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Table 2 Associations between intake of flavonoid levels and serum uric acid, NHANES (2007–2010)

From: Association between dietary intake of flavonoids and hyperuricemia: a cross-sectional study

Variable

Serum Uric Acid β (95% CI)

Categorical variable

Continuous variable

Q1

Q2

Q3

Q4

Q5

p-trend

Ln-transformed

p-value

Isoflavones

 Model 1

Referent

/

-0.23(-0.39, -0.07)

-0.04(-0.12, 0.04)

-0.08(-0.18, 0.02)

0.05

-0.08(-0.13, -0.04)

 < 0.01

 Model 2

Referent

/

-0.24(-0.39, -0.10)

-0.06(-0.13, 0.00)

-0.09(-0.17, -0.01)

 < 0.01

-0.05(-0.10, -0.01)

0.03

 Model 3

Referent

/

-0.15(-0.30, 0.00)

-0.04(-0.11, 0.04)

-0.04(-0.13, 0.06)

0.10

-0.04(-0.08, 0.00)

0.08

Anthocyanidins

 Model 1

Referent

-0.23(-0.41, -0.04)

-0.20(-0.31, -0.09)

-0.21(-0.33, -0.09)

-0.32(-0.42, -0.22)

 < 0.001

-0.07(-0.09, -0.04)

 < 0.001

 Model 2

Referent

-0.23(-0.39, -0.08)

-0.15(-0.25, -0.05)

-0.18(-0.30, -0.07)

-0.23(-0.33, -0.13)

 < 0.001

-0.03(-0.06, -0.01)

0.01

 Model 3

Referent

-0.20(-0.34, -0.06)

-0.12(-0.22, -0.02)

-0.13(-0.25, -0.02)

-0.14(-0.24, -0.04)

 < 0.001

-0.03(-0.05, 0.00)

0.04

Flavan-3-ols

 Model 1

Referent

-0.02(-0.18,0.13)

-0.03(-0.16,0.09)

-0.12(-0.27,0.03)

0.01(-0.14,0.16)

0.71

0.00(-0.02,0.02)

0.88

 Model 2

Referent

-0.12(-0.26, 0.01)

-0.12(-0.23, 0.00)

-0.23(-0.37, -0.08)

-0.08(-0.20, 0.05)

0.07

0.00(-0.02, 0.01)

0.77

 Model 3

Referent

-0.08(-0.21, 0.06)

-0.05(-0.16, 0.07)

-0.12(-0.26, 0.01)

0.00(-0.11, 0.11)

0.81

0.00(-0.01, 0.02)

0.57

Flavanones

 Model 1

Referent

-0.22(-0.39, -0.04)

-0.09(-0.23, 0.04)

-0.13(-0.23, -0.03)

-0.20(-0.30, -0.10)

 < 0.001

-0.04(-0.06, -0.02)

 < 0.01

 Model 2

Referent

-0.01(-0.20, 0.18)

-0.03(-0.14, 0.09)

-0.07(-0.17, 0.03)

-0.19(-0.28, -0.10)

 < 0.001

-0.04(-0.05, -0.02)

 < 0.001

 Model 3

Referent

-0.05(-0.23, 0.14)

-0.01(-0.13, 0.10)

-0.04(-0.14, 0.06)

-0.14(-0.23, -0.04)

0.02

-0.03(-0.05, -0.01)

 < 0.01

Flavones

 Model 1

Referent

0.00(-0.09, 0.08)

-0.06(-0.16, 0.03)

-0.10(-0.19, -0.01)

0.09(-0.03, 0.21)

0.40

0.05(-0.03,0.14)

0.22

 Model 2

Referent

0.03(-0.06, 0.13)

-0.03(-0.13, 0.08)

-0.07(-0.16, 0.03)

0.01(-0.10, 0.12)

0.44

-0.03(-0.10, 0.05)

0.48

 Model 3

Referent

0.06(-0.04, 0.16)

0.01(-0.11, 0.13)

-0.01(-0.10, 0.08)

0.06(-0.05, 0.16)

0.74

0.00(-0.07, 0.07)

0.97

Flavonols

 Model 1

Referent

-0.01(-0.14,0.11)

0.04(-0.08,0.16)

0.22(0.12,0.32)

0.24(0.12,0.37)

 < 0.001

0.10(0.06,0.14)

 < 0.001

 Model 2

Referent

-0.05(-0.15, 0.04)

-0.04(-0.14, 0.06)

0.06(-0.01, 0.14)

0.03(-0.06, 0.12)

0.02

0.02(-0.01, 0.05)

0.21

 Model 3

Referent

-0.02(-0.11, 0.07)

0.00(-0.10, 0.09)

0.12(0.04, 0.19)

0.07(-0.01, 0.16)

 < 0.01

0.04(0.01, 0.07)

0.03

All of flavonoids

 Model 1

Referent

0.09(-0.05,0.22)

-0.03(-0.15,0.10)

-0.07(-0.16,0.03)

0.05(-0.09,0.19)

0.75

0.00(-0.02,0.03)

0.87

 Model 2

Referent

-0.06(-0.16, 0.04)

-0.11(-0.22, 0.00)

-0.21(-0.32, -0.11)

-0.07(-0.18, 0.04)

0.03

-0.01(-0.03,0.01)

0.29

 Model 3

Referent

-0.01(-0.10, 0.08)

-0.05(-0.16, 0.05)

-0.11(-0.20, -0.02)

0.01(-0.08, 0.10)

0.51

0.00(-0.02, 0.02)

0.93

  1. The dietary intake of flavonoids was categorized into five quintiles and tests for trend (p–trend) based on variable containing the median value for each quintile. ln-transformed flavonoid also was utilized as continuous variables and p-value was used to test significance. Bold indicated statistically significant
  2. Model 1 was a crude model with no adjusted covariates; Model 2 was adjusted for sex, age, race/ethnicity, poverty status, education, smoking status, alcohol consumption, and BMI; Model 3 was further adjusted for hyperlipidemia, CKD, DM, and hypertension based on Model 2