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Table 3 ORs and 95% CIs for pregnancy complications with the categories of maternal platelet count and tHcy level

From: Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications

 

GDM

ICP

PE

PIH

OR (95%CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

OR (95%CI)

P value

Unadjusted model

 Platelet count (109/L)

  Q1 (< 164)

Ref

 

Ref

 

Ref

 

Ref

 

  Q2 (164–198)

0.77 (0.65, 0.92)

0.004

0.61 (0.50, 0.75)

 < 0.001

0.71 (0.54, 0.95)

0.019

0.78 (0.54, 1.14)

0.203

  Q3 (199–236)

0.69 (0.57, 0.83)

 < 0.001

0.60 (0.49, 0.74)

 < 0.001

0.63 (0.47, 0.84)

0.002

0.84 (0.59, 1.22)

0.365

  Q4 (> 236)

0.59 (0.49, 0.71)

 < 0.001

0.49 (0.40, 0.61)

 < 0.001

0.84 (0.65, 1.11)

0.219

1.09 (0.77, 1.54)

0.618

 P for trend

 

 < 0.001

 

 < 0.001

 

0.225

 

0.442

 tHcy level (μmol/L)

  Q1 (< 7.07)

Ref

 

Ref

 

Ref

 

Ref

 

  Q2 (7.07–8.10)

1.08 (0.90, 1.30)

0.413

1.46 (1.15, 1.87)

0.002

1.46 (1.05, 2.04)

0.025

1.32 (0.90, 1.95)

0.153

  Q3 (8.11–9.38)

1.10 (0.92, 1.32)

0.309

1.48 (1.17, 1.89)

0.001

1.78 (1.29, 2.46)

 < 0.001

1.44 (0.99, 2.11)

0.057

  Q4 (> 9.38)

0.84 (0.69, 1.02)

0.072

2.29 (1.83, 2.86)

 < 0.001

2.50 (1.84, 3.39)

 < 0.001

1.66 (1.14, 2.40)

0.008

 P for trend

 

0.067

 

 < 0.001

 

 < 0.001

 

0.008

  tHcy ≤ 15

Ref

 

Ref

 

Ref

 

Ref

 

  tHcy > 15

0.26 (0.10, 0.71)

0.008

2.10 (1.35, 3.29)

0.001

4.26 (2.76, 6.60)

 < 0.001

1.04 (0.38, 2.84)

0.932

Adjusted model

 Platelet count (109/L)a

  Q1 (< 164)

Ref

 

Ref

 

Ref

 

Ref

 

  Q2 (164–198)

0.85 (0.71, 1.03)

0.098

0.76 (0.61, 0.95)

0.016

0.81 (0.59, 1.10)

0.179

0.72 (0.49, 1.07)

0.103

  Q3 (199–236)

0.85 (0.70, 1.04)

0.118

0.84 (0.67, 1.05)

0.122

0.72 (0.52, 0.99)

0.046

0.75 (0.51, 1.10)

0.142

  Q4 (> 236)

0.76 (0.62, 0.94)

0.012

0.68 (0.53, 0.87)

0.002

0.92 (0.67, 1.27)

0.614

0.87 (0.60, 1.28)

0.483

 P for trend

 

0.016

 

0.005

 

0.608

 

0.663

 tHcy level (μmol/L)b

  Q1 (< 7.07)

Ref

 

Ref

 

Ref

 

Ref

 

  Q2 (7.07–8.10)

1.16 (0.95, 1.41)

0.139

1.34 (1.04, 1.73)

0.023

1.50 (1.06, 2.14)

0.023

1.42 (0.95, 2.12)

0.090

  Q3 (8.11–9.38)

1.33 (1.09, 1.61)

0.005

1.34 (1.03, 1.73)

0.027

1.90 (1.34, 2.68)

 < 0.001

1.57 (1.05, 2.35)

0.028

  Q4 (> 9.38)

1.22 (0.98, 1.52)

0.074

1.90 (1.48, 2.45)

 < 0.001

2.76 (1.95, 3.90)

 < 0.001

1.98 (1.31, 2.99)

0.001

 P for trend

 

0.040

   

 < 0.001

 

0.001

  ≤ 15 μmol/L

Ref

 

Ref

 

Ref

 

Ref

 

  > 15 μmol/L

0.32 (0.10, 1.01)

0.053

1.69 (1.03, 2.78)

0.038

5.09 (3.05, 8.47)

 < 0.001

1.20 (0.42, 3.42)

0.734

  1. Adjusted for age, gravidity, parity, BMI, assisted reproduction, neonatal sex, RBC and WBC count, hs-CRP, total bilirubin, direct bilirubin, ALT, AST, urea nitrogen, creatinine, HDL-C, LDL-C, total cholesterol, triglyceride, vitamin B12, folic acid and TBA levels
  2. Abbreviations: GDM Gestational diabetes mellitus, ICP Intrahepatic cholestasis of pregnancy, PE Pre-eclampsia, PIH Pregnancy induced hypertension, OR Odds ratio, CI Confidence interval, Q Quartile, BMI Body mass index, RBC Red blood cell, WBC White blood cell, TBA Total bile acid, hs-CRP High sensitive C-reactive protein, ALT Alanine aminotransferase, AST Aspartate aminotransferase, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, tHcy total homocysteine
  3. aadditionally adjusted for tHcy level
  4. badditionally adjusted for platelet count
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BMC Public Health

ISSN: 1471-2458

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