Table 2 Syndemic scores over time from March 2018-April 2021 and Trend Analyses (N = 766 reporting on 2396 study visits)

Normal/Mild

263

301

384

405

0

220

149

1722

Moderate/Severe

101

82

141

118

0

89

50

581

Total

364

383

525

523

n/a

309

199

2303

%

27.7%

21.4%

26.9%

22.6%

n/a

28.8%

25.1%

OR

95% CI

p-value

1.03

0.94

1.12

0.572

HADS Depression

Mar 2018-Aug 2018

Sep 2018-Feb 2019

Mar 2019-Aug 2019

Sep 2019-Mar 2020

Apr 2020 – Aug 2020

Sep 2020-Feb 2021

Mar 2021-Apr 2021

Total

Normal/Mild

342

357

499

486

0

269

172

2125

Moderate/Severe

23

27

27

37

0

42

27

183

Total

365

384

526

523

n/a

311

199

2308

%

6.3%

7.0%

5.1%

7.1%

n/a

13.5%

13.6%

OR

95% CI

p-value

1.35

1.17

1.56

< 0.001

Polysubstance use in P6M

Mar 2018-Aug 2018

Sep 2018-Feb 2019

Mar 2019-Aug 2019

Sep 2019-Mar 2020

Apr 2020 – Aug 2020

Sep 2020-Feb 2021

Mar 2021-Apr 2021

Total

No

208

215

304

301

0

190

132

1350

Yes

159

176

229

225

0

123

69

981

Total

367

391

533

526

n/a

313

201

2331

%

43.3%

45.0%

43.0%

42.8%

n/a

39.3%

34.3%

OR

95% CI

p-value

0.89

0.82

0.97

0.007

High risk or Harmful Drinking measured by AUDIT-C

Mar 2018-Aug 2018

Sep 2018-Feb 2019

Mar 2019-Aug 2019

Sep 2019-Mar 2020

Apr 2020 – Aug 2020

Sep 2020-Feb 2021

Mar 2021-Apr 2021

Total

Score less than 4

166

185

276

304

0

189

132

1252

Score 4 or more

201

201

260

232

0

129

72

1095

Total

367

386

536

536

n/a

318

204

2347

%

54.8%

52.1%

48.5%

43.3%

n/a

40.6%

35.3%

OR

95% CI

p-value

0.74

0.67

0.81

< 0.001