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Using an autologistic regression model to identify spatial risk factors and spatial risk patterns of hand, foot and mouth disease (HFMD) in Mainland China
© Bo et al.; licensee BioMed Central Ltd. 2014
Received: 12 July 2013
Accepted: 4 April 2014
Published: 14 April 2014
There have been large-scale outbreaks of hand, foot and mouth disease (HFMD) in Mainland China over the last decade. These events varied greatly across the country. It is necessary to identify the spatial risk factors and spatial distribution patterns of HFMD for public health control and prevention. Climate risk factors associated with HFMD occurrence have been recognized. However, few studies discussed the socio-economic determinants of HFMD risk at a space scale.
HFMD records in Mainland China in May 2008 were collected. Both climate and socio-economic factors were selected as potential risk exposures of HFMD. Odds ratio (OR) was used to identify the spatial risk factors. A spatial autologistic regression model was employed to get OR values of each exposures and model the spatial distribution patterns of HFMD risk.
Results showed that both climate and socio-economic variables were spatial risk factors for HFMD transmission in Mainland China. The statistically significant risk factors are monthly average precipitation (OR = 1.4354), monthly average temperature (OR = 1.379), monthly average wind speed (OR = 1.186), the number of industrial enterprises above designated size (OR = 17.699), the population density (OR = 1.953), and the proportion of student population (OR = 1.286). The spatial autologistic regression model has a good goodness of fit (ROC = 0.817) and prediction accuracy (Correct ratio = 78.45%) of HFMD occurrence. The autologistic regression model also reduces the contribution of the residual term in the ordinary logistic regression model significantly, from 17.25 to 1.25 for the odds ratio. Based on the prediction results of the spatial model, we obtained a map of the probability of HFMD occurrence that shows the spatial distribution pattern and local epidemic risk over Mainland China.
The autologistic regression model was used to identify spatial risk factors and model spatial risk patterns of HFMD. HFMD occurrences were found to be spatially heterogeneous over the Mainland China, which is related to both the climate and socio-economic variables. The combination of socio-economic and climate exposures can explain the HFMD occurrences more comprehensively and objectively than those with only climate exposures. The modeled probability of HFMD occurrence at the county level reveals not only the spatial trends, but also the local details of epidemic risk, even in the regions where there were no HFMD case records.
Enterovirus 71 (EV71) is a common cause of hand, foot, and mouth disease (HFMD), may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. Outbreaks of hand, foot and mouth disease associated with EV71 infections have occurred in the Asia Pacific region since 1997 . HFMD is a children's common infectious disease that mainly occurs in children under five years old . In most cases, the disease is mild and self-limiting. However, severe clinical presentations with neurological symptoms such as meningitis, encephalitis, polio-like paralysis, and pulmonary edema may occur , which can cause serious injury or even death to young children. Outbreaks of HFMD have been reported many times in the countries of Western Pacific Region over the last decade [4–7]. There were large-scale HFMD outbreaks in Mainland China in 2008 and 2009 that led to 488,955 reported cases and a morbidity of 37/100,000 during the year 2008 and 1,155,525 cases, a mortality of 0.0095/100,000 and a fatality of 0.26/1000 during the year 2009 . HFMD can produce a pandemic in a short period of time due to its highly infectious characteristic, thus poses a serious threat to the public health.
Many studies have extensively investigated the disease transmission characteristics, the risk factors, and the spatial distribution patterns of HFMD risk. It was found that the transmission pattern of HFMD shows strong seasonal characteristics. The epidemic peaks occurred in spring and early summer in Mainland China . The highest incidence of HFMD was in summer in Taiwan, China . The epidemics have inter-years periodic characteristics, as they occur once every three years In Malaysia . At the temporal scale of weeks, HFMD incidence has a significant association with weekly temperature and precipitation with 1–2 weeks in Singapore  and 7 weeks in China .
Odds ratio (OR) is used to measure the risk of a disease exposed to the determinants, which has been widely used to identify risk factors in epidemiology . It indicates the strength of the association between the exposures and disease. An OR value greater than 1 indicates that the exposure is a risk factor, a value less than 1 indicates a protective factor and a value equal to 1 indicates an unrelated factor. Previous studies on the OR values of the significant HFMD risk factors showed that 1.0 to 2.9 years old children have the highest risk (OR > 2.3). Boys were more susceptible than girls (OR > 1.56). Infant cases had the highest incidences of severe disease (OR > 1.4) and death (OR > 2.4). Enterovirus 71 is more strongly associated with severe disease compared with Coxsackie A16 (OR > 16) . Playing with neighborhood children (OR = 11), visiting an outpatient clinic for another reason > 1 week before the onset of HFMD (OR = 20), community exposures to crowded places (OR = 7.3) , rural/urban areas (OR = 2.1), drinking behavior (OR = 2.441), infant hand washing before/after dinner (OR = 0.505) , float population (OR = 4.507), toy sucking (OR = 3.220)  and being in a low-income families are other risk factors .
Besides the personal characteristics above, climate variables as the spatial risk factors associated with HFMD occurrence have been recognized. Using the Bayesian Maximum Entropy (BME) model and self-organizing map (SOM) algorithm, the number of HFMD cases has been shown to have a close relationship to monthly precipitation in Mainland China . Child population density (CPD) and climatic factors were the potential determinants of HFMD incidence in most areas of the Mainland China . Weekly mean temperature and cumulated rainfall are significantly associated with HFMD incidence with a time lag of 1–2 weeks in Singapore . A higher risk of transmission is associated with temperatures in the range of 70°F to 80°F, higher relative humidity, lower wind speed, more precipitation, and greater population density in China . In Japan, a series study found that ambient temperature and relative humidity were significantly linked with increased HFMD occurrence . The association between climate variables and HFMD also has been examined in many provinces and cities of China, such as Beijing , Hong Kong , Guangdong province , Shenzhen  and Guangzhou city .
In previous studies, few studies have discussed the socio-economic exposures as the risk factors of HFMD occurrence at a space scale, not to mention combined with climate exposures. Methodologically, the spatial autocorrelation is prevalent in the data in social and economic sciences . The neglect of the spatial autocorrelation could result in a biased and under-performing model in health risk assessment [24, 25]. In spatial epidemiology, researchers are concerned more about the spatial distribution pattern of the epidemic risk more than just identifying risk factors, so it is important to predict the spatial distribution of the HFMD risk.
To address the problems and challenges mentioned above, both climate and socio-economic exposure factors were selected as potential determinants to explore the spatial risk factors of HFMD occurrence in Mainland China. We built an autologistic regression model that takes spatial autocorrelation effect of variables into account to identify the risk factors with OR values and model the spatial distribution of the HFMD risk over Mainland China at the county level. The study revealed the local variations of HFMD epidemic risk at county level by mapping the probability of disease occurrence in each geographic unit.
The monthly climate data of May 2008 were provided by the China Meteorological Data Sharing Service System. The original data were collected from 727 meteorological stations over the whole area of China. We used ordinary kriging interpolation  and spatial aggregation technology to estimate each county’s mean value of the climate factors. Seven routine climate variables were used as candidates to explore the climate risk factors of HFMD occurrence : monthly average wind speed, monthly average precipitation, monthly average temperature, monthly average temperature difference, monthly average atmospheric pressure, monthly average sunshine duration and monthly average relative humidity.
We also collected the social and economic data as potential risk factors for HFMD occurrence from the City (County) Social Economic Statistical Yearbook of China, the Regional Statistical Economic Yearbook of China and the Urban Statistical Yearbook of China in 2008. Unlike the climate data, the socio-economic factors were for the entire year of 2008. There is no monthly data available. The candidate socio-economic exposed indicators include population density, the proportion of student population, per capita household savings, the number of hospital beds per capita, industrial output value, number of industrial enterprises, product GDP per capita, number of telephones per capita and other factors.
The geographical administrative division data were obtained from the Chinese National Administration of Surveying, Mapping and Geoinformation. The data were published in 2010, so we updated, amended, merged and split the original vector data according to the latest administrative divisions’ code published by the National Bureau of Statistics of the People's Republic of China (http://www.stats.gov.cn, as of December 31, 2008), to guarantee the data were consistent with the HFMD records in every unit. As a result, HFMD data, climate data, and socio-economic data were all geo-linked to the vector geographical administrative division data in a geo-spatial database.
Logistic and autologistic regression model
where P i (probability of the occurrence of a disease) is the expected value of the dependent variable y i (so that y i = 1 if a sample has disease case and y i =0, otherwise), x is the independent variables (potential exposed factors), β is the estimated coefficient, i is the index of the records, such as a geographical unit. Significance levels for variables to be included in the model are often set as 0.05 or 0.1.
The predicted result P i denotes the probability of an event occurring for every geographic unit. x is independent variables. Autocov is the autocovariate variable. β and r are the coefficients of variables in the equation. i is the index of the geographical units.
Spatial autocorrelation is frequently encountered in spatial data. Typically, disease occurrences and spatial risk factors are positively autocorrelated such that nearby units in space tend to have more similar values than would be expected by random chance. Thus, models that ignore the spatial autocorrelation may be inappropriate because they might overestimate the importance of environmental variables . In addition, models that ignore spatial autocorrelation effect could include variables that have little or no relevance to the response variable, creating false conclusions in modeling spatial distribution of diseases. This problem could be solved by incorporating spatial autocorrelation (autocovariate) into logistic regression models, which would result in model improvements such as increased predictive accuracy and model versatility .
The autocovariate variable (Autocov i ) is a weighted average of the probabilities of the geographic units amongst a set of k i neighbors of the geographic unit i. A method of with a certain distance (20000 m) of the centroid is used to define the neighbors of the geographic unit i in this study. The spatial weight between the geographic unit i and j is w ij = 1/h ij , where h ij is the Euclidean distance between the centroids of geographic unit i and j, and represents the probability estimated by the ordinary logistic regression model [29, 33]. The autocovariate variables were incorporated into the ordinary logistic regression formula stepwisely until each parameter was statistically significant. We used the statistical software SPSS 19 to solve the ordinary logistic regression model and evaluate the model results. ArcGIS 10 was used to process the autocovariate variables data, conduct spatial analysis and create the thematic maps of risk factors and disease risk.
where β is the coefficient of the environmental variable x. In epidemiology, an OR value higher than 1.0 indicates that the variable (exposure factor) is a positively correlated risk factor, lower than 1.0 means a negatively correlated risk factor and equal to 1.0 indicates an unrelated factor. For instance, it is common to describe the OR value of two in terms of a twofold risk of developing a disease compared with the reference group . We obtained the OR value of every exposed factor and identified the risk factors of HFMD using this method.
Identification of risk variables
Method for identifying the risk factors was carried out in SPSS 19.0. All the climate and socio-economic variables (Additional file 1) were included into the analysis to determine which of them were significantly associated with HFMD occurrence. Two types of determinants are suspected potentially to cause HFMD, the climatic and the socio-economic. The candidate climatic variables reflect the monthly average status of wind speed, precipitation, temperature, temperature difference, atmospheric pressure, sunshine duration, and relative humidity. Socio-economic variables were taken into account to identify the significant related variables to the HFMD occurrence, which reflect the population, regional comprehensive economy, agriculture, industry and investment, education, public health and social security of the administrative division unit. We conducted transformation processing for some socio-economic indicators before modeling to guarantee the comparability between administrative division units. For example, the number of hospital beds is divided by the population into a number of beds for every million people. All variables were standardized.
Secondly, we used the stepwise regression method to exclude the variables without statistical significance to establish the best predictive regression model. In statistics, stepwise regression includes regression models in which the choice of predictive variables is conducted by an automatic procedure. Here, we used forward stepwise regression. At the beginning, the model is without any independent variable. Then, introducing variables into the model one by one, each time selecting one variable with the smallest p value (significance) and that the p value < α 1 (threshold value) into the model. Once we introduced a variable into the regression model, we needed to investigate whether the model had a variable with p value > α 2 (threshold value). If it existed, then it was excluded from the model, and the model was re-fitted. Introducing the variables step by step until there were no more variables can satisfy the above conditions. In this experiment, we set α 1 =0.05 and α 2 =0.1 as threshold values when using ordinary logistic regression. As a result, the selected variables were statistically significant.
Spatial distribution of the risk factors
In May 2008, among the recorded geographical units, 12.06% were reported to have no HFMD cases (dependent variable =0), and 87.94% were reported to have more than one HFMD case (dependent variable =1). Figure 1 displays the spatial distribution of the HFMD-dependent values in Mainland China. The distribution of HFMD occurrence shows a strong spatial aggregation that mainly concentrates in eastern, southern and central China. Other regions near the center of the aggregation also present a serious aggregation, such as the south-eastern part in north China and the southern part in northeast China. It is easier to have HFMD cases when the surrounding counties have cases. This spatial autocorrelation characteristic makes it necessary to consider the spatial effect in a logistic regression model .
Validation of the models
In our case, the model was evaluated based on the goodness of fit, the prediction accuracy, and the equation coefficients of model [33, 35, 47]. An autologistic regression model needs the autocovariate variable first, and this step requires the prediction results of the ordinary logistic regression model. The ordinary logistic regression model is an intermediate step in building a spatial model (Figure 2). The performance of the logistic and autologistic regressions models are listed to indicate that they both pass the significance tests. In addition, we selected 30% of samples from all geographical units as the verified dataset using stratified random sampling [48, 49], and the remaining 70% of samples (1383 records) were used for model building. For the binary value of disease, we stratified the whole area into having case and no case stratas, and selected the samples based on the simple random sampling method in the two stratas respectively.
Goodness of fit
Summary statistics of the logistic and autologistic regression model
Modeling sample proportion
Cox & Snell R Square
Nagelkerke R Square
The prediction accuracy of the spatial autologistic regression model
Modeling (70% samples)
The whole region
Verification (30% samples)
The whole region
The OR values obtained for the independent parameters
Sig. in logistic
Coefficient in autologistic
95% CI of OR
Average wind speed
Number of above-scale enterprises
Proportion of the student population
In addition, the added spatial variable (autocovariate variable) has a significant reduction of the contribution of the constant in the equation (from OR = 17.25 to OR = 1.25). This reduction indicated that the added spatial variable expresses the spatial effect in the constant term and reduces the residual error of the constant. Therefore, it is very meaningful to introduce the residual spatial autocorrelation into the model because the spatial autologistic regression model excavates inherent errors that are caused by spatial autocorrelation effect in the ordinary logistic regression model.
Spatial distribution of the probability of HFMD occurrence
Autologistic regression model
There are often marked spatial autocorrelations in prediction residual terms in the regression analysis for public health risk assessment due to the spatial effects that are not captured in the model [46, 47]. The ordinary logistic regression model is a non-spatial model, and it is based on the assumption that the relationship between disease risk and potential explanatory factors is a stationary spatial process. It is reasonable to assume that the explanatory factors and the relationship between HFMD and the potential risk factors would not change significantly across the whole region for a small and homogenous region of interest. However, the topography, climate and socio-economic factors change greatly over regions in regard to a large region such as China with a territory over 9.6 million square kilometers . It is impossible to maintain the spatial stationary assumption in such a large and heterogeneous area. As a result, the neglect of the spatial effect in a regression analysis could result in a biased and under-performing model in health risk assessment .
The autologistic regression model is a spatial model that considers the spatial residual autocorrelation effect in the model. It introduces a spatial residual autocorrelation variable based on a rational assumption that the relationships between the risks of the exposure factors and the risk of HFMD occurrence are more similar in nearby regions. Only nearby counties are included in the spatial autocovariate variable, and every included county is given a weight according to its spatial distance to the destination county. The spatial autocovariate variable also reflects the global spatial trend of the probability the HFMD occurrence, as is shown in Figure 4.
The autologistic regression model also reduces the contribution of the residual significantly, which reflects the spatial inherent residuals, by introducing a spatial autocorrelation variable. The constant in the regression model is the prediction residual error of the model. The smaller the contribution of the constant is, the better the explanatory power of the model is. By introducing the spatial autocovariate variable, the contribution of the constant is reduced significantly in the autologistic model. It changes from OR = 17.25 (for logistic regression) to OR = 1.25 (for autologistic regression). However, the spatial autocovariate variable can be comprehended as the spatial inherent residual to reflect spatial effect in space data, which can reduce bias in health risk assessment. The spatial autocovariate variable helped to remove inherent residual errors from the ordinary logistic regression model.
The main shortcoming of the autologistic regression model is that it’s only suitable for the binary or multiple category dependent variables. The other one is that the autologistic regression model does not have a spatio-temple type so far, which cannot satisfy the need for the analysis of spatio-temporal variation of disease risk.
Identification of risk factors
This study used an autologistic regression model to identify risk factors of HFMD in Mainland China from 29 potential exposed variables (Additional file 1). The results indicate that both climate and socio-economic factors were significant spatial risk factors for HFMD occurrence in Mainland China in May 2008. The significant spatial risk factors are monthly average temperature (OR = 1.379), monthly average precipitation (OR = 1.4354), monthly average wind speed (OR = 1.186), population density (OR = 1.953), the number of industrial enterprises above designated size (OR = 17.699) and the proportion of student population (OR = 1.286). All the risk factors are positively correlated to the occurrence of HFMD.
Our study revealed that the climate factors, such as the air temperature, relative humidity, wind speed and the precipitation, are risk factors associated with the occurrence of HFMD, which is consistent with the conclusions of previous studies in Mainland China, Taiwan and Hong Kong [2, 4, 19].
To our knowledge, this is the first study to explore the socio-economic factors of HFMD from a spatial analysis point of view. It is worth mentioning that introducing spatial socio-economic factors into HFMD risk assessment can explain the spatial pattern of HFMD risk more comprehensively and objectively, than previous studies that are mainly concerned with climate risk factors. We found that in addition to the climate factors, population density, the number of industrial enterprises above designated size and the proportion of student population had significant contributions to the risk of HFMD incidence. The number of industrial enterprises has the largest value of OR (OR = 17.699) among all socio-economic factors, which indicates the level of industry of a county is very risky. It has been confirmed that air pollution is closely related to the industrial level, which would lead to many epidemic diseases and weaken the immunity especially between children and elderly people . We can also find that heavy industrial areas in Figure 3f are significantly consistent with the distribution of cluster disease areas in Figure 1. It makes the value of OR much larger. This indicates that level of industrialization of a county can influence the air pollution level, concentration of PM2.5 and Children's immunity, which thereby affecting the HFMD outbreak.
The comprehensive effect of the climate and social-economic factors makes the regression model have more convincing power and application value. In addition, the autocovariate variable (OR = 18.800) also occupies an important contribution in the autologistic model. It indicates that except for the climate and social-economic factors, the HFMD occurrence risk is related to the spatial location. Thus, the autocovariate variable can be seen as the third type of risk factor addition to the climate and social-economic factors.
The risk in local areas
In spatial epidemiology, researchers are concerned more about the degree of epidemic risk in each geographic unit (counties and cities) at the local spatial scale than the identification of risk factors. We identified the spatial risk factors of HFMD throughout the Mainland China. Another purpose of this research was to determine the combined and interactive effects of these spatial risk factors on HFMD occurrence, which can be called local disease risk. We modeled the probability P i of the HFMD occurrence to each geographical unit to express the spatial distribution pattern of risk (Figure 5).
Using the probability P i of the HFMD occurrence to identify the risk in local areas has many advantages over traditional epidemiological studies. First of all, compared with the original data, the high value region in Figure 5 is consistent with the distribution of cluster disease area in Figure 1. The risk areas are mainly distributed in eastern, southern and central China. Furthermore, the spatial distribution map for probability fills the missing data places where there are no HFMD collection agencies and reflects the risks in those no-data regions. Secondly, spatialized probability obviously displays more local details of epidemic risk. For instance, previously we only knew it was hit the hardest by the HFMD in the eastern China from Figure 4. Now, we can identify that the risk in the east areas is more serious, and the risk in the north is more serious than the risk in the south. There are also three stepped transitions of HFMD risk level in the southwest of China from west to east. The particular risk areas are in Beijing, Tianjin, Shandong, Henan Guangzhou and Sichuan province. Finally, identifying the local areas epidemic risk can provide valuable information regarding the allocation of public health resources for prevention and treatment purposes compared with traditional epidemiology. In this context, we calculated the probability of HFMD occurrence in each geographical unit, connected them to the spatial features and produced a disease risk hierarchical thematic map to show the spatial distribution pattern of HFMD local risk with GIS technology.
There are some biases in the study that may affect the results. First and most importantly, the underreporting of HFMD cases in clinics and hospitals is a potential limitation of our study because of the individual disease severity and the gap between the levels of regional medical resources , and regional differences in the reporting of HFMD cases can influence the dependent variable and verification accuracy. Secondly, because the socio-economic factors are annual average data, the spatial heterogeneity might be hidden or smooth, which could result in uncertainty. Thirdly, bias could come from the sampling error when choosing modeling data and validation data, which cannot be avoided. That is, if there is sampling, bias will occur. Finally, confounding bias is a widespread uncertainty in epidemiological analysis, especially in spatial epidemiology in which socio-economic factors are strong predictors of the vast majority of health outcomes but when exposed to many environmental-related factors, the confounding phenomenon will be more obvious.
Using a spatial autologistic regression model, we found that HFMD occurrence is heterogeneously related to the climate and socio-economic factors distributed at the county level unit over the Mainland China. The combined effect of socio-economic and climate indicators can explain the determents of HFMD outbreak more comprehensively and objectively. The spatial autologistic regression model that considers spatial autocorrelation and heterogeneity has a relative good goodness of fit and prediction accuracy of HFMD occurrence. The spatial autologistic regression model also reduces the residuals in the ordinary logistic regression model significantly. The spatial autologistic model can be used to geographically differentiate the local risk of disease occurrence by the variation of explanatory spatial risk factors. Through the spatial probability risk map, people can identify risk characteristics in local areas to determine the spatial distribution pattern of HFMD occurrence. Such conclusions could guide local public health institutes to rationally allocate public health resources and improve their preparedness for an outbreak according to region-specific conditions. As a result, the spatial autologistic regression model is effectively used to identify spatial risk factors and spatial patterns of the risk of HFMD. The experimental process and results may provide a theoretical basis, epidemic prediction and determination of the focus areas for national HFMD prevention and control in China.
This study was jointly supported by MOST (2012CB955503; 2012ZX10004-201; 201202006) and the State Key Lab of Remote Sensing Science.
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