Table 3 Univariable and Multivariable Generalized linear mixed Models Assessing PrEP Interruptions* (N = 280 participants reporting on 828 study visits)

Annual income

828

Less than 30,000

199

(27.6)

35

(32.4)

30,000 to 59,999

264

(36.7)

34

(31.5)

0.70

0.31

1.57

0.383

60,000 or higher

257

(35.7)

39

(36.1)

0.92

0.38

2.19

0.841

Ethnicity

828

Canadian

318

(44.2)

49

(45.4)

Aboriginal

7

(1.0)

1

(0.9)

0.95

0.02

56.35

0.978

European

173

(24.0)

24

(22.2)

0.69

0.26

1.86

0.461

Asian

146

(20.3)

17

(15.7)

0.60

0.21

1.75

0.352

African/Caribbean/Black

8

(1.1)

NA

Mixed Race

16

(2.2)

5

(4.6)

2.28

0.20

26.48

0.509

Another ethnicity

52

(7.2)

12

(11.1)

2.06

0.53

8.04

0.298

Sexual identity

828

Gay

608

(84.4)

91

(84.3)

Bisexual

26

(3.6)

2

(1.9)

0.64

0.08

5.09

0.676

Another sexual identity

86

(11.9)

15

(13.9)

0.83

0.31

2.25

0.718

Gender identity

828

Cisgender

675

(93.8)

101

(93.5)

Another gender identity

45

(6.3)

7

(6.5)

0.98

0.25

3.80

0.975

Highest level of education

828

High school or less

49

(6.8)

7

(6.5)

Greater than high school

671

(93.2)

101

(93.5)

0.77

0.19

3.09

0.707

Current employment

828

No

130

(18.1)

21

(19.4)

Yes

590

(81.9)

87

(80.6)

0.82

0.37

1.84

0.629

Current relationship with a main partner

828

No

408

(56.7)

49

(45.4)

Yes

312

(43.3)

59

(54.6)

2.13

1.12

4.05

0.021

3.58

1.62

7.92

0.002

Time period

828

Before COVID (MAR 2018 to MAR 16 2020)

559

(77.6)

48

(44.4)

After COVID (SEP 2020 to APR 2021)

161

(22.4)

60

(55.6)

9.76

4.81

19.81

< 0.001

9.25

4.06

21.1

< 0.001

Overall PrEP eligibility

822

No

129

(18.0)

41

(38.3)

Yes

586

(82.0)

66

(61.7)

0.20

0.10

0.43

< 0.001

0.25

0.11

0.60

0.002

Syndemic Conditions

HADS Anxiety

813

Normal/Mild (score 10 or less)

533

(75.5)

78

(72.9)

Moderate/Severe (score 11 to 21)

173

(24.5)

29

(27.1)

1.21

0.60

2.46

0.597

HADS Depression

810

Normal/Mild (score 10 or less)

653

(92.9)

90

(84.1)

Moderate/Severe (score 11 to 21)

50

(7.1)

17

(15.9)

4.45

1.58

12.55

0.005

4.80

1.43

16.16

0.011

Polysubstance use P6M

813

No

352

(49.9)

58

(54.2)

Yes

354

(50.1)

49

(45.8)

0.61

0.31

1.20

0.152

Not selected

Binge drinking measured by Alcohol Use AUDIT-C

820

No (Score less than 4)

320

(44.8)

50

(47.6)

Yes (Score 4 or more)

395

(55.2)

55

(52.4)

0.70

0.36

1.36

0.288

IPV experiences

826

No

475

(66.2)

88

(81.5)

Yes

243

(33.8)

20

(18.5)

0.26

0.12

0.58

0.001

0.38

0.15

0.95

0.038

Experiences growing up as a child: Sexual abuse

815

Never

550

(77.5)

88

(83.8)

Ever

160

(22.5)

17

(16.2)

0.58

0.22

1.55

0.277

Experiences growing up as a child: Touched

816

Never

453

(63.7)

75

(71.4)

Ever

258

(36.3)

30

(28.6)

0.55

0.24

1.30

0.175

Experiences growing up as a child: Threatened

812

Never

636

(90.0)

96

(91.4)

Ever

71

(10.0)

9

(8.6)

0.95

0.25

3.55

0.933

Experiences growing up as a child: Sexual things

816

Never

526

(74.0)

86

(81.9)

Ever

185

(26.0)

19

(18.1)

0.54

0.21

1.38

0.197

Continuous Variables

Total N

Median

(Q1-Q3)

Median

(Q1-Q3)

OR

95% CI

P-value

P6M Number of male sex partners

828

8

(4–15)

2

(1–5)

0.92

0.88

0.96

< 0.001

Not Selected

Treatment Optimism Scale

828

22

(20–25)

21

(18–25)

0.92

0.86

0.99

0.028

0.93

0.85

1.02

0.107

Age

828

33

(29–40)

32

(27–36)

0.98

0.94

1.01

0.182

0.94

0.89

0.98

0.009