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Table 4 Univariate and multilevel multivariable regression model for factors associated with self-reported diagnosis of gonorrhea (overall and symptomatic) in 68 countries1

From: Comparison of the burden of self-reported bacterial sexually transmitted infections among men having sex with men across 68 countries on four continents

 

Gonorrhea all

Classified symptomatic gonorrhea

Univariate analyses (N = 197,843)

Multivariable analysis (N = 182,449)

Univariate analyses (N = 192,315)

Multivariable analysis (N = 186,599)

OR

95% CI

p

aOR

95% CI

p

OR

95% CI

p

aOR

95% CI

p

Region

Central-West Europe (AT, CH, DE, LI, LU)

ref.

           

West Europe (BE, FR, IE, NL, MC, UK)

2.08

1.31–3.30

0.002

1.06

0.86–1.31

0.586

1.56

1.02–2.38

0.038

1.26

0.88–1.80

0.207

Southwest Europe (AD, ES, IT, MT, PT, SM)

1.02

0.62–1.68

0.925

1.20

0.89–1.62

0.241

0.91

0.57–1.45

0.693

0.72

0.48–1.07

0.103

Northwest Europe (DK, FI, IS, NO, SE)

0.97

0.60–1.58

0.913

0.77

0.58–1.02

0.064

0.89

0.56–1.41

0.616

0.89

0.60–1.32

0.561

Northeast Europe (EE, LT, LV)

0.18

0.07–0.45

< 0.001

0.55

0.13–2.34

0.414

0.17

0.04–0.74

0.018

0.17

0.04–0.71

0.015

Central-East Europe (CZ, HU, PL, SK, SL)

0.57

0.35–0.92

0.021

0.95

0.69–1.32

0.780

0.62

0.39–1.00

0.050

0.55

0.36–0.83

0.004

Southeast Europe (AL, BA, BU, CY, HR, GR, HR, ME, MK, RO, RS, TR, XK)

0.53

0.34–0.82

0.004

0.95

0.68–1.33

0.768

0.46

0.29–0.72

0.001

0.34

0.22–0.51

< 0.001

East Europe (BY, MD, RU, UA)

0.44

0.26–0.74

0.002

0.56

0.40–0.78

0.001

0.69

0.41–1.16

0.159

0.46

0.29–0.73

0.001

Middle East (IL, LB)

1.31

0.69–2.48

0.416

2.43

1.58–3.75

< 0.001

1.17

0.59–2.31

0.649

0.78

0.42–1.43

0.417

Philippines

0.76

0.36–1.62

0.479

0.78

0.48–1.24

0.291

1.07

0.54–2.14

0.841

0.87

0.48–1.56

0.629

Canada

1.66

0.79–3.48

0.181

0.96

0.69–1.33

0.793

1.20

0.62–2.32

0.592

0.89

0.51–1.54

0.666

Mexico

0.74

0.35–1.56

0.431

0.64

0.41–0.99

0.045

0.58

0.30–1.11

0.099

0.39

0.22–0.67

0.001

Central America (CR, GT, HN, NI, PA, SV)

0.74

0.46–1.19

0.219

0.74

0.52–1.05

0.095

0.78

0.48–1.27

0.322

0.62

0.40–0.96

0.033

Andean region (BO, EC, CO, PE, VE, SR)

0.78

0.49–1.24

0.290

0.81

0.56–1.18

0.276

0.83

0.53–1.29

0.400

0.58

0.40–0.86

0.007

Southern Cone (AR, CL, UY, PY)

0.68

0.41–1.13

0.140

0.64

0.44–0.94

0.023

0.77

0.48–1.26

0.299

0.55

0.36–0.84

0.005

Brazil

0.96

0.46–2.01

0.912

0.69

0.45–1.04

0.074

0.60

0.31–1.15

0.124

0.34

0.20–0.58

< 0.001

Survey artefacts

             

French translation

no

ref.

           

yes

1.62

1.41–1.87

< 0.001

1.59

1.38–1.83

< 0.001

1.03

0.78–1.37

0.822

0.89

0.68–1.15

0.368

Major data discrepancies

no

ref.

           

yes

1.28

1.20–1.36

< 0.001

1.20

1.12–1.28

< 0.001

1.06

0.94–1.20

0.320

0.98

0.86–1.11

0.710

Sample composition

             

Age group

< 25 years

ref.

           

25–29 years

1.47

1.38–1.57

< 0.001

1.18

1.10–1.27

< 0.001

1.26

1.12–1.42

< 0.001

1.06

0.94–1.19

0.375

30–39 years

1.44

1.35–1.53

< 0.001

1.01

0.94–1.08

0.777

1.20

1.07–1.34

0.001

0.91

0.81–1.02

0.101

40–49 years

1.04

0.97–1.11

0.287

0.67

0.62–0.73

< 0.001

0.83

0.73–0.95

0.005

0.57

0.50–0.66

< 0.001

50 + years

0.57

0.53–0.62

< 0.001

0.42

0.38–0.46

< 0.001

0.48

0.40–0.56

< 0.001

0.36

0.30–0.42

< 0.001

Settlement size (inhabitants)

village/countryside (< 10,000)

ref.

           

small town (10,000–99,999)

1.24

1.12–1.38

< 0.001

1.16

1.04–1.29

0.010

1.48

1.20–1.82

< 0.001

1.38

1.12–1.70

0.003

medium town (100,000–499,999)

1.71

1.55–1.88

< 0.001

1.38

1.24–1.53

< 0.001

1.84

1.51–2.24

< 0.001

1.61

1.31–1.96

< 0.001

big city (500,000–999,999)

2.17

1.96–2.40

< 0.001

1.50

1.35–1.67

< 0.001

2.54

2.08–3.10

< 0.001

2.06

1.68–2.52

< 0.001

very big city (≥ 1 million)

2.72

2.48–2.99

< 0.001

1.66

1.50–1.84

< 0.001

2.94

2.44–3.55

< 0.001

2.28

1.88–2.76

< 0.001

Diagnosed HIV

no

ref.

           

yes

2.06

1.96–2.17

< 0.001

1.36

1.27–1.45

< 0.001

1.38

1.23–1.54

< 0.001

1.03

0.91–1.16

0.672

Financial coping

comfortable

ref.

           

neither struggling nor comfortable

0.99

0.95–1.04

0.702

0.99

0.94–1.04

0.748

0.98

0.89–1.07

0.600

0.97

0.89–1.07

0.574

struggling

1.00

0.94–1.06

0.886

0.96

0.89–1.02

0.173

0.94

0.84–1.05

0.281

0.91

0.81–1.02

0.116

Testing behavior

             

Last STI screen

no screening

ref.

           

> 6–12 months ago

0.50

0.45–0.55

< 0.001

0.32

0.29–0.36

< 0.001

      

1–6 months ago

1.24

1.17–1.30

< 0.001

0.50

0.47–0.53

< 0.001

      

within the previous 4 weeks

2.28

2.15–2.42

< 0.001

0.68

0.63–0.73

< 0.001

      

Anal swab in the previous 12 months

no

ref.

           

yes

7.07

6.73–7.42

< 0.001

5.06

4.76–5.37

< 0.001

      

Sexual behavior

             

Number of sex partners, previous 12 months

none or one

ref.

           

2–4

1.55

1.41–1.70

< 0.001

1.37

1.20–1.58

< 0.001

1.66

1.40–1.98

< 0.001

1.52

1.19–1.95

0.001

5–7

2.70

2.46–2.96

< 0.001

2.09

1.80–2.42

< 0.001

3.14

2.65–3.72

< 0.001

2.65

2.04–3.44

< 0.001

8–10

3.51

3.18–3.89

< 0.001

2.46

2.11–2.86

< 0.001

3.79

3.15–4.56

< 0.001

3.01

2.29–3.96

< 0.001

11–20

5.27

4.85–5.74

< 0.001

3.38

2.93–3.91

< 0.001

4.86

4.15–5.69

< 0.001

3.70

2.85–4.80

< 0.001

> 20

10.34

9.53–11.21

< 0.001

5.01

4.34–5.79

< 0.001

8.40

7.21–9.78

< 0.001

5.79

4.47–7.51

< 0.001

Anal intercourse, condom use with last nonsteady partner (NSP)

no anal intercourse with NSP

ref.

           

never condom with NSP

3.80

3.41–4.23

< 0.001

1.44

1.23–1.69

< 0.001

3.40

2.78–4.17

< 0.001

1.54

1.16–2.03

0.003

seldom condom with NSP

7.67

6.98–8.42

< 0.001

1.78

1.52–2.07

< 0.001

5.59

4.67–6.69

< 0.001

1.77

1.35–2.33

< 0.001

sometimes condom with NSP

6.71

6.13–7.34

< 0.001

1.66

1.43–1.92

< 0.001

5.48

4.63–6.49

< 0.001

1.73

1.32–2.25

< 0.001

mostly condom with NSP

4.90

4.51–5.32

< 0.001

1.39

1.21–1.60

< 0.001

4.61

3.96–5.36

< 0.001

1.42

1.11–1.83

0.006

always condom with NSP

2.26

2.07–2.47

< 0.001

0.90

0.78–1.04

0.146

2.33

1.99–2.73

< 0.001

0.90

0.70–1.16

0.400

no answer condom with NSP

1.30

1.15–1.47

< 0.001

0.84

0.71–0.98

0.030

1.22

0.97–1.54

0.088

0.72

0.54–0.96

0.024

PrEP use

never/ don’t know

ref.

           

when needed

4.68

4.13–5.30

< 0.001

1.63

1.41–1.89

< 0.001

3.58

2.80–4.58

< 0.001

1.95

1.51–2.51

< 0.001

former daily use

3.83

3.10–4.74

< 0.001

1.70

1.33–2.17

< 0.001

3.10

2.03–4.72

< 0.001

1.81

1.18–2.78

0.007

current daily use

5.99

5.50–6.51

< 0.001

1.75

1.58–1.94

< 0.001

2.80

2.28–3.43

< 0.001

1.25

1.01–1.55

0.040

Multipartner sex during last NSP sex

no

ref.

           

yes

2.31

2.19–2.43

< 0.001

1.11

1.04–1.18

0.001

1.94

1.75–2.15

< 0.001

1.07

0.96–1.19

0.244

Country level rates

             

Country-level screening rates (quartiles)

0.81%–

ref.

           

1.92–

0.85

0.60–1.19

0.340

0.87

0.72–1.04

0.116

      

4.28–

1.07

0.72–1.59

0.728

1.29

1.02–1.62

0.031

      

7.63–35.96%

2.04

1.42–2.92

< 0.001

1.62

1.13–2.33

0.009

      

Country-level partner notification rates (quartiles)

25.00%–

ref.

           

61.29%–

0.81

0.55–1.20

0.292

0.49

0.39–0.63

< 0.001

      

73.08%–

0.93

0.62–1.41

0.741

0.48

0.37–0.62

< 0.001

      

83.33–100%

1.04

0.68–1.59

0.864

0.46

0.35–0.61

< 0.001

      
 

cons.

   

0.02

0.01–0.02

< 0.001

   

0.00

0.00–0.01

< 0.001

Random part

             

68 countries1

random intercept

   

0.01

0.00–0.03

    

0.05

0.02–0.10

 
  1. 1 This study includes 68 countries, with four European microstates included in neighboring (Andorra, Liechtenstein) or surrounding (Monaco, San Marino) countries, and with Albania, Montenegro and Kosovo merged to form a region; this results in 62 country-like entities included in the random part of the model
  2. Abbreviations: OR odds ratio; aOR adjusted odds ratio; CI confidence interval; STI sexually transmitted infection; NSP non-steady partner; PrEP pre-exposure prophylaxis
  3. Country labels: see Table 2