Cost-utility and budget impact analyses of cervical cancer screening using self-collected samples for HPV DNA testing in Thailand

Table 3 Costs

Costs	Values	Ranges	References
Direct medical costs (THB per visit)
Self-collected sample kit for HPV DNA testing (included PCR)	280	100, 1000	Roche
Pelvic examination	104	100, 149	HITAP, 2009 [30]
Cytology test (Pap smear)	143	115, 171	HITAP, 2009 [30]
Clinician-sampling for HPV DNA testing	104	100, 149	Assumption
PCR-based HPV DNA detection	280	100, 1000	Roche
Colposcopy	373	356, 1000	HITAP, 2009 [30]
Pathology test	224	180, 267	HITAP, 2009 [30]
Disease management costs (THB per year)
CIN1	38 258	*	Siriraj Hospital database
CIN2	40 581	*	Siriraj Hospital database
CIN3	46 637	*	Siriraj Hospital database
Stage 1	91 604	*	Siriraj Hospital database
Stage 2	106 310	*	Siriraj Hospital database
Stage 3	132 847	*	Siriraj Hospital database
Stage 4	191 628	*	Siriraj Hospital database
Direct non-medical costs (THB per visit)
Travel to primary care	59	52, 67	HITAP, 2009 [30]
Travel to hospital	158	133, 183	HITAP, 2009 [30]
Postal service fee	37	20, 100	Thai Postal Service
Food	58	47, 70	HITAP, 2009 [30]

^*Management costs varied using measures of variability, including standard error, 5th percentile, and 95th percentile of the costs per visit. Details are provided in Supplementary Appendix 2
CIN, cervical intraepithelial neoplasia; HPV DNA, human papillomavirus deoxyribonucleic acid; PCR, polymerase chain reaction; THB, Thai baht

ISSN: 1471-2458