogle Scholar
- Jaszmann L: Epidemiology of climacteric and postclimacteric complaints. Ageing and Estrogens. Edited by: Van Keep P, Lauritzen C. 1973, Basel: Karger, 22-34.Google Scholar
- Hardy R, Kuh D: Change in psychological and vasomotor symptom reporting during the menopause. Soc Sci Med. 1988, 55 (11): 1975-88. 10.1016/S0277-9536(01)00326-4.View ArticleGoogle Scholar
- Holte A: Influences of natural menopause on health complaints: a prospective study of healthy Norwegian women. Maturitas. 1992, 14 (2): 127-41. 10.1016/0378-5122(92)90005-O.View ArticlePubMedGoogle Scholar
- Stadberg E, Mattsson LA, Milsom I: Factors associated with climacteric symptoms and the use of hormone replacement therapy. Acta Obstet Gynecol Scand. 2000, 79 (4): 286-92. 10.1034/j.1600-0412.2000.079004286.x.View ArticlePubMedGoogle Scholar
- Aegidius KL, Zwart JA, Hagen K, Schei B, Stovner LJ: Hormone replacement therapy and headache prevalence in postmenopausal women. The Head-HUNT study. Eur J Neurol. 2007, 14 (1): 73-8. 10.1111/j.1468-1331.2006.01557.x.View ArticlePubMedGoogle Scholar
- Dixon A, Gatchel RJ: Gender and parental status as predictors of chronic low back pain disability: a prospective study. J Occupational Rehab. 1999, 9 (3): 195-200. 10.1023/A:1021353818130.View ArticleGoogle Scholar
- Papageorgiou AC, Croft PR, Ferry S, Jayson MI, Silman AJ: Estimating the prevalence of low back pain in the general population. Evidence from the South Manchester Back Pain Survey. Spine. 1995, 20: 1889-94. 10.1097/00007632-199509000-00009.View ArticlePubMedGoogle Scholar
- Croft PR, Macfarlane GJ, Papageorgiou AC, Thomas E, Silman AJ: Outcome of low back pain in general practice: a prospective study. BMJ. 1998, 316: 1356-59.View ArticlePubMedPubMed CentralGoogle Scholar
- Wallander MA, Johansson S, Ruigómez A, García Rodríguez LA: Unspecified abdominal pain in primary care: the role of gastrointestinal morbidity. Int J Clin Pract. 2007, 61: 1663-70. 10.1111/j.1742-1241.2007.01529.x.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/9/37/prepub
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