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Table 2 Laboratory findings for the 4 groups of patients upon admission to the hospital

From: Immune Dysregulation in SARS-CoV-2 patients coinfected with Mycobacterium tuberculosis (Mtb) or HIV in China

 

Delta group

(n = 103)

Mtb group

(n = 52)

HIV group

(n = 11)

Omicron variant (n = 384)

P1-value

P2-value

P3-value

P4-value

White blood cell, × 109/L

4.98 (4.00-6.21)

4.10 (3.20–5.40)

3.57 (2.58–5.46)

4.91 (4.06–6.22)

0.017

0.023

0.336

0.935

 < 4

25 (24%)

25 (48%)

6 (55%)

87 (23%)

0.0028

0.074

0.750

0.729

 4–10

76 (74%)

26 (50%)

5 (45%)

293 (76%)

··

··

··

··

 > 10

2 (2%)

1 (2%)

0

4 (1%)

··

··

··

··

Neutrophil, × 109/L

2.72 (2.05–3.91)

2.5 (1.6–3.1)

1.99 (1.31–2.79)

2.43 (1.82–4.33)

0.181

0.055

0.25

0.011

Lymphocyte, × 109/L

1.54 (1.23–2.10)

1.26 (0.83–1.58)

1.15 (0.78–1.67)

1.89 (1.49–2.41)

0.001

0.113

0.89

< 0.0001

 <1.0

15 (15%)

17 (33%)

5 (45%)

15 (15%)

0.0085

0.032

0.647

0.001

Eosinophil, × 109/L

0.08 (0.03–0.14)

0.065 (0.02–0.15)

0.07 (0.03–0.17)

205 (173-241.5)

0.658

0.007

0.018

< 0.0001

Platelet, × 109/L

164 (119–204)

144.5 (107.5-197.8)

155 (91–165)

175 (144–193)

0.549

0.484

0.718

< 0.0001

 < 100

13 (13%)

9 (17%)

3 (27%)

19 (6%)

0.89

0.94

0.732

0

 ≥ 100

91 (87%)

43 (83%)

7 (64%)

315 (94%)

··

··

··

··

Haemoglobin, g/L

128 (119–146)

121 (94–143)

128 (107–140)

143 (131–159)

0.315

0.736

0.846

0.018

Prothrombin time, s

11.8 (11.4–12.4)

11.8 (11.4–12.8)

11.8 (11.3–11.8)

11.7 (10.9–12.5)

0.528

0.488

0.32

0.0003

D-dimer, mg/L

0.33 (0.19–0.60)

0.3 (0.2–0.8)

0.60 (0.23–1.15)

0.04 (0.02–0.09)

0.538

0.695

0.945

0

 ≥ 1.0

10 (10%)

9 (17%)

3 (27%)

2 (0.5%)

0.76

0.72

0.732

0.91

Alanine aminotransferase, U/L

17 (12–29)

17 (11-24.5)

17 (12–54)

17 (12–26)

0.513

0.436

0.683

0

Aspartate aminotransferase, U/L

23 (17–30)

26.5 (20.0-45.5)

20 (15–36)

24 (21–30)

0.013

0.998

0.066

0

Albumin, g/L

42.68 (40.16–45.60)

40.5 (35.3–43.9)

42.4 (38.6–45.3)

43 (41.1–45.1)

0.001

0.932

0.114

0.699

Total Bilirubin, µmol/L

11.2 (8.48–15.03)

9.2 (6.35–11.28)

8.6 (5.2–11.8)

8.5 (6.0-12.4)

0.594

0.580

0.798

0.018

Blood urea nitrogen, µmol/L

4.44 (3.82–5.21)

4.9 (4.2–6.4)

5.30 (4.88–6.14)

3.9 (3.5–4.3)

0.252

0.516

0.970

0.203

Creatinine, µmol/L

59.5 (49-71.5)

61.0 (52.0-72.3)

71 (49–80)

69 (62–78)

0.138

0.126

0.48

0

 ≥ 133

2 (2%)

3 (6%)

2 (18%)

58 (15%)

0.59

0.13

0.207

0

Creatinine kinase, U/L

61.5 (38.7–91.7)

37.5 (24.2–76.5)

47.5 (25.6-120.6)

86 (63–116)

0.277

0.948

0.488

0.044

Lactate dehydrogenase, U/L

200 (173–243)

224 (175–269)

213 (165–271)

158 (140–180)

0.026

0.872

0.317

< 0.0001

 ≥ 250

25 (24%)

17 (33%)

3 (27%)

8 (2%)

0.031

0.90

1.0

0

C-reactive protein, mg/L

3.9 (1.5–18.5)

10.9 (3.3–29.8)

1.55 (0.85–2.53)

1.57 (0.14–4.20)

0.204

0.624

0.258

< 0.0001

 > 10

36 (35%)

24 (46%)

0

28 (7%)

0.27

0.83

0.11

0

NLR

1.73 (1.26–2.63)

2.04 (1.38–3.40)

1.49 (1.08–2.55)

1.31 (0.91–1.81)

0.842

0.457

0.417

< 0.0001

PLR

99.4 (72.66-135.21)

118.89 (80.2-192.96)

139.53 (62.60-178.41)

106.53 (83.22-143.87)

0.690

0.974

0.814

0

Pneumonia

63 (61%)

38 (73%)

11 (100%)

116 (30%)

0.14

0.033

0.17

0

Bilateral involvement of chest radiographs

66 (50%)

32 (62%)

7 (64%)

51 (13%)

0.22

0.43

1.0

0

  1. P1-value comparing the delta group and TB group, P2-value comparing the delta group and HIV group and P3-value comparing Mtb group and HIV group are from χ², or ANOVA. P4-value comparing the delta group and omicron group is from χ², Fisher’s exact test, or Mann-Whitney U test. NLR, neutrophil-lymphocyte ratio; PLR, planet-lymphocyte ratio