Association between metabolic healthy obesity and female infertility: the national health and nutrition examination survey, 2013–2020

Table 3 Risk of infertility for BMI and WC among metabolic healthy and unhealthy group

Metabolic health obesity phenotypes	n/N	Model 1		Model 2		Model 3
Metabolic health obesity phenotypes	n/N	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Body Mass Index (kg/m²) categories
Per 1 unit		1.05(1.02,1.09)	< 0.001	1.05(1.02,1.08)	0.004	1.06(1.02,1.09)	0.004
MHN	25/220	1.00(Reference)	-	1.00(Reference)	-	1.00(Reference)	-
MHOW	19/252	0.73(0.31,1.73)	0.469	0.61(0.25,1.47)	0.263	0.67(0.28,1.64)	0.373
MHO	70/433	1.86(0.97,3.58)	0.063	1.65(0.83,3.28)	0.152	1.75(0.88,3.50)	0.109
P for trend			0.034		0.067		0.053
Per 1 unit		1.04(1.02,1.06)	< 0.001	1.03(1.01,1.05)	0.002	1.04(1.01,1.06)	0.002
MUN	90/928	1.00(Reference)	-	1.00(Reference)	-	1.00(Reference)
MUOW	61/632	1.08(0.73,1.61)	0.684	1.04(0.70,1.54)	0.837	1.01(0.68,1.51)	0.950
MUO	164/1077	1.96(1.32,2.90)	0.001	1.74(1.16,2.63)	0.009	1.85(1.15,2.97)	0.012
P for trend			0.002		0.01		0.012
WC (cm) categories
Per 1 unit		1.03(1.01,1.04)	0.001	1.03(1.01,1.04)	0.001	1.03(1.01,1.04)	0.007
MHLW	11/131	1.00(Reference)	-	1.00(Reference)	-	1.00(Reference)	-
MHMW	15/143	1.74(0.75,4.03)	0.190	1.43(0.65,3.19)	0.368	1.40(0.63,3.13)	0.398
MHO	88/631	2.55(1.35,4.84)	0.005	1.98(1.00,3.92)	0.049	2.01(1.03,3.95)	0.042
P for trend			0.006		0.063		0.05
Per 1 unit		1.02(1.01,1.03)	< 0.001	1.02(1.01,1.03)	< 0.001	1.02(1.01,1.03)	< 0.001
MULW	42/549	1.00(Reference)	-	1.00(Reference)	-	1.00(Reference)
MUMW	48/494	1.73(0.95,3.15)	0.075	1.54(0.85,2.80)	0.153	1.50(0.84,2.68)	0.167
MUO	225/1594	2.78(1.79,4.32)	< 0.001	2.31(1.45,3.67)	< 0.001	2.24(1.36,3.70)	0.002
P for trend			< 0.001		< 0.001		0.002

Abbreviations: BMI, body mass index; WC, waist circumstance; OR, odds ratio; CI, confidence interval; MHN, metabolic healthy normal weight; MHOW, metabolic healthy overweight; MHO, metabolic healthy obesity; MUN, metabolic unhealthy normal weight; MUOW, metabolic unhealthy overweight; MUO, metabolic unhealthy obesity.
Note: Model 1: Adjusted for nothing.
Model 2: Adjusted for baseline age.
Model 3: Adjusted for model 2 plus race, marital status, poverty income ratio, drinking status, smoking status, education level, pregnant history, physical activity.

ISSN: 1471-2458