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Evaluation of the Mercy weight estimation method in Ouelessebougou, Mali
© Dicko et al.; licensee BioMed Central Ltd. 2014
Received: 1 January 2014
Accepted: 14 March 2014
Published: 21 March 2014
This study evaluated the performance of a new weight estimation strategy (Mercy Method) with four existing weight-estimation methods (APLS, ARC, Broselow, and Nelson) in children from Ouelessebougou, Mali.
Otherwise healthy children, 2 mos to 16 yrs, were enrolled and weight, height, humeral length (HL) and mid-upper arm circumference (MUAC) obtained by trained raters. Weight estimation was performed as described for each method. Predicted weights were regressed against actual weights. Agreement between estimated and actual weight was determined using Bland-Altman plots with log-transformation. Predictive performance of each method was assessed using residual error (RE), percentage error (PE), root mean square error (RMSE), and percent predicted within 10, 20 and 30% of actual weight.
473 children (8.1 ± 4.8 yr, 25.1 ± 14.5 kg, 120.9 ± 29.5 cm) participated in this study. The Mercy Method (MM) offered the best correlation between actual and estimated weight when compared with the other methods (r2 = 0.97 vs. 0.80-0.94). The MM also demonstrated the lowest ME (0.06 vs. 0.92-4.1 kg), MPE (1.6 vs. 7.8-19.8%) and RMSE (2.6 vs. 3.0-6.7). Finally, the MM estimated weight within 20% of actual for nearly all children (97%) as opposed to the other methods for which these values ranged from 50-69%.
The MM performed extremely well in Malian children with performance characteristics comparable to those observed for U.S and India and could be used in sub-Saharan African children without modification extending the utility of this weight estimation strategy.
In pediatric medicine, the provision of basic health services necessitates knowledge of the child’s weight. Weight is essential for evaluating normal growth and development, examining the adequacy of nutrition, and delivering proper medication doses when children fall ill. Accurately assessing weight is especially important in African settings where an estimated one in four children are nutritionally compromised [1–3]. Sadly, a substantial fraction of children in West and Central Africa do not have access to health care, and the vast majority of facilities to which these children have access do not have functional, calibrated, scales that demonstrate the precision necessary to accurately determine weight [4–9]. Consequently, weight estimation is relied upon heavily as a surrogate for scale-derived weights.
Though there exist numerous published strategies for pediatric weight estimation, they remain less than ideal for use in African settings. Most methods were developed using Western standards for growth and development and few have been validated for use in African populations [10–15]. Even when applied to the population in whom they were defined, the predictive power of these methods falls short. Most fail to account for the extremes of body composition and stature that are observed in children of the same age, some require multiple or complex formulae, others require subjective determinations of habitus, and essentially all of them have restrictions on the age or length of children for whom they are designed [15–20].
In response to the lack of a robust, broadly-applicable weight estimation method for children investigators recently developed the Mercy Method . It is an anthropometric-based method that predicts weight in children 2 months through 16 years of age. It incorporates surrogates of both height and girth which prove to be more accurate estimates relying on a single variable. It is not based on age which may be unavailable in countries where birth records are not maintained and does not require total body length which may be difficult to obtain in uncooperative children or those being swaddled by a caregiver. The Mercy Method was shown to be highly accurate irrespective of nutritional status and predicts weight within 20% of actual in 98% of U.S. children . A recent validation study in South Asia demonstrated that this method performed exceptionally well in children from India . This study was undertaken to examine the performance of the Mercy Method in a West African pediatric population.
Subjects and study design
This was a prospective, single-center study conducted in July- August 2011, in Mali. Otherwise healthy children 2 months through 16 years of age living in the village of Ouelessebougou were eligible for participation. The study was explained and advertised during meeting with the community leaders and health workers in Ouelessebougou. Parents were asked to bring their children to the research center and to provide individual informed consent. All the children presenting to the research center and for whom informed consent and assent (7–17 years) were obtained were enrolled unless they presented with any of the following exclusion criteria: 1) known or apparent limb deformities, 2) unable to be positioned for height/length measurements, 3) underlying pathological condition that would produce abnormal body composition for age (e.g. severe edema). To ensure that an appropriate cross-section of children was sampled, participants were stratified by age in one year age brackets (e.g. 0–1 years, 1–2 years…16-17 years) prior to enrollment. All children were enrolled with written informed permission, and assent where appropriate, under a protocol that was reviewed and approved by the University of Bamako Ethics Committee (EC) and the Ethics Committee of the World Health Organization, Geneva. Since the local language of Ouelessebougou is a spoken language, for parents and children who cannot read and understand French, the permission/assent forms were verbally translated into the local language from the EC approved French language document in presence of an independent witness.
Children came to study site on the day of their participation where anthopometric measurements including; height, weight, humeral length and mid-upper arm circumference were performed by one of four trained raters. Children able to stand unassisted were positioned with their heels, buttocks, and head in contact with the height rule of a portable stadiometer. The head was aligned in the Frankfort horizontal plane and the head piece of the stadiometer lowered making very effort to compress the hair prior to recording the child’s height. In infants unable to stand, recumbent length was measured using an infantometer. The child was placed on an examining table, the head oriented in the Frankfort plane, and gentle pressure applied at the knees to keep the legs straight before marking the length. Each participant was weighed in there undergarments or other light weight clothing using a portable scale that was calibrated daily. Humeral Length (HL) was measured from the most upper edge of the posterior border of the acromion process, down the posterior surface of the arm, to the tip of the olecranon process. Mid-upper arm circumference (MUAC) was measured at the midpoint of the humerus with the arm hanging down at the child’s side. Both HL and MUAC were measured to the nearest millimeter using a standard vinyl tape measure.
All raters obtaining measurements were required to undergo a quality control assessment prior to their involvement with the study participants. Raters performed each of the study related anthropometric measurements in triplicate on 6 adult volunteers to assess inter- and intra-rater reliability. Intra-rater reliability was required to be less than 5% for each anthropometric measure across all volunteers in order for the individual to qualify as a study rater.
Data were collected on individual case report forms (CRFs) and verified before entry into an Excel database. Data entry was performed by a single investigator and independently verified by a second study team member against hard copies of the original CRFs. The Mercy method of weight estimation was applied to the quality assured data as previously described [21, 23]. In brief, the MUAC and HL measures for each child were rounded up or down to the nearest 1.0 cm. The corresponding fractional weight value for was obtained from the published table and then the fractional weights for MUAC and HL summed to generate an estimated weight for that child. The largest weight value was assigned to children whose humeral length exceeded the upper bound (i.e. the largest value) of the published Mercy method . Data on age and height were similarly applied to four other commonly used weight estimation methods; Advanced Pediatric Life Support (APLS), Australian Resuscitation Council (ARC), Broselow, and Nelson [10–12, 15].
The predictive performance of each weight estimation method was evaluated statistically and graphically. Residual error (RE) was calculated by taking the difference of the predicted and actual weights. Percentage error (PE) was calculated by dividing the actual weight into the ME and multiplying by 100. Root mean square error (RMSE) was calculated by taking the square root of the average squared error. Agreement between estimated weight and actual weight was determined by calculating the intraclass correlation coefficient. Bland-Altman plots, with 95% limits of agreement, were constructed to evaluate the agreement between the each weight estimation method and the observed weight. Given that traditional Bland-Altman plots assume that the mean and standard deviation of the differences are constant across the range which is often not the case when weight is examined over a broad range of pediatric ages, the plots constructed for this study were generated from log-transformed data. Finally, to evaluate reliability between raters, the intraclass correlation coefficient (ICC) was determined using a two-way random effects model and an absolute agreement definition. All mathematical and statistical analyses were performed with Microsoft Excel 2003 and SPSS v12.
The study protocol and inform consent document were reviewed and approved by the Ethical Committee of the Faculty of Medicine, Pharmacy and Dentistry of the University of Bamako, and the Institutional Review Board of Children Mercy Hospital in Kansas City, Missouri. Individual, written, informed consent was obtained from a parent or guardian of each subject, prior to screening and enrolment, in addition of the assent from children over the age of 7 years.
Demographic and anthropometric characteristics of the children enrolled in the study
Number of subjects enrolled
8.1 ± 4.8
25.1 ± 14.5
120.9 ± 29.5
25.3 ± 6.8
17.8 ± 3.7
15.6 ± 2.4
23.1 ± 23.5
Regression parameters and predictive performance of the Mercy method (overall and by rater) and the other comparator weight estimation methods
0.06 ± 2.58
0.38 ± 1.69
-0.85 ± 2.59
1.80 ± 2.15
-0.46 ± 2.86
4.36 ± 5.27
1.61 ± 5.48
1.50 ± 2.00
4.10 ± 5.30
1.6 ± 9.3
1.8 ± 7.9
-1.1 ± 9.2
7.3 ± 8.2
0.4 ± 9.2
23.6 ± 21.4
9.6 ± 18.0
8.2 ± 10.4
19.8 ± 21.6
Three children in this study had an humeral length that exceeded the upper bound of the published Mercy method. In these children, the largest fractional weight for humeral length was assigned and resulted in predicted weights that were within 4.1, 4.5, and 11.5% of actual weight for each child, respectively. By contrast, no child presented with a HL below the smallest bin value of the published method. Similarly, no measures fell beyond the lower or upper bounds of MUAC.
The coefficients of variation for intra-rater variability assessed prior to study initiation were very low averaging 0.11%, 1.36% and 0.67% for height, UAC and HL measures, respectively. Inter-rater reliability, as measured by an ICC of 0.998, was also excellent. Despite the high level of agreement between raters, predictive performance of the Mercy method did appear to demonstrate modest differences between raters (Table 2).
Discussion and conclusion
Weight estimation tools address a critical medical need in settings where there is no opportunity to directly weigh children. No previously published method provides accurate estimates of weight across a broad range of age, length, stature and ethnicity. By using surrogates for length and girth, the Mercy Method addresses the principal limitations inherent in many of the existing weight estimation strategies and permits application across a broader pediatric population.
In Malian children, the Mercy Method demonstrated goodness-of-fit criteria comparable to those observed for the method when applied to children in the U.S. and superior to those of other commonly used methods [21, 23]. The average absolute error observed in this study (0.06 kg) represents slight overestimation of weight by the Mercy Method with comparable performance across all BMI percentile categories. Importantly, the Mercy Method predicted weight within 10% of actual weight for more than 70% of the enrolled children and within 20% of actual for more than 95% of the children that were studied. The performance of the Mercy Method in Malian children comparable to those observed for the method when applied to children in the U.S. and India. This indicated that the Mercy Method could be used for accurate weight estimation without modification in west and sub-Saharan Africa children who were more similar in characteristics and environment to Malian children. Consequently, the Mercy TAPE, a device that applies the Mercy method  appears to offer the best option for weight estimation of children.
This work was funded by the World Health Organization. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy or views of the World Health Organization. The authors thank the study participants and the community of the Ouelessebougou. The authors appreciate the contributions of Safiatou N’Diaye who helped with the scribe, Bakary Samake, Siaka Doumbia who assisted with the recruitment, Adama Samake, Gabriel Samake who assisted with the consent and Kanny Diallo who performed an external quality control of data entry. Finally the authors are indebted to Dr. V. Sharma for establishing the relationship between the participating institutions.
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