Table 1 General characteristics of vaccinated and unvaccinated groups based on vaccination type

Zoster

All

854,745

8,490,813

Gender

Male

407,361

47.7

4,046,215

47.7

Female

447,384

52.3

4,444,598

52.3

Age

70–74

519,822

60.8

5,177,036

61.0

75–79

275,698

32.3

2,733,974

32.2

80–84

58,401

6.8

572,024

6.7

85–89

610

0.1

5,821

0.1

90 + 

214

0.03

1,958

0.02

Ethnicity

White

702,463

82.2

6,636,714

78.2

Asian

25,113

2.9

226,362

2.7

Black

10,488

1.2

116,742

1.4

Other

8,569

1.0

93,022

1.1

Unknown

108,112

12.6

1,417,973

16.7

IMD

1 (least deprived)

236,851

27.7

2,238,248

26.4

2

205,189

24.0

2,000,088

23.6

3

171,309

20.0

1,721,476

20.3

4

137,555

16.1

1,412,409

16.6

5 (most deprived)

103,292

12.1

1,112,569

13.1

Unknown

549

0.1

6,023

0.1

Baseline comorbidities:

Any malignancy

193,171

22.6

1,905,820

22.4

1.01 (1.00, 1.01)

Cerebrovascular disease

85,038

9.9

858,129

10.1

0.98 (0.98, 0.99)

Chronic pulmonary disease

171,459

20.1

1,587,020

18.7

1.07 (1.07, 1.08)

Congestive heart failure

44,400

5.2

454,834

5.4

0.97 (0.96, 0.98)

Diabetes with chronic complications

103,028

12.1

909,926

10.7

1.12 (1.12, 1.13)

Diabetes without chronic complications

161,741

18.9

1,443,053

17.0

1.11 (1.11, 1.12)

AIDS/HIV

194

0.02

4,855

0.1

0.40 (0.34, 0.46)

Hemiplegia or paraplegia

8,184

1.0

105,649

1.2

0.77 (0.75, 0.79)

Metastatic solid tumour

14,187

1.7

195,887

2.3

0.72 (0.71, 0.73)

Mild liver disease

14,457

1.7

160,340

1.9

0.90 (0.88, 0.91)

Moderate or severe liver disease

5,505

0.6

65,993

0.8

0.83 (0.81, 0.85)

Myocardial infarction

61,399

7.2

588,844

6.9

1.03 (1.03, 1.04)

Peptic ulcer disease

59,548

7.0

571,816

6.7

1.03 (1.02, 1.04)

Peripheral vascular disease

50,170

5.9

502,301

5.9

0.99 (0.98, 1.00)

Renal disease

143,735

16.8

1,371,452

16.2

1.04 (1.03, 1.05)

Rheumatic disease

55,879

6.5

653,749

7.7

0.85 (0.84, 0.86)

Antiviral treatment history (at baseline)

90,344

10.6

845,499

10.0

1.06 (1.05, 1.07)

Influenza

All

742,487

7,219,770

Gender

Male

344,460

46.4

3,351,283

46.4

Female

398,027

53.6

3,868,487

53.6

Age

70–74

307,303

41.4

3,071,413

42.5

75–79

201,955

27.2

1,992,571

27.6

80–84

130,963

17.6

1,271,165

17.6

85–89

68,996

9.3

640,653

8.9

90 + 

33,270

4.5

243,968

3.4

Ethnicity

White

607,439

81.8

5,468,741

75.7

Asian

21,003

2.8

167,049

2.3

Black

9,630

1.3

106,665

1.5

Other

7,763

1.0

75,869

1.1

Unknown

96,652

13.0

1,401,446

19.4

IMD

1 (least deprived)

199,952

26.9

1,877,787

26.0

2

172,867

23.3

1,664,335

23.1

3

149,466

20.1

1,460,983

20.2

4

122,125

16.4

1,204,077

16.7

5 (most deprived)

97,481

13.1

1,005,699

13.9

Unknown

596

0.1

6,889

0.1

Baseline comorbidities:

Any malignancy

201,889

27.2

1,730,019

24.0

1.13 (1.12, 1.13)

Cerebrovascular disease

98,482

13.3

880,249

12.2

1.07 (1.06, 1.08)

Chronic pulmonary disease

154,449

20.8

1,254,053

17.4

1.19 (1.19, 1.20)

Congestive heart failure

57,757

7.8

485,843

6.7

1.13 (1.12, 1.14)

Diabetes with chronic complications

91,204

12.3

742,247

10.3

1.19 (1.18, 1.20)

Diabetes without chronic complications

141,673

19.1

1,176,490

16.3

1.17 (1.16, 1.17)

AIDS/HIV

277

0.04

2,564

0.04

1.06 (0.93, 1.19)

Hemiplegia or paraplegia

10,097

1.4

101,623

1.4

0.95 (0.93, 0.97)

Metastatic solid tumour

17,522

2.4

160,371

2.2

1.06 (1.05, 1.08)

Mild liver disease

15,922

2.1

142,440

2.0

1.09 (1.07, 1.11)

Moderate or severe liver disease

5,612

0.8

49,966

0.7

1.10 (1.07, 1.13)

Myocardial infarction

61,985

8.3

522,655

7.2

1.14 (1.13, 1.15)

Peptic ulcer disease

55,733

7.5

487,815

6.8

1.10 (1.09, 1.11)

Peripheral vascular disease

52,918

7.1

457,310

6.3

1.11 (1.10, 1.12)

Renal disease

163,397

22.0

1,396,081

19.3

1.12 (1.11, 1.12)

Rheumatic disease

63,273

8.5

540,088

7.5

1.13 (1.12, 1.14)

Antiviral history (at baseline)

81,419

11.0

716,244

9.9

1.10 (1.10, 1.11)