Table 2 Associations with vaccination breakthroughs– results of univariable and multivariable Cox proportional hazards survival regression

Age¹

2,623

0.972

0.965–0.979

< 0.001

0.974

0.966–0.981

< 0.001

Sex

 Male

1,215

Reference

Reference

 Female

1,408

1.260

0.995–1.549

0.055

1.231

0.970–1.561

0.087

Body Mass Index

2,571

0.995

0.971–1.020

0.699

1.015

0.991–1.040

0.214

Vaccination status*

 Primary immunization

262

Reference

Reference

 Primary immunization + booster

2,361

0.483

0.356–0.652

< 0.001

0.613

0.451–0.832

0.002

Smoking

 No smoker

2,074

Reference

 Smoker

543

1.154

0.876–1.519

0.309

Chronic lung disease

 No

2,405

Reference

 Yes

218

0.730

0.453–1.177

0.197

Cardiovascular disease

 No

1,996

Reference

 Yes

627

0.636

0.467–0.864

0.004

Immunodeficiency

 No

2,554

Reference

 Yes

69

1.030

0.510–2.080

0.934

Cancer

 No

2,559

Reference

 Yes

64

0.683

0.282–1.654

0.399