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Table 2 Global DALYs attributable to lead exposure in 1990 and 2019, and the temporal trend from 1990 to 2019

From: Patterns of global burden of 13 diseases attributable to lead exposure, 1990–2019

Cause of DALYs

1990

 

2019

 

1990–2019

DALYs

No.×105 (95% UI)

ASDR

per 100 000

(95%UI)

Age-standardized

PAF, %

No. (95%UI)

 

DALYs

No.×105 (95% UI)

ASDR

per 100 000

(95%UI)

Age-standardized

PAF, %

No. (95%UI)

 

AAPC of

ASDR (95%CI)

AAPC of age-standardized

PAF (95%CI)

All causes

          

 Both

160.25

(103.21, 221.68)

378.01

(240.55, 524.18)

0.76

(0.48, 1.05)

 

216.76

(138.13, 302.98)

267.52

(170.57, 373.44)

0.82

(0.53, 1.14)

 

-1.19

(-1.24, -1.14)

0.28

(0.23, 0.33)

 Female

58.31

(34.51, 84.98)

260.52

(150.50, 383.12)

0.56

(0.33, 0.82)

 

80.43

(48.18, 117.28)

188.85

(113.07, 274.64)

0.62

(0.38, 0.90)

 

-1.12

(-1.19, -1.05)

0.36

(0.29, 0.44)

 Male

101.94

(68.25, 136.87)

512.87

(339.34, 692.87)

0.95

(0.63, 1.28)

 

136.34

(88.81, 188.24)

357.56

(233.38, 493.30)

1.00

(0.67, 1.37)

 

-1.24

(-1.30, -1.18)

0.20

(0.15, 0.26)

Disease type

          

Cardiovascular diseases

128.85

(77.34, 186.47)

318.54

(190.85, 461.21)

4.50

(2.70, 6.45)

 

177.35

(104.88, 256.6)

216.80

(128.35, 314.82)

4.46

(2.67, 6.35)

 

-1.32

(-1.39, -1.25)

-0.04

(-0.16, 0.08)

 Rheumatic heart disease

3.20

(1.69, 5.44)

7.18

(3.87, 12.16)

2.53

(1.40, 4.25)

 

2.14

(1.07, 3.73)

2.58

(1.28, 4.55)

1.95

(1.00, 3.42)

 

-3.46

(-3.58, -3.34)

-0.91

(-1.02, -0.80)

 Ischemic heart disease

54.09

(31.78, 79.51)

134.35

(78.06, 199.09)

4.27

(2.50, 6.29)

 

83.69

(48.96, 124.49)

102.26

(59.74, 152.87)

4.56

(2.72, 6.68)

 

-0.94

(-1.01, -0.88)

0.22

(0.04, 0.40)

 Stroke

54.37

(32.53, 79.52)

133.36

(80.09, 195.09)

4.88

(2.94, 7.03)

 

67.39

(39.12, 98.16)

81.97

(47.86, 119.11)

4.64

(2.73, 6.69)

 

-1.66

(-1.76, -1.57)

-0.18

(-0.26, -0.09)

 Hypertensive heart disease

13.08

(5.90, 26.76)

33.36

(14.33, 69.08)

9.11

(4.15, 18.20)

 

17.70

(6.64, 38.45)

22.04

(8.09, 47.48)

8.20

(3.12, 17.26)

 

-1.43

(-1.56, -1.30)

-0.36

(-0.42, -0.31)

 Non-rheumatic valvular heart disease

0.20

(0.09, 0.35)

0.53

(0.23, 0.88)

1.18

(0.54, 1.95)

 

0.32

(0.15, 0.54)

0.40

(0.18, 0.68)

1.12

(0.52, 1.89)

 

-0.92

(-1.09, -0.75)

-0.19

(-0.25, -0.12)

 Cardiomyopathy and myocarditis

0.62

(0.26, 1.08)

1.57

(0.65, 2.70)

0.97

(0.41, 1.68)

 

0.74

(0.29, 1.37)

0.92

(0.36, 1.68)

0.80

(0.32, 1.47)

 

-1.85

(-1.88, -1.81)

-0.69

(-0.92, -0.46)

 Atrial fibrillation and flutter

1.02

(0.53, 1.65)

2.75

(1.44, 4.45)

2.50

(1.40, 3.71)

 

2.27

(1.25, 3.63)

2.85

(1.56, 4.57)

2.66

(1.55, 3.89)

 

0.13

(0.10, 0.15)

0.22

(0.19, 0.25)

 Aortic aneurysm

0.47

(0.21, 0.81)

1.15

(0.51, 2.00)

2.26

(1.06, 3.66)

 

0.70

(0.35, 1.15)

0.85

(0.42, 1.40)

2.08

(1.05, 3.34)

 

-1.06

(-1.19, -0.93)

-0.29

(-0.40, -0.19)

 Peripheral artery disease

0.10

(0.04, 0.19)

0.27

(0.11, 0.54)

1.22

(0.55, 2.08)

 

0.20

(0.09, 0.38)

0.25

(0.11, 0.48)

1.30

(0.60, 2.20)

 

-0.26

(-0.30, -0.22)

0.23

(0.19, 0.27)

 Endocarditis

0.20

(0.10, 0.33)

0.45

(0.22, 0.74)

1.97

(0.99, 3.27)

 

0.28

(0.13, 0.50)

0.34

(0.15, 0.62)

1.55

(0.71, 2.69)

 

-0.92

(-1.07, -0.77)

-0.80

(-0.84, -0.76)

 Other cardiovascular and circulatory diseases

1.50

(0.80, 2.43)

3.56

(1.94, 5.75)

2.34

(1.28, 3.67)

 

1.92

(1.04, 3.04)

2.33

(1.26, 3.69)

2.10

(1.16, 3.26)

 

-1.45

(-1.50, -1.40)

-0.36

(-0.46, -0.27)

Mental disorders

25.18

(11.43, 43.54)

44.18

(19.98, 76.61)

2.80

(1.31, 4.70)

 

27.16

(12.10, 48.35)

35.70

(15.89, 63.6)

2.29

(1.06, 3.89)

 

-0.74

(-0.75, -0.72)

-0.70

(-0.71, -0.69)

 Idiopathic developmental intellectual disability

25.18

(11.43, 43.54)

44.18

(19.98, 76.61)

66.50

(35.59, 84.36)

 

27.16

(12.1, 48.35)

35.70

(15.89, 63.6)

61.94

(32.07, 80.16)

 

-0.74

(-0.75, -0.72)

-0.25

(-0.25, -0.24)

Diabetes and kidney diseases

6.23

(3.73, 9.08)

15.29

(9.19, 22.14)

1.29

(0.76, 1.88)

 

12.25

(7.08, 18.18)

15.02

(8.68, 22.26)

1.09

(0.62, 1.64)

 

-0.06

(-0.17, 0.04)

-0.57

(-0.67, -0.47)

 Chronic kidney disease

6.23

(3.73, 9.08)

15.29

(9.19, 22.14)

3.16

(1.90, 4.63)

 

12.25

(7.08, 18.18)

15.02

(8.68, 22.26)

2.92

(1.70, 4.33)

 

-0.06

(-0.17, 0.04)

-0.28

(-0.36, -0.21)

  1. Note: DALYs, disability-adjusted life years; ASDR, age-standardized DALY rate; PAF, population attributable fraction; AAPC, average annual percentage change; UI, uncertainty interval; CI, confidence interval