Non-linear associations of HOMA2-IR with all-cause mortality in general populations: insights from NHANES 1999–2006

Table 3 The associations of HOMA2-IR with CV mortality in study participants

HOMA2-IR	Events, n (%)	HR (95% CI), P value
HOMA2-IR	Events, n (%)	Model 1		Model2		Model3
Cardiovascular mortality All participants
Per SD	555(7.8%)	1.24(1.10–1.40)	< 0.001	1.24(1.11–1.39)	< 0.001	1.12(0.97–1.31)	0.130
Tertile 1	172(7.3%)	Ref.		Ref.		Ref.
Tertile 2	166(7.1%)	0.95(0.74–1.22)	0.691	0.98(0.76–1.26)	0.859	0.86(0.65–1.13)	0.268
Tertile 3	217(9.1%)	1.22(0.92–1.61)	0.165	1.26(0.96–1.66)	0.098	0.91(0.63–1.30)	0.598
P for trend			0.147		0.089		0.621
BMI < 25 kg/m2
Per SD	148(6.6%)	1.17(0.96–1.43)	0.128	1.18(0.96–1.45)	0.121	1.15(1.00-1.33)	0.056
Tertile 1	47(6.3%)	Ref.		Ref.		Ref.
Tertile 2	40(5.4%)	1.12(0.64–1.95)	0.702	1.12(0.61–2.05)	0.709	1.50(0.82–2.75)	0.189
Tertile 3	61(8.0%)	1.21(0.82–1.79)	0.343	1.20(0.79–1.83)	0.399	1.36(0.86–2.15)	0.195
P for trend			0.359		0.417		0.244
25 ≤ BMI < 30 kg/m2
Per SD	207(8.1%)	1.15(1.00-1.33)	0.053	1.11(0.97–1.28)	0.142	1.09(0.94–1.26)	0.252
Tertile 1	63(7.6%)	Ref.		Ref.		Ref.
Tertile 2	63(7.4%)	0.96(0.65–1.41)	0.825	0.91(0.61–1.34)	0.619	0.89(0.59–1.34)	0.573
Tertile 3	81(9.4%)	0.99(0.66–1.49)	0.977	0.95(0.64–1.41)	0.785	0.85(0.54–1.34)	0.491
P for trend			0.992		0.813		0.496
BMI ≥ 30 kg/m2
Per SD	200(8.7%)	1.25(1.02–1.53)	0.030	1.24(1.03–1.48)	0.022	1.06(0.85–1.32)	0.624
Tertile 1	74(9.8%)	Ref.		Ref.		Ref.
Tertile 2	47(6.1%)	0.66(0.41–1.06)	0.084	0.65(0.42-1.00)	0.052	0.64(0.39–1.05)	0.078
Tertile 3	79(10.3%)	1.19(0.78–1.83)	0.418	1.20(0.80–1.82)	0.379	0.86(0.53–1.42)	0.566
P for trend			0.385		0.350		0.611

Model 1 was adjusted for age, gender, race; Model 2 was adjusted for age, gender, race, smoking status, education level, family income to poverty ratio, marital status; Model 3was adjusted for age, gender, race, smoking status, education level, family income to poverty ratio, marital status, hypertension, diabetes, BMI, SBP, LDL-C, HDL-C, TG, HbA1c, eGFR

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