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BMC Series Focus Issue

Neglected Tropical Diseases

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Neglected tropical diseases (NTDs) threaten more than 1.7 billion people living in the poorest and most marginalized communities worldwide. These diseases blind, disable and disfigure people, taking away not only their health, but also their chances of staying in school, earning a living, or even being accepted by their family or community.

The BMC Series is proud to present this focus issue dedicated to neglected tropical diseases. Browse our biology and medical titles for insight into recent research in the field.

Research articles

Chagas disease

A behavioral design approach to improving a Chagas disease vector control campaign in Peru
Alison M. Buttenheim, Michael Z. Levy, Ricardo Castillo-Neyra, Molly McGuire, Amparo M. Toledo Vizcarra, Lina M. Mollesaca Riveros, Julio Meza, Katty Borrini-Mayori, Cesar Naquira, Jere Behrman and Valerie A. Paz-Soldan
BMC Public Health 2019 19:1272

Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU
João Luís Reis-Cunha, Rodrigo P. Baptista, Gabriela F. Rodrigues-Luiz, Anderson Coqueiro-dos-Santos, Hugo O. Valdivia, Laila Viana de Almeida, Mariana Santos Cardoso, Daniella Alchaar D’Ávila, Fernando Hugo Cunha Dias, Ricardo Toshio Fujiwara, Lúcia M. C. Galvão, Egler Chiari, Gustavo Coutinho Cerqueira and Daniella C. Bartholomeu
BMC Genomics 2018 19:816

Dengue fever

Treatment seeking behavior and associated factors of suspected dengue fever among Shan people in eastern Shan special region IV, Myanmar: a cross-sectional study
Hui Liu, Jian-Wei Xu, Zadan Ai, Yan Yu and Bian Yu
BMC Health Services Research 2020 20:318

Spatiotemporal multi-disease transmission dynamic measure for emerging diseases: an application to dengue and zika integrated surveillance in Thailand
Chawarat Rotejanaprasert, Andrew B. Lawson and Sopon Iamsirithaworn
BMC Medical Research Methodology 2019 19:200

El Niño Southern Oscillation as an early warning tool for dengue outbreak in India
Malay Pramanik, Poonam Singh, Gaurav Kumar, V. P. Ojha and Ramesh C. Dhiman
BMC Public Health 2020 20:1498

Transcriptomic analyses of Aedes aegypti cultured cells and ex vivo midguts in response to an excess or deficiency of heme: a quest for transcriptionally-regulated heme transporters
Heather Eggleston and Zach N. Adelman
BMC Genomics 2020 21:604

Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle
Sharon Rose Hill, Tanvi Taparia and Rickard Ignell
BMC Genomics 2021 22:71

Analysis of the virus propagation profile of 14 dengue virus isolates in Aedes albopictus C6/36 cells
Atitaya Hitakarun, Suwipa Ramphan, Nitwara Wikan and Duncan R. Smith
BMC Research Notes 2020 13:481

Schistosomiasis

Association of Schistosoma haematobium infection morbidity and severity on co-infections in pre-school age children living in a rural endemic area in Zimbabwe
Tariro L. Mduluza-Jokonya, Thajasvarie Naicker, Luxwell Jokonya, Herald Midzi, Arthur Vengesai, Maritha Kasambala, Emilia Choto, Simbarashe Rusakaniko, Elopy Sibanda, Francisca Mutapi and Takafira Mduluza
BMC Public Health 2020 20:1570

Developmental gene expression profiles of the human pathogen Schistosoma japonicum
Geoffrey N Gobert, Luke Moertel, Paul J Brindley and Donald P McManus
BMC Genomics 2009 10:128

The Schistosoma mansoni phylome: using evolutionary genomics to gain insight into a parasite’s biology
Larissa Lopes Silva, Marina Marcet-Houben, Laila Alves Nahum, Adhemar Zerlotini, Toni Gabaldón and Guilherme Oliveira
BMC Genomics 2012 13:617

Leishmaniasis

Relationship of Leishmania RNA Virus (LRV) and treatment failure in clinical isolates of Leishmania major
Mohsen Abtahi, Gilda Eslami, Serena Cavallero, Mahmood Vakili, Saeedeh Sadat Hosseini, Salman Ahmadian, Mohammad Javad Boozhmehrani and Ali Khamesipour
BMC Research Notes 2020 13:126

Psychosocial burden of localised cutaneous Leishmaniasis: a scoping review
Issam Bennis, Vincent De Brouwere, Zakaria Belrhiti, Hamid Sahibi and Marleen Boelaert
BMC Public Health 2018 18:358

Leprosy

Knowledge on leprosy and its management among primary healthcare providers in two districts of Bangladesh
Humayun Kabir and Shahed Hossain
BMC Health Services Research 2019 19:787

Epidemiological situation of leprosy in a province in China: a long time to diagnosis and a high rate of deformity
Qing-Ping Zhang, Ge Li, Chao Li, Zhao-Xing Lin and Ping Chen
BMC Public Health 2020 20:1790

Trends of the leprosy control indicators in Benin from 2006 to 2018
Ronald Sètondji Gnimavo, Parfait Djossou, Ghislain Emmanuel Sopoh, Gimatal Esaï Anagonou, Yves Thierry Barogui, Akpéédjé Anita Carolle Wadagni, Jean-Gabin Houezo and Roch Christian Johnson
BMC Public Health 2020 20:1254

Relationship between psychological health and quality of life of people affected by leprosy in the community in Guangdong province, China: a cross-sectional study
Mingzhou Xiong, Xiaohua Wang, Ting Su, Bin Yang, Ming Li and Daocheng Zheng
BMC Public Health 2019 19:424

Lymphatic Filariasis 

Financial burden impact quality of life among lymphatic Filariasis patients
Samuel Opoku Asiedu, Alexander Kwarteng, Emmanuel Kobla Atsu Amewu, Priscilla Kini, Bill Clinton Aglomasa and John Boulard Forkuor
BMC Public Health 2021 21:174

Onchocerciasis

Socioeconomic impacts of elimination of onchocerciasis in Abu-Hamed focus, northern Sudan: lessons after elimination
Ayman Ahmed, Anas Elbashir, Asgad A. Mohamed, Asha A. Alim, Asia Mubarak, Duaa Abdelrahman, Eilaf Mohammed, Nouh S. Mohamed, Arwa H. Elaagip, Isam M. A. Zarroug, Noma Mounkaila and Hanan Tahir
BMC Research Notes 2020 13:256

Status of parasitological indicators and morbidity burden of onchocerciasis after years of successive implementation of mass distribution of ivermectin in selected communities of Yeki and Asosa districts, Ethiopia
Gebremedhin Gebrezgabiher, Zeleke Mekonnen, Delenasaw Yewhalaw and Asrat Hailu
BMC Public Health 2020 20:1233

Rabies

Epidemiology of human exposure to rabies in Nunavik: incidence, the role of dog bites and their context, and victim profiles
Sarah Mediouni, Mario Brisson and André Ravel
BMC Public Health 2020 20:584

Human African Trypanosomiasis (African Sleeping Sickness)

Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons
Elizabeth Bilsland, Tatyana A. Tavella, Renata Krogh, Jamie E. Stokes, Annabelle Roberts, James Ajioka, David R. Spring, Adriano D. Andricopulo, Fabio T. M. Costa and Stephen G. Oliver
BMC Biotechnology 2018 18:22

Blood signatures for second stage human African trypanosomiasis: a transcriptomic approach
Julius Mulindwa, Enock Matovu, John Enyaru and Christine Clayton
BMC Medical Genomics 2020 13:14

Detecting bracoviral orthologs distribution in five tsetse fly species and the housefly genomes
Kelvin M. Kimenyi, Muna F. Abry, Winnie Okeyo, Enock Matovu, Daniel Masiga and Benard W. Kulohoma
BMC Research Notes 2020 13:318

Soil transmitted helminths

Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical trial
Doris Pierce, Lea Merone, Chris Lewis, Tony Rahman, John Croese, Alex Loukas, Malcolm McDonald, Paul Giacomin and Robyn McDermott
BMC Endocrine Disorders 2019 19:136

An integrated health delivery platform, targeting soil-transmitted helminths (STH) and canine mediated human rabies, results in cost savings and increased breadth of treatment for STH in remote communities in Tanzania
Felix Lankester, Alicia Davis, Safari Kinung’hi, Jonathan Yoder, Catherine Bunga, Shayo Alkara, Imam Mzimbiri, Sarah Cleaveland and Guy H. Palmer
BMC Public Health 2019 19:1398

Echinococcosis

Differential diagnosis between hepatic alveolar echinococcosis and intrahepatic cholangiocarcinoma with conventional ultrasound and contrast-enhanced ultrasound
Zeng-Cheng Wa, Ting Du, Xian-Feng Li, Hui-Qing Xu, Qiu-Cuo Suo-Ang, Li-Da Chen, Hang-Tong Hu, Wei Wang and Ming-De Lu
BMC Medical Imaging 2020 20:101

The application of laparoscopy combined with indocyanine green fluorescence imaging technique for hepatic cystic echinococcosis
Yu-Peng Li, Zhi-Gang Ma, Tuerhongjiang Tuxun, Zhi-De Li, Yuan Meng and Xiong Chen
BMC Surgery 2020 20:249

Prevalence of human alveolar echinococcosis in China: a systematic review and meta-analysis
Xuanzhuo Wang, Guodong Dai, Min Li, Wanzhong Jia, Zhongmin Guo and Jiahai Lu
BMC Public Health 2020 20:1105

Environmental, climatic and host population risk factors of human cystic echinococcosis in southwest of Iran
Mohammad Amin Ghatee, Koorosh Nikaein, Walter Robert Taylor, Mehdi Karamian, Hasan Alidadi, Zahra Kanannejad, Faezeh Sehatpour, Fateme Zarei and Gholamreza Pouladfar
BMC Public Health 2020 20:1611

Additional reading

Synthesis, crystal structure and larvicidal activity of novel diamide derivatives against Culex pipiens
Rui Wu, Cong Zhu, Xiu-Jiang Du, Li-Xia Xiong, Shu-Jing Yu, Xing-Hai Liu, Zheng-Ming Li and Wei-Guang Zhao
Chemistry Central Journal 2012 6:99

Analysis of viral diversity for vaccine target discovery
Asif M. Khan, Yongli Hu, Olivo Miotto, Natascha M. Thevasagayam, Rashmi Sukumaran, Hadia Syahirah Abd Raman, Vladimir Brusic, Tin Wee Tan and J. Thomas August
BMC Medical Genomics 2017 10(Suppl 4):78

Interdisciplinary development of a standardized introduction to gene drives for lay audiences
Cynthia E. Schairer, Cynthia Triplett, Anna Buchman, Omar S. Akbari and Cinnamon S. Bloss
BMC Medical Research Methodology 2020 20:273

Integrated approach in the control and management of skin neglected tropical diseases in three health districts of Côte d’Ivoire
Aboa Paul Koffi, Théodore Ange Kouakou Yao, Yves Thierry Barogui, Gabriel Diez, Simplice Djakeaux, Marie Hélène Zahiri, Ghislain Emmanuel Sopoh, Silvia Santos, Kingsley Bampoe Asiedu, Roch Christian Johnson and Henri Assé
BMC Public Health 2020 20:517

Genomic analyses of aminoacyl tRNA synthetases from human-infecting helminths
Preeti Goel, Suhel Parvez and Amit Sharma
BMC Genomics 2019 20:333

Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi
Marilyn Parsons, Elizabeth A Worthey, Pauline N Ward and Jeremy C Mottram
BMC Genomics 2005 6:127

Expert Delphi survey on research and development into drugs for neglected diseases
Angela Fehr, Petra Thürmann and Oliver Razum
BMC Health Services Research 2011 11:312

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