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Table 5 Mediating role of WBCs in the association between furan exposure and COPD risk

From: Inflammation mediates the association between furan exposure and the prevalence and mortality of chronic obstructive pulmonary disease: National Health and Nutrition Examination Survey 2013–2018

WBCs

(1000 cells/uL)

ACME

ADE

Average total effect

Mediated proportion (%)

P-value

β (95%CI)

β (95%CI)

β (95%CI)

Monocytes

2.93 × 10− 3 (1.22 × 10− 3, 0.01)***

3.07 × 10− 2 (6.66 × 10− 3, 0.09)*

3.36 × 10− 2 (1.08 × 10− 2, 0.10)*

8.73

0.026

Neutrophils

7.02 × 10− 3 (1.86 × 10− 3, 0.01)***

2.66 × 10− 2 (5.01 × 10− 3, 0.09)*

3.36 × 10− 2 (1.11 × 10− 2, 0.10)*

20.90

0.020

Basophils

3.68 × 10− 3 (1.03 × 10− 3, 0.01)***

2.99 × 10− 2 (3.93 × 10− 3, 0.09)*

3.36 × 10− 2 (6.67 × 10− 3, 0.10)*

10.94

0.024

  1. Adjusted for cotinine, age, gender, marital status, ethnicity, educational attainment, past-year alcohol drinking, and BMI. Abbreviations: WBCs, white blood cells; COPD, chronic obstructive pulmonary disease; ACME, average causal mediation effect; ADE, average direct effect; BMI, body mass index; CI, confidence interval. * 0.01 ≤ P < 0.05, ***P < 0.001
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BMC Public Health

ISSN: 1471-2458

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