Table 1 The characteristics of study population by the quartiles of maternal platelet count (n = 11,553)
From: Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications
| Â | Quartiles of platelet count (109/L) | P value | |||
|---|---|---|---|---|---|
Q1 (< 164, n = 2825) | Q2 (164–198, n = 2931) | Q3 (199–236, n = 2904) | Q4 (> 236, n = 2893) | ||
Maternal characteristics | |||||
 Age (years) | 29.1 ± 4.4 | 28.7 ± 4.4 | 28.4 ± 4.3 | 28.1 ± 4.5 | < 0.001 |
  < 35 | 2439 (86.3%) | 2586 (88.2%) | 2600 (89.5%) | 2605 (90.0%) | < 0.001 |
   ≥ 35 | 386 (13.7%) | 345 (11.8%) | 304 (10.5%) | 288 (10.0%) | |
 BMI (kg/m2)a | 26.9 ± 3.2 | 27.1 ± 3.3 | 27.4 ± 3.4 | 27.8 ± 3.5 | < 0.001 |
   < 25 | 777 (27.8%) | 794 (27.3%) | 700 (24.4%) | 586 (20.5%) | < 0.001 |
  25–29 | 1545 (55.2%) | 1578 (54.3%) | 1570 (54.7%) | 1589 (55.5%) | |
   ≥ 30 | 478 (17.1%) | 532 (18.3%) | 601 (20.9%) | 688 (24.0%) | |
 Gravidity | |||||
   < 3 | 1937 (68.6%) | 2092 (71.4%) | 2088 (71.9%) | 2095 (72.4%) | 0.007 |
   ≥ 3 | 888 (31.4%) | 839 (28.6%) | 816 (28.1%) | 798 (27.6%) | |
 Parity | |||||
  No child | 1608 (56.9%) | 1773 (60.5%) | 1753 (60.4%) | 1802 (62.3%) | < 0.001 |
   ≥ 1 child | 1217 (43.1%) | 1158 (39.5%) | 1151 (39.6%) | 1091 (37.7%) | |
 Gestational age (week) | 38.7 ± 1.6 | 38.7 ± 1.5 | 38.7 ± 1.7 | 38.6 ± 1.8 | 0.184 |
 Systolic BP (mmHg) | 120.9 ± 12.2 | 120.6 ± 12.0 | 120.9 ± 11.8 | 121.5 ± 12.1 | 0.032 |
 Diastolic BP (mmHg) | 74.4 ± 8.3 | 74.4 ± 8.2 | 74.4 ± 8.1 | 74.9 ± 8.4 | 0.095 |
 Assisted reproduction | 71 (2.5%) | 64 (2.2%) | 66 (2.3%) | 63 (2.2%) | 0.814 |
 Delivery mode | |||||
  Vaginal delivery | 1663 (58.9%) | 1654 (56.4%) | 1665 (57.3%) | 1660 (57.4%) | 0.311 |
  Cesarean section | 1163 (41.1%) | 1277 (43.6%) | 1239 (42.7%) | 1233 (42.6%) | |
 Pregnancy complications | |||||
  GDM | 295 (10.4%) | 252 (8.6%) | 225 (7.7%) | 193 (6.7%) | < 0.001 |
  ICP | 246 (8.7%) | 166 (5.7%) | 164 (5.6%) | 135 (4.7%) | < 0.001 |
  PE | 115 (4.1%) | 91 (3.1%) | 80 (2.8%) | 108 (3.7%) | 0.026 |
  PIH | 61 (2.2%) | 53 (1.8%) | 57 (2.0%) | 74 (2.6%) | 0.220 |
  PTB | 179 (6.3%) | 187 (6.4%) | 187 (6.4%) | 238 (8.2%) | 0.009 |
Newborn characteristics | |||||
 Sex | |||||
  Female | 1273 (45.0%) | 1360 (46.4%) | 1387 (47.8%) | 1426 (49.3%) | 0.009 |
  Male | 1553 (55.0%) | 1571 (53.6%) | 1517 (52.2%) | 1467 (50.7%) | |
 Birth length (cm) | 49.8 ± 1.4 | 49.9 ± 1.3 | 49.8 ± 1.5 | 49.8 ± 1.5 | 0.297 |
 Birth weight (g) | 3346.0 ± 498.1 | 3353.2 ± 480.1 | 3339.9 ± 492.5 | 3330.5 ± 513.3 | 0.576 |
 Weight for gestational age | |||||
  SGA | 260 (9.2%) | 261 (8.9%) | 261 (9.0%) | 240 (8.3%) | 0.827 |
  AGA | 2119 (75.0%) | 2221 (75.8%) | 2209 (76.1%) | 2193 (75.8%) | |
  LGA | 447 (15.8%) | 449 (15.3%) | 434 (14.9%) | 460 (15.9%) | |
 Laboratory results | |||||
  MPV ( fl) | 12.1 ± 1.1 | 11.4 ± 1.0 | 11.0 ± 1.0 | 10.5 ± 0.9 | < 0.001 |
  RBC (1012/L) | 4.0 ± 0.3 | 4.0 ± 0.4 | 4.0 ± 0.3 | 4.1 ± 0.4 | < 0.001 |
  WBC (109/L) | 8.1 ± 2.1 | 8.6 ± 2.1 | 8.9 ± 2.2 | 9.4 ± 2.3 | < 0.001 |
  Vitamin B12 (pmol/L) | 170.6 ± 76.7 | 167.0 ± 75.3 | 156.2 ± 63.1 | 149.4 ± 66.3 | < 0.001 |
  Folic acid (nmol/L) | 30.2 ± 14.9 | 28.3 ± 14.7 | 25.9 ± 14.0 | 22.7 ± 13.2 | < 0.001 |
  tHcy (μmol/L) | 8.5 ± 2.8 | 8.4 ± 2.6 | 8.5 ± 2.6 | 8.7 ± 2.7 | 0.002 |
  TBA (μmol/L) | 5.9 ± 7.5 | 5.0 ± 4.0 | 5.1 ± 5.2 | 5.0 ± 6.6 | < 0.001 |
  hs-CRP (mg/L) | 2.6 (1.5–4.4) | 2.7 (1.5–4.9) | 3.0 (1.8–5.2) | 3.4 (1.9–5.8) | < 0.001 |
  Total bilirubin (μmol/L) | 8.3 ± 3.2 | 8.1 ± 3.1 | 7.7 ± 2.7 | 7.5 ± 2.9 | < 0.001 |
  Direct bilirubin (μmol/L) | 1.7 ± 1.2 | 1.6 ± 1.0 | 1.5 ± 0.9 | 1.5 ± 0.9 | < 0.001 |
  ALT (U/L) | 13.9 ± 20.6 | 11.3 ± 11.8 | 10.5 ± 8.2 | 10.4 ± 10.3 | < 0.001 |
  AST (U/L) | 22.4 ± 27.9 | 20.0 ± 9.3 | 19.2 ± 7.1 | 18.9 ± 9.7 | < 0.001 |
  Urea nitrogen (mmol/L) | 3.7 ± 1.0 | 3.6 ± 1.0 | 3.5 ± 0.9 | 3.5 ± 0.9 | < 0.001 |
  Creatinine (umol/L) | 61.4 ± 9.7 | 60.3 ± 9.7 | 59.7 ± 8.5 | 59.2 ± 7.9 | < 0.001 |
  Total cholesterol (mmol/L) | 6.3 ± 1.2 | 6.4 ± 1.2 | 6.4 ± 1.2 | 6.5 ± 1.2 | < 0.001 |
  Triglyceride (mmol/L) | 4.0 ± 1.9 | 3.9 ± 1.8 | 3.9 ± 1.7 | 4.0 ± 1.8 | 0.342 |
  LDL-C (mmol/L) | 3.3 ± 0.9 | 3.4 ± 0.9 | 3.4 ± 0.9 | 3.4 ± 0.9 | < 0.001 |
  HDL-C (mmol/L) | 1.7 ± 0.4 | 1.7 ± 0.3 | 1.7 ± 0.3 | 1.7 ± 0.3 | 0.121 |