This article has Open Peer Review reports available.
Trends in TB case notification over fifteen years: the case notification of 25 Districts of Arsi Zone of Oromia Regional State, Central Ethiopia
© Hamusse et al.; licensee BioMed Central Ltd. 2014
Received: 8 November 2013
Accepted: 24 March 2014
Published: 3 April 2014
The aims of tuberculosis (TB) control programme are to detect TB cases and treat them to disrupt transmission, decrease mortality and avert the emergence of drug resistance. In 1992, DOTS strategy was started in Arsi zone and since 1997 it has been fully implemented. However, its impact has not been assessed. The aim of this study was, to analyze the trends in TB case notification and make a comparison among the 25 districts of the zone.
A total of 41,965 TB patients registered for treatment in the study area between 1997 and 2011 were included in the study. Data on demographic characteristics, treatment unit, year of treatment and disease category were collected for each patient from the TB Unit Registers.
The trends in all forms of TB and smear positive pulmonary TB (PTB+) case notification increased from 14.3 to 150 per 100,000 population, with an increment of 90.4% in fifteen years. Similarly, PTB+ case notification increased from 6.9 to 63 per 100,000 population, an increment of 89% in fifteen years. The fifteen-year average TB case notification of all forms varied from 60.2 to 636 (95% CI: 97 to 127, P<0.001) and PTB+ from 10.9 to 163 per 100,000 population (95% CI: 39 to 71, p<0.001) in the 25 districts of the zone. Rural residence (AOR, 0.23; 95% CI: 0.21 to 0.26) and districts with population ratio to DOTS sites of more than 25,000 population (AOR, 0.40; 95% CI: 0.35 to 0.46) were associated with low TB case notification. TB case notifications were significantly more common among 15-24 years of age (AOR, 1.19; 95% CI:1.03 to 1.38), PTB- (AOR, 1.46; 95% CI: 1.33 to 64) and EPTB (AOR, 1.49; 95% CI; 1.33 to 1.60) TB cases.
The introduction and expansion of DOTS in Arsi zone has improved the overall TB case notification. However, there is inequality in TB case notification across 25 districts of the zone. Further research is, recommended on the prevalence, incidence of TB and TB treatment outcome to see the differences in TB distribution and performance of DOTS in treatment outcomes among the districts.
Despite the availability of effective treatment since the mid-1990s, TB remains a major public health problem and the second leading cause of death worldwide [1–3]. In 2011 there were about 8.7 million new TB cases and 1.4 million deaths worldwide from the disease . In 1993, the World Health Organization (WHO) declared TB as a global public health emergency and recommended Directly Observed Treatment Short course (DOTS) as a standard strategy to control the disease [5, 6]. DOTS aim to detect 70% of infectious cases and successfully treat 85% of them to interrupt the transmission, reduce mortality and prevent emergence of drug resistance [5, 6].
In WHO Global TB report, Ethiopia ranked 7th among 22 High Burden Countries and 3rd in Africa in 2011 [3, 7]. Moreover, TB is one of the most important infectious diseases responsible as 3rd cause of hospital admission and the second top causes of death in Ethiopia [3, 8]. According to the 2011 national TB survey result, the prevalence of all forms of TB was 240 and PTB + was 108 per 100,000 population . However, studies from northern, southern and central Ethiopia [10–16] have shown that the prevalence of smear PTB + ranged from 76 to 189 per 100,000 population suggesting TB prevalence varied across different geographical locations of the country. Moreover, evidences form northern Ethiopia and other African counties have shown there is clustering of TB cases and variation in TB prevalence rate across different geographic settings [15, 17–20].
DOTS was piloted in Ethiopia in the mid of 1992 in Arsi and Bale zones of Oromia regional state . In 2010, it was gradually scaled up to the entire country and came up to have a 100% district and 90% health facility coverage . Three studies, two from southern and one from northern Ethiopia, showed that the implementation of DOTS strategy over ten, eight and three years had improved the trends in TB case notification and treatment success with the expansion of DOTS programme to the general health services [5, 23, 24].
To our knowledge, no study has evaluated the progress of DOTS strategy in the trends of TB case notification and made comparison of its performance across districts in the country. In fact, Arsi was one of the nationally selected zones that piloted DOTS programme in 1992 . However, performance of the programme including trends in TB case notification has not been assessed in the zone. The aim of this study was, therefore, to analyse trends in TB case notification over fifteen years and make comparisons among the 25 districts of Arsi zone of Oromia Regional State, Central Ethiopia.
Arsi, one of the zones of Oromia Regional State, is located at 175 km southeast of Addis Ababa. It has one urban and 24 rural district with 3.1 million people residing in an area of 21,120 km2. It is also one of the most densely populated zones with 148 people per km2. About 89% of the population lives in rural areas while the remaining 11% resides in urban areas. In 2011 about 70% of zonal population lived within two-hour walking distance from a public health facility. According to the national standard universal health service coverage, population living within two-hour walking distance or 10 km radius of either a health centre or a hospital is considered to have access to DOTS and other health services . Moreover, a hospital or a health centre with DOTS service during the study period was considered as a DOTS site. Accordingly, DOTS population coverage of each district of the zone was computed by taking population living within two-hour walking distance or 10 km radius (estimated at 250,000 for hospital and 25,000 for health centre) of a hospital or a health centre as nominator, and the total number of mid-year population of each district as denominator multiplied by 100.
Since 1997, the DOTS programme has been gradually expanding to the general health services of the zone. In 2011, DOTS strategies were fully integrated into all health facilities of the zone and used both as TB diagnostic and treatment units. These treatment units have standard TB Unit Registers from the National Tuberculosis and Leprosy Control Programme (TLCP).
Study design and data collection
This was a facility-based retrospective longitudinal study design. In this case, we reviewed the profile of all forms of TB cases registered between September 1, 1997 and August 31, 2011 to analyze the trends in TB case notification and make compression of TB performance across districts in Arsi Zone of Oromia Regional State, Central Ethiopia.
All forms of TB cases registered during the study period in all health institutions that provided DOTS services in 25 districts of the zone (73 health centres and one hospital) were included in the study. TB Unit Registers in all health facilities during the period were identified by the principal investigator and brought to the regional health bureau office between January and March 2013. Then, 10 trained data clerks collected TB patients’ information on sex, age, address, TB type, patient category, date treatment started, and HIV testing and their status from the TB Unit Registers and entered the data onto a computer programme (SPSS version 20) from April to June 2013.
Definitions of terms
Based on the National Tuberculosis and Leprosy Control Programme guideline (NLCP) adopted from WHO , the various types of tuberculosis (TB) are defined as follows:
Pulmonary TB smear-positive (PTB+) is a patient with at least two initial sputum smear positive for acid-fast bacilli (AFB) by direct microscopy or a patient with only one sputum smear positive for AFB and with chest radiographic abnormalities consistent with active pulmonary TB followed by clinician’s decision.
Pulmonary TB smear-negative (PTB-) is a patient with at least three initial sputum smear negative for AFB by direct microscopy and with chest radiographic abnormalities consistent with active pulmonary TB and no clinical response to two weeks of broad spectrum antibiotic therapy followed by clinician’s decision.
Extra pulmonary tuberculosis (EPTB) is tuberculosis involving organs other than the lungs, such as skin, abdomen, joints and bones, lymph nodes, pleura, genitourinary tract, and meninges. The diagnosis is based on fine needle aspiration (FNA) for histopathological examination or biochemical analysis of ascetic/pleural/cerebrospinal fluid followed by clinician’s decision to treat it with a full course of anti-TB drugs. However, a patient with three initial sputum smear negative for AFB at health centre and with no clinical response to two weeks of broad spectrum antibiotic therapy, and also suspected of EPTB at health centre were referred to hospital for further radiological and histopathological investigation before diagnosis as TB cases at health centre level.
Area of residence, sex, age, HIV status, type of TB, patient category and population ratio to health facilities with DOTS service [25–28] were used as independent variables, whereas TB case notification was taken as dependent variable. The independent and dependent variables were further categorized into groups for analysis.
NB: ATBCN is fifteen-year average of TB case notification
Since 2008, all TB patients have been offered provide initiated voluntary counselling and testing service for HIV. Hence, TB-HIV co-infection rate for each district was computed by taking all TB patients tested for HIV and found to be HIV positive as nominator and all TB patients tested for HIV during the study period as denominator multiplied by 100.
Data were coded and double entered by trained data clerks using Epi-info statistical software version 7. Later, they were exported to IBM SPSS version 20 for data checking, cleaning, and bivariate and multiple logistic regression analysis. Descriptive analyses such as frequency, mean, and standard deviation were computed as appropriate. Adjusted odds ratio was used to determine the strength of association between the study variables at 95% CI and P value <0.05. The model adequacy and co-linearity assumptions were checked to be satisfied based on appropriate methods designed for the study.
In the bivariate and multivariate binary logistic regression analyses of TB case notification, we excluded Assela town (urban district) from the analysis of fifteen-year average of all forms of TB case notification of districts in the zone. This was because Assela Referral Hospital in Assela town was used as referral center for TB cases from the entire zonal population and the neighboring zones. Therefore, if we take the population of the town as a denominator to calculate its TB case notification, we might overestimate the TB case notification of the zone and the town. Consequently, after excluding Assela town form the analysis, the fifteen year-average of all forms of TB case notification of the 24 rural districts of the zone was found to be 120/100,000 population and the study subjects were normally distributed. Therefore, we took this as cut-off value in the dichotomization of all forms of TB case notification into below 120 and above 120 per 100,000 in the bivariate and multivariate binary logistic regression analyses.
Ethical approval was obtained from institutional Review Board of Oromia Regional State Health Bureau, Ethiopia. Formal permission to use the data was obtained from the officials.
General characteristics of the study subjects
General characteristics of the study subjects (n = 41,965), Arsi Zone, Oromia Regional State, Central Ethiopia, 1997-2011
The Trends in DOTS Site Expansion and TB Case Notification
Likewise, PTB + case notification of the zone increased from 7 in 1997 to 63 per 100 000 population in 2011 with an increase of 89% in fifteen years. Similarly, the trend in TB case detection rate (CDR) of the zone went up from 6.4% in 1997 to 34.5% in 2001, and from 48.3% in 2007 to 58.7% in 2011 ( = 26.8, P <0.001) (Figure 1c). Similar to the trend in all forms of TB case notification, PTB + in the first four years of DOTS introduction increased from 6.9 in 1997 to 41 per 100,000 population in 2000. However, through the years 2001 to 2010, with the exception of 2007, the trend stabilized in the range between 35 and 46 per 100,000 population (Figure 1a).
Fifteen-year average TB case notification by districts
Yearly average TB case notification/100,000 population and TB/HIV co-infection rate (%), 25 districts in Arsi Zone of Oromia region, Centeral Ethiopia (1997-2011)
Name of district
Average fifteen-year mid-year population
No. of TB cases notified (Avg.)
TB case notification/100,000
Number of tested
HIV positive (%)
Similarly, the 15-year-average of PTB + case notification for the 25 districts of the zone was 42.3 per 100,000 population. Table 2 and Figure 2 show that the fifteen-year average PTB + case notification for five districts was high and above 50 per 100,000 population compared to other seven districts with case notification of less than 20 per 100,000 population. As observed in all forms of TB, the highest fifteen-year average PTB + case notification was observed in Assela town (163 per 100,000) followed by Dodota district (150.2 per 100,000 population). The lowest was from Tiyo (10.9 per 100,000) preceded by Munessa (14.9 per 100,000 population) (Table 2).
Factors associated with case notification rate among patients registered from 1997-2011 in Arsi Zone, Oromia Regional State, Central Ethiopia
Category of case notification
COR (95% CI)
AOR (95% CI)
Residence (N = 39,471)
Sex (N = 41,583)
Age (N = 41,591)
TB Type (41,919)
Population ratio to DOTS sites in the districts (N = 41,965)
The study has confirmed that the expansion of DOTS strategy led to improved TB case notification across 25 districts of Arsi zone. However, it was identified that there is inequality and uneven distribution in TB case notification among the districts. The new knowledge about difference in TB case notification across districts is an important indication calling for investigation to identify if this difference is related to difference in the prevalence of the disease or to the existence of undetected TB patients among districts with low TB case notification.
These findings are significant particularly in resource-constrained settings where there is limited health infrastructure and inadequate physical and financial access across different geographical settings. If this inequality in TB case notification resulted from access to health care, then it may limit the effectiveness of DOTS strategy to attain the global WHO 70% TB case detection rate and 85% treatment success rate aimed at interrupting TB transmission, reducing mortality and preventing emergence of drug resistance [5, 31].
The DOTS strategy was initially introduced in 1992 as a national pilot in a health centre and a hospital in Arsi zone [8, 21] followed by systematic scaling up of the control programme to other health facilities. This stepwise DOTS expansion started in health facilities at the district capital and then continued to sub-district level health facilities. Meanwhile, with the exception of health facilities under construction, full DOTS service coverage was achieved in eight years. This goes in line with previous reports from Southern Ethiopia where 73% of zonal  and full zonal and districts  DOTS service coverage were achieved in seven years following the introduction of DOTS strategy.
The continuous DOTS-site expansion in Arsi zone over the past fifteen years might be due to high political commitment in securing necessary resource for the establishment of laboratory network for effective TB diagnosis, treatment, and monitoring, and in ensuring an uninterrupted supply of anti-TB drugs [5, 32].
Consequently, between 1997 and 2011, TB case notification increased from 14 to 150 for all forms and from 6.9 to 63 per 100,000 population for PTB+. This finding substantiates results of previous studies in Southern Ethiopia where the ten-year trend in all forms of TB case notification increased from 45 to 143  and PTB + from 49 to 126 per 100,000 population in eight years . However, our study showed that under the current passive TB case findings, the trend in TB case notification did not persistently increase though out the study period. This might warrant the involvement of health extension workers in active TB case finding in the Ethiopian context so as to achieve the MDG of 70% of TB case detection rate .
The case detection rate (CDR), estimated by the proportion of PTB + cases notified form the total expected PTB + incidence cases in the community, showed an increase from 7% in 1997 to 63% in 2011. Previous studies [5, 23] also indicated that the trends in PTB + CDR more than doubled in eight years. Likewise, in Vietnam the CDR increased by more than six-fold in fifteen years . The most likely explanation for the increase in CDR over time could be due to the real increase in PTB + case detection rate following decentralization of DOTS strategy led to improved access to laboratory service.
The other reason could be the improvement in recoding and reporting of detected TB cases following the introduction of DOTS without real increase of TB case detection rate . Nevertheless, the increased trend might also be due to true increase in TB incidence cases fueled by the powerful interaction between HIV and tuberculosis . The TB and HIV co-infection among tested TB patients in our study was 9.4%. It might also be due to the notification of large backlog of TB cases that resulted from improved TB diagnostic access .
The upward trend in CDR in this study was slightly higher than report from Southern Ethiopia  but lower than other reports from the same region and Vietnam [23, 32]. The explanation for this discrepancy might be due to variation in DOTS performance across different study areas. The difference could also be due to the variation in disease burden across different geographical settings [15, 17–20].
The PTB + case notification and CDR of the zone steadily increased during the first six years of DOTS implementation. However, despite a notable increase in the number of TB diagnostic centres, the PTB + case notification and CDR seem to be stable during the years 2002–2010. The result corroborates the previous report that indicated the number of reported TB cases did not proportionally increase with the number of TB DOTS sites after five years of DOTS introduction . Moreover, the finding confirms pervious study reports where an increase in the trends of PTB + case detection rate in the first five years [5, 23] and seven years  of DOTS introduction was followed by stabilizing of case detection rates. The expansion of DOTS-sites may help to improve case notification to a certain point while increase in coverage may contribute to marginal increment in case finding unless other community level interventions are introduced .
In the mathematical model used to predict the WHO target of 70% TB case detection rate and 85% cure rate in countries where the incidence of tuberculosis is stable and HIV-1 absent, there would be a reduction of TB incidence rate by 11% and death rate due to TB by 12% per year . However, in this study where there is low PTB + CDR (63%) and high prevalence rate of HIV among TB patients (9.4%), it is not convincing to argue that the decline in TB incidence led to stability in PTB + case detection rate after six years of DOTS implementation.
In this study, we identified variations in TB case notifications among 24 rural districts and one urban district of Arsi zone. The findings show that TB case notification of Dodota district among the 24 rural districts was very high compared to Tiyo, Amigna, Shirka, Sude and Tena districts. Such a situation in Dodota district might be explained by the true increase in TB incidence cases fueled by the powerful interaction between HIV and tuberculosis  as TB and HIV co-infection of the district is very high (16.4%) compared to 9.4% of zonal average.
The overall fifteen-year average PTB + case notification of the districts was 42.3 per 100,000 population with a fourteen fold variation between different districts (10.9 to 150 per 100,000 in rural and 166 per 100,000 in urban areas). This dissimilarity in PTB + case notification among districts may be an indication of inequity in TB case findings or heterogeneity in TB incidences across 25 districts [15, 17, 18, 37] caused by diversity in TB risk factors [32, 38]. This difference could be a result of the defect in the current passive facility-based TB case findings of DOTS policy in uniformly notifying TB cases across districts either due to limited ability of the health system to detect TB cases or poor health care seeking behaviour particularly for those with TB .
In this study factors like area of residence, age of patients, type of TB and the ratio of population size to DOTS sites were found to be associated with the level of TB case notification. This is in agreement with studies conducted elsewhere [26–28] where TB case notification was associated with urban residence, age of patient, access in TB care and type of TB.
Although our study demonstrated the usefulness of facility-based data analysis at district level, it has some limitations. This retrospective facility-based longitudinal study has no socio-economic and environmental data which is the inherent limitation of retrospective study. Therefore, the absence of socio-economic and environmental data in this study could affect the result as it might have an association with the variation in TB case notification. There might also be bias in TB case notification of the districts due to the extrapolation of census data from 1997 and 2007 to get up-to-date denominator of the population. However, there might be unevenly distributed population growth rate across years of the study period and districts. If this were the case, there would be either under or overestimation of TB case notification. The notification in some districts might be overestimated due to existence of some health facilities with good history of TB care that could attract more patients from nearby districts.
The introduction and expansion of DOTS in Arsi zone has improved the overall TB case notification. However, there is inequality across the 25 districts of the zone. Universal achievement of the global WHO target of 70% case detection rate across different geographical settings with diversity in socio-economic condition will continue to be a challenge. This study demonstrated to public health professionals the importance of using existing health facilities data in providing necessary information about TB case notification across different districts. Thus, it is important to enable the concerned bodies to try out more locally applicable and effective strategies to attain MDG in TB control. To this end, further research is recommended on the prevalence and incidence of tuberculosis and also on TB treatment outcome to see the differences in the distribution of the disease and performance of DOTS strategy in treatment outcomes across the 25 districts.
We would like to thank the Oromia Regional Health Bureau, Mr Dejene Teshome and the staff of respective health facilities involved in the study for their genuine support during the field data collection.
- World Health Organisation: The World Health Report Changing History. 2004, Geneva: WHOGoogle Scholar
- World Health Organization (WHO): An International Road Map for Tuberculosis Research: Towards a World Free of Tuberculosis. 2011, Geneva: WHOGoogle Scholar
- World Health Organization (WHO): Global Tuberculosis Report. 2012, Geneva: WHOGoogle Scholar
- World Health Organization: Global Tuberculosis Report. 2011, Geneva: WHOGoogle Scholar
- Yassin MA, Datiko DG, Shargie EB: Ten-year experiences of the tuberculosis control programme in the southern region of Ethiopia. Int J Tuberc Lung Dis. 2006, 10 (10): 1166-1171. PubMed PMID: 17044212 Epub 2006/10/19. engPubMedGoogle Scholar
- Keshavje S, Farmer PE: Tuberculosis, Drug Resistance, and the History of Modern Medicine. N Engl J Med. 2012, 367: 931-936. 10.1056/NEJMra1205429.View ArticleGoogle Scholar
- World Health Organization (WHO): Global Tuberculosis Report. 2009, Geneva: WHOGoogle Scholar
- Ministry of Health of Ethiopia (MOH): Tuberculosis, Leprosy and TB/HIV Prevention and Control Programme Manual. 2008, Addis Ababa: MOH, 4Google Scholar
- Federal Ministry of Health of Ethiopia (FMOH): First Ethiopian National Population Based Tuberculosis Prevalence Survey. 2011, Addis Ababa, Ethiopia: FMOHGoogle Scholar
- Tadesse T, Demissie M, Berhane Y, Kebede Y, Abebe M: Two-thirds of smear-positive tuberculosis cases in the community were undiagnosed in Northwest Ethiopia: population based cross-sectional study. PLoS ONE. 2011, 6 (12): e28258-10.1371/journal.pone.0028258. PubMed PMID: 22164256 Pubmed Central PMCID: 3229563 Epub 2011/12/14. engView ArticlePubMedPubMed CentralGoogle Scholar
- Shargie EB, Yassin MA, Lindtjorn B: Prevalence of smear-positive pulmonary tuberculosis in a rural district of Ethiopia. Int J Tuberc Lung Dis. 2006, 10 (1): 87-92. PubMed PMID: 16466043 Epub 2006/02/10. engPubMedGoogle Scholar
- Shargie EB, Morkve O, Lindtjorn B: Tuberculosis case-finding through a village outreach programme in a rural setting in southern Ethiopia: community randomized trial. Bull World Health Organ. 2006, 84 (2): 112-119. 10.2471/BLT.05.024489. PubMed PMID: 16501728 Pubmed Central PMCID: 2626531 Epub 2006/02/28. engView ArticlePubMedPubMed CentralGoogle Scholar
- Deribew A, Abebe G, Apers L, Abdissa A, Deribe F, Woldemichael K, Jira C, Tesfaye M, Shiffa J, Aseffa A, Bezabih M, Abeje T, Colebunders R: Prevalence of pulmonary TB and spoligotype pattern of Mycobacterium tuberculosis among TB suspects in a rural community in Southwest Ethiopia. BMC Infect Dis. 2012, 12 (1): 54-10.1186/1471-2334-12-54. PubMed PMID: 22414165 Epub 2012/03/15. EngView ArticlePubMedPubMed CentralGoogle Scholar
- Demissie M, Zenebere B, Berhane Y, Lindtjorn B: A rapid survey to determine the prevalence of smear-positive tuberculosis in Addis Ababa. Int J Tuberc Lung Dis. 2002, 6 (7): 580-584. PubMed PMID: 12102296, Epub 2002/07/10. engPubMedGoogle Scholar
- Tadesse T, Demissie M, Berhane Y, Kebede Y, Abebe M: The Clustering of Smear-Positive Tuberculosis in Dabat, Ethiopia: A Population Based Cross Sectional Study. PLOS ONE. 2013, 8 (5): e65022-10.1371/journal.pone.0065022. http://www.plosone.org,View ArticlePubMedPubMed CentralGoogle Scholar
- Yassin MADDG, Olivia T, Markos P, Aschalew M, Shargie EB DH, Mesay RK, Suvanand S, Blok EL, Sally T: Innovative Community-Based Approaches Doubled Tuberculosis Case Notification and Improved Treatment Outcome in Southern Ethiopia. PLOS ONE. 2013, 8 (5): e63174-10.1371/journal.pone.0063174.View ArticlePubMedPubMed CentralGoogle Scholar
- Tiwari N, Adhikari C, Tewari A, Kandapol V: Investigation of geo-spatial hotspots for the occurrence of tuberculosis in Almora district, India, using GIS and spatial scan statistic. Int J Health Geogr. 2006, 5: 33-10.1186/1476-072X-5-33. DOI: 10.1186/1476-072X-5-33View ArticlePubMedPubMed CentralGoogle Scholar
- Nunes C: Tuberculosis incidence in Portugal: spatiotemporal clustering. Int J Health Geogr. 2007, 6: 30-10.1186/1476-072X-6-30. doi: 10.1186/1476-072X-6-30View ArticlePubMedPubMed CentralGoogle Scholar
- Munch SWPVL Z, Booysen CN, Zietsman HL, Enarson DA, Beyers N: Tuberculosis transmission patterns in a high-incidence area: a spatial analysis. INT J TUBERC LUNG DIS. 2003, 7 (3): 271-277.Google Scholar
- Touray K, Adetifa IM, Jallow A, Rigby J, Jeffries D, Cheung YB, Donkor S, Adegbola RA, Hill PC: Spatial analysis of tuberculosis in an Urban West African setting: Is there evidence of clustering?. Trop Med Int Health. 2010, 15 (6): 664-672. 10.1111/j.1365-3156.2010.02533.x.View ArticlePubMedGoogle Scholar
- Getahun B, Ameni G, Biadgilign S, Medhin G: Mortality and associated risk factors in a cohort of tuberculosis patients treated under DOTS programme in Addis Ababa, Ethiopia. BMC Infect Dis. 2011, 11: 127-10.1186/1471-2334-11-127. PubMed PMID: 21575187. Pubmed Central PMCID: 3118140. Epub 2011/05/18. engView ArticlePubMedPubMed CentralGoogle Scholar
- Federal Ministry of Health of Ethiopia (FMOH): National TB/Leprosy Control Program Report. 2010, Addis Ababa: FMOHGoogle Scholar
- Shargie EB, Lindtjorn B: DOTS improves treatment outcomes and service coverage for tuberculosis in South Ethiopia: a retrospective trend analysis. BMC Public Health. 2005, 6 (5): 5-62. PubMed PMID: 15938746. Pubmed Central PMCID: 1173119. Epub 2005/06/09. engGoogle Scholar
- Berhe G, Enquselassie F, Aseffa A: Treatment outcome of smear-positive pulmonary tuberculosis patients in Tigray Region, Northern Ethiopia. BMC Public Health. 2012, 12: 537-10.1186/1471-2458-12-537.View ArticlePubMedPubMed CentralGoogle Scholar
- Oromia Regional Health Bureau (ORHB): Annual Report Of Health Service and Health Programme. 2011, Addis Ababa, Ethiopia: ORHBGoogle Scholar
- Datiko DG, Yassin MA, Chekol LT, Kabeto LE, Lindtjorn B: The rate of TB-HIV co-infection depends on the prevalence of HIV infection in a community. BMC Public Health. 2008, 8: 266-10.1186/1471-2458-8-266. PubMed PMID: 18667068. Pubmed Central PMCID: 2542368. Epub 2008/08/01. engView ArticlePubMedPubMed CentralGoogle Scholar
- Narasimhan R, Wood J, RainaMacIntyre C, Mathai D: Risk Factors for Tuberculosis. Hindawi Publishing Corporation Pulmonary Medicine. 2013, http://dxdoiorg/101155/2013/828939,Google Scholar
- Dlodlo RA, Fujiwara PI, Enarson DA: Should tuberculosis treatment and control be addressed differently in HIV-infected and -uninfected individuals?. Eur Respir J. 2004, 25 (4): 11-17.Google Scholar
- Central Statistical Agency (Ethiopia) and ORC Macro: Ethiopia Demographic and Health Survey 2005. 2007, Addis Ababa, Ethiopia and Calverton, Maryland, USA: Central Statistical Agency and ORC MacroGoogle Scholar
- Central Statistical Agency (CSA): Ethiopian Population and Housing Census. 1997, Addis Ababa, Ethiopia: CSAGoogle Scholar
- Keshavje S, Farmer PE: Tuberculosis Drug Resistance and the History of Modern Medicine. NEJ M. 2012, 367: 931-936. 10.1056/NEJMra1205429.View ArticleGoogle Scholar
- Huong NT, Duong BD, Co NV, Quy HT, Tung LB, Bosman MC, Gebhardt AC, Velema JP, Broekmans JF, Borgdorff MW: Establishment and development of the National Tuberculosis Control Programme in Vietnam. Int J Tuberc Lung Dis. 2005, 9 (2): 151-156.PubMedGoogle Scholar
- Datiko DG, Lindtjorn B: Health extension workers improve tuberculosis case detection and treatment success in southern Ethiopia: a community randomized trial. PLoS ONE. 2009, 4 (5): e5443-10.1371/journal.pone.0005443. PubMed PMID: 19424460. Pubmed Central PMCID: 2678194. Epub 2009/05/09. engView ArticlePubMedPubMed CentralGoogle Scholar
- Obermeyer Z, Abbott-Klafter J, Christopher J, Murray L: Has the DOTS Strategy Improved Case Finding or Treatment Success? An Empirical Assessment. PLoS ONE. 2008, 3 (3): e1721-10.1371/journal.pone.0001721. http://www.plosone.org,View ArticlePubMedPubMed CentralGoogle Scholar
- Corbett EL, Watt CJ, Walker N, Maher D, Williams BG: The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med. 2003, 163: 1009-1021. 10.1001/archinte.163.9.1009.View ArticlePubMedGoogle Scholar
- Dye C, Garnett GP, Sleeman K, Williams BG: Prospects for worldwide tuberculosis control under the WHO DOTS strategy. Lancet. 1998, 352: 1886-1891. 10.1016/S0140-6736(98)03199-7.View ArticlePubMedGoogle Scholar
- Tessema B, Beer J, Merker M, Emmrich F, Sack U, Rodloff AC, Niemann S: Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in Northwest Ethiopia: new phylogenetic lineages found in Northwest Ethiopia. BMC Infect Dis. 2013, 13 (131): http://wwwbiomedcentralcom/1471-2334/13/131,Google Scholar
- Randremanana RV, Sabatier P, Rakotomanana F, Randriamanantena A, Richard V: Spatial clustering of pulmonary tuberculosis and impact of the care factors in Antananarivo City. Trop Med Int Health. 2009, 14 (4): 429-437. 10.1111/j.1365-3156.2009.02239.x.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/14/304/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.