Sex differences in impact of cumulative systolic blood pressure from childhood to adulthood on albuminuria in midlife: a 30-year prospective cohort study

Table 3 Association of SBP incremental AUC groups with midlife albuminuria by sex

Characteristics	N (%)	Unadjusted		Model 1		Model 2
Characteristics	N (%)	OR(95%CI)	P value	OR(95%CI)	P value	OR(95%CI)	P value	P*
Total subjects
Low	50 (8.9%)	1.00	-	1.00	-	1.00	-	0.040
Middle	64 (11.4%)	1.32 (0.89–1.94)	0.168	1.42 (0.92–2.18)	0.112	1.48 (0.94–2.31)	0.089
High	76 (13.5%)	1.60 (1.10–2.34)	0.015^#	1.52 (0.94–2.45)	0.087	1.60 (0.98–2.62)	0.062
Male Subjects
Low	20 (9.7%)	1.00	-	1.00	-	1.00	-
Middle	30 (9.1%)	0.93 (0.52–1.69)	0.820	0.87 (0.45–1.66)	0.665	1.00 (0.50–2.02)	0.992
High	51 (11.5%)	1.21 (0.70–2.09)	0.494	0.90 (0.47–1.75)	0.764	1.08 (0.54–2.17)	0.829
Female Subjects
Low	30 (8.5%)	1.00	-	1.00	-	1.00	-
Middle	34 (14.7%)	1.86 (1.10–3.14)	0.020	1.90 (1.07–3.40)	0.029	1.83 (1.01–3.33)	0.046
High	25 (21.2%)	2.91 (1.63–5.19)	< 0.001^#	2.52 (1.25–5.07)	0.010^#	2.34 (1.14–4.79)	0.020^#

Model 1: adjusted for age, gender, systolic blood pressure, body mass index at baseline, body mass index, waist, hips, smoking, alcohol consumption, exercise, and history of hypertension, diabetes, hyperlipidaemia in 2017.
Model 2: adjusted for model 1 + fasting blood glucose, ALT, AST, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, serum uric acid and serum creatinine.
P*: p value for interaction terms of incremental AUC and sex.
^#: p value was considered significant after false discovery rate correction.

ISSN: 1471-2458