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Table 3 The estimated annual percentage change (APC) and 95% confidence intervals (CI) of mortality rates by cause of deaths for different subgroup cases

From: Trends in cause of death among patients with renal cell carcinoma in the United States: a SEER-based study

Characteristics

All-cause

Died from RCC

Died from other cause

Period

APC (95% CI)

P-value

Period

APC (95% CI)

P-value

Period

APC (95% CI)

P-value

Overall patients

1992–1997

16.8% (11.9–21.9)

 < 0.001

1992–1996

19.8% (11.1–29.2)

 < 0.001

1992–2001

13.1% (10.9–15.4)

 < 0.001

1997–2018

2.0% (1.6–2.3)

 < 0.001

1996–2018

-0.5% ( -0.9–0.1)

0.009

2001–2018

3.7% (3.2–4.1)

 < 0.001

Age

 < 60

1992–1994

65.0% (28.6–111.6)

 < 0.001

1992–1994

69.5% (25.1–129.7)

0.002

1992–2001

14.1% (9.6–18.8)

 < 0.001

1994–2018

2.3% (2.0–2.5)

 < 0.001

1994–2018

-0.3% ( -0.70–1)

0.099

2001–2018

5.3% (4.5–6.0)

 < 0.001

60–70

1992–1997

18.2% (12.4–24.3)

 < 0.001

1992–1997

15.0% (7.9–22.6)

 < 0.001

1992–2001

15.5% (12.2–18.8)

 < 0.001

1997–2018

2.6% (2.2–2.9)

 < 0.001

1997–2018

-0.6% ( -1.1–0.01)

0.034

2001–2018

4.7% (4.1–5.3)

 < 0.001

 > 70

1992–1998

13.3% (9.2–17.6)

 < 0.001

1992–1995

28.1% (13.0–45.3)

 < 0.001

1992–1999

15.8% (12.1–19.7)

 < 0.001

1998–2018

1.5% (1.1–1.9)

 < 0.001

1995–2018

-0.4% ( -0.8–0.01)

0.0501

1999–2018

3.0% (2.6–3.4)

 < 0.001

Sex

Male

1992–1997

17.1% (11.4–23.2)

 < 0.001

1992–1996

21.0% (9.7–33.5)

0.001

1992–2002

11.4% (9.4–13.5)

 < 0.001

1997–2018

2.0% (1.6–2.3)

 < 0.001

1996–2018

-0.3% ( -0.8–0.2)

0.180

2002–2018

3.3% (2.8–3.8)

 < 0.001

Female

1992–1996

21.5% (13.3–30.4)

 < 0.001

1992–1994

23.6% (16.2–31.4)

 < 0.001

1992–1999

18.3% (13.1–23.7)

 < 0.001

1996–2018

1.8% (1.5–2.1)

 < 0.001

1994–2018

-1.2% ( -1.4–1.0)

 < 0.001

1999–2018

4.0% (3.5–4.5)

 < 0.001

Race

White

1992–1997

17.1% (12.0–22.4)

 < 0.001

1992–1996

20.1% (11.4–29.6)

 < 0.001

1992–2001

13.7% (11.5–15.9)

 < 0.001

1997–2018

2.1% (1.8–2.4)

 < 0.001

1996–2018

-0.4% ( -0.8- -0.01)

0.039

2001–2018

3.9% (3.5–4.3)

 < 0.001

Black

1992–1995

35.1% (15.5–58.1)

0.001

1992–1995

33.8% (9.4–63.6)

0.007

1992–1999

14.4% (7.7–21.6)

 < 0.001

1995–2018

2.0% (1.6–2.4)

 < 0.001

1995–2018

-0.8% (-1.4–0.3)

0.007

1999–2018

3.2% (2.5–4.0)

 < 0.001

Stage

Localized

1992–2003

15.1% (11.7–18.5)

 < 0.001

1992–2002

14.1% (8.4–20.0)

 < 0.001

1992–2005

13.7% (11.3–16.1)

 < 0.001

2003–2018

2.8% (1.9–3.8)

 < 0.001

2002–2018

-0.1% ( -1.5–1.3)

0.902

2005–2018

3.0% (2.0–4.1)

 < 0.001

Regional

1992–1999

15.9% (8.1–24.2)

 < 0.001

1992–1996

31.9% (7.7–61.4)

0.010

1992–2001

16.7% (11.2–22.4)

 < 0.001

1999–2018

-0.4% ( -1.4–0.6)

0.390

1996–2018

-1.4% ( -2.3–0.4)

0.008

2001–2018

0.9% ( -0.2–1.9)

0.097

Distant

1992–2015

-0.01% (-0.8- 0.8)

0.916

1992–2015

-0.2% ( -1.0–0.6)

0.589

1992–2015

-0.1% ( -0.6–0.5)

0.804

2015–2018

-49.0% (-62.4–30.8)

 < 0.001

2015–2018

-52.3% ( -66.3- -32.7)

 < 0.001

2015–2018

-22.3% ( -29.6–14.2)

 < 0.001

  1. RCC renal cell carcinoma, APC annual percentage change, CI confidence interval