Table 3 Associations with moderate-to-severe course of COVID-19– results of univariable and multivariable Fine and Gray subdistribution hazard regression

Age¹

2,618

0.964

0.950–0.978

< 0.001

0.962

0.949–0.977

< 0.001

Sex

 Male

1,214

Reference

Reference

 Female

1,404

2.524

1.404–4.537

0.002

2.570

1.435–4.603

0.002

Body Mass Index

2,583

1.014

0.952–1.079

0.669

1.032

0.982–1.084

0.211

Vaccination status*

 Primary immunization

262

Reference

 Primary immunization + booster

2,361

0.819

0.457–1.468

0.502

Smoking

 No smoker

2,071

Reference

Reference

 Smoker

541

1.978

1.156–3.384

0.013

1.965

1.147–3.367

0.012

Chronic lung disease

 No

2,405

Reference

Reference

 Yes

218

2.585

1.346–4.964

0.004

2.826

1.465–5.450

0.002

Cardiovascular disease

 No

1,996

Reference

 Yes

627

0.723

0.376–1.392

0.332