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Table 4 Mortality risk association analysis (period 2006–2019) by sex and class of nitrogen oxides (NOx) exposure

From: Cardiorespiratory diseases in an industrialized area: a retrospective population-based cohort study

Cause (ICD-10 code)

Exposure class

MEN

WOMEN

n

HR

1-p

CI95%

N

HR

1-p

CI95%

Diseases of the circulatory system

(I00-I99)

1 (ref.)

113

   

151

   

2

334

1.18

0.835

0.94–1.48

407

1.07

0.483

0.87–1.31

3

118

1.37

0.977

1.04–1.79

160

1.27

0.956

1.01–1.60

4

11

1.35

0.654

0.72–2.54

8

0.68

0.700

0.33–1.40

Trend

 

1.40

0.919

0.96–2.05

 

0.96

0.187

0.66–1.38

Heart diseases

(I00-I52)

1 (ref.)

68

   

79

   

2

225

1.28

0.905

0.96–1.72

265

1.33

0.963

1.02–1.75

3

71

1.32

0.883

0.93–1.87

101

1.49

0.989

1.10–2.04

4

10

1.95

0.946

0.99–3.85

6

0.94

0.114

0.41–2.18

Trend

 

1.51

0.922

0.95–2.39

 

1.18

0.554

0.77–1.83

Ischemic Heart Diseases (IHD)

(I20-I25)

1 (ref.)

24

   

23

   

2

66

0.99

0.032

0.60–1.64

66

1.10

0.286

0.66–1.84

3

18

0.90

0.256

0.47–1.71

25

1.01

0.035

0.56–1.85

4

3

1.69

0.593

0.49–5.79

< 3

   

Trend

 

1.40

0.542

0.57–3.41

 

n.c.

  

Acute Myocardial Infarction (AMI)

(I21)

1 (ref.)

10

   

10

   

2

22

0.73

0.542

0.32–1.67

23

0.81

0.393

0.36–1.81

3

6

0.52

0.774

0.18–1.51

6

0.56

0.714

0.19–1.63

4

< 3

   

< 3

   

Trend

 

n.c.

   

n.c.

  

Cerebrovascular diseases

(I60-I69)

1 (ref.)

21

   

42

   

2

75

1.60

0.924

0.95–2.68

113

1.08

0.293

0.74–1.57

3

38

2.50

0.999

1.44–4.35

49

1.41

0.885

0.92–2.17

4

< 3

   

< 3

   

Trend

 

n.c.

   

n.c.

  

Disease of the respiratory system

(J00-J99)

1 (ref.)

32

   

22

   

2

78

0.93

0.238

0.60–1.46

46

0.90

0.304

0.52–1.55

3

19

0.74

0.674

0.41–1.34

16

1.01

0.033

0.52–1.99

4

< 3

   

< 3

   

Trend

 

n.c.

   

n.c.

  

Acute respiratory diseases

(J00-J06; J10-J18; J20-J22)

1 (ref.)

10

   

4

   

2

27

1.11

0.205

0.50–2.47

14

1.34

0.380

0.42–4.26

3

5

0.73

0.415

0.24–2.23

8

2.31

0.815

0.67-8.00

4

< 3

   

< 3

   

Trend

 

n.c.

   

n.c.

  

Chronic diseases of the lower respiratory tract (except asthma)

(J40-J44; J47)

1 (ref.)

9

   

11

   

2

27

1.19

0.331

0.53–2.69

12

0.51

0.843

0.20–1.30

3

7

0.92

0.134

0.33–2.55

< 3

   

4

< 3

   

< 3

   

Trend

 

n.c.

   

n.c.

  
  1. Notes –The analyses were performed in the period 2006–2019 and adjusted for age classes, proximity or not to the selected roads and socio-economic deprivation index. ICD10: International Classification of Diseases, 10th revision; n: numerosity; HR: Hazard Ratio; CI95%: Confidence Interval at 95% of probability; 1-p: strength of evidence in favour of an excess/defect of mortality risk; Trend: risk trend for 1 µg/m3 NOx increment; 1 (ref.): exposure class 1, reference (0.01–0.27 µg/m3); 2: exposure class 2 (0.27–0.49 µg/m3); exposure class 3 (0.49–1.02 µg/m3); exposure class 4 (1.02–2.47 µg/m3); n.c.: not calculated