Table 3 Additive interaction of hypertension and obesity on the risk of type 2 diabetes mellitus by gender

Hypertension

Abdominal obesity

No

No

Ref. (1.00)

Ref. (1.00)

Ref. (1.00)

Ref. (1.00)

No

Yes

1.87 (1.20, 2.92)

1.50 (1.14, 1.98)

2.51 (1.61, 3.91)

2.12 (1.35, 3.34)

Yes

No

2.62 (1.19, 5.70)

1.66 (1.18, 2.35)

3.62 (1.65, 7.94)

2.24 (1.02, 4.98)

Yes

Yes

4.66 (2.93, 7.41)

2.38 (1.67, 3.41)

6.89 (4.34, 10.95)

4.02 (2.47, 6.47)

Interactive effect

RERI: 1.17 (-0.76, 3.11)

AP: 0.25 (-0.15, 0.65)

SI: 1.47 (0.68, 3.17)

RERI: 0.27 (-1.01, 1.54)

AP: 0.11 (-0.41, 0.63)

SI: 1.23 (0.41, 3.68)

RERI: 1.74 (-0.99, 4.48)

AP: 0.25 (-0.13, 0.63)

SI: 1.42 (0.75, 2.68)

RERI: 0.61 (-1.12, 2.33)

AP: 0.23 (0.08, 0.37)

SI: 1.26 (0.60, 2.61)

Hypertension

General obesity

No

No

Ref. (1.00)

Ref. (1.00)

Ref. (1.00)

Ref. (1.00)

No

Yes

1.55 (1.21, 1.99)

1.43 (1.04, 1.97)

1.79 (1.39, 2.29)

1.81 (1.40, 2.36)

Yes

No

2.64 (1.98, 3.55)

1.58 (1.17, 2.15)

3.35 (2.49, 4.51)

2.11 (1.53, 2.91)

Yes

Yes

4.43 (3.23, 6.10)

2.53 (1.63, 3.82)

4.18 (3.04, 5.73)

2.94 (2.10, 4.05)

Interactive effect

RERI: 1.25 (-0.11, 2.60)

AP: 0.28 (0.03, 0.52)

SI: 1.56 (0.97, 2.52)

RERI: 0.62 (-0.26, 1.49)

AP: 0.23 (-0.05, 0.52)

SI: 1.59 (0.81, 3.12)

RERI: 0.04 (-1.37, 1.44)

AP: 0.01 (-0.32, 0.34)

SI: 1.02 (0.64, 1.58)

RERI: -0.06 (-1.10, 0.96)

AP: -0.02 (-0.38, 0.34)

SI: 1.02 (0.56, 1.66)