Table 2 Association between aMED, sleep disorder and mortality

All-cause mortality

Higher aMED

Reference

Median aMED

1.25 (1.10–1.44)

0.001

1.49 (1.30–1.71)

< 0.0001

1.35 (1.16–1.57)

0.0001

1.36 (1.14–1.63)

0.0006

Lower aMED

1.50 (1.32–1.69)

< 0.0001

1.77 (1.58–1.98)

< 0.0001

1.45 (1.27–1.66)

< 0.0001

1.42 (1.20–1.67)

< 0.0001

aMED(continuous)

1.12 (1.08–1.16)

< 0.0001

1.18 (1.15–1.22)

< 0.0001

1.11 (1.07–1.15)

< 0.0001

1.09 (1.04–1.15)

0.0005

Sleep disorder*

1.63 (1.39–1.91)

< 0.0001

1.41 (1.21–1.63)

< 0.0001

1.49 (1.26–1.75)

< 0.0001

1.42 (1.15–1.75)

0.0011

CVD mortality

Higher aMED

Reference

Median aMED

1.19 (0.95–1.49)

0.1275

1.44 (1.14–1.82)

0.0025

1.27 (0.98–1.66)

0.0703

1.05 (0.94–1.50)

0.1023

Lower aMED

1.35 (1.07–1.70)

0.0107

1.59 (1.27-2.00)

< 0.0001

1.28 (1.05–1.65)

0.0321

1.13 (1.05–1.51)

0.0422

aMED(continuous)

1.10 (1.03–1.18)

0.0035

1.17 (1.09–1.25)

< 0.0001

1.09 (1.01–1.17)

0.0341

0.99 (0.85–1.15)

0.8960

Sleep disorder*

1.84 (1.34–2.51)

0.0001

1.66 (1.22–2.27)

0.0013

1.83 (1.36–2.47)

< 0.0001

1.61 (1.10–2.35)

0.0148

Cancer mortality

Higher aMED

Reference

Median aMED

0.99 (0.68–1.43)

0.9377

1.16 (0.81–1.66)

0.427

1.07 (0.73–1.56)

0.7411

1.32 (0.79–2.21)

0.29

Lower aMED

1.16 (0.91–1.47)

0.2457

1.35 (1.07–1.72)

0.0132

1.20 (0.93–1.55)

0.1713

1.21 (0.78–1.87)

0.3947

aMED(continuous)

1.04 (0.99–1.11)

0.1424

1.10 (1.04–1.17)

0.0007

1.06 (0.99–1.13)

0.0920

1.07 (0.96–1.19)

0.2454

Sleep disorder*

1.11 (0.79–1.55)

0.5493

0.93 (0.67–1.30)

0.6736

0.98 (0.69–1.39)

0.9166

1.04 (0.64–1.68)

0.8804