Skip to main content

The health of Arab-Americans living in the United States: a systematic review of the literature

Abstract

Background

Despite substantial attention paid to Arab-Americans (AAs) in the media and in public discourse, there is limited research about the health of AAs in the United States (US) in the public health literature. This review aims to synthesize the extant peer-reviewed literature concerned with the health of AAs living in the US.

Methods

We summarize existing research on the prevalence, relative burden compared to other ethnic and racial groups, and determinants of diseases within each morbidity cluster among AAs living in the US.

Results

Available evidence suggests that the health of AAs may differ from that of other ethnic and racial groups in the US, and that exposures specific to this ethnic group, such as immigration, acculturation, and discrimination may be important in the etiology of several diseases among AAs.

Conclusion

Given the growth of this ethnic group and its marginalization in the current sociopolitical climate, more research about the health of AAs in the US seems warranted. We summarize relevant methodological concerns and suggest avenues for future research.

Peer Review reports

Background

Arab-Americans (AAs) are residents of the United States (US) who trace their ancestral, cultural, or linguistic heritage or identity back to one of 22 Arab countries. Many recent high profile events–including the ongoing Arab-Israeli conflict, the September 11, 2001 attacks, and the war in Iraq–have put this group under increasing scrutiny in the popular press [1, 2]. Despite this greater attention to AAs in the media and in public discourse in the US, there is limited research about the health and well-being of AAs in the US in the epidemiologic and public health literature.

There are many reasons why health indicators among AAs may be different than those in the general population at large. First, AAs are disproportionately recent immigrants to the US [3]. Second, they share a set of cultural norms, heavily influenced by Islamic behavioral restrictions, that may substantially influence health behaviors. Third, this group has, in the past few decades, been marginalized from the general population, and increasingly so in the past several years [4, 5].

The aim of this review was to systematically assess the peer-reviewed literature concerned with the health of AAs living in the US and to summarize the prevalence and correlates of key health indicators among AAs. We considered the peer-reviewed epidemiologic and public health literature about AA health since 1980. In so doing, we aimed to synthesize current knowledge about the health of AAs, inform practitioners to particular health risks within the Arab-American (AA) community, and encourage research that can address unanswered questions about the health of this ethnic group.

Arab-Americans in the US

Arab immigration to the US occurred in three waves. The first began in 1875 and was comprised largely of Syrian and Lebanese Christian immigrants, most of whom were uneducated and worked unskilled jobs in the US. Following World War I, the Quota and Johnson-Reed Acts of 1924 limited the number of Arab immigrants allowed entry into the US each year, bringing to a close the first generation of Arab immigration.

Post World War II pro-immigration policy ushered in the second wave of Arab immigrants. The demographic characteristics of Arab immigrants during this wave differed substantially from the first: the majority came to the US fleeing post-war political upheavals in Egypt, Syria, Iraq, and Palestine. In contrast to those who immigrated during the first wave, this group was better educated, spoke fluent English, and worked white-collar jobs in the US.

The third wave of Arab immigration to the US began in 1965 after the Immigration Act of that year ended the quota system favoring European immigrants. This generation was the best educated compared to Arab immigrants during the other two waves [6–11]. The 1990s saw an immense increase in the number of Arab immigrants to the US: it is estimated that the AA population grew by 65% between 1990 and 2000 [3]. Most recent estimates of the AA population in the US range from 1.2 million-3.5 million [3, 12].

Approximately 94% of AAs in the US live in metropolitan areas, which is substantially higher than the 80% of the general US population living in metropolitan areas [3]. Michigan is the state with the highest concentration of AAs of any US state (at about 1%) and, in particular, the largest urban concentration of AAs in the US lives in metropolitan Detroit, MI, which is home to approximately 400,000 AAs. California, with approximately 715,000 AAs, is the state with the largest absolute population of AAs in the US [12].

As compared to the general US population, AAs are on the whole better educated, more affluent, and more likely to be entrepreneurs or own businesses [3]. The largest current proportion of AAs in the US is Roman Catholic (35%), followed by Muslim (24%), and then Eastern Orthodox Christian (18%). Thirty-nine percent of AAs in the US are of Lebanese origin, while Egyptian-Americans and Syrian-Americans comprise 12% each. More than 80% of AAs in the US are American citizens [3].

Methods

This review assesses current knowledge about the health of AAs and will encompass the peer-reviewed literature published between 1980 and 2008. We limited our review to these years in order to reflect current thinking about the relation between ethnicity and health. The literature reviewed was identified through the MEDLINE, Web of Science, BIOSYS previews, and Current Content Connect databases using the Web of Knowledge interface, and it covered empirical studies about any aspect of AA health in the US. All queries were carried out by the primary author during the month of July, 2008. A detailed account of the search strategy and results is provided in the additional files 1 &2.

We restricted our review to those studies that empirically and specifically assessed the health of AAs living in the US. The search was limited to English-language studies. Keywords and terms used for the search included the following: Arab, America*, Middle*Eastern, Chaldean, Diabet*, glucose, metaboli*, "heart disease", infarct*, heart, MI, CVD, atherosclero*, stroke, ischemi*, cancer, neoplas*, tumor, leukemia, lymphoma, depress*, anxiety, PTSD, post*trauma*, substance, mood, schizophren*, mental, psych, matern*, pregnan*, ped*, preterm, birth, abuse, tobacco, smok*, water*pipe. We also assessed the references of all papers reviewed to identify any papers that were not detected using the systematic searches.

Results

The original search provided 88 publications of which 54 were removed because they were either meeting abstracts or were not empiric in design (i.e., commentaries or discussion pieces). This review, therefore, covers 34 studies, which are reviewed in detail in Table S1, included in the additional files [additional file 2]. There were no papers referenced in any of these papers that were not detected by our systematic review. We organized our findings around eight morbidity clusters: diabetes, cardiovascular disease (CVD), tobacco use, psychological well-being, cancer, women and children's health, health and illness psychology, and miscellaneous reports. The studies reviewed here assess the health of AAs in the US using two empirical study designs: 27 of the studies were cross-sectional analyses and the remaining 7 were retrospective cohort analyses or medical chart reviews. We found no articles published about the health of AAs that used a prospective cohort design. Also, 26 of the articles that we found concerning the health of AAs were carried out in Michigan. Of those, 24 took place in metropolitan Detroit. Of the reviewed articles, only 7 reported direct comparisons of health metrics between AAs and other racial/ethnic groups. Throughout this section, we will first summarize point estimates of health indicators where available, highlighting differences between point estimates for AAs compared to other groups in the US population, and then we will discuss measures of association assessing determinants of each health indicator among AAs in the US.

Cardiovascular Disease

There is little consensus in the literature about the burden of cardiovascular disease (CVD) and its risk factors among AAs relative to other groups. The prevalence of hypertension among AAs is between 13–20% [13–15]. The prevalence of hypertension among AAs is comparable to that among non-Hispanic whites (23–25%) [14, 16], higher than among African-Americans (8%) in a comparative study [15], but lower than among African-Americans (32%) according to data from the third National Health and Nutrition Examination Survey (NHANES III) [16]. The prevalence of other risk factors for CVD, including overweight, is higher among AAs as compared to the general US population [17].

Two studies have assessed the determinants of CVD risk factors among AAs. In one study, elevated body mass index (BMI) was associated with elevated blood pressure, increased blood glucose, increased total cholesterol and decreased high-density lipoprotein (HDL)-cholesterol among AAs [17]. Length of stay in the US was positively associated with risk for hypertension in another study [14].

Tobacco Use

Two studies assessed the prevalence of tobacco use among AA adults. In one study, tobacco use was found to be more prevalent among AA adults than among the general US adult population. In a randomly selected sample of 237 AA adults in Michigan, 39% of respondents were current smokers, as compared to 29% both in Michigan and nationally [18]. Eleven percent of respondents were former smokers, as compared to 23% in Michigan and 26% nationally [18, 19]. This study concluded that AAs had a higher smoking rate, a lower quitting rate, and a much lower quit ratio when compared with national and state data. Determinants of smoking in this sample were young age and male gender [20]. Another study found that the prevalence of smoking during pregnancy among AAs (6%) was lower than that published among non-Hispanic whites (20%) and African-Americans (13%) [21, 22].

Several studies have assessed the prevalence and determinants of tobacco use among AA adolescents. The prevalence of ever smoking a cigarette among AA teens was between 29–45% across several studies, while the prevalence of one-month history of smoking was between 7–17% in the extant studies about the prevalence of adolescent tobacco use among AAs [23–25]. Rates of ever smoking (50%) and one-month history of smoking (22%) were higher among the general population of US adolescents than among AAs [25–27]. Water-pipe (a traditional Arab pipe used to smoke tobacco) smoking was more prevalent among AA youth than among the general adolescent population [25, 28].

There are several risk factors for tobacco use among AA adolescents that have been identified; these include male gender, peer-smokers, lack of religious influence, lack of perceived negative consequences of smoking, poor grades, high stress, family members who smoke, reporting many hours of smoking exposure daily, receiving offers to smoke, tobacco-related advertisements and mail, belief that tobacco can help make friends, and having a US-born mother [23–25]. Among the general population, determinants of adolescent smoking include parental socioeconomic status, personal income, parental smoking, parental attitudes, sibling smoking, peer smoking, peer attitudes and norms of smoking, family environment, attachment to family and friends, school factors, risk behaviors, lifestyle, stress, and depression/distress [29]. The only determinant of water-pipe smoking found among a sample of 297 AA adolescents of Yemeni descent was experimental tobacco use, which itself was significantly correlated with age and peer smoking influence [30]. Predictors of water-pipe use in the general population in this study included cigarette use, marijuana use, and male gender [28].

Diabetes

Several studies have assessed the prevalence and determinants of diabetes and related endocrine diseases among AAs in the US. However, there is little consensus in the literature about the burden of diabetes among AAs relative to the general US population. In cross-sectional analyses using convenience samples in metropolitan Detroit, the prevalence of diabetes among AAs was shown to be between 16–33% [15, 31, 32]. This suggests that the prevalence of diabetes among AAs is greater than among non-Hispanic whites (9%), African-Americans (10%), and Hispanics (11%), when compared with data from NHANES III [33, 34]. By contrast, in a national study using data from the National Health Interview Survey (NHIS) 2000–2003, the prevalence of diabetes among persons born in the Arab world was 5% as compared to 7% among non-Hispanic whites [14]. In a third, comparative study of African-American and AA women in Michigan, there was no significant difference between the prevalence of diabetes among AA women (28%) and African-American women (22%) [15].

One study considered the prevalence of metabolic syndrome among AAs, which was comparable to the general US population (age-adjusted, according to Adult Treatment Plan III (ATP III) standards) using NHANES III data [35, 36]. Metabolic syndrome was prevalent in 23% of AAs according to ATP III standards and in 28% of AAs according to World Health Organization (WHO) standards [35].

Three studies explicitly assessed the determinants of diabetes and related health indicators among AAs. In one study, age at immigration, duration in the US, activity in Arab organizations, and consumption of Arabic food were all shown to be associated with increased risk for dysglycemia after adjusting for age and BMI [37]. Another study showed that length of time in the US was negatively associated with diabetes prevalence [14]. A different study showed that determinants of diabetes among AAs also included older age, higher BMI, higher diastolic and systolic blood pressures, and higher total cholesterol and triglyceride counts [32]. The determinants of non-insulin dependant diabetes mellitus (NIDDM) among AAs, aside from acculturation, are similar to those among the general public [38].

Berlie and colleagues [39] assessed adherence to ADA guidelines among 53 AAs with diagnoses of Type II diabetes. AAs had better lipid control but worse blood pressure control than the general public. Pharmacotherapy among AAs was less aggressive than recommended by the ADA.

Psychological Well-being

Three studies have assessed the determinants of AA mental health in the US and three have assessed the mental health of Iraqi refugees specifically. A study among AAs in northcentral Florida showed that self-reports of recent discrimination were positively correlated with psychological distress and negatively correlated with self-esteem and environmental mastery [40]. A separate study among AAs from 19 states and the District of Columbia (DC) showed that among Christian AAs, less integration and more marginalization were associated with lower family dysfunction. Greater family dysfunction along with greater Arab religious/family values and acculturative stress were predictors of depression. However, in the same study, among Muslim AAs, less Arab religious/family values, less religiosity and greater marginalization were associated with family dysfunction. Greater family dysfunction and less religiosity were associated with depression [11]. A third study concerning the psychological well-being of AA elders showed that immigrant status was associated with lower life satisfaction and more frequent feelings of depression [41]. Perceived discrimination and acculturative stress have also been shown to be associated with risk for mental disorder among other ethnic and racial minorities in the US [42–45].

Three studies assessed the mental health of Iraqi refugees. In a chart review of 375 AA mental health clinic patients, Iraqi patients were more likely to be diagnosed with post-traumatic stress disorder (PTSD), more likely to have physical complaints, and more likely to have full remission after care than other AA patients [46]. A different study found that the mean number of medical complaints among those Iraqi refugees with PTSD was 10.4, 9.4 among those with depression, 8.7 among those with other disorders, and 10.6 among those with unknown illness [47]. The third study, among 32 Iraqi Gulf war refugees, found that 59% of respondents met the threshold for PTSD, which was associated with specific distress associated with pain before war [48].

Cancer

We are aware of only one study that was specifically concerned with cancer among AAs. Schwartz and colleagues [49] calculated age-adjusted AA proportional incidence ratios of site-specific cancers from all cancer cases in metropolitan Detroit between 1973–2002. AAs had 36% greater proportions of liver cancer, 44% greater thyroid cancer, 29% greater leukemia, 28% greater brain, 25% greater kidney, and 24% greater bladder cancers compared to non-Arab whites. They had 25% less skin melanoma, 27% less esophagus and 20% less oral cavity cancers than non-Arab whites.

Women and Children's Health

Two studies assessed the prevalence and two assessed the determinants of adverse birth outcomes among AA women. AAs are at lower risk for adverse birth outcomes than the general US population. One study considered all births in Michigan between 1993–2002. Among this sample, the prevalence of preterm birth (PTB) among women of Arab ancestry was 8%, and the prevalence of PTB among foreign-born AA women was significantly lower than that among non-Hispanic white women (9%) [50]. Another study found that the prevalence of low birth weight (LBW) among a sample of 823 AA mothers enrolled in the Women, Infants, and Children program in Dearborn, Michigan (MI) was 5%, which was lower than the prevalence of LBW in both Michigan (7%) and the US (8%) [21].

Two studies assessed the determinants of adverse birth outcomes among AA women. According to El Reda and colleagues [50], determinants of PTB among native-born AA women include pregnancy-related hypertension and lack of prenatal care visits. In the same study, determinants of PTB among foreign-born AA women were use of Medicaid, pregnancy-related hypertension, and diabetes. Those among native-born whites were age greater than 35, education below high school, lack of prenatal care visits, male gendered infant, tobacco use during pregnancy, chronic hypertension, pregnancy-related hypertension, and diabetes [50].

In a specific analysis concerning risk for adverse birth outcomes in the context of maternal stress, Lauderdale [51] assessed the effects of the terrorist attacks of September 11, 2001 on risk for adverse birth outcomes among AAs in California. Risk for LBW (OR = 1.3) and PTB (OR = 1.5) increased among Arab-named mothers in the six months following the terrorist attacks of September 11, 2001 as compared to the same six-month period in the year prior. If the infant's name was ethnically distinctive, relative risk for LBW among AAs was 2.3. Lauderdale found no change in the birth outcomes of non-Arab named women following the attacks of September 11, 2001 as compared to before the attacks.

Health and Illness Psychology

The literature about the health and illness psychology of AAs is concerned with self-reported health and activity limitations, health care needs, HIV/AIDS knowledge and attitudes, and attitudes toward domestic abuse among AAs.

Read and colleagues [52] assessed comparative self-rated health and activity limitations between Arab immigrants and US-born whites. They found that Arab immigrants do not differ from US-born whites in self-rated health and are less likely to report limitations in activity after adjustment for demographic and cultural factors. Arab immigrants who are citizens report worse health while their peers who are not officially American do not significantly differ from the general population after controlling for duration of US residency.

In a subjective health care needs assessment among 15 men and 32 women in California, Laffrey and colleagues [53] found that the five most prevalent health concerns in the AA community were upper respiratory infection (36%), cardiovascular disease/hypertension (23%), emotional problems (17%), diabetes (15%), and social/family stress (13%).

Kulwicki and Cass [54] assessed the knowledge and attitudes of AAs about HIV/AIDS. AAs were generally less knowledgeable about HIV/AIDS transmission and had more misconceptions about the disease than the general public in the US based on NHIS data [55].

One study assessed attitudes toward domestic abuse among AAs [56]. Fifty-eight percent of women and 59% of men approved of a man slapping his wife if she hit him first during an argument. If a man learned of his wife's infidelity, 48% of women and 23% of men approved of the man slapping her. Eighteen percent of women believed a man could kill his wife if she was unfaithful.

Miscellaneous Reports

Miscellaneous reports about the health of AAs were concerned with proportional cause-specific mortality, asthma, cystic fibrosis (CF) carrier frequency, trace element profiles, and dermatologic diseases.

Nasseri [57] explored proportional mortality ratios (PMR) among AAs in California for several common causes of mortality. PMRs for coronary heart disease (PMR = 1.3), suicide (PMR = 2.0), and diabetes (PMR = 1.9) among AA men were significantly elevated compared to non-Hispanic white men. Those for chronic obstructive pulmonary disorder (COPD) (PMR = 0.6) and HIV/AIDS (PMR = 0.5) were significantly lower among AA men than among non-Hispanic white men. PMRs for coronary heart disease (PMR = 1.3) and diabetes (PMR = 2.0) among AA women were significantly elevated compared to non-Hispanic white women and those for COPD (PMR = 0.2) and homicide (PMR = 0.5) among AA women were significantly lower compared to non-Hispanic white women [57].

The prevalence and correlates of asthma among AAs were studied by Johnson and colleagues [58]. They found that the prevalence of asthma among AAs was lower than among the general population in Michigan and the US. Twelve percent of the adult AA population was identified as being at high risk for asthma, while 8% had been diagnosed with asthma. This compares to 10% in Michigan as well as nationwide that had been diagnosed with asthma during their lifetime in a published report [59]. Age, acculturation, and socioeconomic status (SES) were predictive of asthma prevalence [59].

Wei and colleagues [60] studied CF carrier frequency among AAs and found that 1/115 of 805 AA patients undergoing preconception CF career screening in Detroit, MI were carriers. The observed CF carrier frequency among AAs was lower than frequencies published for African (1/61) and Hispanic Americans (1/58) in the US [61, 62].

Trace element profiles in the toenails of 259 AA adults and children living in metropolitan Detroit, MI were also assessed by Slotnick and colleagues [63]. Compared to published means [64–67] Arab-Americans have lower mean values of the essential elements copper, manganese, and selenium and higher values of the nonessential elements aluminum, cadmium, and nickel.

El-Essawi and colleagues [68] assessed the prevalence of common dermatologic conditions among AAs. They found that the five most prevalent dermatologic conditions among AAs were acne (38%), eczema/dermatitis (26%), warts (20%), fungal skin infections (20%), and melasma (15%). Acne and eczema were also among the most prevalent dermatologic conditions among African-Americans [69] and Hispanic-Americans [70].

Discussion

In this systematic review about the health of AAs in the US, we found that 1) there is little consensus about the relative burdens of CVD or diabetes among AAs compared to other groups, however the best available evidence suggests that the prevalence of hypertension among AAs is between 13–20% and the prevalence of diabetes is between 5–33%; 2) there is limited information about the prevalence of cancers or common mental disorders in this group; 3) there is evidence suggesting that AAs have lower prevalence of adverse birth outcomes and adolescent tobacco use compared to the general US population and to majority groups in the US; 4) the determinants of common morbidities among AAs are similar to those within the general population, although there is evidence that acculturation, immigration, and discrimination-associated stress are involved in the etiologies of CVD, diabetes, mental illness, and/or adverse birth outcomes among AAs.

There are several methodological limitations to the extant literature that challenge our current understanding of the health of AAs in the US and hinder the systematic comparison of the health of AAs to the health of other ethnic groups in the US. We will discuss each of these limitations in turn aiming to describe how these limitations influence our interpretation of the literature.

First, the central limitation to our understanding of the health of AAs in the US is the relative paucity of published studies concerning the health of this ethnic group. Our search of the literature yielded only 34 studies. This challenges our inference about the health of AAs in the US in several ways. First, there is little consensus about the prevalence and correlates of major morbidities such as diabetes and CVD among AAs relative to other ethnic groups. Because these diseases account for much of the chronic disease burden in the US, understanding the prevalence and correlates of these diseases among AAs is a primary concern. Second, there is little to no research about the prevalence and correlates of several important health indicators, such as all-cause mortality, common mental disorders, site-specific cancers, HIV/AIDS and other infectious diseases, and chronic pain conditions. Third, the literature about AA health has yielded few studies explicitly concerned with the health effects of potentially important exposures, such as immigration, acculturation, and discrimination among AAs. For example, as an ethnic group, AAs have been systematically targeted for discrimination–more so since the terrorist attacks of September 11, 2001 and the subsequent wars in Afghanistan and Iraq [4, 5]. However, there are only two studies of which we are aware that explicitly explore the relation between discrimination and health among AAs. One study considered the effects of post-September 11, 2001 discrimination-associated stress on AA birth outcomes, and the other considered the effects of discrimination on AA mental health. Both studies found that discrimination was either indirectly or directly associated with worse health among AAs [40, 51]. However, because the current literature about the health effects of discrimination among AAs is limited to two studies, the effects of discrimination cannot be generalized to health indicators that have not been explicitly associated with this exposure. Similarly, there are few studies that systematically assess the effects of immigration and acculturation on AA health.

The second methodological limitation to our understanding of AA health is the paucity of prospective studies that include data about AAs. Twenty-seven out of 34 studies that assessed the health of AAs in the US used cross-sectional analyses. The remaining 7 studies used either retrospective cohort analyses or medical chart reviews. We did not identify any studies that prospectively assessed the health of Arab-Americans in the US. Prospective cohort studies about the health of AAs in the US would be important for several reasons. First, without the use of prospective studies it is impossible to establish population-based incidence rates for health indicators among AAs. Second, prospective studies would allow inference about the causal and temporal mechanisms that underlie associations between Arab ethnicity and health indicators. Third, prospective studies are needed to help understand whether some of the observed associations between social exposures such as immigration, acculturation, and discrimination and health play different roles across the life course [71, 72]. A corollary to this limitation is that there is essentially no literature about the health of Arab immigrants to the US at baseline. We are not aware of any studies that assess the health of new arrivals to the US from Arab countries and assess subsequent changes in health post-immigration.

A third limitation is that many of the extant studies about the health of AAs use place of birth to demarcate Arab ethnicity. The use of place of birth as a marker for ethnicity unfortunately confounds ethnicity with migrant status which presents particular challenges. Migrant status in and of itself may be a determinant of AA health, positively or negatively [73–81]. In addition, there are likely factors that are associated with the health of migrants that are not relevant to the US-born AA population. For example, it has been suggested that acculturation is associated with both better [37] and worse [11, 54, 56] health indicators among AAs. The use of place of birth as a marker for ethnicity in a large portion of the literature about the health of AAs precludes the generalizability of study findings to native-born AAs.

Fourth, many of the extant studies concerning the health of AA have used convenience samples in one area with a high AA concentration. Twenty-six of the 34 (76%) studies reviewed above sampled AAs in Michigan; 24 of those 26 in Michigan sampled AAs in the southeast part of the state, which includes metropolitan Detroit and Dearborn, MI. Because of its high concentration of AAs, metropolitan Detroit is an attractive study locale for investigators interested in the health of AAs. However, it is possible that health indicators among AAs in Michigan are not representative of those among the US population of AAs. For example, although national data show that AAs are on average more affluent and educated than the general US population [3], SES indicators in health studies among AAs in Michigan are generally lower than those among the general population of the state [20, 31, 35, 50, 52]. Alternatively, it has been shown that ethnic minorities who live in localities with high concentrations of members of their ethnic group are protected against adverse health outcomes [82–85]. Because southeast Michigan is home to the highest concentration of AAs in the US, it is possible that the health of AAs in southeast Michigan differs meaningfully from the health of AAs in other localities in the US.

There are several cautions that should be noted when interpreting the findings of this review. First, we organized our findings around eight morbidity clusters. It is important to note that this organization was likely influenced by the search terms used in the article search methodology. Second, because our inclusion criteria restricted the articles reviewed herein to those published in peer-reviewed journals, there may be publication bias regarding the articles discussed in this review. Therefore, our findings may not accurately reflect current knowledge about Arab-American health in the US. Third, while several of the topics discussed in articles reviewed in the "Miscellaneous Reports" portion of the results may represent defined morbidity clusters in their own right, there was not sufficient published research to establish any of them as such with regard to the health of AAs living in the US.

Conclusion

We suggest that five directions for future research emerge from this review. First, investigators interested in the health of AAs or in understanding the health effects of social exposures such as immigration, acculturation and/or discrimination might consider undertaking prospective cohort studies of the health of AAs in the US. Second, because the majority of studies published concerning the health of AAs in the US are set in southeast Michigan, investigators interested in the health of this ethnic group could consider studies using national and statewide datasets or studying the health of AAs in different localities. Third, devising better and more efficient methods of determining Arab ethnicity, such as validated name algorithms [86, 87], may help provide investigators with tools to identify AAs that may be useful for population-based studies. Fourth, state and local health departments concerned with the health of AAs living within their territories might consider collecting data on Arab ancestry or ethnicity to improve health and demographic research about this population. Fifth, little is known about the comparative health of AAs in the US and Arabs in Arab countries. Future work may fruitfully assess the health of AAs on immigration to the US and how the post-immigration environment influences subsequent health in this group and accounts for differences in health indicators between AAs and other ethnic groups in the US or between AAs in the US and Arabs worldwide.

Abbreviations

AAs:

Arab-Americans

AA:

Arab-American

US:

United States

MI:

Michigan

NHANES III:

Third National Health and Nutrition Examination Survey

NHIS:

National Health Interview Survey

PTSD:

Post-traumatic stress disorder

CVD:

Cardiovascular disease

HDL:

High density lipoprotein

BMI:

Body mass index

ATP III:

Adult Treatment Plan III

WHO:

World Health Organization

ADA:

American Diabetes Association

A1c:

Hemoglobin A1c

FL:

Florida

PIR:

Proportional incidence ratio

DC:

District of Columbia

PTB:

Preterm Birth

LBW:

Low birth weight

HIV/AIDS:

Human immunodeficiency virus/acquired immunodeficiency syndrome

PMR:

Proportional mortality ratio

COPD:

Chronic obstructive pulmonary disorder

SES:

Socioeconomic status

CF:

Cystic fibrosis

NIDDM:

non-insulin dependant diabetes mellitus.

References

  1. Persson AV, Musher-Eizenman DR: College students' attitudes toward blacks and Arabs following a terrorist attack as a function ofvarying levels of media exposure. J Appl Soc Psychol. 2006, 35 (9): 1879-92. 10.1111/j.1559-1816.2005.tb02200.x.

    Article  Google Scholar 

  2. Stone RP: Race, faith and fear: General press and black press coverage of Arabs, Muslims and the stigma of terrorism in the United States. 2006, Masters ed.: Baylor University

    Google Scholar 

  3. Arab Americans; demographics. Arab American Institute Foundation. 2008, [http://www.aaiusa.org/arab-americans/22/demographics]

  4. Arab-American Anti-Discrimination Committee Research Institute: Report on hate crimes and discrimination against Arab Americans: The Post September 11 Backlash. 2003, [http://server.traffic.northwestern.edu/events/rps/shora.pdf]

    Google Scholar 

  5. Zogby International: Arab American Institute poll Results: Arab Americans are strong advocates of war against terrorism; overwhelmingly indorse president bush's actions; significant numbers have experienced discrimination since Sept. 11. [http://www.zogby.com/news/readnews.cfm?ID=487]

  6. Abudabbeh N: Arab families. Ethnicity and family therapy. Edited by: McGoldrick M, Giordano J, Pearce JK. 1996, New York, NY: Guilford Press, 333-46. 2

    Google Scholar 

  7. Abu-Laban B, Suleiman MW: Arab-Americans continuity and change. 1989, Belmont, MA: Association of Arab-American University Graduates

    Google Scholar 

  8. El-Badry S: The Arab-American market. Am Demogr. 1994, 16: 22-30.

    Google Scholar 

  9. Naff A: The early Arab immigrant experience. 1985, Southern Illinois University Press, USA

    Google Scholar 

  10. Naff A: The early Arab immigrant experience. The development of Arab-American identity. Edited by: McCarus E. 1985, Ann Arbor, MI: University of Michigan Press

    Google Scholar 

  11. Amer MM, Hovey JD: Socio-demographic differences in acculturation and mental health for a sample of 2nd generation/early immigrant Arab Americans. J Immigr Minor Health. 2007, 9 (4): 335-47. 10.1007/s10903-007-9045-y.

    Article  PubMed  Google Scholar 

  12. de la Cruz , Patricia G, Brittingham A: The Arab population: 2000. 2003, U.S. Census Bureau, USA

    Google Scholar 

  13. Dallo FJ, James SA: Acculturation and blood pressure in a community-based sample of Chaldean-American women. J Immigr Health. 2000, 2 (3): 145-53. 10.1023/A:1009560903668.

    Article  CAS  PubMed  Google Scholar 

  14. Dallo FJ, Borrell LN: Self-reported diabetes and hypertension among Arab Americans in the United States. Ethn Dis. 2006, 16 (3): 699-705.

    PubMed  Google Scholar 

  15. Jamil H, Fakhouri M, Dallo F, et al: Self-reported heart disease among Arab and Chaldean American women residing in southeast Michigan. Ethn Dis. 2008, 18 (1): 19-25.

    PubMed  Google Scholar 

  16. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D: Prevalence of hypertension in the US adult population. Results from the third national health and nutrition examination survey, 1988–1991. Hypertension. 1995, 25 (3): 305-13.

    Article  CAS  PubMed  Google Scholar 

  17. Hatahet W, Khosla P, Fungwe TV: Prevalence of risk factors to coronary heart disease in an Arab-American population in southeast Michigan. Int J Food Sci Nutr. 2002, 53 (4): 325-35. 10.1080/09637480220138124.

    Article  CAS  PubMed  Google Scholar 

  18. Schoenborn C, Boyd G: Smoking and other tobacco use: United States, 1987. 1989, Hyattsville, MD: National Center for Health Statistics

    Google Scholar 

  19. Rafferty AP: Health risk behaviors: Cigarette smoking. Results from the 1990 Michigan behavioral risk factor survey. 1992, Lansing, MI: Michigan Department of Public Health

    Google Scholar 

  20. Rice VH, Kulwicki A: Cigarette use among Arab Americans in the Detroit metropolitan-area. Public Health Rep. 1992, 107 (5): 589-94.

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Kulwicki A, Smiley K, Devine S: Smoking behavior in pregnant Arab Americans. MCN Am J Matern Child Nurs. 2007, 32 (6): 363-7. 10.1097/01.NMC.0000298132.62655.0d.

    Article  PubMed  Google Scholar 

  22. Pregnancy risk assessment monitoring system report 2002. 2005, Lansing, MI: Michigan Department of Community Health

  23. Islam SM, Johnson CA: Correlates of smoking behavior among Muslim Arab-American adolescents. Ethn Health. 2003, 8 (4): 319-37. 10.1080/13557850310001631722.

    Article  PubMed  Google Scholar 

  24. Rice VH, Templin T, Kulwicki A: Arab-American adolescent tobacco use: Four pilot studies. Prev Med. 2003, 37 (5): 492-8. 10.1016/S0091-7435(03)00175-0.

    Article  PubMed  Google Scholar 

  25. Rice VH, Weglicki LS, Templin T, et al: Predictors of Arab American adolescent tobacco use. Merrill-Palmer Q. 2006, 52 (2): 327-42. 10.1353/mpq.2006.0020.

    Article  Google Scholar 

  26. Allen J, Vallone D, Haviland ML, et al: Tobacco use among middle and high school students–United States, 2002. MMWR. 2002, 1096-8. [http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5245a2.htm]

    Google Scholar 

  27. Johnston LD, O'Malley PM, Bachman JG, et al: Monitoring the future: National survey Results on drug use, 1975–2003. secondary school students. 2003, DHHS Publication no (NIH) 04-5507 ed. Bethesda, MD: National Institute on Drug Abuse, 1:

    Google Scholar 

  28. Grekin ER, Ayna D: Argileh use among college students in the united states: An emerging trend. J Stud Alcohol Drugs. 2008, 69 (3): 472-5.

    Article  PubMed  Google Scholar 

  29. Tyas SL, Pederson LL: Psychosocial factors related to adolescent smoking: A critical review of the literature. Tob Control. 1998, 7 (4): 409-20. 10.1136/tc.7.4.409.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Baker OG, Rice V: Predictors of narghile (water-pipe) smoking in a sample of American Arab Yemeni adolescents. J Transcult Nurs. 2008, 19: 24-32. 10.1177/1043659607309141.

    Article  PubMed  Google Scholar 

  31. Jaber LA, Brown MB, Hammad A, et al: Epidemiology of diabetes among Arab Americans. Diabetes Care. 2003, 26 (2): 308-13. 10.2337/diacare.26.2.308.

    Article  PubMed  Google Scholar 

  32. Jaber LA, Slaughter RL, Grunberger G: Diabetes and related metabolic risk factors among Arab Americans. Ann Pharmacother. 1995, 29 (6): 573-6.

    CAS  PubMed  Google Scholar 

  33. Kridli SA, Herman WH, Brown MB, Fakhouri H, Jaber LA: The epidemiology of diabetes and its risk factors among Chaldean Americans. Ethn Dis. Spring. 2006, 16 (2): 351-6.

    Google Scholar 

  34. Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, Wiedmeyer HM, Byrd-Holt DD: Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The third national health and nutrition examination survey, 1988–1994. Diabetes Care. 1998, 21 (4): 518-24. 10.2337/diacare.21.4.518.

    Article  CAS  PubMed  Google Scholar 

  35. Jaber LA, Brown MB, Hammad A, et al: The prevalence of the metabolic syndrome among Arab Americans. Diabetes Care. 2004, 27 (1): 234-8. 10.2337/diacare.27.1.234.

    Article  PubMed  Google Scholar 

  36. Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: Findings from the third national health and nutrition examination survey. JAMA. 2002, 287 (3): 356-9. 10.1001/jama.287.3.356.

    Article  PubMed  Google Scholar 

  37. Jaber LA, Brown MB, Hammad A, et al: Lack of acculturation is a risk factor for diabetes in Arab immigrants in the US. Diabetes Care. 2003, 26 (7): 2010-4. 10.2337/diacare.26.7.2010.

    Article  PubMed  Google Scholar 

  38. Jun H, Bae HY, Lee BR, Koh KS, Kim YS, Lee KW, Kim H, Yoon J: Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) – genetic predisposition and metabolic abnormalities. Adv Drug Deliv Rev. 1999, 35 (2–3): 157-177. 10.1016/S0169-409X(98)00071-4.

    Article  CAS  PubMed  Google Scholar 

  39. Berlie HD, Herman WH, Brown MB, et al: Quality of diabetes care in Arab Americans. Diabetes Res Clin Practice. 2008, 79 (2): 249-55. 10.1016/j.diabres.2007.09.003.

    Article  Google Scholar 

  40. Moradi B, Hasan NT: Arab American persons' reported experiences of discrimination and mental health: The mediating role of personal control. Journal of Counseling Psychology. 2004, 51 (4): 418-28. 10.1037/0022-0167.51.4.418.

    Article  Google Scholar 

  41. Ajrouch KJ: Resources and well-being among Arab-American elders. J Cross Cult Gerontol. 2007, 22 (2): 167-82. 10.1007/s10823-006-9033-z.

    Article  PubMed  Google Scholar 

  42. Caplan S: Latinos, acculturation, and acculturative stress: A dimensional concept analysis. Policy Polit Nurs Pract. 2007, 8 (2): 93-106. 10.1177/1527154407301751.

    Article  PubMed  Google Scholar 

  43. Hwang W, Ting JY: Disaggregating the effects of acculturation and acculturative stress on the mental health of Asian Americans. Cultur Divers Ethnic Minor Psychol. 2008, 14 (2): 147-54. 10.1037/1099-9809.14.2.147.

    Article  PubMed  Google Scholar 

  44. Crockett LJ, Iturbide MI, Torres Stone RA, McGinley M, Raffaelli M, Carlo G: Acculturative stress, social support, and coping: Relations to psychological adjustment among Mexican American college students. Cultur Divers Ethnic Minor Psychol. 2007, 13 (4): 347-55. 10.1037/1099-9809.13.4.347.

    Article  PubMed  Google Scholar 

  45. Williams DR, Neighbors HW, Jackson JS: Racial/ethnic discrimination and health: Findings from community studies. Am J Public Health. 2008, 98 (9 Suppl): S29-37.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Jamil H, Hakim-Larson J, Farrag M, et al: A retrospective study of Arab American mental health clients: Trauma and the Iraqi refugees. Am J Orthop. 2002, 72 (3): 355-61. 10.1037/0002-9432.72.3.355.

    Article  Google Scholar 

  47. Jamil H, Hakim-Larson J, Farrag M, et al: Medical complaints among Iraqi American refugees with mental disorders. J Immigr Health. 2005, 7 (3): 145-52. 10.1007/s10903-005-3671-z.

    Article  PubMed  Google Scholar 

  48. Jamil H, Nassar-McMillan SC, Salman WA, et al: Iraqi gulf war veteran refugees in the US: PTSD and physical symptoms. Soc Work Health Care. 2006, 43 (4): 85-98. 10.1300/J010v43n04_06.

    Article  PubMed  Google Scholar 

  49. Schwartz KL, Kulwicki A, Weiss LK, et al: Cancer among Arab Americans in the metropolitan Detroit area. Ethn Dis. 2004, 14 (1): 141-6.

    PubMed  Google Scholar 

  50. El Reda DK, Grigorescu V, Posner SF, et al: Lower rates of preterm birth in women of Arab ancestry: An epidemiologic paradox-Michigan, 1993–2002. Matern Child Health J. 2007, 11 (6): 622-7. 10.1007/s10995-007-0199-y.

    Article  PubMed  Google Scholar 

  51. Lauderdale DS: Birth outcomes for Arabic-named women in California before and after September 11. Demography. 2006, 43 (1): 185-201. 10.1353/dem.2006.0008.

    Article  PubMed  Google Scholar 

  52. Kulwicki AD, Miller J: Domestic violence in the Arab American population: Transforming environmental conditions through community education. Issues Ment Health Nurs. 1999, 20 (3): 199-215. 10.1080/016128499248619.

    Article  CAS  PubMed  Google Scholar 

  53. Laffrey SC, Meleis AI, Lipson JG, et al: Assessing Arab-American health-care needs. Soc Sci Med. 1989, 29 (7): 877-83. 10.1016/0277-9536(89)90087-7.

    Article  CAS  PubMed  Google Scholar 

  54. Kulwicki A, Cass PS: An assessment of Arab American knowledge, attitudes, and beliefs about AIDS. Image J Nurs Sch. 1994, 26 (1): 13-7. 10.1111/j.1547-5069.1994.tb00288.x.

    Article  CAS  PubMed  Google Scholar 

  55. Adams PF, Hardy AM: AIDS knowledge and attitudes for July-September 1990. provisional data from the national health interview survey. Adv Data. 1991, 1 (198): 1-12.

    Google Scholar 

  56. Read JG, Amick B, Donato KM: Arab immigrants: A new case for ethnicity and health?. Soc Sci Med. 2005, 61 (1): 77-82. 10.1016/j.socscimed.2004.11.054.

    Article  PubMed  Google Scholar 

  57. Nasseri K: Mortality in first generation white immigrants in California, 1989–1999. J Immigr Minor Health. 2008, 10 (3): 197-205. 10.1007/s10903-007-9070-x.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Johnson M, Nriagu J, Hammad A, et al: Asthma prevalence and severity in Arab American communities in the Detroit area, Michigan. J Immigr Health. 2005, 7 (3): 165-78. 10.1007/s10903-005-3673-x.

    Article  PubMed  Google Scholar 

  59. Savoie K, Nriagu J: Air pollution health risk assessment of the Arab American community in Dearborn, Michigan. Report to the US EPA, region 5, air and radiation division. 1999

    Google Scholar 

  60. Wei SN, Feldman GL, Monaghan KG: Cystic fibrosis testing among Arab-Americans. Gen Med. 2006, 8 (4): 255-8.

    Google Scholar 

  61. Watson MS, Cutting GR, Desnick RJ, Driscoll DA, Klinger K, Mennuti M, Palomaki GE, Popovich BW, Pratt VM, Rohlfs EM, Strom CM, Richards CS, Witt DR, Grody WW: Cystic fibrosis population carrier screening: 2004 revision of American college of medical genetics mutation panel. Genet Med. 2004, 6 (5): 387-91.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Richards CS, Bradley LA, Amos J, et al: Standards and guidelines for CFTR mutation testing. Genet Med. 2002, 4 (5): 379-91.

    Article  PubMed  Google Scholar 

  63. Slotnick MJ, Nriagu JO, Johnson MM, et al: Profiles of trace elements in toenails of Arab-Americans in the Detroit area, Michigan. Biol Trace Elem Res. 2005, 107 (2): 113-26. 10.1385/BTER:107:2:113.

    Article  CAS  PubMed  Google Scholar 

  64. Berdanier CD: Trace minerals. Advanced nutrition: Micronutrients. 1998, New York, NY: CRC, 183-219.

    Google Scholar 

  65. Desai BB: Handbook of nutrition and diet. 2000, New York, NY: Marcel Dekker

    Google Scholar 

  66. Kristianson J, Christenson JM, Henriksen T: Determination of nickel in fingernails and forearm skin (stratum corneum). Anal Chim Acta. 2000, 43: 265-72. 10.1016/S0003-2670(99)00568-1.

    Article  Google Scholar 

  67. Peters K, Gammelgaard B, Meene T: Nickel content of fingernails of hospital cleaners. Contact Dermat. 1999, 25: 237-41. 10.1111/j.1600-0536.1991.tb01851.x.

    Article  Google Scholar 

  68. El-Essawi D, Musial JL, Hammad A, et al: A survey of skin diseases and skin-related issues in Arab Americans. J Am Acad Dermatol. 2007, 56 (6): 933-8. 10.1016/j.jaad.2007.01.031.

    Article  PubMed  Google Scholar 

  69. Halder RM, Grimes PE, McLaurin CI, Kress MA, Kenney JA: Incidence of common dermatoses in a predominantly black dermatologic practice. Cutis. 1983, 32 (4): 388-390.

    CAS  PubMed  Google Scholar 

  70. Sanchez MR: Cutaneous diseases in Latinos. Dermatol Clin. 2003, 21 (4): 689-97. 10.1016/S0733-8635(03)00087-1.

    Article  PubMed  Google Scholar 

  71. Kuh D, Ben-Shlomo Y: A life course approach to chronic disease epidemiology. 2004, New York, NY: Oxford University Press, 2

    Chapter  Google Scholar 

  72. Rothman KJ: Epidemiology; An introduction. 2002, New York, NY: Oxford University Press

    Google Scholar 

  73. Marmot MG, Adelstein AM, Bulusu L: Lessons from the study of immigrant mortality. Lancet. 1984, 1 (8392): 1455-7. 10.1016/S0140-6736(84)91943-3.

    Article  CAS  PubMed  Google Scholar 

  74. Shai D, Rosenwaike I: Mortality among Hispanics in metropolitan Chicago: An examination based on vital statistics data. J Chronic Dis. 1987, 40 (5): 445-51. 10.1016/0021-9681(87)90178-0.

    Article  CAS  PubMed  Google Scholar 

  75. Sorlie PD, Backlund E, Johnson NJ, Rogot E: Mortality by Hispanic status in the United States. JAMA. 1993, 270 (20): 2464-8. 10.1001/jama.270.20.2464.

    Article  CAS  PubMed  Google Scholar 

  76. Palloni A, Ewbank DC: Selection processes in the study of racial and ethnic differentials in adult health and mortality. Critical Perspectives on Racial and Ethnic Differences in Health in Late Life. Edited by: Anderson NB, Bulatao RA, Cohen B. 2004, Washington D.C.: National Academies Press, 171-226.

    Google Scholar 

  77. Rubalcava LN, Teruel GM, Thomas D, Goldman N: The healthy migrant effect: New findings from the Mexican family life survey. Am J Public Health. 2008, 98 (1): 78-84. 10.2105/AJPH.2006.098418.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Jasso G, Massey DS, Rozensweig MR, et al: Immigrant health: Selectivity and acculturation. Critical Perspectives on Racial and Ethnic Differences in Health in Late Life. Edited by: Anderson NB, Bulatao RA, Cohen B. 2004, Washington D.C.: National Academies Press, 227-68.

    Google Scholar 

  79. Lechner I, Mielck A: [Decrease in the "healthy migrant effect": Trends in the morbidity of foreign and German participants in the 1984–1992 socioeconomic panel]. Gesundheitswesen. 1998, 60 (12): 715-20.

    CAS  PubMed  Google Scholar 

  80. Rumbout RG, Weeks JR: Unraveling a public health enigma: Why do immigrants experience superior perinatal outcomes. Res Sociol Health Care. 1996, 337-91.

    Google Scholar 

  81. Wingate MS, Alexander GR: The healthy migrant theory: Variations in pregnancy outcomes among US-born migrants. Soc Sci Med. 2006, 62 (2): 491-8. 10.1016/j.socscimed.2005.06.015.

    Article  PubMed  Google Scholar 

  82. Peak C, Weeks JR: Does community context influence reproductive outcomes of Mexican origin women in San Diego, California?. J Immigr Health. 2002, 4 (3): 125-36. 10.1023/A:1015646800549.

    Article  PubMed  Google Scholar 

  83. Ostir GV, Eschbach K, Markides KS, Goodwin JS: Neighbourhood composition and depressive symptoms among older Mexican Americans. J Epidemiol Community Health. 2003, 57 (12): 987-92. 10.1136/jech.57.12.987.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Eschbach K, Ostir GV, Patel KV, et al: Neighborhood context and mortality among older Mexican Americans: Is there a barrio advantage. Am J Public Health. 2004, 94 (10): 1807-12. 10.2105/AJPH.94.10.1807.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Cagney KA, Browning CR, Wallace DM: The Latino paradox in neighborhood context: The case of asthma and other respiratory conditions. Am J Public Health. 2007, 97 (5): 919-25. 10.2105/AJPH.2005.071472.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Morrison PA, Kestenbaum B, Lauderdale DS, et al: Developing an Arab American surname list: Potential demographic and health research applications. Presented at the Annual Meeting of the Southern Demographic Association. Alexandria, Va. 2003

    Google Scholar 

  87. Nasseri K: Construction and validation of a list of common Middle Eastern surnames for epidemiological research. Cancer Detect Prev. 2007, 31 (5): 424-9. 10.1016/j.cdp.2007.10.006.

    Article  PubMed  PubMed Central  Google Scholar 

Pre-publication history

Download references

Acknowledgements

This work was supported by the National Institutes of Health [GM07863 (to AMES), DA022720, MH082729, DA017642, MH078152 (to SG)]. The funding organization had no role in the design of this review.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Abdulrahman M El-Sayed.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

AMES conceived the study, carried out the search, and wrote the manuscript. SG edited the manuscript and participated in its design and coordination. All authors read and approved the final manuscript.

Electronic supplementary material

12889_2009_1675_MOESM1_ESM.pdf

Additional file 1: El-Sayed and Galea review search strategy. Details about the search strategy employed during the literature search and results thereof. (PDF 48 KB)

Additional File 2: Arab-American Health Table S1. Details about each of the studies. (ZIP 44 KB)

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

El-Sayed, A.M., Galea, S. The health of Arab-Americans living in the United States: a systematic review of the literature. BMC Public Health 9, 272 (2009). https://doi.org/10.1186/1471-2458-9-272

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/1471-2458-9-272

Keywords