Genetic association of telomere length, obesity and tobacoo smoking with idiopathic pulmonary fibrosis risk

BMC Public Health

Table 2 Effect of telomere length and associated factors on idiopathic pulmonary fibrosis risk

Exposures	Modes	No. of SNPs ^a	P value for MR	OR (95%CI)	P value for Cochran’s Q	P value for MR-Egger intercept
Telomere
Telomere length	IVW	96	<0.001	0.459 (0.327~0.643)	0.384	0.110
	MR-Egger	96	<0.001	0.284 (0.145~0.556)
Telomere length ^b	IVW	85	<0.001	0.475 (0.336~0.670)	0.665	0.121
	MR-Egger	85	<0.001	0.298 (0.152~0.586)
Tobacco smoking
Heavy smoking	IVW	19	0.627	1.066 (0.823~1.382)	0.903	0.860
	MR-Egger	19	0.891	1.032 (0.663~1.607)
Smoking initiation	IVW	77	0.571	1.113 (0.769~1.611)	0.155	0.561
	MR-Egger	77	0.495	1.905 (0.303~11.987)
Age of initiation	IVW	20	0.001	0.136 (0.040~0.464)	0.134	0.104
	MR-Egger	20	0.251	102.692 (0.049~2.136e+05)
Age of initiation ^c	IVW	16	0.001	0.108 (0.029~0.402)	0.300	0.643
	MR-Egger	16	0.943	1.505 (2.592e-05~8.742e+04)
Smoking cessation	IVW	19	0.540	0.852 (0.511~1.422)	0.841	0.865
	MR-Egger	19	0.975	0.974 (0.195~4.860)
Maternal smoking	IVW	50	0.002	15.487 (2.679~89.543)	0.404	0.717
	MR-Egger	50	0.812	2.995 (0.001~2.446e+04)
Maternal smoking ^c	IVW	40	0.011	13.183 (1.820~95.484)	0.421	0.631
	MR-Egger	40	0.968	1.228 (6.682e-05~2.256e+04)
Alcohol drinking
Heavy drinking	IVW	29	0.405	1.446 (0.607~3.442)	0.542	0.861
	MR-Egger	29	0.610	1.704 (0.226~12.874)
Obesity
Body mass index	IVW	443	0.005	1.386 (1.106~1.737)	0.264	0.069
	MR-Egger	443	0.006	2.354 (1.276~4.340)
Body mass index ^d	IVW	403	0.005	1.425 (1.114~1.823)	0.201	0.164
	MR-Egger	403	0.001	3.200 (1.586~6.455)
Body fat percentage	IVW	315	0.017	1.502 (1.075~2.097)	0.090	0.130
	MR-Egger	315	0.031	3.384 (1.127~10.163)
Body fat percentage ^d	IVW	294	0.003	1.702 (1.202~2.409)	0.143	0.083
	MR-Egger	294	0.011	4.603 (1.424~14.880)

^a IVW = Inverse variance weighted; SNP = SNP = Single nucleotide polymorphism; OR = Odds ratio; 95%CI = 95% Confidence interval; P value for MR = P value for Mendelian randomization
^b The SNPs associated with smoking or obesity were excluded. ^c The SNPs associated with telomere length or obesity were excluded. ^d The SNPs associated with telomere length or smoking were excluded

ISSN: 1471-2458