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The prevalence of hypertension, obesity and dyslipidemia in individuals of over 30 years of age belonging to minorities from the pasture area of Xinjiang
© Yao et al; licensee BioMed Central Ltd. 2010
Received: 17 August 2009
Accepted: 24 February 2010
Published: 24 February 2010
The prevalence of population-wide hypertension, obesity and dyslipidemia has not been well studied in the pasture area of Xinjiang. The present epidemiological study was performed to determine the prevalence of hypertension, obesity and dyslipidemia in minority populations from the pasture area of Xinjiang and to discuss the potential risk factors for hypertension.
A population-based, cross-sectional study in the Xinjiang pasture area was performed which included 2251 participants aged over 30 years (90.33% participation rate) of whom 71.26% were Kazaks. Several risk factors were considered: hypertension (defined as systolic or diastolic blood pressure or both of at least 140/90 mmHg measured on one occasion or treatment for hypertension) overweight/obesity (body mass index ≥ 25 kg/m2) alcohol intake, smoking/tobacco use and dyslipidemia. Outcomes were prevalence of hypertension, obesity and dyslipidemia and the associated risk factors of hypertension detected by multivariate logistic regression analysis taking into account various metabolic and lifestyle characteristics.
The prevalence of hypertension, overweight/obesity and dyslipidemia in all participants from the pasture area of Xinjiang was 51.9%, 47.9% and 49.2% respectively. Independently, the prevalence and awareness of hypertension was 52.6% and 15.3% among Kazaks (n = 1604), 54.6% and 14.1% among Uygurs (n = 418), 39.5% and 16.1% among Mongolians (n = 81) and 43.9% and 18.2% among non-Xinjiang-born Han immigrants (n = 148). The prevalence of overweight/obesity in Kazaks, Uygurs, Mongolians and Han immigrants was 46.7%, 48.9%, 62.5% and 50.3%, respectively. The prevalence of dyslipidemia in the four ethnic groups mentioned was 53.5%, 34.8%, 49.3% and 47.3%, respectively. The mean blood pressure in all participants was 136/86 mmHg (pre-hypertensive), the mean BMI was 24.7 kg/m2. Based on multiple logistic regression analysis, the significant risk factors for hypertension were age [1.07(1.06-1.09), P < 0.0001], overweight/obesity [overweight: 1.61(1.22-2.13), p = 0.0007; obesity: 1.95 (1.33-2.87), p = 0.0007], hypercholesterolemia [1.30(1.15-1.47), p < 0.0001] and an alcohol intake of over 30 g/day [2.22(1.43-3.45), p = 0.0004].
The considerably high prevalence of hypertension, overweight/obesity and dyslipidemia among the minority population aged over 30 from the pasture area of Xinjiang calls for effective preventive measures. Age, increased body mass index, hypercholesterolemia and ≥30 g/d alcohol intake can be counted as risk factors for hypertension, but further genetic or environmental clarification would be desirable to explain the unusually high prevalence of the conditions mentioned above.
Cardiovascular diseases (CVDs) are the leading cause of death in China , as in most industrialized countries. Hypertension, often combined with obesity and dyslipidemia, is one of the four most important predictors of CVDs , as well as stroke, being present in more than 70% of all cases . Epidemiological data indicates that the prevalence of hypertension varies greatly between different countries  and diverse ethnic populations [5, 6].
Kazaks, Uygurs and Mongolians are the major minorities in Xinjiang--the northwest of China. Their main employment is that of herdsmen or peasants in the pasture area. Kazaks, the main nomad ethnic group in the pasture area of Xinjiang, have been reported to have a higher prevalence of hypertension , while obesity is common in Uygurs and Mongolians . Liu et al  concluded that the significant differences in mean blood pressure and prevalence of hypertension between Han, Kazaks, Uygurs and Tibetan ethnic groups are likely to be caused by different diet-related habits. It is known that alcohol, salty food and meat are traditionally popular among these minorities. This disposition is greatly related to the cold weather in Xinjiang. However, as nomad minorities usually live far from large city centres and move around within the pasture area, large-scale population-based investigations on hypertension, obesity and dyslipidemia are still sparse and the true prevalence among these ethnic groups is therefore not fully known.
The first aim of this study was to assess the prevalence of hypertension, obesity and dyslipidemia in Kazaks, Uygurs and Mongolians aged over 30 from the pasture area of Xinjiang. A secondary aim was to determine if the previously reported high prevalence of hypertension, obesity and dyslipidemia in Xinjiang-born Kazaks could be detected in a large population-based sample and if it could be attributed to metabolic and lifestyle factors.
A study of men and women of more than 30 years of age was performed in three counties - Hefeng, Fuhai and Xinyuan, where most of the residents are Kazaks. In the pasture area of Xinjiang between October 1997 and February 1998, all persons older than 30 living in the above three counties were invited to participate in a thorough health screening study. The participants underwent physical examination including measurements of height, weight as well as electrocardiogram. Fasting blood samples were taken for analysis, and a comprehensive questionnaire with validated questions was completed. All participants received preventive individualized cardiovascular lifestyle advice, and participants newly diagnosed for hypertension were referred to primary care or hospitals.
The study was approved by the ethics committee at People's Hospital of Xinjiang Uygur Autonomous Region, and all participants gave their written consent.
Nearly all the Kazaks of the province of Xinjiang live in the pasture areas which are mostly located in the north of the region. We used a stratified sampling method to select a representative sample of the general population of Kazaks of this area. Three counties (Hefeng, Fuhai and Xinyuan County) were chosen and, based on the government record of registered residence, one participant was randomly selected from each household.
In this way, a total of 2492 participants, 1051 men and 1441 women, were randomly selected from 28 villages of the three counties and were invited to participate. Those who were younger than 30 years old, 84 males and 156 females, were excluded from the analysis, which is motivated by the higher risk of secondary hypertension in individuals younger than 30 years. Furthermore, one 68-year-old female dwarf with height 93 cm was excluded as well. Finally, 2251 individuals (90.33%) were analyzed, 967 men (42.96%) and 1284 women (57.04%). The proportion of participants from the three counties were: Fuhai (n = 566, 25.14%), Hefeng (n = 1030, 45.76%) and Xinyuan (n = 655, 29.10%). The ethnic distribution of the subjects in the present study were: 1604 Kazaks (71.26%), 418 Uygurs (18.57%) and 81 (3.6%) Mongolians. Additionally, 148 Han immigrants, 6.57% of the total sample, were included in this study. As their original provinces or cultural and geographical regions were unknown, all Han immigrants were considered as one group for the purpose of analysis.
Hypertension, obesity and dyslipidemia
Blood pressure was measured three times by the same physician from the hospital's hypertension department. After resting for 5 to 10 minutes in a quiet and warm room, blood pressure was measured with a table sphygmomanometer. For the purposes of analysis, the mean of the three measured values was considered. A wider cuff was used if the participant's upper arm circumference was above 32 cm. New hypertension was defined as systolic blood pressure greater than 140 mmHg and/or diastolic blood pressure greater than 90 mmHg. Known hypertension was defined as hypertension or intake of antihypertensive drugs as self-reported in the questionnaire. Hypertension was in any case defined as either new or known according to the standard guidelines . The awareness of hypertension was defined as having been informed of the hypertensive status by a health professional in the previous year.
Body mass index (BMI) was calculated as weight (kg) divided by height squared (m2). Obesity was defined as body mass index (BMI) ≥ 30 kg/m2 and overweight as 25 kg/m2 ≤ BMI < 30 kg/m2.
Blood lipids and lipoproteins were measured on samples obtained after an overnight fast (12 h at least). Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) were measured in EDTA plasma. Hypercholesterolemia was defined as TC >5.7 mmol/L, increased LDL-c as LDL-c >3.6 mmol/L, hypertriglyceridemia as TGs >1.7 mmol/L, and reduced HDL-c as HDL-c <0.9 mmol/L. Dyslipidemia was defined by the presence of one or more than one abnormal serum lipid concentration.
Smoking habits were coded as current daily smoker, former smoker or lifetime non-smoker. Similarly, the alcohol intake was recorded as current alcohol-intake, former alcohol-intake or no history of alcohol-intake. Furthermore, for participants with current alcohol-intake, the questionnaire had questions concerning present intake of beer, wine, spirits and others. Average daily intake of alcohol was calculated and three categories of drinking groups were defined as follows: no (0 g alcohol/day), <30 g/day and ≥ 30 g/day alcohol intake.
Differences in categorical data among Kazak, Uygur, Mongolian and Han groups were examined by χ2 test and differences in quantitative data by ANOVA, followed by Post-hoc test (Tukey). Logistic regression analysis was performed for exposure dose and risk factors of hypertension. All statistical procedures were performed with SAS 9.1.3 (SAS Institute Inc., Cary, NC, USA). All tests were two tailed and the significance level was set at α = 0.05.
General characteristics of the whole population
N = 2251
Systolic BP (mmHg)
Diastolic BP (mmHg)
Smoking (n, %)*
Alcohol intake (n, %)*
The awareness of hypertension and the prevalence of hypertension, overweight and dyslipidemia
Results of logistic regression
Simple and multiple logistic regression for covariate factors and their associations to hypertension
Comparison of blood pressure related variables, metabolic and lifestyle characteristics between Kazaks and the other ethnic groups
The characteristics of the four ethnic groups from the pasture area of Xinjiang
47.28 (46.70~ 47.86)
Alcohol intake* Δ
Prevalence of hypertension, overweight/obesity and dyslipidemia
This epidemiological survey mainly reported considerable prevalence of hypertension (about 52%), overweight/obesity (near 48%) and dyslipidemia (over 50%), combined with low awareness of hypertension (15% only) in the representative sample of the population living in the pasture area of Xinjiang.
The Kazaks, Mongolians and Uygurs recruited in this study are herdsmen or peasants. Their ancestral allocation to the pasture area of Xinjiang goes back for hundreds of years, and they form a relatively homogeneous group with regard to socioeconomic status, occupational and dietary exposures. Few large-scale epidemiological studies have focused on the prevalence of hypertension, overweight/obesity and dyslipidemia among the minorities from the pasture area of Xinjiang in the last decade. Although the large-scale population-based survey in 1995 on the prevalence of hypertension in different ethnic groups in China  reported much lower prevalence of the above-mentioned conditions, to our knowledge, most Kazaks and Uygurs involved in the study came from big cities or towns in Xinjiang, while the Mongolians were from the Inner Mongolia Autonomous Region. Therefore, different prevalences were reported in diverse populations and regions, which is a common result of epidemiological investigations. In some small-scale surveys on hypertension in Kazaks, Uygurs and Mongolians of Xinjiang, the results varied greatly. For example, a study including 119 cases  showed that the prevalence of hypertension in residential Kazaks of Urumqi was 42.0%. Liu et al  data showed the prevalence of Uygurs as 24.3% (264 cases) and Kazaks as 37.9% (99 cases). Data from the Hebukesel pastoral area of Xinjiang demonstrated that the detection rate of hypertension in Kazaks and Mongolians was 55.09% in 2003. In 2005, Wang et al  reported in a study of 3732 Mongolians, Kazaks, Uygurs and Hans over 30 years of age in Bortala Prefecture of Xinjiang that the prevalence of overweight and obesity were 36.02% and 27.39% respectively, which was lower than that in our data. Additionally, the low awareness of hypertension displayed in the Guideline for the Prevention and Treatment of Hypertension in China (2005) was confirmed in the present study. Our data calls for the urgent need to develop effective strategies for prevention and treatment of hypertension in Xinjiang.
Associated risk factors
Our study confirmed the conventional risk factors for hypertension - age, increased BMI, hypercholesterolemia and high alcohol intake (≥30 g/d) - in all participants and specifically in the Kazak population. It is well understood that the aging process affects hypertension . Also positive association between BMI and blood pressure has been well documented . Our study demonstrates that obese individuals, classified by BMI, have significantly larger odds ratio for hypertension than overweight ones. However, we observed significant interaction effects between ethnics and overweight/obesity both for SBP as well as DBP. In particular Mongolians have the highest prevalence in overweight/obesity but the lowest prevalence of hypertension. However, the number of Mongolians included in this study is relatively small, and further research will be necessary to figure out the reasons for this observation.
The results of a 7-year follow-up study on Finnish men  suggests that dyslipidemia characteristic of the metabolic syndrome predicts the development of hypertension. Although TG, HDL-C and LDL-c levels were significantly different in our four ethnic groups (Table 3) multiple logistic regression suggested that hypercholesterolemia was positively associated with hypertension in the whole population, not only in Kazaks, which indicates that hypercholesterolemia is a potential determinants of hypertension.
Numerous studies have suggested that excessive alcohol intake causes an increase in blood pressure [17–21]. But in recent years, some researchers claimed that light or moderate alcohol intake might actually benefit hypertension patients [22, 23]. Interestingly, in this study, ≥30 g/d alcohol intake was associated with hypertension adjusted for age, sex, smoking and plasma lipid level while the positive association could not be observed for an intake of alcohol <30 g/d. However, only large-scale, prospective and randomized trials might elucidate the actual role of alcohol in hypertension.
Apart from the direct influence of alcohol on blood pressure levels, one might consider that, traditionally among Kazaks, Uygurs and Mongolians in Xinjiang, alcohol consumption is associated with an increased consumption of animal fat or salted food, which could lead to an increase in fibrinogen levels. The male population in particular customarily drinks spirit to deal with the cold weather, as well as having an increased intake of animal fat and salt. Additionally, salted milk tea is enjoyed in large quantities coupled with a low consumption of vegetables, which are scarcely available in the area. Here it should be mentioned that 307 missing values of alcohol intake involved a special alcoholic beverage brewed from horse milk. Over-consumption of this may cause drunkenness, but it is difficult to assess the amount of alcohol within this specific beverage. These missing values may affect the logistic model in the statistical analysis.
hardly any minority women smoke because of ethnical and behavioural restrictions,
229 subjects who failed to report tobacco consumption smoke 'Mohe tobacco' (special tobacco leaves found in Xinjiang) and were considered as missing values for the logistic model.
Some general limitations should be also mentioned. First, the number of minority participants except for Kazaks was too small to allow further analysis. This is a problem when considering the differences between ethnic groups. For example, Han population of Xinjiang mostly consists of immigrants from other provinces, different in cultural background, language, reasons for migration, duration of stay in Xinjiang and age when migrating. Therefore, our conclusions cannot automatically be attributed to all Han immigrants. Second, the study was not primarily designed to compare multiple ethnics and Kazak participants, but the high percentage of residents with different ethnicities in the Xinjiang pasture area made this contingently possible. The data from Mongolians might be biased due to the rather small sample size in this study. Third, blood pressure was measured three times, but only on one occasion, which may overestimate the prevalence of hypertension. Such an over-estimation should, however, be the same in all studied groups, and single-occasion blood pressure measurements are common practice in epidemiological studies [5, 30, 31]. Finally, we unfortunately did not have data on intake of salt and macronutrient factors that may have an impact on blood pressure . With respect to the high prevalence of hypertension, obesity and dyslipidemia found in Kazaks and Uygurs, there may be a risk of residual confounding by factors we were not able to adjust for, like e.g. the physical activity level of participants. However, keeping these limitations in mind, our study may provide a baseline database and preliminary results for further studies on the association of hypertension and its risk factors with lifestyle in different ethnic groups from the pasture area of Xinjiang.
In summary, about half of the over 30-year-old minority participants from the pasture area of Xinjiang have hypertension, overweight/obesity and dyslipidemia, respectively, while the awareness of hypertension was as low as 15%. This emphasizes the need for primary preventive measures addressing minorities of the pasture area of Xinjiang, which should not only focus on hypertension but also include its associated risk factors. Further, the genetic and environmental factors and their interaction on hypertension should be considered to clarify the mechanism of hypertension.
The authors gratefully acknowledge the Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang for the professional assistance. The study was supported by grants from the National Natural Scientific Fundation Committee of China (Proj. No. 30260038, 30240045).
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