- Research article
- Open Access
- Open Peer Review
Blood pressure patterns in rural, semi-urban and urban children in the Ashanti region of Ghana, West Africa
© Agyemang et al; licensee BioMed Central Ltd. 2005
- Received: 18 May 2005
- Accepted: 01 November 2005
- Published: 01 November 2005
High blood pressure, once rare, is rapidly becoming a major public health burden in sub-Saharan/Africa. It is unclear whether this is reflected in children. The main purpose of this study was to assess blood pressure patterns among rural, semi-urban, and urban children and to determine the association of blood pressure with locality and body mass index (BMI) in this sub-Saharan Africa setting.
We conducted a cross-sectional survey among school children aged 8–16 years in the Ashanti region of Ghana (West-Africa). There were 1277 children in the study (616 boys and 661 females). Of these 214 were from rural, 296 from semi-urban and 767 from urban settings.
Blood pressure increased with increasing age in rural, semi-urban and urban areas, and in both boys and girls. The rural boys had a lower systolic and diastolic blood pressure than semi-urban boys (104.7/62.3 vs. 109.2/66.5; p < 0.001) and lower systolic blood pressure than urban boys (104.7 vs. 107.6; p < 0.01). Girls had a higher blood pressure than boys (109.1/66.7 vs. 107.5/63.8; p < 0.01). With the exception of a lower diastolic blood pressure amongst rural girls, no differences were found between rural girls (107.4/64.4) and semi-urban girls (108.0/66.1) and urban girls (109.8/67.5). In multiple linear regression analysis, locality and BMI were independently associated with blood pressure in both boys and girls.
These findings underscore the urgent need for public health measures to prevent increasing blood pressure and its sequelae from becoming another public health burden. More work on blood pressure in children in sub-Saharan African and other developing countries is needed to prevent high blood pressure from becoming a major burden in many of these countries.
- Diastolic Blood Pressure
- High Blood Pressure
- Blood Pressure Level
- Blood Pressure Profile
- Ashanti Region
High blood pressure has been identified as one of the leading causes of cardiovascular disease and premature mortality in the world . In traditional African societies, high blood pressure, once rare,  is rapidly becoming a major public health burden [3–6]. The recent data show prevalence rates as high as 33% in some communities [3, 4]. The increasing prevalence of hypertension is well reflected in the increasing stroke and cardiovascular disease morbidity and mortality [7–9].
In children, blood pressure tracking patterns confirm that persistent blood pressure elevation may be related to hypertension in adulthood [10, 11]. The emerging data also suggest that primary hypertension is detectable and occurs commonly in the young . In addition, the presence of elevated blood pressure in childhood has been linked with left ventricular hypertrophy . As a result, in most western countries assessment and management of blood pressure in childhood is strongly recommended to promote improved cardiovascular health in adulthood . Many epidemiological studies in various countries have been conducted to determine normal standard reference levels for age, sex, and body size [12, 14]. However, in sub-Saharan African countries, blood pressure data on children and adolescents are very scarce. In Ghana for example, apart from the blood pressure profiles made in the 1970s on 5–12 year-olds in the Accra region, no other published data are available . It is also unclear whether the recent rapid increases in blood pressure and prevalence of hypertension in adults [4, 5, 15] are reflected in children. Given the fast health transition towards non-communicable diseases and changes in lifestyle associated with urbanization [1, 16], there is an urgent need for research on blood pressure in children so that appropriate cost-effective interventions can be introduced early in life to prevent the double burden of diseases in adulthood. The main purpose of this study was to assess blood pressure patterns among children in rural, semi-urban and urban settings in Ghanaian and to determine the association of blood pressure with locality and BMI in this Sub-Saharan African setting.
Data were collected in seven primary schools among healthy children between the ages of 8 to 16 years in the cool season (August–September 2004). Four schools in the urban regional capital (Kumasi) were randomly selected from the schools' lists, two schools in semi-urban and one school in rural setting. Rural refers here to a village without electricity and main water supply, where the main occupation is subsistence farming. The sub-urban villages have electricity and main water supply, and the main occupation is subsistence farming. The schools were visited prior to the data collection in order to obtain permission from the relevant school principals as well as from the children. Following the local rules, the village chiefs and elders were also contacted in advance to obtain their permission. Because only physical measurements were made, only verbal informed consent was sought from the children and their guardians before measurements were taken. Data collection took place during normal school hours. In each school, all children age 8–16 years were included except for one big school in the regional capital where every other class was included. None of the children in the schools refused to participate in this study. Height was measured without shoes with a measuring tape to the nearest 0.5 cm. Weight was measured to the nearest 0.1 kg after removal of shoes, jackets, heavier clothing and pocket contents (using an Electronic Korona Profimed scale, Germany). Body mass index (BMI) was calculated as weight (kg) divided by height (m2). Children were classified as being overweight according to the BMI-for-age cut-off points corresponding to an adult BMI of 25 kg/m2 . Blood pressure and pulse were measured in the morning with a validated oscillometric automated digital blood pressure device (Omron M5-I monitor). Using appropriate cuff sizes, two readings with one-minute interval were taken on the right arm with the child in a seated position after at least five minutes rest. The mean of the two readings was used for analysis. The same trained staff made blood pressure measurements in all locations. In each school, prior to blood pressure measurements in children, all the teachers including the head-teacher had their blood pressure measured in front of the children to allay apprehension. The Committee on Human Research Publication and Ethics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana approved the study protocol.
Age specific mean systolic and diastolic blood pressure levels were determined for rural, semi-urban and urban groups. The association between blood pressure and age was examined using linear regression analysis. Multiple linear regression analysis enabled age-adjusted comparisons of systolic and diastolic blood pressure levels to be made between gender and locality. Multiple linear regression analyses were also performed separately for boys and girls to assess the independent contribution of locality and BMI to systolic and diastolic blood pressure after adjustment for other factors associated with blood pressure in univariate analyses, including age and resting heart rate. All statistical analyses were performed using SPSS for Windows version 11.5 (SPSS Inc. Chicago, USA).
Characteristics of the population, anthropometrics and blood pressure levels by gender and locality
Boys (n = 616)
Girls (n = 661)
Rural (n = 111)
Semi-urban (n = 143)
Urban (n = 362)
Rural (n = 103)
Semi-urban (n = 153)
Urban (n = 405)
Blood pressure levels
Mean (SE) Systolic and diastolic blood pressure (mm Hg) by age group and locality
Rural (n = 213)
Semi-urban (n = 296)
Rural versus semi-urban and urban
As table 1 shows, the age adjusted mean systolic and diastolic blood pressures were significantly lower in rural boys than they were in semi-urban boys. Compared with urban boys, rural boys had a significantly lower age adjusted mean systolic blood pressure but a similar diastolic blood pressure. Among girls, the age adjusted mean systolic and diastolic blood pressure levels were lower in rural girls compared with urban girls, although only the diastolic blood pressure difference was statistically significant. No significant differences were found between rural girls and semi-urban girls except for a lower resting heart rate in semi-urban girls.
Multiple regression analysis of factors associated with systolic and diastolic blood pressure
Systolic blood pressure
Diastolic blood pressure
Blood pressure increased with age in rural, semi-urban and urban areas, and in both boys and girls. Blood pressure levels were lower in the rural population than in the semi-urban and urban populations. Locality and BMI were independently associated with blood pressure in both boys and girls.
Discussion of key findings
The increase in blood pressure with age is consistent with previous reports in Ghana [4, 5, 14]. This was not only seen in semi-urban and urban settings but also in the rural setting. Less than half a century ago, ancestral African populations living traditional lives showed a lower mean blood pressure with little or no increase with increasing age, and low prevalence of hypertension . However, in this present study, both systolic and diastolic blood pressure increased with increasing age (3 mmHg and 1.0 mmHg per year of age) in rural children. These findings seem to suggest that the protective effect against high blood pressure in rural settings in sub-Saharan Africa is fading. One possible explanation for these blood pressure trends in rural setting may be changes in lifestyles amongst these societies [18, 19]. These findings do not bode well for the future, especially at a time when urbanization and westernization are proceeding at a faster rate . In 2003 for example, stroke and cardiovascular disease were the 6th and the 7th most common causes of death in the Ashanti region of Ghana . Increased blood pressure is a major contributing factor for stroke and cardiovascular diseases .
The lower blood pressure level found among rural school children is also consistent with the adult studies in Ghana [4, 5] and other reports in sub-Saharan Africa [20, 21]. For example, in Cappuccio et al's study, blood pressure was generally lower amongst rural dwellers than amongst semi-urban dwellers in Ghana . In the present study, rural and urban differences in diastolic blood pressure still remained amongst both boys and girls even after adjustments for potential confounding factors. The reasons for these differences are unclear and further studies are needed to identify other factors that may contribute to the differences we observed. Boys had more favourable blood pressure profiles than girls. These gender differences in blood pressure patterns are consistent with earlier findings in the Greater Accra region of Ghana in both children  and adult  studies but contrast with findings of Cappuccio and colleagues in the Ashanti region of Ghana . This is surprising given that Cappuccio et al's study was conducted in the same region as ours. Nonetheless, gender differences in blood pressure are generally inconsistent among African origin populations. In our recent report on blood pressure levels in ethnic minority children in the UK , blood pressure levels were generally more favorable for girls than for boys of African descent, while for adults, blood pressure patterns were more favourable for men than for women .
The strong and independent association between BMI and blood pressure is worrisome, especially for females in urban Ghana. Although the mechanisms by which BMI may lead to hypertension are poorly understood, it is now generally recognised that high BMI significantly increases the risk of hypertension. The impact of increasing BMI on high blood pressure has been clearly demonstrated in several populations [24, 25]. Cooper and colleagues showed that the prevalence of high blood pressure increased as BMI increased across African descent populations . In our study, both urban boys and girls had a higher BMI and were more likely to be overweight compared to their rural counterparts. Sinaiko and colleagues' prospective study showed that increases in weight and BMI in childhood were significantly associated with an increased risk of high blood pressure and other cardiovascular diseases in adulthood . If the increasing frequency of overweight children is left unchecked while urbanization and westernization continue, it may lead to an increase in hypertension and other cardiovascular risks in future generations of Ghanaians . In addition, the multiple regression models explained only 8% to 28% of the variance in systolic and diastolic blood pressures. This indicates that more work is needed to identify the other factors that contribute to an increase in blood pressure among children in this sub-Saharan African setting.
Like many population-based surveys, our blood pressure level was based on an average of two measurements at a single visit. A more precise estimate of blood pressure level would be obtained by multiple measurements obtained during several visits. Also, evidence suggests that during puberty blood pressure increases more rapidly, with a significant gender difference in the age of onset . In the present study, pubertal status was not assessed and this may affect our study results. One other possible limitation is the use of blood pressure measurement techniques such as an automated oscillometric device, as opposed to auscultatory mercury manometers in children. However, the Omron M5-I device we used in this study has been shown to be a valid instrument for use amongst children . Despite these potential shortcomings, the findings from this study are consistent with those from adult studies [4, 5, 15]. Our results may well be representative of the Ashanti Region of Ghana as a whole and may be used to formulate local health policy. Also, because this study provides a comprehensive assessment of children in three different localities, its results should serve as a wake-up call for sub-Saharan Africa countries and other developing countries to step up cost-effective measures early in life to prevent the double burden of diseases in adulthood.
This study shows an increase in blood pressure with age among these sub-Saharan African children in both rural and urban settings. This increase in blood pressure corresponds with the increasing prevalence of hypertension reported among adults. Blood pressure was positively associated with BMI in both boys and girls. These findings underscore the urgent need for public health measures to prevent high blood pressure and its sequelae from becoming another public health burden. In view of the scarcity of resources in Ghana as well as in many other developing nations, activities aimed at controlling increasing blood pressure in children have to compete with many other pressing health needs. Nevertheless, the long-term health problems that can result from increased blood pressure in children can be considerable. It is therefore important that measures be taken to reduce the risks of these problems and thereby optimize the health outcomes for future generations. Reducing the mean population blood pressure level by even as little as 2–3 mmHg could have a major impact in reducing associated morbidity and mortality . A small pilot study of a nutritional education program in one village in Ghana resulted in the reduction in mean systolic and diastolic blood pressure by 6.4/4.5 mmHg within four weeks . With careful implementation, such cost-effective measures may lead to an important reduction in blood pressure especially among city children, thereby sparing the next generation from high blood pressure related complications [31, 32]. More work on blood pressure in children in sub-Saharan African and other developing countries is desperately needed, since high blood pressure is becoming a major public health issue in many countries.
We are very grateful to Professor Raj Bhopal (University of Edinburgh) and Dr Karien Stronks (Academic Medical Center, Amsterdam), Drs Ank de Jonge (University of Nijmegen) for providing advice that helped to improve the earlier version of this paper. We thank Dr van Montfrans and Dr Lizzy Brewster for useful advice prior to data collection. We thank all the nurses, the school children and the teachers for making this study possible. We are also indebted to the two reviewers for providing comments that helped to improve the earlier version of this paper. This project was supported by the Health Research and Development Council of the Netherlands (ZonMw).
- Murray CJ, Lopez AD: Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet. 1997, 349: i1269-1276. 10.1016/S0140-6736(96)07493-4. ii1436–1442View ArticleGoogle Scholar
- Shaper AG, Wright DH, Kyobe J: Blood pressure and body build in three nomadic tribes of northern Kenya. East Afr Med J. 1969, 46: 273-81.PubMedGoogle Scholar
- Edwards R, Unwin N, Mugusi F, Whiting D, Rashid S, Kissima J, Aspray TJ, Alberti KG: Hypertension prevalence and care in an urban and rural area of Tanzania. J Hypertens. 2000, 18: 145-52. 10.1097/00004872-200018020-00003.View ArticlePubMedGoogle Scholar
- Cappuccio FP, Micah FB, Emmett L, Kerry SM, Antwi S, Martin-Peprah R, Phillips RO, Plange-Rhule J, Eastwood JB: Prevalence, detection, management, and control of hypertension in Ashanti, West Africa. Hypertension. 2004, 43: 1017-22. 10.1161/01.HYP.0000126176.03319.d8.View ArticlePubMedGoogle Scholar
- Amoah AG: Hypertension in Ghana: a cross-sectional community prevalence study in greater Accra. Ethn Dis. 2003, 13: 310-5.PubMedGoogle Scholar
- van der Sande MA, Milligan PJ, Nyan OA, Rowley JT, Banya WA, Ceesay SM, Dolmans WM, Thien T, McAdam KP, Walraven GE: Blood pressure patterns and cardiovascular risk factors in rural and urban gambian communities. J Hum Hypertens. 2000, 14: 489-496. 10.1038/sj.jhh.1001050.View ArticlePubMedGoogle Scholar
- Walker RW, McLarty DG, Kitange HM, Whiting D, Masuki G, Mtasiwa DM, Machibya H, Unwin N, Alberti KG: Stroke mortality in urban and rural Tanzania. Adult Morbidity and Mortality Project. Lancet. 2000, 355: 1684-7. 10.1016/S0140-6736(00)02240-6.View ArticlePubMedGoogle Scholar
- Thorogood M, Connor MD, Lewando-Hundt G, Tollman S, Ngoma B, SASPI Project Team: Secondary prevention of stroke – results from the Southern Africa StrokePrevention Initiative (SASPI) study. Bull World Health Organ. 2004, 82: 503-8.PubMedPubMed CentralGoogle Scholar
- Connor MD, Thorogood M, Casserly B, Dobson C, Warlow CP, SASPI Project Team: Prevalence of stroke survivors in rural South Africa: results from the Southern Africa Stroke Prevention Initiative (SASPI) Agincourt field site. Stroke. 2004, 35: 627-32. 10.1161/01.STR.0000117096.61838.C7.View ArticlePubMedGoogle Scholar
- Bao W, Threefoot SA, Srinivasan SR, Berenson GS: Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. Am J Hypertens. 1995, 8: 657-65. 10.1016/0895-7061(95)00116-7.View ArticlePubMedGoogle Scholar
- Lauer RM, Clarke WR: Childhood risk factors for high adult blood pressure: the Muscatine Study. Pediatrics. 1989, 84: 633-41.PubMedGoogle Scholar
- National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents: The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004, 114 (2 Suppl 4th Report): 555-76. 10.1542/peds.114.2.S2.555.View ArticleGoogle Scholar
- Daniels SR, Loggie JM, Khoury P, Kimball TR: Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation. 1998, 97: 1907-11.View ArticlePubMedGoogle Scholar
- Blankson JM, Larbi EB, Pobee JO: Blood pressure levels of African children. J Chronic Dis. 1977, 30: 735-43. 10.1016/0021-9681(77)90002-9.View ArticlePubMedGoogle Scholar
- Agyemang C, Bruijnzeels E, Owusu-Dabo W: Factors associate with hypertension awareness, treatment and control in Ghana, West Africa. J Hum Hypertens. 1-5. 2005; Aug 25Google Scholar
- Cappuccio FP: Epidemiologic transition, migration and cardiovascular disease. Int J Epidemiol. 2004, 33: 387-8. 10.1093/ije/dyh091.View ArticlePubMedGoogle Scholar
- Cole TJ, Bellizzi MC, Flegal KM, Dietz WH: Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000, 320: 1240-1243. 10.1136/bmj.320.7244.1240.View ArticlePubMedPubMed CentralGoogle Scholar
- Kaufman JS, Owoaje EE, James SA, Rotimi CN, Cooper RS: Determinants of hypertension in West Africa: contribution of anthropometric and dietary factors to urbanrural and socioeconomic gradients. Am J Epidemiol. 1996, 143: 1203-18.View ArticlePubMedGoogle Scholar
- Whelton SP, Chin A, Xin X, He J: Effect of aerobic exercise on blood pressure: a metaanalysis of randomized, controlled trials. Ann Intern Med. 2002, 136: 493-503.View ArticlePubMedGoogle Scholar
- Obika LF, Adedoyin MA, Olowoyeye JO: Pattern of paediatric blood pressure in rural, semi-urban and urban communities in Ilorin, Nigeria. Afr J Med Sci. 1995, 24: 371-7.Google Scholar
- Proctor MH, Moore LL, Singer MR, Hood MY, Nguyen US, Ellison RC: Risk profiles for non-communicable diseases in rural and urban schoolchildren in the Republic of Cameroon. Ethn Dis. 1996, 6: 235-43.PubMedGoogle Scholar
- Agyemang C, Bhopal R, Bruijnzeels M: Do variations in blood pressures of South Asian, African and Chinese descent children reflect those of the adult populations in the UK? A review of cross-sectional data. J Hum Hypertens. 2004, 18: 229-37. 10.1038/sj.jhh.1001658.View ArticlePubMedGoogle Scholar
- Agyemang C, Bhopal R: Is the blood pressure of people from African origin adults in the UK higher or lower than that in European origin white people? A review of cross-sectional data. J Hum Hypertens. 2003, 17: 523-34. 10.1038/sj.jhh.1001586.View ArticlePubMedGoogle Scholar
- Kaufman J, Barkey N: Hypertension in Africa: an overview of prevalence rates and causal risk factors. Ethn Dis. 1993, 3 (Suppl): S83-101.PubMedGoogle Scholar
- Johnson JL, Heineman EF, Heiss G, Hames CG, Tyroler HA: Cardiovascular disease risk factors and mortality among black women and white women aged 40–64 years in Evans County, Georgia. Am J Epidemiol. 1986, 123: 209-20.PubMedGoogle Scholar
- Cooper R, Rotimi C, Ataman S, McGee D, Osotimehin B, Kadiri S, Muna W, Kingue S, Fraser H, Forrester T, Bennett F, Wilks R: The prevalence of hypertension in seven populations of West African origin. Am J Public Health. 1997, 87: 160-8.View ArticlePubMedPubMed CentralGoogle Scholar
- Sinaiko AR, Donahue RP, Jacobs DR, Prineas RJ: Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children's Blood Pressure Study. Circulation. 1999, 99: 1471-6.View ArticlePubMedGoogle Scholar
- El Assaad MA, Topouchian JA, Asmar RG: Evaluation of two devices for self-measurement of blood pressure according to the international protocol: the Omron M5-I and the Omron 705IT. Blood Press Monit. 2003, 8: 127-33.View ArticlePubMedGoogle Scholar
- Voors AW, Foster TA, Frerichs RR, Webber LS, Berenson GS: Studies of blood pressures in children, ages 5–14 years, in a total biracial community: the Bogalusa heart study. Circulation. 1976, 54: 319-327.View ArticlePubMedGoogle Scholar
- Whelton PK: Epidemiology of hypertension. Lancet. 1994, 344: 101-6. 10.1016/S0140-6736(94)91285-8.View ArticlePubMedGoogle Scholar
- Cappuccio FP, Plange-Rhule J, Phillips RO, Eastwood JB: Prevention of hypertension and stroke in Africa. Lancet. 2000, 356: 677-8. 10.1016/S0140-6736(05)73821-6.View ArticlePubMedGoogle Scholar
- Kerry SM, Emmett L, Micah FB, Martin-Peprah R, Antwi S, Phillips RO, Plange-Rhule J, Eastwood JB, Cappuccio FP: Rural and semi-urban differences in salt intake, and its dietary sources, in Ashanti, West Africa. Ethn Dis. 2005, 15: 33-39.PubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/5/114/prepub
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