Table 2 Characteristics of input parameters representing between dose correlation
Variable | Definition | Value(s) | Distribution | Assumption |
|---|---|---|---|---|
cor(0,1) | Correlation between ‘dose zero’ and dose one | 1 | Fixed | Most commonly the administration of 1st dose of MCV |
cor(1,2) | Correlation between first dose and second dose | -1 to 1 | Uniform | Following administration of the 1st dose of MCV, subsequent doses are delivered as per the routine immunisation schedule or SIAs. Therefore, correlation parameter values are sampled randomly from a uniform distribution to reflect various real-life settings |
cor(2,3) | Correlation between first two doses and third dose | -1 to 1 | Uniform | |
cor(3,4) | Correlation between first three doses and fourth dose | -1 to 1 | Uniform | |
cor(k-1,k), k > 5 | Correlation between first k-1 doses and kth dose | -1 | Fixed | We assume that individuals are unlikely to receive subsequent doses should they have already received 4 doses (perfect negative BdC) |