Association of hypertension and depression with mortality: an exploratory study with interaction and mediation models

Table 4 Interaction between hypertension and depression with all-cause and CVD mortality

		All-cause Mortality	CVD mortality
Interaction on multiplicative scale, HR (95% CI)	Model 1	0.7 (0.5-1.0), P=0.034	0.7 (0.4-1.2), P=0.208
	Model 2	0.8 (0.6-1.2), P=0.426	0.9 (0.5-1.6), P=0.659
	Model 3	0.9 (0.6-1.4), P=0.587	1.0 (0.5-2.1), P=0.955
Interaction on additive scale, RERI (95% CI)	Model 1	0.4 (-0.5-1.3), P=0.412	0.9 (-3.9-5.6), P=0.723
	Model 2	-0.1 (-0.6-0.4), P=0.605	0.2 (-1.1 -1.5), P=0.758
	Model 3	-0.1 (-0.6-0.4), P=0.243	0.2 (-0.9-1.3), P=0.668
Interaction on additive scale, AP (95% CI)	Model 1	0.1 (-0.1-0.2), P=0.444	0.1 (-0.5-0.7), P=0.704
	Model 2	-0.1 (-0.3-0.2), P=0.586	0.1 (-0.4-0.5), P=0.753
	Model 3	-0.1 (-0.5-0.4), P=0.654	0.1 (-0.4-0.6), P=0.665

Model 1 did not adjust any confounders. Model 2 was adjusted for age, gender, race/ethnicity, education, and income. Model 3 was adjusted for age, gender, race/ethnicity, education, income, obesity, diabetes, dyslipidemia, history of CVD, history of cancer, length of physical activity, smoking, alcohol use, antidepressant use, and substance use
HR Hazard ratio, RERI Relative excessive risk due to interaction, AP Proportion attributable to the interaction, CVD Cardiovascular disease

ISSN: 1471-2458