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Table 2 Base-case results from (a) societal perspective (including productivity loss) and (b) with direct costs only (no productivity loss)

From: COVID-19 testing protocols to guide duration of isolation: a cost-effectiveness analysis

Optiona

Testing cost

Medical cost

Productivity loss for index infection

Net cost

Secondary infections

Incremental cost

Secondary infections averted

Incremental cost per secondary infection averted

2a. Societal perspective (including productivity loss)

5-day isolation, no test

$0

$33,086

$0

$33,086

23.04

n/a

n/a

n/a

Symptom check on day 5

$0

$25,605

$19,368

$44,973

17.83

$11,887

5.21

Extended dominatedb

Antigen test on day 5 (8-day isolation)

$1,000

$14,391

$38,564

$53,954

10.02

$20,868

13.02

Extended dominated b

Antigen test on day 6

$1,000

$4,132

$58,056

$63,189

2.88

$30,103

20.16

$1,493

Antigen test on day 5

$1,000

$8,159

$64,273

$73,432

5.68

$10,243

-2.80

Dominated

PCR test on day 5

$15,000

$5,112

$72,099

$92,211

3.56

$29,022

-0.68

Dominated

2b. Direct costs only (no productivity loss)

Antigen test on day 6

$1,000

$4,132

-

$5,132

2.88

n/a

n/a

Dominant

Antigen test on day 5

$1,000

$8,159

-

$9,159

5.68

$4,027

-2.80

Dominated

Antigen test on day 5, (8-day isolation)

$1,000

$14,391

-

$15,391

10.02

$10,258

-7.14

Dominated

PCR test on day 5

$15,000

$5,112

-

$20,112

3.56

$14,979

-0.68

Dominated

Symptom check on day 5

$0

$25,605

-

$25,605

17.83

$20,472

-14.95

Dominated

5-day isolation, no test

$0

$33,086

-

$33,086

23.04

$27,953

-20.16

Dominated

  1. Values are per 100 people. De-isolation protocols are compared to previous non-dominated protocol
  2. a Isolation duration is up to 10 days unless otherwise noted
  3. b Strategy is extended dominated, i.e., a more expensive strategy (lower in the table) has a lower cost/infection averted ratio. Ratios that are not shown due to weak dominance are as follows: $2,282 for symptom check on day five versus no test; $1,150 for antigen test on day five of eight-day isolation versus symptom check; $1,603 for antigen test on day five of eight-day isolation versus no test; and $1,293 for antigen test on day six versus antigen test on day five of eight-day isolation