Table 2 Data collected from CUC study

Electronic questionnaire

 Demographics and socio-economic status

Sex, ethnic group, date of birth, national ID number, contact information, height, weight, tablets use, household income, household population

 Address information

Home address before college, high / junior high/primary school name and address^a, home address at birth day^a

 Smoking

Current/past smoker, starting age smoking, number of cigarettes, passive smoking exposure

 Alcohol consumption

Drinking status, types of drink, frequency of drinking

 Home cooking

Cooking oil type, cooking fuel type, ventilation method during cooking, cooking method

 Diet

Frequency of three meals a day^b, staple food type, different foods consumed type, diet taste

 Water and other beverages

Daily water intake, drinking water type, drinking water temperature, favorite beverage type, drinking other beverages frequency

 Refrigeration

Whether to install cooling equipment^b, whether use of air-conditioning^b, air conditioner setting temperature^b

 Heating

Heating type^b

 Outdoor

Average daily outdoor stay time

 Physical activity

Whether to exercise in the past three months

 Sleep

Pittsburgh sleep quality index (PSQI)

 Disease history and family history

  Ophthalmology diseases

Conjunctivitis, iritis, nearsightedness, farsightedness, other ophthalmology diseases

  Respiratory diseases

Allergic rhinitis, asthma, chronic bronchitis, pneumonia, emphysema, tuberculosis, other respiratory diseases

  Digestive system diseases

Gastrointestinal disease, liver disease, gallbladder disease, pancreatic disease, other digestive system diseases

  Oral disease

Mouth ulcers, bleeding gums, caries, periodontitis, other oral disease.

  Genitourinary system diseases

Nephritis, kidney stones, cystitis, gout, polycystic ovary, other genitourinary system diseases

  Cardiovascular diseases

Hypertension, heart disease, hyperlipidemia, other cardiovascular diseases

  Endocrine system diseases

Diabetes, thyroid disease, hashimoto’s thyroiditis, other endocrine system diseases

  Mental diseases

Depression, anxiety, mania, schizophrenia, obsessive compulsive disorder, suicidal tendency, other mental diseases

  Skin diseases

Eczema, dermatitis, vitiligo, psoriasis, systemic lupus erythematosus, other skin system diseases

  Tumor

Leukemia, lung cancer, liver cancer, stomach cancer, osteosarcoma, other tumor

  Nervous system disease

Nervous headache, dizziness, epilepsy, other nervous system disease

  History of other diseases

 Treatment situation

Whether the above disease has been treated, hospitalization in the past three years, injuries and diagnosis and treatment in the past two weeks

 Menstruation (for women)

Age of menarche, Menstrual cycle, menstrual duration, menstrual volume, dysmenorrhea, whether the menstrual cycle regular^c, psychological feelings before and during menstruation^c, Physical sensation before and during menstruation^c

 psychological conditions

7-item generalized anxiety disorder (GAD-7), patient health questionnaire depression (PHQ-9)

 Takeout^c

Frequency of takeout, favorite type of takeaway cooking, favorite type of takeaway food, takeaway lunch box

Medical examination

 Lung function

Slow vital capacity, forced vital capacity, maximum voluntary ventilation

 Fasting blood

Heavy metal, Metabolomics

Exposure characterization

 Daily air pollution data

Sulfur dioxide, nitrogen dioxide, nitric oxide, particles with an aerodynamic diameter of 10 μm or less (PM₁₀), particles with an aerodynamic diameter of 2.5 μm or less (PM_2.5), ozone (China National Environmental Monitoring Centre)

 10*10km daily average air pollution data

PM_2.5, ozone (Tracking Air Pollution in China)

 Daily meteorological data

Air pressure, air temperature, relative humidity, wind direction and wind speed (National Meteorological Information Centre)

 Residential greenness

Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI)