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Table 4 Mediation and suppression effects of metabolic traits on the associations of fish and meat consumption with NAFLD

From: Association of fish and meat consumption with non-alcoholic fatty liver disease: Guangzhou Biobank Cohort Study

Mediator or suppressor

Coefficients (95% CI) for indirect effect

Fatty fish

Other fish

Aquatic and sea food

Red meat

Poultry

Processed meat

BMI, kg/m2

0.025 (-0.077, 0.127)

-0.045 (-0.121, 0.031)

0.050 (-0.066, 0.166)

-0.031 (-0.096, 0.034)

0.034 (-0.049, 0.117)

0.158 (0.029, 0.287) *

WC, cm

0.001 (-0.115, 0.116)

-0.009 (-0.084, 0.065)

0.049 (-0.088, 0.185)

-0.052 (-0.136, 0.032)

0.047 (-0.050, 0.143)

0.203 (0.058, 0.348) **

Log-FPG, mmol/L

0.019 (-0.011, 0.048)

-0.009 (-0.029, 0.012)

0.001 (-0.035, 0.037)

-0.010 (-0.032, 0.012)

0.002 (-0.021, 0.025)

0.054 (0.017, 0.091) **

SBP, mmHg

0.022 (-0.004, 0.047)

0.007 (-0.012, 0.026)

-0.049 (-0.077, -0.020) **

-0.032 (-0.052, -0.013) **

-0.008 (-0.031, 0.014)

0.021 (-0.011, 0.052)

DBP, mmHg

0.029 (-0.003, 0.061)

0.005 (-0.014, 0.024)

-0.013 (-0.043, 0.017)

-0.016 (-0.038, 0.007)

-0.003 (-0.031, 0.025)

0.032 (-0.009, 0.073)

Log-TG, mmol/L

-0.007 (-0.054, 0.040)

0.006 (-0.027, 0.040)

-0.019 (-0.074, 0.035)

-0.022 (-0.054, 0.009)

0.018 (-0.019, 0.055)

0.068 (0.005, 0.131) *

TC, mmol/L

0.001 (-0.003, 0.003)

0.001 (-0.003, 0.003)

0.001 (-0.008, 0.009)

-0.001 (-0.003, 0.002)

-0.001 (-0.003, 0.003)

0.002 (-0.010, 0.013)

HDL-C, mmol/L

-0.029 (-0.070, 0.012)

-0.009 (-0.038, 0.021)

-0.060 (-0.108, -0.012) *

0.001 (-0.027, 0.027)

0.004 (-0.028, 0.035)

0.007 (-0.036, 0.050)

LDL-C, mmol/L

0.002 (-0.00, 0.006)

-0.001 (-0.003, 0.003)

0.002 (-0.004, 0.009)

-0.001 (-0.003, 0.003)

-0.002 (-0.007, 0.003)

-0.001 (-0.005, 0.005)

  1. NAFLD, non-alcoholic fatty liver disease; BMI, body mass index; WC, waist circumference; Log-FPG, log-transformed fasting plasma glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure; Log-TG, log-transformed triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. *, P < 0.05. **, P < 0.01